Nobiletin reduces LPL-mediated lipid accumulation and pro-inﬂammatory cytokine secretion through upregulation of miR-590 expression

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成果类型：

期刊论文

作者：

He, Ping-Ping;Shen, Qian-Qian;Wen, Min;Zou, Jie-Qiong;Wang, Yan;...

通讯作者：

Ouyang, Xin-Ping;Tang, Chao-Ke

作者机构：

[Liu, Juan; He, Ping-Ping; Zou, Jie-Qiong; Shen, Qian-Qian; Wang, Yan; Wen, Min; Chen, Ye-Shi; Yang, Jiao-Xing; Su, Hua; Hu, Li-Zhi] Univ South China, Sch Nursing, Hengyang 421001, Hunan, Peoples R China.

[He, Ping-Ping; Ouyang, Xin-Ping; Tang, Chao-Ke] Univ South China, Inst Cardiovasc Res, Key Lab Atherosclerol Hunan Prov, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Hunan, Peoples R China.

[Liu, Juan; Zou, Jie-Qiong; Wang, Yan; Yang, Jiao-Xing; Hu, Li-Zhi] Univ South China, Affiliated Hosp 1, Hengyang 421001, Hunan, Peoples R China.

[Zheng, Xi -Long] Univ Calgary, Dept Biochem & Mol Biol, Libin Cardiovasc Inst Alberta, Cumming Sch Med,Hlth Sci Ctr, 3330 Hosp Dr NW, Calgary, AB T2N 4N1, Canada.

[Ouyang, Xin-Ping] Univ South China, Dept Physiol, Neurosci Inst, Hengyang Med Coll, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Ouyang, Xin-Ping; Tang, Chao-Ke] U

Univ South China, Dept Physiol, Hengyang 421001, Hunan, Peoples R China.

Univ South China, Inst Cardiovasc Res, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

*Atherosclerosis;*LPL;*MiR-590;*Nobiletin

期刊：

Biochemical and Biophysical Research Communications

ISSN：

0006-291X

年：

2019

卷：

508

期：

页码：

97-101

DOI：

10.1016/j.bbrc.2018.11.075

基金类别：

The authors gratefully acknowledge the financial supports from the Natural Sciences Foundation of Human Provincial Science and Technology Department ( 2018JJ3455 ), Scientific Research Aid Program for Chinese Medicine of Human Province ( 201524 ),The start-up funds for Ph.Ds in University of South China ( 2014XQD36 , 2015XQD37 ), High Level Talents Aid Program in University of South China ( 2017-27,2017-28 ) and Major project of Nursing School of University of South China ( HLPY006 ).

机构署名：

本校为第一且通讯机构

院系归属：

医学院

药学与生物科学学院

护理学院

摘要：

Nobiletin has protective effects on cardiovascular diseases, but the mechanism is not clear. In this study, we examined whether nobiletin affects the expression of miR-590/LPL and its relative effects on lipid accumulation and pro-inflammatory cytokine secretion in human THP-1 macrophages. RT-qPCR analysis showed that nobiletin increased the expression of miR-590. Western blot analysis showed that nobiletin-suppressed LPL expression was enhanced by miR-590 mimic and abrogated by miR-590 inhibitor. Oil Red O staining and high-performance liquid ...

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Nobiletin reduces LPL-mediated lipid accumulation and pro-inﬂammatory cytokine secretion through upregulation of miR-590 expression

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