摘要：
Electrosorption holds extraordinary promise for uranium (U(VI)) capture but is still limited by the finite accessible active sites of electrode materials, poor surface wettability and its intrinsic co-ion repulsion effect. Here we originally designed KOH-etched porous graphitic carbon nitride (g-C3N4) as active material, and multi-functional crosslinked xanthan gum-polyacrylic acid (XG-PAA) as binder to fabricate g-C3N4-X electrode for U(VI) capture. The abundant in-plane nanopores on 2D g-C3N4 lamellar, rich O- and N-containing active sites, and 3D tough interconnected conductive architecture, endowed g-C3N4-X electrode with fast electron/ion transport channels, alleviated co-ions exclusion, superior electrochemical properties, and hydrophilicity. These unique structure characteristics enabled U(VI) ions to form micro electric-field attraction with negatively charged COO- groups in advance to alleviate co-ion repulsion, then to electro-migrate towards and coordinate with active sites, and eventually to be electrocatalytic reduced into U(IV) deposits. Consequently, the g-C3N4-X electrode exhibited a 1.87 times faster adsorption kinetics, a much higher removal ratio of 98.1% within 70 min than traditional PVDF-bound electrode. Meanwhile, the cumulative adsorption capacity of g-C3N4-X electrode after six cycles was up to 1459.1 mg g−1. This efficient, scalable, and cost-effective g-C3N4-X electrode represents a significant step forward toward the practical applications of U(VI) electrosorption.
摘要：
Metal halide perovskite (MHP) detectors are highly esteemed for their outstanding photoelectric properties and versatility in applications. However, they are unfortunately prone to degradation, which constitutes a significant barrier to their sustained performance. This review meticulously delves into the causes leading to their instability, predominantly attributable to factors such as humidity, temperature, and electric fields and, notably, to various radiation factors such as X-rays, gamma-rays, electron beams, and proton beams. Furthermore, it outlines recent advancements in strategies aimed at mitigating these detrimental effects, emphasizing breakthroughs in composition engineering, heterostructure construction, and encapsulation methodologies. At last, this review underscores the needs for future improvements in theoretical studies, material design, and standard testing protocols. In the pursuit of optimizing the chemical stability of MHP detectors, collaborative efforts are in an imperative need. In this way, broad industrial applications of MHP detectors could be achieved.
摘要：
Canopy FGF signaling regulator 2 (CNPY2) is a novel angiogenic growth factor. In recent years, increasing evidence highlights that CNPY2 has important functions in health and disease. Many new blood vessels need to be formed to meet the nutrient supply in the process of tumor growth. CNPY2 can participate in the development of tumors by promoting angiogenesis. CNPY2 also enhances neurite outgrowth in neurologic diseases and promotes cell proliferation and tissue repair, thereby improving cardiac function in cardiovascular diseases. Regrettably, there are few studies on CNPY2 in various diseases. At the same time, its biological function and molecular mechanism in the process and development of disease are still unclear. This paper reviews the recent studies on CNPY2 in cervical cancer, renal cell carcinoma, prostate cancer, colorectal cancer, lung cancer, gastric cancer, hepatocellular carcinoma, cerebral ischemia-reperfusion injury, spinal cord ischemia-reperfusion injury, Parkinson's disease, ischemic heart disease, myocardial ischemia-reperfusion injury, myocardial infarction, heart failure, and non-alcoholic fatty liver disease. The biological function and molecular mechanism of CNPY2 in these diseases have been summarized in this paper. Many drugs that play protective roles in tumors, cardiovascular diseases, non-alcoholic fatty liver disease, and neurologic diseases by targeting CNPY2, have also been summarized in this paper. In addition, the paper also details the biological functions and roles of canopy FGF signaling regulator 1 (CNPY1), canopy FGF signaling regulator 3 (CNPY3), canopy FGF signaling regulator 4 (CNPY4), and canopy FGF signaling regulator 5 (CNPY5). The mechanism and function of CNPY2 should be continued to study in order to accelerate disease prevention in the future.
通讯机构：
[Peng, AG ] U;Univ South China, Sch Nucl Sci & Technol, Hengyang 421001, Peoples R China.
关键词：
(137)Cs;(239+240)Pu;Distribution characteristics;Lake East dongting;Lake sediments
摘要：
Plutonium-239+240 and (137)Cs in the environment can usually be used to track the impact of nuclear activities on the environment, and have become important tools in environmental geochemical studies. In this study, nine sediment cores (E1-E9) in Lake East Dongting were collected and measured for the activity concentration of (239+240)Pu, (137)Cs and the atomic ratio of (240)Pu/(239)Pu, and then their vertical distribution characteristics were analyzed. The results show that: the activity concentrations of (137)Cs and (239+240)Pu in Lake East Dongting ranged from 5.26±0.43 to 28.6±2.23 Bq kg(-1) and 0.29±0.02 to 1.37±0.09 Bq kg(-1), with an average of 7.48±0.68 Bq kg(-1) and 0.39±0.03 Bq kg(-1), respectively. The atomic ratios of (240)Pu/(239)Pu are 0.168±0.012-0.211±0.015, which are basically consistent with the global atmospheric deposition. The vertical profiles of (137)Cs and (239+240)Pu in sediment cores show obvious single-peak distribution in E1-E6 and bimodal distribution in E7-E9. The results of sedimentation rates calculated by (137)Cs and (239+240)Pu method ranged from 0.59cm y(-1) to 1.99cm y(-1) with a mean of 1.18cm y(-1) and 0.61cm y(-1) to 2.18cm y(-1) with a mean of 1.26cm y(-1). The inventories of (137)Cs and (239+240)Pu in nine sediment cores are 5.87-10.8 kBq m(-2) and 307-545 Bq m(-2), which are about 8-14 and 9-15 times the inventory in the global average atmospheric deposition at the same latitude respectively. Comparing the results of the sedimentation rates and the inventories from different sampling points indicates that extreme climatic events and human activities have a significant impact on sediment environment of Lake East Dongting.
摘要：
Uranium contamination is a key issue in the sustainable development of nuclear energy. In this study, a cellulose/sericite hybrid aerogel with a layer-stacked network structure (MCC/AS-P) was prepared for uranium-contaminated wastewater treatment. Systematic characterization and multiple-batch static adsorption experiments were conducted to analyze the aerogel's preparation, adsorption, and desorption. The kinetics demonstrated a noticeable transition between mass transfer diffusion control and mass transfer control, approaching adsorption equilibrium within 8 min and 180 min, respectively, wherein polymer layers led to a more stable adsorption process. Adsorption isotherm and thermodynamic studies established that the theoretical adsorption capacity of MCC/AS-P for U(VI) at T = 298 K could reach 374.5 mg.g(-1). The adsorption behavior was endothermic and spontaneous, and the DFT calculations demonstrated that the adsorption energy of MCC/AS for UO22+ was 506.5 kcal/mol. Temperature, U(VI) concentration, and desorption can all lead to a transition of the dominant mechanism between chemisorption and physisorption. After six swelling-deswelling adsorption cycles, the adsorption efficiency remained above 80%, and the structure remained intact. Furthermore, the excellent performance in terms of interference resistance and chemical stability offers potential for practical application.
摘要：
In order to improve the reliability and maintainability of rod control power cabinets in nuclear power plants, this paper uses insulated gate bipolar transistors (IGBTs), the key power device of rod control power cabinets, as the object of research on cross-working-condition fault prediction. An improved transfer learning (TL) model based on a temporal convolutional network (TCN) is proposed to solve the problem of low fault prediction accuracy across operating conditions. First, the peak emitter voltage of an IGBT aging dataset is selected as the source domain failure characteristic, and the TCN model is trained after the removal of outliers and noise reduction. Then, the time–frequency features are extracted according to the characteristics of the target domain data, and the target domain representation data are obtained using kernel principal component analysis (KPCA) for dimensionality reduction. Finally, the TCN model trained on the source domain is transferred; the model is fine-tuned according to the target domain data, and the learning rate, the number of hidden layer nodes, and the number of training times in the network model are optimized using the dung beetle optimization (DBO) algorithm to obtain the optimal network, making it more suitable for target sample fault prediction. The prediction results of this TCN model, the long short-term memory (LSTM) model, the gated recurrent unit (GRU) model, and the recursive neural network (RNN) model are compared and analyzed by selecting prediction performance evaluation indexes. The results show that the TCN model has a better predictive effect. Comparing the prediction results of the TCN-based optimized transfer learning model with those of the directly trained TCN model, the mean square error, root mean square error, and mean absolute error are reduced by a factor of two to three, which provides an effective solution for fault prediction across operating conditions.
摘要：
Curcumin (CUR) exhibits a definite curative effect in the treatment of depression. To identify potential antidepressant targets and mechanisms of action of CUR. This study used network pharmacology to explore the signaling pathways and CUR-related targets in depression. C57BL/6J mice (male,12-14weeks old) were randomly divided into four groups (n = 8): saline-treated (control mice), lipopolysaccharide (LPS, 2mg/kg/day, intraperitoneally), LPS + CUR (50mg/kg/day, intragastrically), and LPS + CUR + LY294002 (7.5mg/kg/day, intraperitoneally). After 1week, behavioral tests were performed. Then, neuronal damage in the prefrontal cortex of mice was evaluated by hematoxylin-eosin (HE) staining. We uncovered the main active mechanism of CUR against depression using Western blotting and enzyme-linked immunosorbent assay (ELISA). Gene set enrichment analysis (GSEA) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways showed that the most significantly enriched pathway in CUR against depression was the PI3K-Akt pathway. Moreover, 52 targets were significantly correlated with the PI3K-Akt signaling pathway and CUR-related targets. In addition, among the top 50 targets ranked by degree in the protein-protein interaction (PPI) network, there were 23 targets involved in the 52 intersection targets. Administration of LPS alone extended immobility time in the open field test (OFT) and tail suspension test (TST) and decreased sucrose consumption in the sucrose preference test (SPT). Pretreatment with CUR relieved LPS-induced changes in the behavioral tests, activity of the PI3K-Akt signaling pathway, neuronal damage in the prefrontal cortex (PFC), and inflammatory response. Moreover, inhibition of the PI3K-Akt signaling pathway by LY294002 blocked the therapeutic effects of CUR. Our study indicates that CUR may be an effective antidepressant agent in an LPS-induced mouse model, partly because of its anti-inflammatory action through the PI3K-Akt signaling pathway.
摘要：
An improved metallized polyethylene terephthalate (PET) substrate prepared by catechol (CA) and tetraethylenepentamine (TEPA) composites modification with electroless deposition (ELD) copper layer is presented. Through the polymerization of CA with TEPA, amino and imino groups were generated to adsorb the activated particles required for metallization. To achieve the practical application of this method, different catalytic approaches were validated. Under different catalytic conditions, the catalytic effect of UV light was most pronounced, reaching almost four times than that in darkness. The resulting solid copper layers exhibited highly reliable electrical properties, including a low resistivity of 2.73 mu omega cm, tightly spaced crystalline particles and excellent mechanical properties. The fabricated metallized PET substrates were verified for use in flexible circuit boards, demonstrating the compatibility of the proposed CA-TEPA composites modification method with the PET substrates. This method provides an effective approach to the metallization of the PET substrates, which has a widespread application in manufacturing of flexible electronics such as film capacitors.
摘要：
This review provides an overview of the recent synthesis methods developed and made available for thiophene products preparation. Thiophene being an important sulfur‐containing heterocyclic motif finds use in pharmaceuticals, functional materials, organic chemistry and natural products, its efficient synthesis is equally important. Abstract Thiophene, as an important sulfur‐containing heterocyclic, is widely used in pharmaceuticals, functional materials, and natural products. Furthermore, thiophene is of great interest to synthetic chemists due to its diverse reactivities. Over the past few decades, many synthetic strategies are developed for functionalized thiophenes. Several reviews have been reported. However, there is no review on thiophene synthesis summarized based on the sulfur sources. The current review envisioned to summary the synthesis methods for thiophene with the respect of sulfur sources and give support for choose the appropriate tools to obtain thiophene substrates.
摘要：
Background: SN-38, recognized as the primary active derivative of the pivotal chemotherapeutic agent CPT-11, demonstrates substantially enhanced efficacy in colorectal cancer (CRC) management compared to CPT-11. Nonetheless, challenges such as low stability, inadequate aqueous solubility, limited bioavailability, and nonspecific targeting to cancer cells hinder its clinical adoption. In the present research, we synthesized SN-38loaded liposomes cloaked with macrophage membranes (SN-38@MM-LPs) to assess their therapeutic potential and safety profile in addressing CRC. Methods: SN-38@MM-LPs were synthesized using an incubation extrusion technique, combining a macrophage membrane with liposomes (LPs). It was characterized by size, zeta potential, transmission electron microscopy observations, polydispersity index and coomassie bright blue staining. CCK-8, EdU, and flow cytometry assays were performed to evaluate the viability and apoptosis rates of HCT116 and HCT8 cells after treatment with SN38@MM-LPs. A cellular uptake assay was conducted to evaluate the internalization of SN-38@MM-LPs in vitro. Moreover, the biodistribution, therapeutic efficacy, and safety of SN-38@MM-LPs were further assessed in orthotopic HCT116 xenograft model mice. Results: Characterization results revealed that SN-38@MM-LPs possess a spherical morphology with a consistent size distribution (129 nm) and a drug loading efficiency of 5.54 +/- 0.73%. SN-38 curtailed the growth and promoted apoptosis in both HCT8 and HCT116 cells. The impact of SN-38 was accentuated when delivered via SN-38@LPs and SN-38@MM-LPs. Notably, in the orthotopic xenograft model, SN-38@MM-LPs manifested superior tumor-targeting capabilities and therapeutic outcomes. Additionally, SN-38@MM-LPs presented negligible hepatic toxicity. Conclusions: SN-38@MM-LPs showcased potent and targeted antitumor actions in CRC. Consequently, SN38@MM-LPs emerge as a potential nanoparticle formulation that could amplify the antitumor efficacy of SN38, simultaneously mitigating liver toxicity concerns.
期刊：
Journal of Environmental Radioactivity,2024年272:107331 ISSN：0265-931X
通讯作者：
Hong, CS
作者机构：
[Wen, Jiale; Xie, Bingbing; Hong, CS; Hong, Changshou; Wang, Hong; Wang, Yuhang] Univ South China, Sch Resources Environm & Safety Engn, Hengyang 421001, Peoples R China.;[Wang, Hong] Univ South China, Sch Nucl Sci & Technol, Hengyang 421001, Peoples R China.;[Wen, Jiale; Xie, Bingbing; Hong, Changshou; Wang, Hong; Wang, Yuhang] Univ South China, Hunan Prov Engn Technol Res Ctr Uranium Tailings T, Hengyang 421001, Peoples R China.
通讯机构：
[Hong, CS ] U;Univ South China, Sch Resources Environm & Safety Engn, Hengyang 421001, Peoples R China.
关键词：
Numerical simulation;Radon concentration field;Ramp;Temperature field
摘要：
By introducing the parameters of radon exhalation rate and radon diffusion coefficient, the distribution of radon concentration field on ramp under the condition of superposition of temperature field and flow field is simulated. The simulation results show that the distribution of radon concentration in the ramp under the condition of low-speed ventilation is greatly affected by the temperature field and flow field, and the change of radon exhalation caused by temperature is the main factor leading to the change of radon concentration in the ramp. The change of temperature will cause the overall increase of radon concentration in the ramp. Under the condition of constant flow field, the radon concentration in the chamber is more than two times higher than the average radon concentration in the ramp. Some areas severely exceeded the limit.
通讯机构：
[Yin, XH ] U;Univ South China, Sch Nursing, Hengyang, Hunan, Peoples R China.
关键词：
Prehabilitation;Frailty;Aged;Meta-analysis
摘要：
Objective: The study investigates the impact of preoperative rehabilitation on the surgical prognosis of frail older patients. Method: The effect sizes of all studies retrieved and included by the nine databases were analyzed and expressed as RR and WMD. Results: 8 studies with 902 participants met the criteria for inclusion. A significant reduction in total complications (RR = 0.84, 95 % CI = 0.73 to 0.97, P = 0.021) and the 6MWT after surgery (WMD = 74.76, 95 % CI = 44.75 to 104.77, P = 0.000) was observed in the prehabilitation group. But it had no differences in mortality(RR = 1.89, 95 % CI = 0.75 to 4.72, P = 0.176), readmission rates(RR = 1.04, 95 % CI = 0.56 to 1.91, P = 0.906) and LOS(WMD = -0.24, 95 % CI = -1.00 to 0.52, P = 0.540). Conclusions: Prehabilitation had positive effect on postoperative complications and functional recovery in frail older patients. (c) 2023 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
摘要：
BACKGROUND: Opa-interacting protein 5 antisense transcript 1 (OIP5-AS1) has been demonstrated to play vital roles in development and progression of tumors such as gastric cancer (GC). However, the detailed molecular mechanism of OIP5-AS1 has not been completely elucidated. Our study aimed to investigate the role and the epigenetic regulation mechanism of OIP5-AS1 in GC. METHODS: OIP5-AS1 expression in GC tissues was detected by RT-qPCR. Loss- and gain-of-function experiments were conducted to assess the biological function of OIP5-AS1 in vitro and in vivo. The interaction of OIP5-AS1 with insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) or heterogeneous nuclear nucleoprotein A1 (hnRNPA1) was verified by bioinformatics analysis, RNA pull-down assays, and RNA immunoprecipitation assays. RESULTS: In this study, we identified that OIP5-AS1 is specifically overexpressed in GC tumor tissues and cell lines and correlated with a poor prognosis. The loss of OIP5-AS1 suppressed the proliferation, migration, invasion, epithelial-mesenchymal transition (EMT), and glycolysis of GC cells, but the ectopic expression of OIP5-AS1 had the opposite impact. Meanwhile, knockdown of OIP5-AS1 inhibited tumor growth in patient-derived xenograft models, as well as repressed tumor metastasis. Mechanistically, IGF2BP3 could bind to OIP5-AS1 by N6-methyladenosine (m6A) modification sites on OIP5-AS1, thereby stabilizing OIP5-AS1. Moreover, OIP5-AS1 prevented Trim21-mediated ubiquitination and degradation of hnRNPA1, stabilizing hnRNPA1 protein and promoting the malignant progression of GC by regulating PKM2 signaling pathway. CONCLUSIONS: In conclusion, this study highlighted that OIP5-AS1 is an oncogenic m6A-modified long non-coding RNA (lncRNA) in GC and that IGF2BP3/OIP5-AS1/hnRNPA1 axis may provide a potential diagnostic or prognostic target for GC.
摘要：
Radon-222 (Rn-222) is a global indoor health issue. A total of 74 points were measured in the woodland and grassland with the RAD7 device on the Hongxiang Campus of the University of South China. The results showed that the Rn-222 flux (RF) was 39.0 +/- 30.3 mBq m(-2) s(-1 )and 39.7 +/- 29.3 mBq m(-2) s(-1) in the woodland and grassland, respectively. The value of RF map was lower than 50 mBq m(-2) s(-1) in most campus areas. The results serve as essential reference data for future( 222)Rn risk-health assessment and management strategies on the campus.
作者机构：
[Liu, Li; He, Jingzhe; Wang, Jiaren; Li, Ruining; Li, Qimei; Zeng, Lin; Xiao, Lushan; Li, Yan; Hong, Chang; Cui, Hao] Southern Med Univ, Nanfang Hosp, Hepatol Unit, Guangdong Prov Key Lab Viral Hepatitis Res, Guangzhou, Peoples R China.;[Liu, Li; He, Jingzhe; Wang, Jiaren; Li, Ruining; Li, Qimei; Zeng, Lin; Xiao, Lushan; Li, Yan; Hong, Chang; Cui, Hao] Southern Med Univ, Nanfang Hosp, Dept Infect Dis, Guangzhou, Peoples R China.;[Liu, Li; Wang, Jiaren; Xiao, Lushan] Southern Med Univ, Nanfang Hosp, Big Data Ctr, Guangzhou, Peoples R China.;[Wang, Weizhen] Southern Med Univ, Nanfang Hosp, Dept Ultrasound, Guangzhou, Peoples R China.;[Zhu, Hongbo] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Med Oncol, Hengyang, Hunan, Peoples R China.
通讯机构：
[Xiao, LS ; Liu, L ; Zhu, H ] S;Southern Med Univ, Nanfang Hosp, Guangzhou 510515, Peoples R China.;Southern Med Univ, Nanfang Hosp, Big Data Ctr, Guangzhou 510515, Peoples R China.;Southern Med Univ, Nanfang Hosp, Hepatol Unit, Guangdong Prov Key Lab Viral Hepatitis Res, Guangzhou 510515, Peoples R China.;Southern Med Univ, Nanfang Hosp, Dept Infect Dis, Guangzhou 510515, Peoples R China.
关键词：
CCR;MSFLD;risk factor;UK Biobank
摘要：
OBJECTIVE: Metabolic dysfunction-associated steatotic liver disease (MASLD) affects many populations, and screening out the high-risk populations at an early stage is a challenge. As a sarcopenia index, the relationship between creatinine to cystatin C ratio (CCR) and MASLD remains unclear. This cross-sectional, prospective study aimed to explore the relationship between CCR and MASLD. Design Firstly, explored the correlation between CCR and MASLD in cross-sectional analyses. Then excluded the population with baseeline diagnosis of MASLD and analyzed the association with baseline CCR levels and the onset of MASLD in the population with available follow-up data. Univariate and multivariate logistic regression analyses were used to calculate odds ratios (ORs) to evaluate the association between CCR levels and MASLD. PATIENTS AND MEASUREMENTS: This study included 368,634 participants from the UK Biobank for cross-sectional and prospective analyses. The demographic characteristics and laboratory measurements of all participants were obtained from the UK Biobank. MASLD was diagnosed according to the multi-society consensus nomenclature. Hepatic steatosis was defined as FLI ≥60. RESULTS: We grouped the study participants according to CCR tertiles. In cross-sectional analyses, participants in CCR tertile 1 had the highest MASLD risk (OR: 1.070, 95%CI: 1.053-1.088, p < .001). And the similar association was observed in the prospective analyses (CCR tertile 1 OR: 1.340, 95%CI: 1.077-1.660, p = .009; CCR tertile 2 OR: 1.217, 95%CI: 1.021-1.450, p = .029, respectively). After stratification by gender, the significant association between CCR and the onset of MASLD was only observed in males (CCR tertile 1 OR: 1.639, 95%CI: 1.160-2.317, p = .005; CCR tertile 2 OR: 1.322, 95%CI: 1.073-1.628, p = .005, respectively). CONCLUSION: Our results indicated that lower CCR was significantly associated with higher risk of MASLD, based on which predictive models can be developed to screen populations at high risk of developing MASLD.
期刊：
Fuzzy Sets and Systems,2024年479:108856 ISSN：0165-0114
通讯作者：
Liu, HL
作者机构：
[Xiao, Qizhen; Liu, Hongliang; Liu, HL; Luo, Zhiyong] Univ South China, Sch Math & Phys, Hengyang 421001, Peoples R China.;[Xiao, Qizhen; Liu, Hongliang; Liu, HL] Univ South China, Hunan Key Lab Math Modeling & Sci Comp, Hengyang 421001, Peoples R China.
通讯机构：
[Liu, HL ] U;Univ South China, Sch Math & Phys, Hengyang 421001, Peoples R China.;Univ South China, Hunan Key Lab Math Modeling & Sci Comp, Hengyang 421001, Peoples R China.
关键词：
Aperiodic DoS attacks;Resilient synchronization;Fixed-time stability;Fuzzy neural networks;Reaction-diffusion terms
摘要：
This work focuses on the resilient fixed -time synchronization of delayed fuzzy memristive reaction -diffusion neural networks under denial -of -service (DoS) attacks. To efficaciously tolerate the aperiodic DoS attacks, a new appropriate controller is designed to ensure the fixed -time resilient synchronization of the systems. Moreover, two mild sufficient conditions are first proposed and the constrained techniques of attacking intervals are employed to overcome the challenge of estimating the upper bound of the settling time under aperiodic DoS attacks. Lastly, an example is utilized to illustrate the effectiveness and feasibility of the theoretical result.
作者机构：
[Li, Ye; Zhang, Yuexin; Li, Chunquan; Zhao, Yu; Huang, Xuemei; Xie, Liyuan; Zhang, Guorui; Zhao, Jun; Fan, Shifan; Song, Chao] Univ South China, Hengyang Med Sch, Affiliated Hosp 1, Hengyang 421001, Hunan, Peoples R China.;[Li, Ye; Zhang, Yuexin; Li, Chunquan; Zhao, Yu; Huang, Xuemei; Xie, Liyuan; Zhang, Guorui; Zhao, Jun; Fan, Shifan; Song, Chao] Univ South China, Hengyang Med Sch, MOE Key Lab Rare Pediat Dis, Hengyang 421001, Hunan, Peoples R China.;[Li, Ye; Zhang, Yuexin; Zhang, Qinyi; Li, Chunquan; Zhao, Yu; Huang, Xuemei; Xie, Liyuan; Zhang, Guorui; Fan, Shifan; Song, Chao] Univ South China, Sch Comp, Hengyang 421001, Hunan, Peoples R China.;[Li, Chunquan] Univ South China, Hunan Prov Maternal & Child Hlth Care Hosp, Hengyang Med Sch, Key Lab Birth Defect Res & Prevent,Natl Hlth Commi, Hengyang 421001, Hunan, Peoples R China.;[Li, Ye; Zhang, Yuexin; Li, Chunquan; Zhao, Yu; Huang, Xuemei; Xie, Liyuan; Zhang, Guorui; Fan, Shifan; Song, Chao] Univ South China, Affiliated Hosp 1, Cardiovasc Lab Big Data & Imaging ArtificialIntell, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.
通讯机构：
[Li, CQ ] U;Univ South China, Hengyang Med Sch, Affiliated Hosp 1, Hengyang 421001, Hunan, Peoples R China.;Univ South China, Hengyang Med Sch, MOE Key Lab Rare Pediat Dis, Hengyang 421001, Hunan, Peoples R China.;Univ South China, Sch Comp, Hengyang 421001, Hunan, Peoples R China.;Univ South China, Hunan Prov Maternal & Child Hlth Care Hosp, Hengyang Med Sch, Key Lab Birth Defect Res & Prevent,Natl Hlth Commi, Hengyang 421001, Hunan, Peoples R China.
关键词：
genes;mice;candidate disease gene;inference;multiomics;oncogenes;enhancer of transcription;cell lines;transcription factor
摘要：
Gene regulatory networks (GRNs) are interpretable graph models encompassing the regulatory interactions between transcription factors (TFs) and their downstream target genes. Making sense of the topology and dynamics of GRNs is fundamental to interpreting the mechanisms of disease etiology and translating corresponding findings into novel therapies. Recent advances in single-cell multi-omics techniques have prompted the computational inference of GRNs from single-cell transcriptomic and epigenomic data at an unprecedented resolution. Here, we present scGRN (https://bio.liclab.net/scGRN/), a comprehensive single-cell multi-omics gene regulatory network platform of human and mouse. The current version of scGRN catalogs 237 051 cell type-specific GRNs (62 999 692 TF-target gene pairs), covering 160 tissues/cell lines and 1324 single-cell samples. scGRN is the first resource documenting large-scale cell type-specific GRN information of diverse human and mouse conditions inferred from single-cell multi-omics data. We have implemented multiple online tools for effective GRN analysis, including differential TF-target network analysis, TF enrichment analysis, and pathway downstream analysis. We also provided details about TF binding to promoters, super-enhancers and typical enhancers of target genes in GRNs. Taken together, scGRN is an integrative and useful platform for searching, browsing, analyzing, visualizing and downloading GRNs of interest, enabling insight into the differences in regulatory mechanisms across diverse conditions. Graphical Abstract
期刊：
Case Studies in Thermal Engineering,2024年53:103820 ISSN：2214-157X
通讯作者：
He, Danqiu;Isa, MHM
作者机构：
[Isa, Mohd Hafizal Mohd; Isa, MHM; He, Danqiu; He, DQ] Univ Sains Malaysia, Sch Housing Bldg & Planning, George Town 11800, Malaysia.;[He, Danqiu] Univ South China, Solux Coll Architecture & Design, Hengyang 421001, Peoples R China.
通讯机构：
[Isa, MHM ; He, DQ] U;Univ Sains Malaysia, Sch Housing Bldg & Planning, George Town 11800, Malaysia.
关键词：
Indoor thermal comfort;Heritage building;Neutral temperature;Sustainable development
摘要：
The heritage buildings of a country or region are frequently considered to be of value and sig-nificance to the current generation. This study investigates the winter indoor thermal comfort of heritage buildings in hot summer and cold winter zone of China. Field measurements and questionnaire surveys were used to conduct specific studies on the winter indoor thermal comfort of two typical traditional residential buildings ("Yinziwu" and "Diaojiaolou") in the Yuan River basin heritage building area. The aim is to investigate the current status of building thermal comfort and provide a theoretical basis for promoting their sustainable development. The results show that 1) Indoor air temperatures in both types of buildings are significantly and positively correlated in winter, but both are below the human thermal comfort range. 2) Mean air temperatures measured in "Yinziwu" and "Diaojiaolou" are 8.8 degrees C and 9.4 degrees C, respectively, with neutral air temperatures of 11.1 degrees C and 13.8 degrees C. 3) Thermal sensation, thermal preference, and thermal comfort were significantly correlated in the two buildings, with ooccupants experiencing the coldest phase from 7:00-11:00 and the warmest phase from 15:00-19:00 daily. 4) "Yinziwu" occupants are more tolerant of the cold climate.
摘要：
Multiple pesticides are often used in combination for plant protection and public health. Therefore, it is important to analyze the physiological changes induced by multiple pesticides exposure. The objective of this study was to investigate the combined toxicity of the widely-used organophosphorus and pyrethroid pesticides diazinon, dimethoate, and cypermethrin. Male Wistar rats were administrated by gavage once daily with the three pesticides individual or in combination for consecutive 28 days. The metabolic components of serum and urine samples were detected by using 1H nuclear magnetic resonance (NMR)-based metabolomics method. Histopathological examination of liver and kidneys and serum biochemical determination were also carried out. The results showed that after the 28-day subacute exposure, serum glutamic transaminase and albumin were significantly increased and blood urea nitrogen was significantly decreased in the rats exposed to the mixture of the pesticides compared with the control rats, suggesting that the co-exposure impaired liver and kidney function. Metabolomics analysis indicated that the indicators 14 metabolites were statistically significant altered in the rats after the exposure of the pesticides. The increase in 3-hydroxybutyric acid in urine or decrease of lactate and N-acetyl-L-cysteine in serum could be a potentially sensitive biomarker of the subchronic combined effects of the three insecticides. The reduction level of 2-oxoglutarate and creatinine in urine may be indicative of dysfunction of liver and kidneys. In summary, the exposure of rats to pesticides diazinon, dimethoate, and cypermethrin could cause disorder of lipid and amino acid metabolism, induction of oxidative stress, and dysfunction of liver and kidneys, which contributes to the understanding of combined toxic effects of the pesticides revealed by using the metabolomics analysis of the urine and serum profiles.
