期刊论文

Li, GX

英文

Gastric Cancer

1436-3291

2024

27

1

49-71

10.1007/s10120-023-01437-7

This work was supported by Provincial Natural Science Foundation of Hunan Provincial Science and Technology Department under Grant No. 2023JJ60374 and 2020JJ4552, Clinical Medical Technology Innovation Guidance Project of the Hunan Provincial Science and Technology Department under Grant No. 2020SK51906, General Guidance Project of Hunan Provincial Health Commission under Grant No. 20201937 and 20201951, R&D projects in key areas of Hunan Provincial Science and Technology Department under Grant No. 2020SKC2009 and Major Research Projects of Hunan Provincial Health and Family Planning Commission under Grant No. A2017012.

本校为第一机构

BACKGROUND: Opa-interacting protein 5 antisense transcript 1 (OIP5-AS1) has been demonstrated to play vital roles in development and progression of tumors such as gastric cancer (GC). However, the detailed molecular mechanism of OIP5-AS1 has not been completely elucidated. Our study aimed to investigate the role and the epigenetic regulation mechanism of OIP5-AS1 in GC. METHODS: OIP5-AS1 expression in GC tissues was detected by RT-qPCR. Loss- and gain-of-function experiments were conducted to assess the biological function of OIP5-AS1 in vitro and in vivo. The interaction of OIP5-AS1 with insu...