期刊论文

Wang, Wen-Jun

英文

Clinica Chimica Acta

0009-8981

2015

450

262-272

10.1016/j.cca.2015.08.029

In addition to immune cells, IVD cells themselves are able to produce IL-1β. A low expression of IL-1β is observed in non-degenerate human IVDs, revealing the involvement of IL-1β in normal disk tissue repair and remodeling [38]. However, degenerate and herniated IVDs display higher IL-1β levels than non-degenerate IVDs [38]. Moreover, IL-1β levels in degenerative human IVD tissues increase with severity of degeneration [39]. In AF and NP biopsies intraoperatively collected from ten lumbar disk

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Intervertebral disk degeneration (IDD) is the most common diagnosis in patients with low back pain, a main cause of musculoskeletal disability in the world. Interleukin-1 (IL-1) β is the most important member of the IL-1 family, and has a strong pro-inflammatory activity by stimulating the secretion of multiple pro-inflammatory mediators. IL-1β is highly expressed in degenerative intervertebral disk (IVD) tissues and cells, and it has been shown to be involved in multiple pathological processes during disk degeneration, including inflammatory...