期刊论文

Yang, Yun-Hua

英文

Clinica Chimica Acta

0009-8981

2015

441

33-43

10.1016/j.cca.2014.12.007

The authors gratefully acknowledge the financial support from the National Natural Science Foundation of China ( 81170278 , 81370377 and 81300224 ), Aid Program for Science and Technology Innovative Research Team in Higher Educational Institutions of Hunan Province ( 2008-244 ), and the Construct Program of the Key Discipline in Hunan Province , China ( 2011-76 ).

本校为第一且通讯机构

Interferon-γ (IFN-γ), the sole member in type II IFN predominantly secreted by macrophages and T cells, is a critical regulator of immune function and provides a robust first line of defense against invading pathogens. Binding of IFN-γ to its receptor complex can activate a variety of downstream signaling pathways, particularly the Janus kinase (JAK)/signal transducer and activator of transcription (STAT), to induce gene transcription within the target cells. This pro-inflammatory mediator is highly expressed in atherosclerotic lesions and p...