期刊论文

Yin, Wei-Dong;Tang, Chao-Ke

英文

Biochemical and Biophysical Research Communications

0006-291X

2016

472

3

410-417

10.1016/j.bbrc.2015.10.158

The authors gratefully acknowledge the financial support from the National Natural Sciences Foundation of China ( 81270269 , 81070220 and 81170278 ). The construct program of the key discipline in Hunan province, and Zhengxiang Scholar Program of University of South China ( 2014-004 ).

本校为第一且通讯机构

Angiopoietin-like 4 (Angptl4), a secreted protein, is an important regulator to irreversibly inhibit lipoprotein lipase (LPL) activity. Macrophage LPL contributes to foam cell formation via a so-called"molecular bridge" between lipoproteins and receptors on cell surface. It has been reported that macrophage ANGPTL4 suppresses LPL activity, foam cell formation and inflammatory gene expression to reduce atherosclerosis development. Recently, some studies demonstrated that microRNA-134 is upregulated in atherosclerotic macrophages. Here we demonstrate that miR-134 directly binds to 3'UTR of ANGPT...