摘要：
目的:基于CiteSpace对国内外有关喘息服务的研究现状、热点和趋势进行可视化分析。方法:检索Web of Science(WoS)核心合集和中国知网(CNKI)相关文献记录,通过CiteSpace 6.1.R2对作者...展开更多 目的:基于CiteSpace对国内外有关喘息服务的研究现状、热点和趋势进行可视化分析。方法:检索Web of Science(WoS)核心合集和中国知网(CNKI)相关文献记录,通过CiteSpace 6.1.R2对作者、国家、机构和关键词等内容进行可视化分析。结果:共纳入文献915篇,其中中文文献144篇、外文文献771篇;国内外喘息服务发文量均呈持续增长趋势;研究热点集中于老年人、失能、失智、居家喘息服务等。结论:通过CiteSpace软件直观展现国内外喘息服务研究热点,可为前沿研究提供新的探索视角。收起
摘要：
BackgroundTraditional emulsion adjuvants are limited in clinical application because of their surfactant dependence. Graphene oxide (GO) has unique amphiphilic properties and therefore has potential to be used as a surfactant substitute to stabilize Pickering emulsions. MethodsIn this study, GO-stabilized Pickering emulsion (GPE) was prepared and used as an adjuvant to facilitate an enhanced immune response to the Chlamydia trachomatis (Ct) Pgp3 recombinant vaccine. Firstly, GPE was prepared by optimizing the sonication conditions, pH, salinity, GO concentration, and water/oil ratio. GPE with small-size droplets was characterized and chosen as the candidate. Subsequently, controlled-release antigen delivery by GPE was explored. Cellular uptake behaviors, M1 polarization, and cytokine stimulation by GPE + Pgp3 was considered in terms of the production of macrophages. Finally, GPE's adjuvant effect was evaluated by vaccination with Pgp3 recombinant in BALB/c mouse models. ResultsGPE with the smallest droplet sizes was prepared by sonication under 163 W for 2 min at 1 mg/mL GO in natural salinity with a pH of 2 when the water/oil ratio was 10:1 (w/w). The optimized average GPE droplet size was 1.8 mu m and the zeta potential was -25.0 +/- 1.3 mv. GPE delivered antigens by adsorption onto the droplet surface, demonstrating the controlled release of antigens both in vitro and in vivo. In addition, GPE promoted antigen uptake, which stimulated proinflammatory tumor necrosis factor alpha (TNF-alpha), enhancing the M1 polarization of macrophages in vitro. Macrophage recruitment was also significantly promoted by GPE at the injection site. In the GPE + Pgp3 treatment group, higher levels of immunoglobin (IgG), immunoglobin G1 (IgG1), immunoglobin G2a (IgG2a) sera, and immunoglobin A (IgA) were detected in vaginal fluid, and higher levels of IFN-gamma and IL-2 secretion were stimulated, than in the Pgp3 group, showing a significant type 1 T helper (Th1)-type cellular immune response. Chlamydia muridarum challenging showed that GPE enhanced Pgp3's immunoprotection through its advanced clearance of bacterial burden and alleviation of chronic pathological damage in the genital tract. ConclusionThis study enabled the rational design of small-size GPE, shedding light on antigen adsorption and control release, macrophage uptake, polarization and recruitment, which enhanced augmented humoral and cellular immunity and ameliorated chlamydial-induced tissue damage in the genital tract.
期刊：
Canadian Journal of Nursing Research,2023年55(3):305-318 ISSN：0844-5621
作者机构：
[Zou, Ping] School of Nursing, Nipissing University, Toronto, Ontario, Canada. RINGGOLD: 6057;[Alam, Arzoo] Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada. RINGGOLD: 7938;[Shao, Jing] Institute of Nursing Research, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China;[Luo, Yan] Faculty of Nursing, Health Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi, P. R. China;[Huang, Yanjin] School of Nursing, University of South China, Hengyang, Hunan, P. R. China. RINGGOLD: 34706
摘要：
Canadian Journal of Nursing Research, Volume 55, Issue 3, Page 305-318, September 2023. <br/>BackgroundSouth Asians make up a significant portion of the immigrant population in Canada, and a large portion of them are in their midlife. To improve the midlife transition of South Asian immigrant women, it is necessary to understand their lived experiences.PurposeGuided by the transition theory, this study investigates the midlife experiences of South Asian immigrant women in Canada.MethodsTwenty-two South Asian midlife, immigrant women were recruited to participate in this study from the Greater Toronto Area, Ontario, Canada. This study consisted of one asynchronous online focus group with 12 participants and ten one-on-one telephone interviews. Qualitative content analysis was guided by transition theory.ResultsSouth Asian immigrant women experienced many different transitions in their midlife in Canada. These transitions included changes in their (a) lifestyle, (b) career, (c) family, (d) physical health, (e) mental health, (f) social, (g) environment, and (h) personal development. Women actively managed their transitions using strategies such as exercise, socialization, counseling, and religion. Women expressed the need for social, community, and governmental support to facilitate their midlife transitions.ConclusionTo promote healthy midlife transition, governments need to create better employment policies to facilitate immigrant women settlement, transferring skills, and re-employment in Canada. In addition, health care and community services to promote physical and mental health should be emphasized.
作者机构：
[He, Zhiqing; Huang, YJ; Huang, Yanjin; Wang, Qi; Xu, Chaoyue] Univ South China, Hengyang Med Sch, Sch Nursing, Hengyang, Peoples R China.;[Zou, Ping] Nipissing Univ, Toronto, ON, Canada.;[Yang, Jing] Univ South China, Affiliated Hosp 2, Hengyang, Peoples R China.
通讯机构：
[Huang, YJ ] U;Univ South China, Hengyang Med Sch, Sch Nursing, Hengyang, Peoples R China.
摘要：
BACKGROUND: Coronary Heart Disease (CHD) is one of the most prevalent chronic diseases worldwide. Currently, percutaneous coronary intervention (PCI) with stent implantation is the main clinical treatment for CHD, and patients can achieve better outcomes after stenting. However, adverse cardiovascular events continue to recur, ultimately failing to yield good results. Several symptoms exist after stenting and are associated with health outcomes. Little is known about the symptom patterns of patients during the different postoperative periods. Therefore, this study aims to explore the dynamics of symptoms and clarify the experiences of post-stenting in patients during different periods, which may help the delivery of more specific patient management and improve survival outcomes in the future. METHODS: A mixed method (quantitative/qualitative) design will be adopted. Longitudinal research, including surveys regarding three different periods, will be sued to describe the symptom patterns of patients undergoing PCI with stent implantation, clarifying their focused symptom problems during different time periods or in populations with different features. Qualitative individual interviews aim to understand the feelings, experiences, opinions, and health conditions of patients post-stenting, which can explain and supplement quantitative data. Quantitative data will be analyzed using descriptive statistics, latent class analysis (LCA), and latent translation analysis (LTA). Qualitative data will be analyzed using content analysis. DISCUSSION: This study is the first study to explore the symptom patterns and experiences of patients in various domains after stent implantation using a novel design including quantitative and qualitative methods, which will help the delivery of more specific patient management, reduce the recurrence of adverse cardiovascular events, and improve survival outcomes in the future. It is also meaningful to use PROMIS profile-57 to help patients to proactively focus on their health problems, promote health literacy, and incorporate active patient participation into health management, which is a successful transition from passive medical treatment to active management.
摘要：
Mammalian autophagy-related protein Atg8, including the LC3 subfamily and GABARAP subfamily. Atg8 proteins play a vital role in autophagy initiation, autophagosome formation and transport, and autophagy-lysosome fusion. GABARAP subfamily proteins (GABARAPs) share a high degree of homology with LC3 family proteins, and their unique roles are often overlooked. GABARAPs are as indispensable as LC3 in autophagy. Deletion of GABARAPs fails autophagy flux induction and autophagy lysosomal fusion, which leads to the failure of autophagy. GABARAPs are also involved in the transport of selective autophagy receptors. They are engaged in various particular autophagy processes, including mitochondrial autophagy, endoplasmic reticulum autophagy, Golgi autophagy, centrosome autophagy, and dorphagy. Furthermore, GABARAPs are closely related to the transport and delivery of the inhibitory neurotransmitter γ-GABA(A) and the angiotensin II AT1 receptor (AT1R), tumor growth, metastasis, and prognosis. GABARAPs also have been confirmed to be involved in various diseases, such as cancer, cardiovascular disease, and neurodegenerative diseases. In order to better understand the role and therapeutic potential of GABARAPs, this article comprehensively reviews the autophagic and non-autophagic functions of GABARAPs, as well as the research progress of the role and mechanism of GABARAPs in cancer, cardiovascular diseases and neurodegenerative diseases. It emphasizes the significance of GABARAPs in the clinical prevention and treatment of diseases, and may provide new therapeutic ideas and targets for human diseases. GABARAP and GABARAPL1 in the serum of cancer patients are positively correlated with the prognosis of patients, which can be used as a clinical biomarker, predictor and potential therapeutic target. GABARAP family proteins: autophagy and non-autophagy related functions in diseases. By Figdraw ( https://www.figdraw.com ).
期刊：
International Journal of Nursing Practice,2023年29(6):e13141- ISSN：1322-7114
通讯作者：
Lingling Gao PhD
作者机构：
[Han, Rongrong; Xiang, Zhixuan; Chen, Lu; Gao, Lingling; Yang, Xiao] Sun Yat Sen Univ, Sch Nursing, Guangzhou, Peoples R China.;[Li, Hanbing] Univ South China, Sch Nursing, Hengyang, Peoples R China.;[Zhao, Qian] Gem Flower Xian Changqing Staff Hosp, Party Comm, Xian, Peoples R China.;[Gao, Lingling] Sun Yat sen Univ, Sch Nursing, 74 Zhongshan Rd 2, Guangzhou 510080, Peoples R China.
通讯机构：
[Lingling Gao PhD] P;Professor in Nursing<&wdkj&>School of Nursing, Sun Yat-Sen University, Guangzhou, China
关键词：
clinical practice guidelines;exercise;gestational diabetes mellitus;physical activity;pregnancy;systematic reviews
摘要：
This review aimed to appraise clinical guidelines about exercise for women with gestational diabetes mellitus and summarize consensus and inconsistent recommendations.
Exercise is an effective non-pharmacological therapeutic for gestational diabetes mellitus, but the variety of relevant clinical practice guidelines is confusing for healthcare professionals.
This is a systematic review of clinical practice guidelines.
Websites of guideline development institutions, eight literature databases and organizations of obstetricians, gynaecologists, midwives, and medical sports associations were searched for guidelines published from January 2011 to October 2021.
Two reviewers independently extracted recommendations. Four reviewers assessed guideline quality using the AGREE II instrument independently.
Fifteen guidelines were included. All women with diabetes are recommended to exercise during pregnancy. The consistent recommendations were for pre-exercise screening, for 30 min per exercise session on 5 days of the week or every day after meals, exercise at moderate intensity, using aerobic and resistance exercise, and walking. The main non-consistent recommendations included warning signs for women on insulin during exercise, minimum duration per session, intensity assessment, duration and frequency of sessions for strengthening and flexibility exercise and detailed physical activity giving birth.
Guidelines strongly support pregnant women with diabetes to exercise regularly. Research is needed to make non-consistent recommendations clear.
What is already known about this topic?
What this paper adds?
The implications of this paper:
