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Interferon-γ in foam cell formation and progression of atherosclerosis

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成果类型:
期刊论文
作者:
Yu, Xiao-Hua;Zhang, Jian;Zheng, Xi-Long;Yang, Yun-Hua*;Tang, Chao-Ke
通讯作者:
Yang, Yun-Hua
作者机构:
[Tang, Chao-Ke; Yu, Xiao-Hua] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Key Lab Atherosclerol Hunan Prov, Life Sci Res Ctr, Hengyang 421001, Hunan, Peoples R China.
[Zhang, Jian] Univ South China, Affiliated Hosp 1, Dept Spine, Hengyang 421001, Hunan, Peoples R China.
[Zheng, Xi-Long] Univ Calgary, Hlth Sci Ctr, Cumming Sch Med, Dept Biochem & Mol Biol,Libin Cardiovasc Inst, Calgary, AB T2N 4N1, Canada.
[Yang, Yun-Hua] Univ South China, Affiliated Hosp 1, Dept Pediat, Hengyang 421001, Hunan, Peoples R China.
通讯机构:
[Yang, Yun-Hua] U
Univ South China, Affiliated Hosp 1, Dept Pediat, Hengyang 421001, Hunan, Peoples R China.
语种:
英文
关键词:
Atherosclerosis;Foam cells;IFN-gamma;Myocardial infarction;Stroke
期刊:
Clinica Chimica Acta
ISSN:
0009-8981
年:
2015
卷:
441
页码:
33-43
基金类别:
The authors gratefully acknowledge the financial support from the National Natural Science Foundation of China ( 81170278 , 81370377 and 81300224 ), Aid Program for Science and Technology Innovative Research Team in Higher Educational Institutions of Hunan Province ( 2008-244 ), and the Construct Program of the Key Discipline in Hunan Province , China ( 2011-76 ).
机构署名:
本校为第一且通讯机构
院系归属:
国防科学技术学院
医学院
药学与生物科学学院
摘要:
Interferon-gamma (IFN-gamma), the sole member in type II IFN predominantly secreted by macrophages and T cells, is a critical regulator of immune function and provides a robust first line of defense against invading pathogens. Binding of IFN-gamma to its receptor complex can activate a variety of downstream signaling pathways, particularly the Janus kinase (JAK)/signal transducer and activator of transcription (STAT), to induce gene transcription within the target cells. This pro-inflammatory mediator is highly expressed in atherosclerotic lesions and promotes foam cell formation, but its effe...

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