AIMS: Although anxiety and depression are frequently linked to coronary heart disease, a network analysis of comorbid anxiety and depression and their association with quality of life in patients undergoing percutaneous coronary intervention (PCI) remains unclear from the perspective of symptom interactions. We aimed to investigate the network structure and symptom patterns of anxiety and depression, and their relationship with quality of life in patients undergoing PCI. METHODS AND RESULTS: This study included 528 patients undergoing PCI. The seven-item Generalized Anxiety Disorder Scale, nin...