Ezetimibe-Mediated Protection of Vascular Smooth Muscle Cells from Cholesterol Accumulation through the Regulation of Lipid Metabolism-Related Gene Expression

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成果类型：

期刊论文

作者：

Gong, Yong-Zhen;Sun, Shao-Wei;Yuan, Hao-Yu;Xie, Xue-Jiao;Tuo, Qin-Hui;...

通讯作者：

Xiong, Yan

作者机构：

[Xiong, Yan; Gong, Yong-Zhen] Cent S Univ, Sch Pharmaceut Sci, Dept Pharmacol, Changsha, Hunan, Peoples R China.

[Xiong, Yan] Guangzhou Med Univ, Sch Pharmaceut Sci, Guangzhou Res Inst Snake Venom, Guangzhou 510182, Guangdong, Peoples R China.

[Yuan, Hao-Yu; Liao, Duan-Fang; Sun, Shao-Wei; Yang, Xue-Feng] Univ South China, Life Sci Res Ctr, Inst Cardiovasc Dis, Hengyang, Peoples R China.

[Tan, Xi; Zheng, Xi-Long; Gong, Yong-Zhen; Tuo, Qin-Hui; Liao, Duan-Fang; Xie, Xue-Jiao; Sun, Shao-Wei] Hunan Univ Chinese Med, Div Stem Cell Regulat & Applicat, State Key Lab Chinese Med Powder & Med Innovat Hu, Changsha, Hunan, Peoples R China.

[Zheng, Xi-Long] Univ Calgary, Cumming Sch Med, Libin Cardiovasc Inst Alberta, Dept Biochem & Mol Biol, Calgary, AB, Canada.

通讯机构：

[Xiong, Yan] G

Guangzhou Med Univ, Sch Pharmaceut Sci, Guangzhou Res Inst Snake Venom, Guangzhou 510182, Guangdong, Peoples R China.

语种：

英文

关键词：

Ezetimibe;Liver X receptor;Sterol-regulatory element binding protein 1;ATP-binding cassette transporter A1;Caveolin-1

期刊：

PHARMACOLOGY

ISSN：

0031-7012

年：

2014

卷：

期：

5-6

页码：

214-222

DOI：

10.1159/000368803

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81173047]; Natural Science Foundation of HunanNatural Science Foundation of Hunan Province [12JJ5068]; Construct Program of the Pharmaceutical Science Key Discipline in the Hunan Province

机构署名：

本校为其他机构

院系归属：

国防科学技术学院

医学院

药学与生物科学学院

摘要：

Background: Ezetimibe is a potent inhibitor of Niemann-Pick type C1-Like 1 and has been approved for the treatment of hypercholesterolemia. Our preliminary study showed that ezetimibe promotes cholesterol efflux from vascular smooth muscle cells (VSMCs). Our aim was to investigate the cellular mechanisms underlying the ezetimibe actions. Methods and Results: Rat VSMCs were converted to foam cells by incubation with cholesterol: methyl-beta-cyclodextrin. The intracellular free cholesterol, total cholesterol, and the ratio of cholesteryl ester to total cholesterol were decreased after the incuba...

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Ezetimibe-Mediated Protection of Vascular Smooth Muscle Cells from Cholesterol Accumulation through the Regulation of Lipid Metabolism-Related Gene Expression

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