期刊论文

Tian, Yong-Quan;Zeng, Gu-Qing

英文

Technology in Cancer Research & Treatment

1533-0346

2018

17

1533034617750309

10.1177/1533034617750309

The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This research program was supported by National Natural Science Foundation of China (81272959, 81470130) and a grant from the Educational Committee of Hunan Province (17A188).

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Radiotherapy is the primary treatment for nasopharyngeal carcinoma while radioresistance can hinder efficient treatment. To explore the role of annexin A1 and its potential mechanisms in radioresistance of nasopharyngeal carcinoma, human nasopharyngeal carcinoma cell line CNE2-sh annexin A1 (knockdown of annexin A1) and the control cell line CNE2-pLKO.1 were constituted and CNE2-sh annexin A1 xenograft mouse model was generated. The effect of annexin A1 knockdown on the growth of xenograft tumor after irradiation and radiation-induced DNA damag...