MicroRNA-296: a promising target in the pathogenesis of atherosclerosis?

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Li, Heng;Ouyang, Xin-Ping;Jiang, Ting;Zheng, Xi-Long;He, Ping-Ping*;...

通讯作者：

He, Ping-Ping;Zhao, Guo-Jun

作者机构：

[Li, Heng] Guilin Med Univ, Clin Med Coll, 1 Zhiyuan Rd, Guilin 541100, Guangxi, Peoples R China.

[He, Ping-Ping; Ouyang, Xin-Ping] Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, 28 West Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

[Ouyang, Xin-Ping] Univ South China, Neurosci Inst, Dept Physiol, Med Coll, Hengyang 421001, Hunan, Peoples R China.

[Jiang, Ting] Guilin Med Univ, Off Acad Affairs, Dept Practice Educ, Guilin 541100, Peoples R China.

[Zhao, Guo-Jun; Zheng, Xi-Long] Univ Calgary, Libin Cardiovasc Inst Alberta, Hlth Sci Ctr, Dept Biochem & Mol Biol, 3330 Hosp Dr NW, Calgary, AB T2N 4N1, Canada.

通讯机构：

[He, Ping-Ping] H

[Zhao, Guo-Jun; He, Ping-Ping] U

[Zhao, Guo-Jun] G

Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, 28 West Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

Univ Calgary, Libin Cardiovasc Inst Alberta, Hlth Sci Ctr, Dept Biochem & Mol Biol, 3330 Hosp Dr NW, Calgary, AB T2N 4N1, Canada.

语种：

英文

关键词：

miR-296;Angiogenesis;Inflammation;Atherosclerosis

期刊：

MOLECULAR MEDICINE

ISSN：

1076-1551

年：

2018

卷：

期：

页码：

1-8

DOI：

10.1186/s10020-018-0012-y

基金类别：

National Natural Sciences Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81660082]; Guangxi Natural Sciences Foundation [AA139209]

机构署名：

本校为通讯机构

院系归属：

医学院

护理学院

摘要：

Atherosclerosis has been recognized as an inflammatory disease involving the vascular wall. MicroRNAs are a group of small noncoding RNAs to regulate gene expression at the transcriptional level through mRNA degradation or translation repression. Recent studies suggest that miR-296 may play crucial roles in the regulation of angiogenesis, inflammatory response, cholesterol metabolism, hypertension, cellular proliferation and apoptosis. In this review, we primarily discussed the molecular targets of miR-296 involved in the development of atherosclerosis, which may provide a basis for future inv...

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