National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31400802]; Natural Science Foundation of Hunan Province, ChinaNatural Science Foundation of Hunan Province [2015JJ4043, 2015JJ5003]
机构署名：
本校为第一且通讯机构
院系归属：
国防科学技术学院
药学与生物科学学院
摘要：
Osteosarcoma (OS) is the most common nonhematologic bone malignancy in children and adolescents. Despite the advances of adjuvant chemotherapy and significant improvement of survival, the prognosis remains generally poor. As such, the search for more effective anti-OS agents is urgent. The phosphatidylinositol 3-kinase (PI3K)/Akt pathway is thought to be one of the most important oncogenic pathways in human cancer. An increasing body of evidence has shown that this pathway is frequently hyperactivated in OS and contributes to disease initiation...
