摘要：
In the present work, based on Wentzel-Kramers-Brillouin theory, we systematically study the cluster
radioactivity half-lives of 22 nuclei ranging from 221Fr to 242Cm by using a phenomenological model, which considers
the screened electrostatic effect of Coulomb potential. In this model, there are two adjustable parameters i.e. the
parameter t and g, which are related to the screened electrostatic barrier and the strength of spectroscopic factor,
respectively. The calculated results indicate this model can well reproduce the experimental data while the corre sponding root-mean-square (rms) deviation is 0.660. In addition, we extend this model to predict the half-lives of
possible cluster radioactive candidates whose cluster radioactivity are energetically allowed or observed but not
yet quantified in the evaluated nuclear properties table NUBASE2020. The predicted results are consistent with
the ones obtained by using other theoretical models and/or empirical formulae including the universal decay law
(UDL) proposed by Qi et al. [Phys. Rev. C 80, 044326 (2009)], a semi-empirical model for both α decay and cluster
radioactivity proposed by Santhosh et al. [J. Phys. G 35, 085102 (2008)] and a unified formula of half-lives for α
decay and cluster radioactivity proposed by Ni et al. [Phys. Rev. C 78, 044310 (2008)].
通讯机构：
[Chen, X.] S;School of Nuclear Science and Technology, China
关键词：
triply heavy baryons;holographic QCD;potential energy
摘要：
Using gauge/gravity duality, we study the potential energy and the melting of triply heavy baryon at finite temperature and chemical potential in this paper. First, we calculate the three-quark potential and compare the results with quark-antiquark potential. With the increase of temperature and chemical potential, the potential energy will decrease at large distances. It is found that the three-quark potential will have an endpoint at high temperature and/or large chemical potential, which means triply heavy baryons will melt at enough high temperature and/or large chemical potential. We also discuss screening distance which can be extracted from the three-quark potential. At last,we draw the melting diagram of triply heavy baryons in the T-μ plane.
摘要：
In this study, considering the modified preformation probability Pc to be log(10)P(c)=(A(c)-1)/3log(10)P(alpha)+c ', where P alpha and c ' are the alpha-particle preformation probability and an adjustable parameter proposed by Wang et al. [Chin. Phys. C 45, 044111 (2021)], respectively, we extend a new simple model put forward by Bayrak [J. Phys. G 47, 025102 (2020)] to systematically study the cluster radioactivity half-lives of 28 trans-lead nuclei ranging from( 222)Fr to Cm-242, which is based on the Wentzel-Kramers-Brillouin approximation and Bohr-Sommerfeld quantization condition. For comparison, a universal decay law proposed by Qi et al. [Phys. Rev. C 80, 044326 (2009)], a three-parameter model-independent formula put forward by Balasubramaniam et al. [Phys. Rev. C 70, 017301 (2004)], and the semi-empirical model proposed by Tavares et al. [Eur. Phys. J. A 49, 1 (2013)] are used. Our calculated results reproduce the experimental data well, with a standard deviation of 0.818. Furthermore, we use this model to predict the cluster radioactivity half-lives of 51 possible cluster radioactive candidates whose cluster radioactivities are energetically allowed or observed but not yet quantified in NUBASE2020.
作者机构：
[Luo, Song; Li, Xiao-Hua; Chen, Xun; Qi, LJ; Qi, Lin-Jing; Zhang, Dong-Meng] Univ South China, Sch Nucl Sci & Technol, Hengyang 421001, Peoples R China.;[He, Biao] Cent South Univ, Coll Phys & Elect, Changsha 410083, Peoples R China.;[Wu, Xi-Jun] Univ South China, Sch Math & Phys, Hengyang 421001, Peoples R China.;[Li, Xiao-Hua] Univ South China, Cooperat Innovat Ctr Nucl Fuel Cycle Technol & Equ, Hengyang 421001, Peoples R China.;[Li, Xiao-Hua] Univ South China, Natl Exemplary Base Int Sci, Tech Collaborat Nucl Energy & Nucl Safety, Hengyang 421001, Peoples R China.
通讯机构：
[Qi, LJ ] U;Univ South China, Sch Nucl Sci & Technol, Hengyang 421001, Peoples R China.
关键词：
cluster radioactivity;decay energy;Geiger and Nuttall law;half-lives
摘要：
In this study, derived from Balasubramaniam’s formula [Phys. Rev. C 70, 017301(2004)] and further considering the effect of the parent nucleus mass, blocking effect, and effect of reduced mass on cluster radioactivity half-lives, we propose a new Geiger-Nuttall law that is model-independent to systematically evaluate the halflives of this process for 16 even-even nuclei and 10 odd-A nuclei. For comparison, a single universal curve for cluster radioactivity and α decay proposed by Poenaru [Phys. Rev. C 83, 014601(2011)], a scaling law proposed by Horoi [J. Phys. G: Nucl. Part. Phys. 30, 945(2004)], an extension of the Viola-Seaborg formula from α decay to cluster radioactivity proposed by Ren et al. [Phys. Rev. C 70, 034304(2004)], a new semi-empirical formula for exotic cluster decay proposed by Balasubramaniam et al. [Phys. Rev. C 70, 017301(2004)], and a unified formula for the half-lives of α decay and cluster radioactivity proposed by Ni et al. [Phys. Rev. C 78, 044310(2008)] are also used. The calculated results of our new Geiger-Nuttall law are in good agreement with the experimental half-lives,with the least rms being 0.606, and are better than the compared values. Moreover, we extend this formula to predict the cluster radioactivity half-lives of 51 nuclei whose decay energies are energetically allowed or observed but not yet quantified in NUBASE2020.
作者机构：
[Cheng, Jun-Hao; Li, Xiao-Hua] Univ South China, Sch Nucl Sci & Technol, Hengyang 421001, Peoples R China.;[Zhang, Zhen] Sun Yat Sen Univ, Sino French Inst Nucl Engn & Technol, Zhuhai 519082, Peoples R China.;[Wu, Xi-Jun] Univ South China, Sch Math & Phys, Hengyang 421001, Peoples R China.;[Chu, Peng-Cheng] Qingdao Technol Univ, Sch Sci, Qingdao 266000, Peoples R China.;[Li, Xiao-Hua] Univ South China, Cooperat Innovat Ctr Nucl Fuel Cycle Technol & Eq, Hengyang 421001, Peoples R China.
关键词：
proton radioactivity;Skyrme;Hartree-Fock;macroscopic quantities of nuclear matter
摘要：
In this study, we systematically investigate the proton radioactivity half-lives of 33 spherical nuclei based on the relationship between Skyrme parameters and the macroscopic quantities of nuclear matter. Using the two-potential approach with the spherical Skyrme-Hartree-Fock model, the correlation between proton radioactivity half-life and the macroscopic quantities is analyzed. Moreover, we obtain a new Skyrme parameter set by fitting the two most weighted macroscopic quantities. Compared with the Skyrme parameters MSL0 and the theoretical model of proton radioactivity UDLP, the theoretical proton radioactivity half-life calculated using the new Skyrme parameter set can better reproduce the experimental data.
作者机构：
[Zhai, X. M.; Yang, H.; Lin, S. Y.; Ding, B. J.; Zhang, X. J.; Wu, Z. G.; Liu, L.; Yan, G. H.; Gong, X. Z.; Yan, N.; Zang, Q.; Zhao, H. L.; Wang, M.; Wu, C. B.; Zhao, L. M.; Li, M. H.; Huang, J.] Chinese Acad Sci, Inst Plasma Phys, Hefei 230031, Peoples R China.;[Baek, S. G.; Bonoli, P. T.; Wallace, G. M.] MIT, Plasma Sci & Fus Ctr, Cambridge, MA 02139 USA.;[Li, X. X.] Univ South China, Dept Nucl Phys, Hengyang 421001, Peoples R China.
通讯机构：
[B.J. Ding; M. Wang] I;Institute of Plasma Physics, Chinese Academy of Sciences, Hefei 230031, China
摘要：
Lower hybrid current drive (LHCD) experiments with line-averaged density up to similar to 5.1 x 10(19) m(-3) were performed in EAST L-mode plasmas. When the line-averaged density rises above a critical value, the hard x-ray (HXR) emission falls to the noise level, indicating that the LHCD density limit is encountered. The experimental results show that the LHCD density limit can be increased with higher wave source frequency (f (0)) and higher magnetic field (B (t)). Although a higher LHCD density limit is obtained by a higher magnetic field for both 2.45 GHz and 4.6 GHz waves, the results show a stronger dependence on the magnetic field for the 4.6 GHz case. Analysis suggests that, for normal operation with a relatively low magnetic field (1.6 T <= B (t) <= 2.5 T) on EAST, the dominant mechanisms responsible for the LHCD density limit are different between the 2.45 GHz and 4.6 GHz waves. The wave accessibility plays a more significant role during 4.6 GHz LHCD experiments, while parasitic losses due to parametric decay instability (PDIs) dominate the accessibility issue in the 2.45 GHz case. Collisional loss in the scrape-off layer (SOL) may explain the 4.6 GHz result when combined with the accessibility limit at high density and low temperature.
作者：
Liu, Hong Bo;Liu, Guan Nan;Sun, Ai Ping;Xiao, Zheng Yao;Li, Xin Xia
期刊：
Journal of the Korean Physical Society,2022年81(5):397-402 ISSN：0374-4884
通讯作者：
Xin Xia Li
作者机构：
[Li, Xin Xia; Liu, Guan Nan; Xiao, Zheng Yao; Liu, Hong Bo] Univ South China, Dept Nucl Phys, Hengyang 421001, Peoples R China.;[Liu, Hong Bo] Hengyang Normal Univ, Sch Phys & Elect Engn, Hengyang 421008, Peoples R China.;[Sun, Ai Ping] Southwestern Inst Phys, POB 432, Chengdu 610041, Sichuan, Peoples R China.
通讯机构：
[Xin Xia Li ] D;Department of Nuclear Physics, University of South China, Hengyang, People’s Republic of China
关键词：
Helicon wave;Off-axis current drive;HL-2M;AORSA
摘要：
Helicon waves have been proposed for efficient off-axis current drive in high-performance tokamaks. The HL-2M tokamak will be operated with high plasma beta approaching to
$$\beta _{N}\sim 4.0\%$$
, which provides a good platform to apply helicon wave system in the machine. Based on the helicon wave dispersion relation, effects of electron Landau damping and transit time magnetic pumping on wave absorption are analyzed according to the HL-2M plasma, and then, an optimized scheme of helicon wave parameter is proposed. The evolution of helicon wave electric field and produced current drive are calculated by the AORSA full-wave code. It shows that current drive efficiency of 100 kA/MW can be generally received in the machine. Moreover, the AORSA results are actively benchmarked with the ray-tracing code, and the results show a good consistency. Finally, the numerical convergence and the consumption of computation resources on grid point numbers in AORSA code are discussed.
期刊：
Fusion Engineering and Design,2021年172:112897 ISSN：0920-3796
通讯作者：
Li, Xinxia
作者机构：
[Li, Xinxia; Li, Guozhuang; Liu, Hongbo] Univ South China, Dept Nucl Phys, Hengyang 421001, Peoples R China.;[Li, Xinxia] Chinese Acad Sci, Inst Plasma Phys, Hefei 230031, Peoples R China.;[Liu, Hongbo] HengYang Normal Univ, Coll Phys & Elect Engn, Hengyang 421008, Peoples R China.
通讯机构：
[Li, Xinxia] U;Univ South China, Dept Nucl Phys, Hengyang 421001, Peoples R China.
关键词：
CFETR;Helicon wave;Plasma current drive;Tokamak
摘要：
The China Fusion Engineering Testing Reactor (CFETR) is a tokamak reactor and aims to eventually reach DEMO relevant fusion power level of 1 GW. A lower single null configuration of the divertor design is proposed for the machine. To obtain the high performance operation of the plasma, both the hybrid and steady-state operating scenarios are suggested. In these scenarios, the plasma beta of <beta(e)> similar to 1.6% has been generally reached. In the paper, helicon wave propagation and current drive in CFETR are studied through GENRAY/CQL3D code. An analysis of the wave damping factor in CFETR plasma indicates that the electron Landau damping is dominant for the core plasma. According to the dimensionless parameter xi(e) and beta(e), a strong wave damping region is found. Based on the GENRAY simulation, the single pass power absorptions are generally obtained in both scenarios. Scanning of generated current on the launched poloidal angle indicates that high current drive efficiency is produced at theta similar to 30 degrees. For helicon wave with frequency f = 700 MHz, calculations of the current drive show that off-axis current drive about 30 kA/MW and 50 kA/MW are obtained in the hybrid and steady-state scenarios respectively. Simultaneously, the lower plasma density and high temperature promote the high current generation. Moreover, the obtained current drive and its peak position are shown to be sensitive to the launched n(//) similar to Finally, the helicon wave with frequency f = 700 MHz and launched n(//) similar to 2.0-3.0 is proposed to be a promising scheme for effective off-axis current drive in CFETR.
作者：
Liu, Hong Bo;Li, Xin Xia*;Xiao, Zheng Yao;Zhang, Ding Zong;Sun, Ai Ping
期刊：
Journal of the Korean Physical Society,2021年79(12):1135-1140 ISSN：0374-4884
通讯作者：
Li, Xin Xia
作者机构：
[Li, Xin Xia; Xiao, Zheng Yao; Liu, Hong Bo] Univ South China, Dept Nucl Phys, Hengyang 421001, Peoples R China.;[Liu, Hong Bo; Zhang, Ding Zong] Hengyang Normal Univ, Sch Phys & Elect Engn, Hengyang 421008, Peoples R China.;[Sun, Ai Ping] Southwestern Inst Phys, POB 432, Chengdu 610041, Sichuan, Peoples R China.
通讯机构：
[Li, Xin Xia] U;Univ South China, Dept Nucl Phys, Hengyang 421001, Peoples R China.
关键词：
Tokamak;HL-2M;Helicon wave;Current drive
摘要：
The helicon wave heating and current drive in the HL-2M tokamak for the steady-state scenario is studied numerically. Based on the theory of fast wave current drive proposed by Chiu, we analyze the characteristics of helicon waves damping for the HL-2M tokamak. For wave frequencies larger than 420 MHz, strong wave damping occurs, and electron Landau damping is dominant. Moreover, a strong wave absorption region associated with the dimensionless parameters
$$\beta _{e}$$
and
$$\xi _{e}$$
that depend on the wave frequency is obtained. The helicon wave propagation and current drive are simulated using the GENRAY/CQL3D code. The results show that an off-axis current drive with profiles peak at
$$\rho \sim 0.4$$
can be generally received at a wave frequency
$$f\sim 500$$
MHz and the launched parallel refractive index
$$n_{//}=3.8$$
and that the current drive efficiency reaches up to
$$\sim$$
140 kA/MW. A scan of
$$n_{//}$$
showed that both the current drive profile peak and the generated current could be adjusted by changing the launched
$$n_{//}$$
. Finally, a feasible scheme for the helicon wave off-axis current drive in the HL-2M tokamak is proposed.
作者机构：
[张振华] Department of Nuclear Physics, School of Nuclear Science and Technology, University of South China, Hengyang, 421001, China;[Qiu Q.-T.; 陈进琥; 马长升; 段敬豪] Department of Radiation Physics Technology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, 250117, China;[刘陈路] Department of Nuclear Physics, School of Nuclear Science and Technology, University of South China, Hengyang, 421001, China, Department of Radiation Physics Technology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, 250117, China
通讯机构：
[Zhang, Z.-H.] D;Department of Nuclear Physics, China
作者机构：
[Li, Xinxia; Liu, Hongbo] Univ South China, Dept Nucl Phys, Hengyang 421001, Peoples R China.;[Li, Xinxia; Li, Miaohui; Xiang, Nong] Chinese Acad Sci, Inst Plasma Phys, Hefei 230031, Peoples R China.
通讯机构：
[Li, Xinxia] U;Univ South China, Dept Nucl Phys, Hengyang 421001, Peoples R China.
关键词：
Helicon wave;Plasma current drive;Tokamak
摘要：
Recent experiments of Experimental Advanced Superconducting Tokomak (EAST) have successfully demonstrated a long-pulse steady-state scenario with improved plasma performance through integrated operation. The helicon wave (fast wave at omega > 20 omega(ci)) current drive in the EAST plasma with high beta(e) operation is studied numerically by means of GENRAY/CQL3D treatment. A theoretical analysis of the wave damping factor shows that electron Landau damping dominates the wave absorption process and effective current drive occurs in the central plasmas for low beta(e) operation. High beta (similar to 1.3) leads to even stronger Landau damping single-path wave absorption is found. The numerical calculation predicts a broad distribution of current drive with good efficiency in EAST plasma. Moreover, the current drive efficiency is proven to be sensitive to the plasma parameters, specially the initial parallel index of refraction n(//). A possible scenario of helicon wave current drive is proposed for the high beta(e) EAST operation. (C) 2020 Elsevier B.V. All rights reserved.
作者机构：
[Tang, Dan; Ou, Weiwei; Wang, Deming; Chen, Quan; Wang, Jiazheng; Xiao, Ji] Univ South China, Affiliated Hosp 2, Dept Anesthesiol, Hengyang 421001, Peoples R China.;[Mo, Zhongcheng] Univ South China, Dept Histol & Embryol, Hengyang 421001, Peoples R China.;[Tang, Chaoke] Univ South China, Inst Cardiovasc Res, Life Sci Res Ctr, Key Lab Atherosclerol Hunan Prov, Hengyang 421001, Peoples R China.;[Peng, Liangyu] Univ South China, Affiliated Hosp 1, Dept Anesthesiol, Hengyang 421001, Peoples R China.
通讯机构：
[Wang, Deming; Peng, Liangyu] U;Univ South China, Affiliated Hosp 2, Dept Anesthesiol, Hengyang 421001, Peoples R China.;Univ South China, Affiliated Hosp 1, Dept Anesthesiol, Hengyang 421001, Peoples R China.
关键词：
liver X receptor;cytokine;mRNA decay;tristetraprolin;mitogen-activated protein kinase
摘要：
Liver X receptors (LXRs) have anti-inflammatory properties. Whether LXRs play a role in post-transcriptional control of inflammatory cytokine expression is not clear. Here, we firstly identified that the synthetic LXR agonist T0901317 promoted IL-1β, IL-6 and TNFa mRNA degradation. Moreover, T0901317 destabilized TNFa mRNA through its 3'-untranslated region. In addition, T0901317 increased the expression of tristetraprolin (TTP), while antagonizing TTP with siRNA abrogated T0901317-mediated inflammatory cytokine mRNA decay. Interestingly, T0901317 repressed LPS-induced phosphorylation of ERK1/2 and p38 mitogen-activated protein kinase (MAPK) in THP-1 macrophages. The evidence presented here confirms that LXR activation with T0901317 inhibits the phosphorylation of ERK1/2 and p38 MAPK, likely resulting in the increased expression of TTP and the decay of LPS-induce inflammatory cytokine mRNAs.
作者机构：
[王程] Institute of Cardiovascular Disease, Key Laboratory for Arteriosclerology of Hunan Province, University of South China, Hengyang 421001, China;[王程] Department of Spine Surgery, the First Affiliated Hospital, University of South China, Hengyang 421001, China;[王文军; 晏怡果; 杨威] Department of Spine Surgery, the First Affiliated Hospital, University of South China, Hengyang 421001, China;[于小华] Life Science Research Center, University of South China, Hengyang 421001, China;[张健] Department of Hand and Micro-surgery, the First Affiliated Hospital, University of South China, Hengyang 421001, China
期刊：
Journal of Physiology and Biochemistry,2016年72(4):657-667 ISSN：1138-7548
通讯作者：
Yi, Guang-Hui
作者机构：
[Jiang, Yue; Peng, Xiao-Shan; Liu, Xing; Ren, Kun; Yi, Guang-Hui; Suo, Rong; Tang, Zhen-Li] Univ South China, Inst Cardiovasc Dis, Key Lab Arteriosclerol Hunan Prov, 28 W Changsheng Rd, Hengyang City 421001, Hunan, Peoples R China.;[Xiong, Sheng-Lin] You Country Peoples Hosp, Zhuzhou 412300, Hunan, Peoples R China.;[Zhang, Qing-Hai] Univ South China, Affiliated Hosp 1, Clin Res Inst, Hengyang 421001, Hunan, Peoples R China.;[Mo, Zhong-Cheng] Univ South China, Inst Cardiovasc Res, Life Sci Res Ctr, Key Lab Atherosclerol Hunan Prov, Hengyang 421001, Hunan, Peoples R China.
通讯机构：
[Yi, Guang-Hui] U;Univ South China, Inst Cardiovasc Dis, Key Lab Arteriosclerol Hunan Prov, 28 W Changsheng Rd, Hengyang City 421001, Hunan, Peoples R China.
关键词：
S1P;SR-BI;ABCA1;SphK;S1P receptors;Release
摘要：
Sphingosine-1-phosphate (S1P), which has emerged as a pivotal signaling mediator that participates in the regulation of multiple cellular processes, is derived from various cells, including vascular endothelial cells. S1P accumulates in lipoproteins, especially HDL, and the majority of free plasma S1P is bound to HDL. We hypothesized that HDL-associated S1P is released through mechanisms associated with the HDL maturation process. ApoA-I, a major HDL apolipoprotein, is a critical factor for nascent HDL formation and lipid trafficking via ABCA1. Moreover, apoA-I is capable of promoting bidirectional lipid movement through SR-BI. In the present study, we confirmed that apoA-I can facilitate the production and release of S1P by HUVECs. Furthermore, we demonstrated that ERK1/2 and SphK activation induced by apoA-I is involved in the release of S1P from HUVECs. Inhibitor and siRNA experiments showed that ABCA1 and SR-BI are required for S1P release and ERK1/2 phosphorylation induced by apoA-I. However, the effects triggered by apoA-I were not suppressed by inhibiting ABCA1/JAK2 or the SR-BI/Src pathway. S1P released due to apoA-I activation can stimulate the (ERK1/2)/SphK1 pathway through S1PR (S1P receptor) 1/3. These results indicated that apoA-I not only promotes S1P release through ABCA1 and SR-BI but also indirectly activates the (ERK1/2)/SphK1 pathway by releasing S1P to trigger their receptors. In conclusion, we suggest that release of S1P induced by apoA-I from endothelial cells through ABCA1 and SR-BI is a self-positive-feedback process: apoA-I-(ABCA1 and SR-BI)-(S1P release)-S1PR-ERK1/2-SphK1-(S1P production)-(more S1P release induced by apoA-I).
期刊：
Advances in Clinical Chemistry,2015年71:171-203 ISSN：0065-2423
通讯作者：
Tang, Chao-Ke
作者机构：
[Tang, Chao-Ke; Yu, Xiao-Hua] Univ South China, Life Sci Res Ctr, Key Lab Atherosclerol Hunan Prov, Mol Target New Drug Discovery & Cooperat Innovat, Hengyang, Peoples R China.;[Zheng, Xi-Long] Univ Calgary, Hlth Sci Ctr, Dept Biochem & Mol Biol, Libin Cardiovasc Inst Alberta,Cumming Sch Med, Calgary, AB, Canada.
通讯机构：
[Tang, Chao-Ke] U;Univ South China, Life Sci Res Ctr, Key Lab Atherosclerol Hunan Prov, Mol Target New Drug Discovery & Cooperat Innovat, Hengyang, Peoples R China.
作者：
Cui Li-Bao;Yu Xiao-Hua;Jiang Chong-Hui;Tang Ya-Ling;Ouyang Xin-Ping;...
期刊：
生物化学与生物物理进展,2015年42(9):866-876 ISSN：1000-3282
通讯作者：
Tang Chao-Ke
作者机构：
[Ouyang Xin-Ping; Yao Feng; Yu Xiao-Hua; Cui Li-Bao; He Ping-Ping; Tang Chao-Ke; Lu Yun-Cheng; Zhang Min; Tang Ya-Ling] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Key Lab Atherosclerol Hunan Prov, Inst Cardiovasc Res,Life Sci Res Ctr, Hengyang 421001, Peoples R China.;[Jiang Chong-Hui; Cui Li-Bao] Cent Hosp Hengyang, Dept Pharm, Hengyang 421001, Peoples R China.
通讯机构：
[Tang Chao-Ke] U;Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Key Lab Atherosclerol Hunan Prov, Inst Cardiovasc Res,Life Sci Res Ctr, Hengyang 421001, Peoples R China.
关键词：
ABCA1;ABCG5;ABCG8;Atherosclerosis;HDL-C;Inflammation;Probucol;SR-B I
摘要：
Probucol is a potent hypolipidemic drug that decreases plasma high-density lipoprotein cholesterol (HDL-C) levels but attenuates atherosclerosis. However, the detailed mechanisms are not fully understood. The aim of this study was to explore the molecular mechanisms of the HDL-C-lowering and antiatherogenic effects of probucol. New Zealand white rabbits were randomly divided into normal diet group, normal diet+probucol group, high fat diet (HFD) group and HFD+probucol (HFD+P) group. After 7 weeks of treatments, the extent of the atherosclerotic lesions, hepatic lipid accumulation and plasma levels of triglycerides, total cholesterol, low-density lipoprotein cholesterol and HDL-C were significantly reduced in HFD+P group as compared to HFD group. Probucol effectively inhibited down-regulation of hepatic scavenger receptor class B type I (SR-B I) expression, and ATP-binding cassette (ABC) transporters G5 (ABCG5) and G8 (ABCG8) expression in the liver and small intestine induced by HFD but further promoted HFD-induced reduction in hepatic ABC transporter A1 (ABCA1) expression. In addition, probucol also significantly prevented HFD-induced increases of tumor necrosis factor-alpha, interleukin-1, interleukin-6 and monocyte chemotactic protein-1 levels in the aortic arch and plasma. Thus, our data provide strong evidence that probucol alleviates atherosclerosis through regulating ABCA I, SR-B I, ABCG5 and ABCG8 expression and inhibiting the secretion of proinflammatory cytokines in hypercholesterolemic rabbits.
