期刊论文

Tang, Chao-Ke

英文

Advances in Clinical Chemistry

0065-2423

2015

70

1-30

10.1016/bs.acc.2015.03.004

The authors gratefully acknowledge the financial support from the National Natural Sciences Foundation of China (81170278, 81370377, and 81300224), Aid Program for Science and Technology Innovative Research Team in Higher Educational Institutions of Hunan Province (2008–244), and the construct program of the key discipline in Hunan Province, China (2011–76).

本校为第一且通讯机构

Atherosclerosis is a chronic inflammatory disease of the arterial wall with lipid-laden lesions, involving a complex interaction between multiple different cell types and cytokine networks. Inflammatory responses mark all stages of atherogenesis: from lipid accumulation in the intima to plaque formation and eventual rupture. One of the most important regulators of inflammation is the transcription factor nuclear factor-kappa B (NF-kappa B), which is activated through the canonical and noncanonical pathways in response to various stimuli. NF-kappa B has long been regarded as a proatherogenic fa...