期刊论文

Yi, Guang-Hui

英文

Journal of Physiology and Biochemistry

1138-7548

2016

72

4

657-667

10.1007/s13105-016-0504-6

This work was sponsored by the National Natural Science Foundation of China (Nos. 81270360 and 31400652), Scientific Research Fund of Hunan Provincial Education Department (13C838), the Science and Technology Planning Project of Hunan Provincial Science and Technology Department (2014FJ2012), the Aid Program for Science and Technology Innovative Research Team in Higher Educational Institutions (2008-244) of Hunan Province, and the construct program of the key discipline in Hunan Province, China (Basic Medicine Sciences in University of South China, Xiangjiaofa No. [2011]76).

本校为第一且通讯机构

Sphingosine-1-phosphate (S1P), which has emerged as a pivotal signaling mediator that participates in the regulation of multiple cellular processes, is derived from various cells, including vascular endothelial cells. S1P accumulates in lipoproteins, especially HDL, and the majority of free plasma S1P is bound to HDL. We hypothesized that HDL-associated S1P is released through mechanisms associated with the HDL maturation process. ApoA-I, a major HDL apolipoprotein, is a critical factor for nascent HDL formation and lipid trafficking via ABCA1. Moreover, apoA-I is capable of promoting bidirect...