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Hepatitis B core virus-like particles bearing Pgp3 antigen enhance immune response against genital chlamydial infection in mice

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成果类型:
期刊论文
作者:
Wang, Xinglv;Shi, Keliang;Zhao, Lanhua;Cheng, Shan;Chen, Lili;...
通讯作者:
Li, ZY
作者机构:
[Li, Zhongyu; Shi, Keliang; Li, ZY; Wang, Xinglv; Zhao, Lanhua; Chen, Lili; Cheng, Shan] Univ South China, Inst Pathogen Biol, Hunan Prov Key Lab Special Pathogens Prevent & Con, Sch Nursing,Hengyang Med Coll, Hengyang 421001, Hunan, Peoples R China.
通讯机构:
[Li, ZY ] U
Univ South China, Inst Pathogen Biol, Hunan Prov Key Lab Special Pathogens Prevent & Con, Sch Nursing,Hengyang Med Coll, Hengyang 421001, Hunan, Peoples R China.
语种:
英文
关键词:
Adjuvant;Chlamydia trachomatis;HBc-VLP;Immunoprotection;Pgp3
期刊:
International Immunopharmacology
ISSN:
1567-5769
年:
2025
卷:
146
页码:
113663
基金类别:
Science Foundation of China [2024JJ5341]; Key Guidance Project of Hunan Provincial Health Commission [C202304127239]
机构署名:
本校为第一且通讯机构
院系归属:
医学院
护理学院
摘要:
Chlamydia trachomatis Pgp3 protein-induced immunoprotection is effective but incomplete, which requires the suitable adjuvants to enhance its immune response. Within this context, Hepatitis B core virus-like particles (HBc-VLP) emerge as nanoscale protein particles capable of incorporating either endogenous or exogenous antigens or epitopes. In this study, HBc-Pgp3 chimeric protein was accomplished by integrating the identified dominant epitope of the Pgp3 protein into the major immunodominant region of a truncated HBc-VLP, which was realized i...

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