Sortilin: A novel regulator in lipid metabolism and atherogenesis

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成果类型：

期刊论文

作者：

Zhong, Li-yuan;Cayabyab, Francisco S.;Tang, Chao-ke;Zheng, Xi-long;Peng, Tian-hong*;...

通讯作者：

Peng, Tian-hong;Lv, Yun-cheng

作者机构：

[Lv, Yun-cheng; Zhong, Li-yuan; Peng, Tian-hong; Peng, TH; Lv, YC] Univ South China, Lab Clin Anat, Hengyang 421001, Peoples R China.

[Cayabyab, Francisco S.] Univ Saskatchewan, Coll Med, Dept Surg, Saskatoon, SK S7N 5E5, Canada.

[Tang, Chao-ke] Univ South China, Life Sci Res Ctr, Key Lab Atherosclerol Hunan Prov, Inst Cardiovasc Res, Hengyang 421001, Peoples R China.

[Zheng, Xi-long] Univ Calgary, Hlth Sci Ctr, Libin Cardiovasc Inst Alberta, Dept Biochem & Mol Biol, 3330 Hosp Dr NW, Calgary, AB T2N 4N1, Canada.

通讯机构：

[Peng, TH; Lv, YC] U

Univ South China, Lab Clin Anat, Hengyang 421001, Peoples R China.

语种：

英文

关键词：

Atherosclerosis;Lipid metabolism;Low-density lipoprotein;Sortilin

期刊：

Clinica Chimica Acta

ISSN：

0009-8981

年：

2016

卷：

460

页码：

11-17

DOI：

10.1016/j.cca.2016.06.013

基金类别：

National Natural Sciences Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81570408]; Hunan Provincial Natural Science Foundation of ChinaNatural Science Foundation of Hunan Province [14JJ2091]; Scientific Research Fund of Hunan Provincial Education DepartmentHunan Provincial Education Department [12C0339]; start-up funds for Ph.Ds in University of South China [2014XQD37]; Zhengxiang scholar program of the University of South China; construct program of the key discipline in Hunan Province

机构署名：

本校为第一且通讯机构

院系归属：

国防科学技术学院

医学院

药学与生物科学学院

摘要：

Several lines of evidence have shown that SORT1 gene within 1p13.3 locus is an important modulator of the low density lipoprotein-cholesterol (LDL-C) level and atherosclerosis risk. Here, we summarize the effects of SORT1, which codes for sortilin, on lipid metabolism and development of atherosclerosis and explore the mechanisms underlying sortilin effects on lipid metabolism especially in hepatocytes and macrophages. Recent epidemiological evidence demonstrated that sortilin has been implicated as the causative factor and regulates lipid metabolism in vivo. Hepatic sortilin overexpression lea...

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Sortilin: A novel regulator in lipid metabolism and atherogenesis

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