期刊论文

Zeng, Xi;Luo, Gui-fang

英文

Life Sciences

0024-3205

2020

241

117113

10.1016/j.lfs.2019.117113

Author contributions YKL and JZ conceptualized the study, performed the analysis, collected data and participated in writing the paper. DMY collected data, acquired funding and participated in writing the paper. CYC participated in the collection of data and in the writing the paper. YZ performed the analysis and editing and also participated in the data collection. GFL and XZ reviewed and edited the paper and jointly designed the structure of the paper. All authors read and approved the final manuscript.

本校为第一且通讯机构

An oncogenic role, p21-activated kinase 5 (PAK5), has proven as a significant mediator for many cellular progression, which is expressed highly in human organs such as lung, liver, kidney, blood vessels endothelial cells and inflammatory cells. PAK5 was primitively detected in the cerebrum and accelerated the filopodia formation in neurocytes. It can reverse the effect of Rho and adjust its activity to mediate maintenance and development of nerve axon by binding with Cdc42-GTP. Moreover, PAK5 has been suggested to mediate protean, multitudinous and inscrutable functions in cancer. Currently, m...