作者机构：
[Zhai, X. M.; Yang, H.; Lin, S. Y.; Ding, B. J.; Zhang, X. J.; Wu, Z. G.; Liu, L.; Yan, G. H.; Gong, X. Z.; Yan, N.; Zang, Q.; Zhao, H. L.; Wang, M.; Wu, C. B.; Zhao, L. M.; Li, M. H.; Huang, J.] Chinese Acad Sci, Inst Plasma Phys, Hefei 230031, Peoples R China.;[Baek, S. G.; Bonoli, P. T.; Wallace, G. M.] MIT, Plasma Sci & Fus Ctr, Cambridge, MA 02139 USA.;[Li, X. X.] Univ South China, Dept Nucl Phys, Hengyang 421001, Peoples R China.
通讯机构：
[B.J. Ding; M. Wang] I;Institute of Plasma Physics, Chinese Academy of Sciences, Hefei 230031, China
关键词：
Magnetic fields;Temperature;Critical value;Current-drive efficiency;Density limit;Hard x-ray emission;High magnetic fields;L-mode plasmas;Lower hybrid current drive;Noise levels;Parametric decay instability;Wave accessibility;Sols
期刊：
Fusion Engineering and Design,2021年172:112897 ISSN：0920-3796
通讯作者：
Li, Xinxia
作者机构：
[Li, Xinxia; Li, Guozhuang; Liu, Hongbo] Univ South China, Dept Nucl Phys, Hengyang 421001, Peoples R China.;[Li, Xinxia] Chinese Acad Sci, Inst Plasma Phys, Hefei 230031, Peoples R China.;[Liu, Hongbo] HengYang Normal Univ, Coll Phys & Elect Engn, Hengyang 421008, Peoples R China.
通讯机构：
[Li, Xinxia] U;Univ South China, Dept Nucl Phys, Hengyang 421001, Peoples R China.
关键词：
CFETR;Helicon wave;Plasma current drive;Tokamak
摘要：
The China Fusion Engineering Testing Reactor (CFETR) is a tokamak reactor and aims to eventually reach DEMO relevant fusion power level of 1 GW. A lower single null configuration of the divertor design is proposed for the machine. To obtain the high performance operation of the plasma, both the hybrid and steady-state operating scenarios are suggested. In these scenarios, the plasma beta of <beta(e)> similar to 1.6% has been generally reached. In the paper, helicon wave propagation and current drive in CFETR are studied through GENRAY/CQL3D code. An analysis of the wave damping factor in CFETR plasma indicates that the electron Landau damping is dominant for the core plasma. According to the dimensionless parameter xi(e) and beta(e), a strong wave damping region is found. Based on the GENRAY simulation, the single pass power absorptions are generally obtained in both scenarios. Scanning of generated current on the launched poloidal angle indicates that high current drive efficiency is produced at theta similar to 30 degrees. For helicon wave with frequency f = 700 MHz, calculations of the current drive show that off-axis current drive about 30 kA/MW and 50 kA/MW are obtained in the hybrid and steady-state scenarios respectively. Simultaneously, the lower plasma density and high temperature promote the high current generation. Moreover, the obtained current drive and its peak position are shown to be sensitive to the launched n(//) similar to Finally, the helicon wave with frequency f = 700 MHz and launched n(//) similar to 2.0-3.0 is proposed to be a promising scheme for effective off-axis current drive in CFETR.
作者机构：
[张振华] Department of Nuclear Physics, School of Nuclear Science and Technology, University of South China, Hengyang, 421001, China;[Qiu Q.-T.; 陈进琥; 马长升; 段敬豪] Department of Radiation Physics Technology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, 250117, China;[刘陈路] Department of Nuclear Physics, School of Nuclear Science and Technology, University of South China, Hengyang, 421001, China, Department of Radiation Physics Technology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, 250117, China
通讯机构：
[Zhang, Z.-H.] D;Department of Nuclear Physics, China
作者机构：
[Li, Xinxia; Liu, Hongbo] Univ South China, Dept Nucl Phys, Hengyang 421001, Peoples R China.;[Li, Xinxia; Li, Miaohui; Xiang, Nong] Chinese Acad Sci, Inst Plasma Phys, Hefei 230031, Peoples R China.
通讯机构：
[Li, Xinxia] U;Univ South China, Dept Nucl Phys, Hengyang 421001, Peoples R China.
关键词：
Helicon wave;Plasma current drive;Tokamak
摘要：
Recent experiments of Experimental Advanced Superconducting Tokomak (EAST) have successfully demonstrated a long-pulse steady-state scenario with improved plasma performance through integrated operation. The helicon wave (fast wave at omega > 20 omega(ci)) current drive in the EAST plasma with high beta(e) operation is studied numerically by means of GENRAY/CQL3D treatment. A theoretical analysis of the wave damping factor shows that electron Landau damping dominates the wave absorption process and effective current drive occurs in the central plasmas for low beta(e) operation. High beta (similar to 1.3) leads to even stronger Landau damping single-path wave absorption is found. The numerical calculation predicts a broad distribution of current drive with good efficiency in EAST plasma. Moreover, the current drive efficiency is proven to be sensitive to the plasma parameters, specially the initial parallel index of refraction n(//). A possible scenario of helicon wave current drive is proposed for the high beta(e) EAST operation. (C) 2020 Elsevier B.V. All rights reserved.
摘要：
Angiopoietin-like 4 (Angptl4), a secreted protein, is an important regulator to irreversibly inhibit lipoprotein lipase (LPL) activity. Macrophage LPL contributes to foam cell formation via a so-called"molecular bridge" between lipoproteins and receptors on cell surface. It has been reported that macrophage ANGPTL4 suppresses LPL activity, foam cell formation and inflammatory gene expression to reduce atherosclerosis development. Recently, some studies demonstrated that microRNA-134 is upregulated in atherosclerotic macrophages. Here we demonstrate that miR-134 directly binds to 3'UTR of ANGPTL4 mRNA to suppression the expression of ANGPTL4. To investigate the potential roles of macrophage miR-134, THP-1 macrophages were transfected with miR-134 mimics or inhibitors. Our results showed that LPL activity and protein were dramatically increased. We also found that miR-134 activated LPL-mediated lipid accumulation. Collectively, our findings indicate that miR-134 may regulate lipid accumulation and proinfiammatory cytokine secretion in macrophages by targeting the ANGPTL4 gene. Our results have also suggested a promising and potential therapeutic target for atherosclerosis. (C) 2016 Elsevier Inc. All rights reserved.
作者机构：
[王程] Institute of Cardiovascular Disease, Key Laboratory for Arteriosclerology of Hunan Province, University of South China, Hengyang 421001, China;[王程] Department of Spine Surgery, the First Affiliated Hospital, University of South China, Hengyang 421001, China;[王文军; 晏怡果; 杨威] Department of Spine Surgery, the First Affiliated Hospital, University of South China, Hengyang 421001, China;[于小华] Life Science Research Center, University of South China, Hengyang 421001, China;[张健] Department of Hand and Micro-surgery, the First Affiliated Hospital, University of South China, Hengyang 421001, China
期刊：
Journal of Physiology and Biochemistry,2016年72(4):657-667 ISSN：1138-7548
通讯作者：
Yi, Guang-Hui
作者机构：
[Jiang, Yue; Peng, Xiao-Shan; Liu, Xing; Ren, Kun; Yi, Guang-Hui; Suo, Rong; Tang, Zhen-Li] Univ South China, Inst Cardiovasc Dis, Key Lab Arteriosclerol Hunan Prov, 28 W Changsheng Rd, Hengyang City 421001, Hunan, Peoples R China.;[Xiong, Sheng-Lin] You Country Peoples Hosp, Zhuzhou 412300, Hunan, Peoples R China.;[Zhang, Qing-Hai] Univ South China, Affiliated Hosp 1, Clin Res Inst, Hengyang 421001, Hunan, Peoples R China.;[Mo, Zhong-Cheng] Univ South China, Inst Cardiovasc Res, Life Sci Res Ctr, Key Lab Atherosclerol Hunan Prov, Hengyang 421001, Hunan, Peoples R China.
通讯机构：
[Yi, Guang-Hui] U;Univ South China, Inst Cardiovasc Dis, Key Lab Arteriosclerol Hunan Prov, 28 W Changsheng Rd, Hengyang City 421001, Hunan, Peoples R China.
关键词：
S1P;SR-BI;ABCA1;SphK;S1P receptors;Release
摘要：
Sphingosine-1-phosphate (S1P), which has emerged as a pivotal signaling mediator that participates in the regulation of multiple cellular processes, is derived from various cells, including vascular endothelial cells. S1P accumulates in lipoproteins, especially HDL, and the majority of free plasma S1P is bound to HDL. We hypothesized that HDL-associated S1P is released through mechanisms associated with the HDL maturation process. ApoA-I, a major HDL apolipoprotein, is a critical factor for nascent HDL formation and lipid trafficking via ABCA1. Moreover, apoA-I is capable of promoting bidirectional lipid movement through SR-BI. In the present study, we confirmed that apoA-I can facilitate the production and release of S1P by HUVECs. Furthermore, we demonstrated that ERK1/2 and SphK activation induced by apoA-I is involved in the release of S1P from HUVECs. Inhibitor and siRNA experiments showed that ABCA1 and SR-BI are required for S1P release and ERK1/2 phosphorylation induced by apoA-I. However, the effects triggered by apoA-I were not suppressed by inhibiting ABCA1/JAK2 or the SR-BI/Src pathway. S1P released due to apoA-I activation can stimulate the (ERK1/2)/SphK1 pathway through S1PR (S1P receptor) 1/3. These results indicated that apoA-I not only promotes S1P release through ABCA1 and SR-BI but also indirectly activates the (ERK1/2)/SphK1 pathway by releasing S1P to trigger their receptors. In conclusion, we suggest that release of S1P induced by apoA-I from endothelial cells through ABCA1 and SR-BI is a self-positive-feedback process: apoA-I-(ABCA1 and SR-BI)-(S1P release)-S1PR-ERK1/2-SphK1-(S1P production)-(more S1P release induced by apoA-I).
摘要：
Several lines of evidence have shown that SORT1 gene within 1p13.3 locus is an important modulator of the low density lipoprotein-cholesterol (LDL-C) level and atherosclerosis risk. Here, we summarize the effects of SORT1, which codes for sortilin, on lipid metabolism and development of atherosclerosis and explore the mechanisms underlying sortilin effects on lipid metabolism especially in hepatocytes and macrophages. Recent epidemiological evidence demonstrated that sortilin has been implicated as the causative factor and regulates lipid metabolism in vivo. Hepatic sortilin overexpression leads to both increased and decreased LDL-C levels by several different mechanisms, suggesting the complex roles of sortilin in hepatic lipid metabolism. Macrophage sortilin causes internalization of LDL and probably a reduction in cholesterol efflux, resulting in the intracellular accumulation of excessive lipids. In addition, sortilin deficiency in an atherosclerotic mouse model results in decreased aortic atherosclerotic lesion. Sortilin involves in lipid metabolism, promotes the development of atherosclerosis, and possibly becomes a potential therapeutic target for atherosclerosis treatment. (C) 2016 Elsevier B.V. All rights reserved.
期刊：
Advances in Clinical Chemistry,2015年71:171-203 ISSN：0065-2423
通讯作者：
Tang, Chao-Ke
作者机构：
[Tang, Chao-Ke; Yu, Xiao-Hua] Univ South China, Life Sci Res Ctr, Key Lab Atherosclerol Hunan Prov, Mol Target New Drug Discovery & Cooperat Innovat, Hengyang, Peoples R China.;[Zheng, Xi-Long] Univ Calgary, Hlth Sci Ctr, Dept Biochem & Mol Biol, Libin Cardiovasc Inst Alberta,Cumming Sch Med, Calgary, AB, Canada.
通讯机构：
[Tang, Chao-Ke] U;Univ South China, Life Sci Res Ctr, Key Lab Atherosclerol Hunan Prov, Mol Target New Drug Discovery & Cooperat Innovat, Hengyang, Peoples R China.
摘要：
Atherosclerosis is a chronic inflammatory disease with deposition of excessive cholesterol in the arterial intima. Peroxisome proliferator-activated receptor alpha (PPARalpha) is a nuclear receptor that can activate or inhibit the expression of many target genes by forming a heterodimer complex with the retinoid X receptor. Activation of PPARalpha plays an important role in the metabolism of multiple lipids, including high-density lipoprotein, cholesterol, low-density lipoprotein, triglyceride, phospholipid, bile acids, and fatty acids. Increased PPARalpha activity also mitigates atherosclerosis by blocking macrophage foam cell formation, vascular inflammation, vascular smooth muscle cell proliferation and migration, plaque instability, and thrombogenicity. Clinical use of synthetic PPARalpha agonist fibrate improved dyslipidemia and attenuated atherosclerosis-related disease risk. This review summarizes PPARalpha in lipid and lipoprotein metabolism and atherosclerosis, and also highlights its potential therapeutic benefits.
作者：
Cui Li-Bao;Yu Xiao-Hua;Jiang Chong-Hui;Tang Ya-Ling;Ouyang Xin-Ping;...
期刊：
生物化学与生物物理进展,2015年42(9):866-876 ISSN：1000-3282
通讯作者：
Tang Chao-Ke
作者机构：
[Ouyang Xin-Ping; Yao Feng; Yu Xiao-Hua; Cui Li-Bao; He Ping-Ping; Tang Chao-Ke; Lu Yun-Cheng; Zhang Min; Tang Ya-Ling] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Key Lab Atherosclerol Hunan Prov, Inst Cardiovasc Res,Life Sci Res Ctr, Hengyang 421001, Peoples R China.;[Jiang Chong-Hui; Cui Li-Bao] Cent Hosp Hengyang, Dept Pharm, Hengyang 421001, Peoples R China.
通讯机构：
[Tang Chao-Ke] U;Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Key Lab Atherosclerol Hunan Prov, Inst Cardiovasc Res,Life Sci Res Ctr, Hengyang 421001, Peoples R China.
关键词：
ABCA1;ABCG5;ABCG8;Atherosclerosis;HDL-C;Inflammation;Probucol;SR-B I
摘要：
Probucol is a potent hypolipidemic drug that decreases plasma high-density lipoprotein cholesterol (HDL-C) levels but attenuates atherosclerosis. However, the detailed mechanisms are not fully understood. The aim of this study was to explore the molecular mechanisms of the HDL-C-lowering and antiatherogenic effects of probucol. New Zealand white rabbits were randomly divided into normal diet group, normal diet+probucol group, high fat diet (HFD) group and HFD+probucol (HFD+P) group. After 7 weeks of treatments, the extent of the atherosclerotic lesions, hepatic lipid accumulation and plasma levels of triglycerides, total cholesterol, low-density lipoprotein cholesterol and HDL-C were significantly reduced in HFD+P group as compared to HFD group. Probucol effectively inhibited down-regulation of hepatic scavenger receptor class B type I (SR-B I) expression, and ATP-binding cassette (ABC) transporters G5 (ABCG5) and G8 (ABCG8) expression in the liver and small intestine induced by HFD but further promoted HFD-induced reduction in hepatic ABC transporter A1 (ABCA1) expression. In addition, probucol also significantly prevented HFD-induced increases of tumor necrosis factor-alpha, interleukin-1, interleukin-6 and monocyte chemotactic protein-1 levels in the aortic arch and plasma. Thus, our data provide strong evidence that probucol alleviates atherosclerosis through regulating ABCA I, SR-B I, ABCG5 and ABCG8 expression and inhibiting the secretion of proinflammatory cytokines in hypercholesterolemic rabbits.
摘要：
Intervertebral disk degeneration (IDD) is the most common diagnosis in patients with low back pain, a main cause of musculoskeletal disability in the world. Interleukin-1 (IL-1) beta is the most important member of the IL-1 family, and has a strong pro-inflammatory activity by stimulating the secretion of multiple pro-inflammatory mediators. IL-1 beta is highly expressed in degenerative intervertebral disk (IVD) tissues and cells, and it has been shown to be involved in multiple pathological processes during disk degeneration, including inflammatory responses, matrix destruction, angiogenesis and innervation, cellular apoptosis, oxidative stress and cellular senescence. However, inhibition of IL-1 beta is found to promote extracellular matrix (ECM) repair and protect against disk regeneration. In this review, after a brief description of IL-1 beta signaling, we mainly focus on the expression profiles, roles and therapeutic potential of IL-1 beta in IDD. A better understanding will help develop novel IL-1 beta-based therapeutic interventions for degenerative disk disease. (C) 2015 Elsevier B.V. All rights reserved.
期刊：
Advances in Clinical Chemistry,2015年70:1-30 ISSN：0065-2423
通讯作者：
Tang, Chao-Ke
作者机构：
[Tang, Chao-Ke; Yu, Xiao-Hua] Univ South China, Key Lab Atherosclerol Hunan Prov, Mol Target New Drug Discovery & Cooperat Innovat, Life Sci Res Ctr, Hengyang, Peoples R China.;[Zheng, Xi-Long] Univ Calgary, Hlth Sci Ctr, Cumming Sch Med, Dept Biochem & Mol Biol,Libin Cardiovasc Inst Alb, Calgary, AB, Canada.
通讯机构：
[Tang, Chao-Ke] U;Univ South China, Key Lab Atherosclerol Hunan Prov, Mol Target New Drug Discovery & Cooperat Innovat, Life Sci Res Ctr, Hengyang, Peoples R China.
摘要：
Atherosclerosis is a chronic inflammatory disease of the arterial wall with lipid-laden lesions, involving a complex interaction between multiple different cell types and cytokine networks. Inflammatory responses mark all stages of atherogenesis: from lipid accumulation in the intima to plaque formation and eventual rupture. One of the most important regulators of inflammation is the transcription factor nuclear factor-kappa B (NF-kappa B), which is activated through the canonical and noncanonical pathways in response to various stimuli. NF-kappa B has long been regarded as a proatherogenic factor, because it is implicated in multiple pathological processes during atherogenesis, including foam cell formation, vascular inflammation, proliferation of vascular smooth muscle cells, arterial calcification, and plaque progression. In contrast, inhibition of NF-kappa B signaling has been shown to protect against atherosclerosis. This chapter aims to discuss recent progress on the roles of NF-kappa B in lipid metabolism and atherosclerosis and also to highlight its potential therapeutic benefits.
摘要：
Adipose tissue is considered as a large gland that can produce paracrine and endocrine hormones. Growing evidence suggests that adipocytes may link obesity to cardiovascular diseases (CVD). Adipose tissue produces a large number of mediators, which affect metabolism, inflammation and coagulation. Omentin, a novel adipocytokine, has come into the center of interest due to its favorable effects on inflammation, glucose homeostasis and CVD. The present review provides a concise and general overview on the roles of omentin in CVD. The knowledge of these concepts may provide a new strategy to reduce disease risks on CVD in the future.
摘要：
Interferon-gamma (IFN-gamma), the sole member in type II IFN predominantly secreted by macrophages and T cells, is a critical regulator of immune function and provides a robust first line of defense against invading pathogens. Binding of IFN-gamma to its receptor complex can activate a variety of downstream signaling pathways, particularly the Janus kinase (JAK)/signal transducer and activator of transcription (STAT), to induce gene transcription within the target cells. This pro-inflammatory mediator is highly expressed in atherosclerotic lesions and promotes foam cell formation, but its effects on the atherogenesis are complex, with both pro- and anti-atherogenic properties. IFN-gamma also contributes to the development of myocardial infarction and stroke, the two main atherosclerotic diseases. Inhibition of IFN-gamma signaling may prevent the development of atherosclerosis and help treat atherosclerotic diseases. Since IFN-gamma may also exert anti-atherogenic effects, the safety and efficacy of anti-IFN-gamma treatment still require careful evaluation in the clinical setting. In the current review, we summarize recent progression on regulation and signaling pathways of IFN-gamma, and highlight its roles in foam cell formation, atherosclerosis, myocardial infarction as well as stroke. An increased understanding of these processes will help to develop novel IFN-gamma-centered therapies for atherosclerotic diseases. (C) 2014 Elsevier B.V. All rights reserved.
