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Role of heterogeneous nuclear ribonucleoprotein K in tumor development

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成果类型:
期刊论文
作者:
Chen, Yuting;Zeng, Ying;Xiao, Zheng;Chen, Shi;Li, Yukun;...
通讯作者:
Zeng, Xi
作者机构:
[Li, Yukun; Xiao, Zheng; Chen, Yuting; Zou, Juan; Chen, Shi; Zeng, Xi] Univ South China, Hengyang Sch Med, Canc Res Inst, Hunan Prov Key Lab Tumor Cellular & Mol Pathol, Hengyang, Peoples R China.
[Zeng, Ying] Univ South China, Sch Nursing, Hengyang, Peoples R China.
[Zeng, Xi] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang, Peoples R China.
[Zeng, Xi] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Canc Res Inst, Hunan Prov Key Lab Tumor Cellular & Mol Pathol, Hengyang 421001, Peoples R China.
通讯机构:
[Zeng, Xi] U
Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Canc Res Inst, Hunan Prov Key Lab Tumor Cellular & Mol Pathol, Hengyang 421001, Peoples R China.
语种:
英文
关键词:
AS;hnRNP K;ncRNAs;posttranslational modification;tumor;virus
期刊:
JOURNAL OF CELLULAR BIOCHEMISTRY
ISSN:
0730-2312
年:
2019
卷:
120
期:
9
页码:
14296-14305
基金类别:
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81641112]; Key Project of Hunan Provincial Education DepartmentHunan Provincial Education Department [18A229]; Foundation of the Construct Program of the Key Discipline in Hunan Province of China [2011-76]
机构署名:
本校为第一且通讯机构
院系归属:
医学院
药学与生物科学学院
护理学院
摘要:
Heterogeneous nuclear ribonucleoprotein K (hnRNP K) is an RNA/DNA special binding protein that participates in regulating the expression of related genes, transcription, RNA alternative splicing, translation, posttranslational modification, cell signal transduction, cell movement, interacts with ncRNAs, and induces angiogenesis. Moreover, several cellular functions forcefully indicated that hnRNP K participates in tumorigenesis. Numerous studies indicated hnRNP K is aberrantly elevated in multiple tumors. In addition, hnRNP K abnormal accumulation in cytoplasmic is also associated with poor pr...

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