摘要：
The formation of the BCR-ABL fusion gene drives human chronic myeloid leukemia (CML). The last 2 decades have witnessed that specific tyrosine kinase inhibitors (TKIs, e.g., imatinib mesylate, IM) against ABL1 improve disease treatment, although some patients still suffer from relapse and TKI resistance. Therefore, a better understanding of the molecular pathology of CML is still urgently needed. miR-181a-5p (miR-181a) acts as a tumor suppressor in CML; however, the molecular mechanism of miR-181a in CML stem/progenitor cells remains elusive. Herein, we showed that miR-181a inhibited the growth of CML CD34(+) cells, including the quiescent subset, and sensitized them to IM treatment, while miR-181a inhibition by a sponge sequence collaborated with BCR-ABL to enhance the growth of normal CD34(+) cells. Transcriptome data and biochemical analysis revealed that SERPINE1 was a bona fide and critical target of miR-181a, which deepened the understanding of the regulatory mechanism of SERPINE1. Genetic and pharmacological inhibition of SERPINE1 led to apoptosis mainly mediated by caspase-9 activation. The dual inhibition of SERPINE1 and BCR-ABL exhibited a significantly stronger inhibitory effect than a single agent. Taken together, this study demonstrates that a novel miR-181a/SERPINE1 axis modulates CML stem/progenitor cells, which likely provides an important approach to override TKI resistance.
期刊：
Cancer Cell International,2024年24(1):1-21 ISSN：1475-2867
通讯作者：
Tan, Yeru;Li, YH
作者机构：
[Jiang, Baohong] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Pharm, Hengyang, Hunan, Peoples R China.;[Zeng, Lijun; Tan, Yeru; Li, YH; Li, Yuehua; Tang, Yuanbin; Luo, Lunqi; Ouyang, Lianjie; Feng, Wenjie; Tan, YR; Wu, Sixuan] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Oncol, Hengyang, Hunan, Peoples R China.;[Wu, Sixuan] Fujian Med Univ, Fujian Canc Hosp, Clin Oncol Sch, Fuzhou, Fujian, Peoples R China.
通讯机构：
[Li, YH ; Tan, YR] U;Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Oncol, Hengyang, Hunan, Peoples R China.
关键词：
Breast cancer;NDUFAF6;NRF2;PD-L1;Immune infiltration;Prognosis
摘要：
Breast cancer is a major global health concern, and there is a continuous search for novel biomarkers to predict its prognosis. The mitochondrial protein NDUFAF6, previously studied in liver cancer, is now being investigated for its role in breast cancer. This study aims to explore the expression and functional significance of NDUFAF6 in breast cancer using various databases and experimental models. We analyzed breast cancer samples from The Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO), and Human Protein Atlas (HPA) databases, supplemented with immunohistochemistry (IHC) staining to assess NDUFAF6 expression. A breast cancer cell xenograft mouse model was used to evaluate tumor growth, apoptosis, and NDUFAF6 expression. Survival probabilities were estimated through Kaplan–Meier plots and Cox regression analysis. A Protein–Protein Interaction (PPI) network was constructed, and differentially expressed genes related to NDUFAF6 were analyzed using GO, KEGG, and GSEA. The relationship between NDUFAF6 expression, immune checkpoints, and immune infiltration was also evaluated. NDUFAF6 was found to be overexpressed in breast cancer patients and in the xenograft mouse model. Its expression correlated with worse clinical features and prognosis. NDUFAF6 expression was an independent predictor of breast cancer outcomes in both univariate and multivariate analyses. Functionally, NDUFAF6 is implicated in several immune-related pathways. Crucially, NDUFAF6 expression correlated with various immune infiltrating cells and checkpoints, particularly promoting PD-L1 expression by inhibiting the NRF2 signaling pathway. The study establishes NDUFAF6 as a potential prognostic biomarker in breast cancer. Its mechanism of action, involving the inhibition of NRF2 to upregulate PD-L1, highlights its significance in the disease's progression and potential as a target for immunotherapy.
摘要：
Halloysite nanotubes (HNTs) are nanomaterials (NMs) derived from natural clays and have been considered as biocompatible NMs for biomedical uses. However, the cardiovascular toxicity of HNTs has not been thoroughly investigated. In this study, we compared the cardiotoxicity of HNTs and multi-walled carbon nanotubes (MWCNTs), focusing on the changes in Kruppel-like factor (KLF)-mediated signaling pathways. Mice were intravenously injected with 50µg NMs, once a day, for 5 days, and then mouse hearts were removed for experiments. While HNTs or MWCNTs did not induce obvious pathological changes, RNA-sequencing data suggested the alterations of KLF gene expression. We further confirmed an increase of Klf15 positive cells, accompanied by changes in Klf15-related gene ontology (GO) terms. We noticed that most of the changed GO terms are related with the regulation of gene expression, and we confirmed that the NMs increased myoneurin (Mynn) but decreased snail family transcriptional repressor 1 (Snai1), two transcription factors (TFs) related with Klf15. Besides, the changed GO terms also include metal ion binding and positive regulation of glucose import, and we verified an increase of phosphoenolpyruvate carboxykinase 1 (Pck1) and insulin receptor (Insr). However, HNTs and MWCNTs only showed minimal impact on cell death signaling pathways, and no increase in apoptotic sites was observed after NM treatment. We concluded that intravenous administration of HNTs and MWCNTs activated a protective TF, namely Klf15 in mouse aortas, to alter gene expression and signaling pathways related with metal ion binding and glucose import.
作者机构：
[Xie, Chao; Wang, Hong; Yu, Tao] Univ South China, Sch Nucl Sci & Technol, Hengyang 421001, Peoples R China.;[Xie, Chao; Wang, Hong; Lu, Wenjun; Wang, Xiangshuai] Univ South China, Sch Resources Environm & Safety Engn, Hengyang 421001, Peoples R China.;[Xie, Chao; Yu, Tao] Univ South China, Key Lab Adv Nucl Energy Technol Design & Safety, Minist Educ, Hengyang 421001, Peoples R China.
通讯机构：
[Wang, H ] U;Univ South China, Sch Nucl Sci & Technol, Hengyang 421001, Peoples R China.;Univ South China, Sch Resources Environm & Safety Engn, Hengyang 421001, Peoples R China.
摘要：
To ensure the safety and stability of the beach surface of the decommissioned uranium mill tailings pond, this paper uses red clay-bentonite and red clay (1:1) to carry out covering layer radon reduction simulation experiments to study the temperature, humidity, and radon reduction effect of the covering layer under natural conditions. The results show that the radon exhalation rate of red clay-bentonite cover layer is only 0.32 times that of red clay, which has a better radon reduction effect. The red clay-bentonite cover layer has better water retention and comparable heat preservation effect than red clay cover layer. The red clay-bentonite and red clay temperature curves follow the same evolution trend and were close together in the same outdoor conditions, and the humidity curves showed a difference of 1% to 3%. Soil temperature is the dominant factor affecting the variation of radon exhalation of red clay-bentonite and red clay covering layer with unsaturated water content.
摘要：
Humans tend to mine objects by learning from a group of images or several frames of video since we live in a dynamic world. In the computer vision area, many researchers focus on co-segmentation (CoS), co-saliency detection (CoSD) and video salient object detection (VSOD) to discover the co-occurrent objects. However, previous approaches design different networks for these similar tasks separately, and they are difficult to apply to each other. Besides, they fail to take full advantage of the cues among inter- and intra-feature within a group of images. In this paper, we introduce a unified framework to tackle these issues from a unified view, term as <bold>UFGS</bold> (<bold>U</bold>nified <bold>F</bold>ramework for <bold>G</bold>roup-based <bold>S</bold>egmentation). Specifically, we first introduce a transformer block, which views the image feature as a patch token and then captures their long-range dependencies through the self-attention mechanism. This can help the network to excavate the patch-structured similarities among the relevant objects. Furthermore, we propose an intra-MLP learning module to produce self-mask to enhance the network to avoid partial activation. Extensive experiments on four CoS benchmarks (PASCAL, iCoseg Internet and MSRC), three CoSD benchmarks (Cosal2015, CoSOD3k, and CocA) and five VSOD benchmarks (DAVIS(16), FBMS, ViSal, SegV2, and DAVSOD) show that our method outperforms other state-of-the-arts on three different tasks in both accuracy and speed by using the same network architecture, which can reach 140 FPS in real-time.
关键词：
autophagy;seizure-induced brain injury;SIRT3;Xyloketal B
摘要：
Brain damage in children due to seizures is irreversible and has been a major public health concern. The herbal monomer Xyloketal B (Xyl-B) can be used as a neuroprotective drug because of its antioxidant, antiapoptotic, and anti-inflammatory effects but with few adverse effects. In this article, we constructed a rat developmental convulsion model and a primary hippocampal neuronal cell convulsion model, through which we studied hippocampal neuronal morphology and neuronal apoptosis using H&E staining and TUNEL staining, respectively. Moreover, we measured TNF-α, IL-6, and IL-1β inflammatory factor levels using ELISA, MDA, and SOD kits. The expression of SIRT3 in hippocampal tissues was determined by qPCR and Western blotting. The expression of autophagy-related proteins such as LC3, p62, and Beclin-1 was evaluated by Western blotting or immunohistochemistry. The role of SIRT3 and autophagic activity with Xyl-B in convulsive seizure-induced brain injury was investigated by knocking down SIRT3 expression levels. Our results showed that Xyl-B plays a neuroprotective role in convulsive seizure-induced brain injury by increasing SIRT3 expression and activating the autophagy pathway. The regulatory role of SIRT3 in the autophagy pathway with Xyl-B treatment was explored by knocking down SIRT3 expression and inhibiting autophagy. Our results revealed that SIRT3 enhances the protective effect of Xyl-B against postconvulsive brain injury by regulating AMPK/mTOR signaling-mediated autophagy.
摘要：
A novel reactive oxygen species‐responsive biodegradable nanoparticle (NP@PolyRHAPM) is designed, in which astaxanthin can reduce intracellular ROS levels and rapamycin‐enhanced autophagy levels, and restore mitochondrial function, hence successfully repolarizing M1 macrophages into M2 phenotypes. This repolarization enhances the proliferation and viability of chondrocytes while inhibiting apoptosis. Overall, this ROS‐responsive nanocarrier system provides a new avenue for progressive OA therapy. Abstract Osteoarthritis (OA) is a chronic joint disease characterized by synovitis and joint cartilage destruction. The severity of OA is highly associated with the imbalance between M1 and M2 synovial macrophages. In this study, a novel strategy is designed to modulate macrophage polarization by reducing intracellular reactive oxygen species (ROS) levels and regulating mitochondrial function. A ROS‐responsive polymer is synthesized to self‐assemble with astaxanthin and autophagy activator rapamycin to form nanoparticles (NP@PolyRHAPM). In vitro experiments show that NP@PolyRHAPM significantly reduced intracellular ROS levels. Furthermore, NP@PolyRHAPM restored mitochondrial membrane potential, increased glutathione (GSH) levels, and promoted intracellular autophagy, hence successfully repolarizing M1 macrophages into the M2 phenotype. This repolarization enhanced chondrocyte proliferation and vitality while inhibiting apoptosis. In vivo experiments utilizing an anterior cruciate ligament transection (ACLT)‐induced OA mouse model revealed the anti‐inflammatory and cartilage‐protective effects of NP@PolyRHAPM, effectively mitigating OA progression. Consequently, the findings suggest that intra‐articular delivery of ROS‐responsive nanocarrier systems holds significant promise as a potential and effective therapeutic strategy for OA treatment.
作者：
Nie, Mingxing;Zou, Liwei;Cui, Hao;Zhou, Xinhui;Wan, Yaping
期刊：
Electronics,2024年13(2):264- ISSN：2079-9292
通讯作者：
Wan, YP
作者机构：
[Wan, YP; Wan, Yaping; Cui, Hao; Zhou, Xinhui; Nie, Mingxing; Zou, Liwei] Univ South China, Sch Comp Sci, Hengyang 421001, Peoples R China.
通讯机构：
[Wan, YP ] U;Univ South China, Sch Comp Sci, Hengyang 421001, Peoples R China.
关键词：
human activity recognition;LoRa wireless RF signal preprocessing;deep learning;feature extraction;differential signal processing
摘要：
This paper introduces a novel approach for enhancing human activity recognition through the integration of LoRa wireless RF signal preprocessing and deep learning. We tackle the challenge of extracting features from intricate LoRa signals by scrutinizing the unique propagation process of linearly modulated LoRa signals—a critical aspect for effective feature extraction. Our preprocessing technique involves converting intricate data into real numbers, utilizing Short-Time Fourier Transform (STFT) to generate spectrograms, and incorporating differential signal processing (DSP) techniques to augment activity recognition accuracy. Additionally, we employ frequency-to-image conversion for the purpose of intuitive interpretation. In comprehensive experiments covering activity classification, identity recognition, room identification, and presence detection, our carefully selected deep learning models exhibit outstanding accuracy. Notably, ConvNext attains 96.7% accuracy in activity classification, 97.9% in identity recognition, and 97.3% in room identification. The Vision TF model excels with 98.5% accuracy in presence detection. Through leveraging LoRa signal characteristics and sophisticated preprocessing techniques, our transformative approach significantly enhances feature extraction, ensuring heightened accuracy and reliability in human activity recognition.
摘要：
Asparagine, an important amino acid in mammals, is produced in several organs and is widely used for the production of other nutrients such as glucose, proteins, lipids, and nucleotides. Asparagine has also been reported to play a vital role in the development of cancer cells. Although several types of cancer cells can synthesise asparagine alone, their synthesis levels are insufficient to meet their requirements. These cells must rely on the supply of exogenous asparagine, which is why asparagine is considered a semi-essential amino acid. Therefore, nutritional inhibition by targeting asparagine is often considered as an anti-cancer strategy and has shown success in the treatment of leukaemia. However, asparagine limitation alone does not achieve an ideal therapeutic effect because of stress responses that upregulate asparagine synthase (ASNS) to meet the requirements for asparagine in cancer cells. Various cancer cells initiate different reprogramming processes in response to the deficiency of asparagine. Therefore, it is necessary to comprehensively understand the asparagine metabolism in cancers. This review primarily discusses the physiological role of asparagine and the current progress in the field of cancer research.
摘要：
The fusion of low-resolution hyperspectral image (LR-HSI) and high-resolution multispectral image (HR-MSI) is a crucial technology for producing high-resolution hyperspectral images. Most existing image fusion algorithms based on deep learning do not fully utilize the ability of neural network to extract and process multi-scale features, which leads to the problem of difficulty in fully learning features and ambiguity of features. In order to overcome these issues, a residual selective kernel attention-based U-net named RSKAU-net is designed for LR-HSI and HR-MSI fusion. RSKAU-net is constructed by a residual selective kernel module with an attention mechanism and a channel attention block. The residual selective kernel attention-based (RSKA) module is designed to process images of different resolutions, which adaptively extracts multi-scale features and efficiently emphasizes significant features through the attention mechanism. The channel attention (CA) module retains important spectral information by assigning different weights to each channel of LR-HSI. The proposed network can enhance the spatial information of LR-HSI while preserving its spectral information. Meanwhile, it effectively fuses the features from the source image to obtain the HR-HSI with rich details. The experimental results demonstrate that the proposed network has advantages in terms of both visual effect and objective quantitative indices when compared to existing HSI-MSI fusion approaches.
期刊：
Journal of Materials Chemistry A,2024年 ISSN：2050-7488
通讯作者：
Ju, J;Qian, XT
作者机构：
[Huang, Chenhui; Kang, Xiaomin; Zhang, Meng] Univ South China, Coll Mech Engn, Hengyang 421001, Peoples R China.;[Zhai, Zhaofeng] Chinese Acad Sci, Inst Met Res, Shenyang 110012, Peoples R China.;[Ju, Jiang] City Univ Hong Kong, Ctr Adv Nucl Safety & Sustainable Dev, Hong Kong 999077, Peoples R China.;[Qian, Xitang; Qian, XT] Hong Kong Univ Sci & Technol, Dept Chem & Biol Engn, Kowloon, Hong Kong, Peoples R China.
通讯机构：
[Qian, XT ] H;[Ju, J ] C;City Univ Hong Kong, Ctr Adv Nucl Safety & Sustainable Dev, Hong Kong 999077, Peoples R China.;Hong Kong Univ Sci & Technol, Dept Chem & Biol Engn, Kowloon, Hong Kong, Peoples R China.
摘要：
Nanofluidic ion regulation membranes have emerged as versatile platforms for applications in molecular/ion separation and energy conversion. The use of two-dimensional (2D) material-based membranes holds great potential for the regulation of nanofluidic ions owing to their unique properties of surface charges, nanochannels, and nanocapillary force. Herein, a class of 2D flexible ion-conductive membranes with surface charge-controllable and voltage-tunable ion transport properties, which are assembled with monolayered Cd vacancy-containing CdPS3 (vc-CdPS3)-based nanosheets, is reported. Importantly, the ion conductivity of the vc-CdPS3 membrane is several orders of magnitude higher than that of bulk salt solutions up to 0.1 M and reaches a plateau of similar to 10 mS cm(-1) in low concentrated solution (<= 1 mM), demonstrating typical charge-controllable nanofluidic ion transport behavior. This membrane exhibits excellent stability and maintains an ion conductivity of 23 and 20 mS cm(-1) under harsh acidic and alkaline conditions, respectively. By applying positive/negative gating voltage, ion transportation within the vc-CdPS3 membrane is tuned, resulting in low/high ion conductivity. The voltage-tunable behavior across a broad spectrum of cations with varying sizes and charges is observed, showcasing the ion-specific switch ratios of 12 and 10 for potassium and sodium ions, respectively, under an applied voltage of 2 V/-2 V. This work demonstrates the potential of vacancy-containing membranes for a variety of membrane separation applications and offer a strategy for preparing efficient ion transport devices.
作者：
Shao, Zuliang;Liu, He*;Lin, Qibin;Wu, Mingyang;Sun, Lei
期刊：
Fuel,2024年362:130790 ISSN：0016-2361
通讯作者：
Liu, He;Lin, QB
作者机构：
[Liu, He; Shao, Zuliang; Lin, QB; Lin, Qibin] Univ South China, Sch Resource Environm & Safety Engn, Hengyang 421001, Peoples R China.;[Liu, He] Wuhan Univ, Sch Civil Engn, Key Lab Safety Geotech & Struct Engn Hubei Prov, Wuhan 430072, Peoples R China.;[Wu, Mingyang] Chinese Acad Sci, Inst Rock & Soil Mech, State Key Lab Geomech & Geotech Engn, Wuhan 430071, Peoples R China.;[Sun, Lei] Univ Toronto, Dept Civil & Mineral Engn, Toronto, ON M5S 1A4, Canada.
通讯机构：
[Liu, H; Lin, QB ] U;Univ South China, Sch Resource Environm & Safety Engn, Hengyang 421001, Peoples R China.
关键词：
Natural gas hydrate;Thermal injection;Heat and mass transfer;Dissociation front;Temperature distribution
摘要：
Natural Gas Hydrate (NGH) is characterized by large reserves and cleanliness, which has attracted wide attention around the world. Thermal stimulation is considered to be one of the possible methods to facilitate hydrate dissociation. In this paper, the hydrate is dissociated through injecting hot water. In order to reveal the influence of the speed and the temperature of injected hot water on the temperature distribution, hydrate dissociation front, gas production rate, and cumulative gas production, a 2D cylindrical mathematical model of thermally-induced hydrate dissociation was established. The results show that the dissociation process can be regarded as a moving boundary ablation process. The dissociation front divides the whole reservoir into three sections: complete dissociation section, ongoing dissociation section, and undissociated section, and the range of ongoing dissociation section is a very narrow area characterized by a relatively intensive temperature contour, which indicates that the temperature drops rapidly during the hydrate dissociation. The temperature at the dissociation front is almost constant under different hot water injection speeds or temperatures. The injection speed and the temperature of hot water seem to have similar effects on hydrate dissociation. The enhanced hot water injection speed or hot water injection temperature will result in a faster gas production rate, a quicker movement of the dissociation front, and a shorter duration time of gas production, however, hot water injection speed and temperature have little impact on the final gas production. The results may provide a guidance for safely and efficiently exploiting NGH.
摘要：
Osteoarthritis (OA) is an age-related musculoskeletal disease that results in pain and functional disability. Stem cell therapy has been considered as a promising treatment for OA. In this study, the therapeutic action and potential mechanism of synovial mesenchymal stem cells (SMSCs)-derived exosomes (Exos) in OA cartilage damage were investigated. Cartilage cells were stimulated with IL-1β to establish an in vitro model of OA cartilage damage. Cartilage cell functions were detected by CCK-8, scratch assay, and flow cytometry, respectively. Inflammatory cytokine levels were assessed by ELISA. Target molecule levels were measured by qRT‒PCR and Western blotting. Exos-induced differential expression of miRNAs in cartilage cells were analyzed by microarray analysis. The interaction between miR-485-3p and neuropilin-1 (NRP1) was validated by dual luciferase reporter and RIP assays. We found that treatment with Exos promoted proliferation, migration, and ECM secretion, but restrained apoptosis and inflammation of IL-1β-exposed cartilage cells via up-regulation of miR-485-3p. Additionally, miR-485-3p directly targeted NRP1 to repress NRP1 expression, which subsequently caused inactivation of the PI3K/Akt pathway. The protective effect of Exos on cartilage damage was counteracted by NRP1 overexpression-mediated activation of the PI3K/Akt pathway. In conclusion, Exos delivered miR-485-3p to attenuate IL-1β-induced cartilage degradation by targeting NRP1 and succedent inactivation of the PI3K/Akt pathway. Our findings shed light on the novel protective mechanism of Exos in OA, which suggest that the restoration of miR-485-3p by Exos might be a novel approach for OA treatment.
摘要：
LaFe1-xMnxO3 (0 <= x <= 0.9) samples were synthesized through the sol-gel method. According to X-ray diffraction (XRD) results, with the increase of Mn doping, the crystal structure of the sample changes from orthogonal Pnma structure to rhombohedral R3c structure, and a two-phase coexistence phenomenon exists within the range of 0.4 <= x <= 0.7. Using Mossbauer spectroscopy, the coexistence range of the two phases and the iron content in each phase were identified. At x=0.4, the Pnma phase contribution (91.1%) dominates, with only a slight R3c phase contribution (8.9%). As the amount of Mn doping gradually increases, the R3c phase becomes dominant at x=0.6 (74.6%), and the Pnma phase completely disappears at x=0.8. This work will provide an important perspective for future researchers studying similar phase coexistence systems.
作者：
Goh, MeeiChyn;Du, Meng;Peng, Wang Rui;Saw, Phei Er;Chen, Zhiyi
期刊：
Drug Delivery,2024年31(1):2300945 ISSN：1071-7544
通讯作者：
Chen, ZY;Saw, PE
作者机构：
[Peng, Wang Rui; Du, Meng; Chen, Zhiyi; Goh, MeeiChyn] Univ South China, Inst Med Imaging, Hengyang Med Sch, Hengyang, Peoples R China.;[Peng, Wang Rui; Chen, Zhiyi] Univ South China, Affiliated Hosp 7, Hunan Vet Adm Hosp, Hengyang Med Sch, Changsha, Peoples R China.;[Saw, Phei Er] Sun Yat Sen Univ, Med Res Ctr,Sun Yat Sen Mem Hosp, Guangdong Prov Key Lab Malignant Tumor Epigenet &, Guangdong Hong Kong Joint Lab RNA Med, Guangzhou, Peoples R China.;[Saw, Phei Er; Saw, PE] Sun Yat Sen Mem Hosp, Nanhai Translat Innovat Ctr Precis Immunol, Foshan, Peoples R China.;[Chen, Zhiyi] Univ South China, Affiliated Changsha Cent Hosp, Hengyang Med Sch, Changsha, Peoples R China.
通讯机构：
[Saw, PE ] S;[Chen, ZY ] U;Univ South China, Inst Med Imaging, Hengyang Med Sch, Hengyang, Peoples R China.;Sun Yat Sen Mem Hosp, Nanhai Translat Innovat Ctr Precis Immunol, Foshan, Peoples R China.
关键词：
Hydrogel;transdermal drug delivery;therapeutic carrier;burn wound;tissue regeneration
摘要：
Burn injuries are prevalent and life-threatening forms that contribute significantly to mortality rates due to associated wound infections. The management of burn wounds presents substantial challenges. Hydrogel exhibits tremendous potential as an ideal alternative to traditional wound dressings such as gauze. This is primarily attributed to its three-dimensional (3D) crosslinked polymer network, which possesses a high water content, fostering a moist environment that supports effective burn wound healing. Additionally, hydrogel facilitates the penetration of loaded therapeutic agents throughout the wound surface, combating burn wound pathogens through the hydration effect and thereby enhancing the healing process. However, the presence of eschar formation on burn wounds obstructs the passive diffusion of therapeutics, impairing the efficacy of hydrogel as a wound dressing, particularly in cases of severe burns involving deeper tissue damage. This review focuses on exploring the potential of hydrogel as a carrier for transdermal drug delivery in burn wound treatment. Furthermore, strategies aimed at enhancing the transdermal delivery of therapeutic agents from hydrogel to optimize burn wound healing are also discussed.
作者机构：
[Cheng, Pin-Jing; Tang, Lei-Xun; Zheng, Bo; Feng, Song; Wang, Hao-Qiang; Li, Xin-Xiang; Zhao, Ji-Rong; Zhao, Da-Jun; Xue, Jie-Ming; Xiao, Min; Luo, Wen; Li, Bao-Qian] Univ South China, Sch Nucl Sci & Technol, Hengyang 421001, Peoples R China.;[Yi, Han; Chen, Yong-Hao] Chinese Acad Sci, Inst High Energy Phys, Beijing 100049, Peoples R China.;[Yi, Han; Chen, Yong-Hao] Spallat Neutron Source Sci Ctr, Dongguan 523803, Peoples R China.;[Liu, Rong; Yang, Yi-Wei; Han, Zi-Jie] China Acad Engn Phys, Inst Nucl Phys & Chem, Mianyang 621900, Peoples R China.
通讯机构：
[Feng, S ] U;Univ South China, Sch Nucl Sci & Technol, Hengyang 421001, Peoples R China.
关键词：
Neutron-induced total cross section;Natural lead;Time-of-flight;TALYS-1.96;CSNS Back-n white neutron beamline
摘要：
The neutron-induced total cross sections of natural lead have been measured in a wide energy range (0.3 eV–20 MeV) on the back-streaming white neutron beamline (Back-n) at the China Spallation Neutron Source. Neutron energy was determined by the neutron total cross-section spectrometer using the time-of-flight technique. A fast multi-cell fission chamber was used as the neutron detector, and a 10-mm-thick high-purity natural lead sample was employed for the neutron transmission measurements. The on-beam background was determined using Co, In, Ag, and Cd filters. The excitation function of
$$^\text {nat}$$
Pb(n, tot) reaction below 20 MeV was calculated using the TALYS-1.96 nuclear-reaction modeling program. The present results were compared with previous results, the evaluated data available in the five major evaluated nuclear data libraries (i.e., ENDF/B-VIII.0, JEFF-3.3, JENDL-5, CENDL-3.2, and BROND-3.1), and the theoretical calculation curve. Good agreement was found between the new results and those of previous experiments and with the theoretical curves in the corresponding region. This measurement obtained the neutron total cross section of natural lead with good accuracy over a wide energy range and added experimental data in the resonance energy range. This provides more reliable experimental data for nuclear engineering design and nuclear data evaluation of lead.
摘要：
Reconstruction of pressure-temperature-time (P-T-t) path of volumetrically-dominant orthogneisses in deeply subducted continental crusts is challenging due to their simple amphibolite-facies mineral assemblages. To provide new insights into this issue, a detailed study of mineral inclusions, trace elements and U-Pb ages within robust zircon containers, together with titanite U-Pb dating and petrology were conducted on ultrahigh-pressure (UHP) orthogneisses from the northern Sulu belt. The following P-T-t conditions of three metamorphic stages were constrained: (i) cathodoluminescence (CL)-grey zircon cores (ca. 238-237 Ma) with flat heavy rare earth element (HREE) patterns include garnet, phengite and omphacite that yield estimated P-T conditions of 2.3-2.8 GPa/730-800 degrees C, corresponding to prograde high-pressure (HP) metamorphism before the UHP peak. (ii) CLdark zircon mantles (ca. 224 Ma) contain multiphase solid inclusions of plagioclase +K-feldspar + quartz and show extremely low Th/U ratios (<= 0.08) and negative Eu anomalies, demonstrating their crystallization from hydrous melt at 2.0-1.8 GPa/890-820 degrees C during HP eclogite-facies exhumation. In addition, titanite grains are characterized by high LREE contents (1939-5239 ppm), Th/U ratios (0.37-0.81) and crystallization temperatures (830-801 degrees C), suggesting their peritectic origin. The lower intercept age (220 +/- 4 Ma) of titanite is broadly consistent with the ages of the zircon mantles, indicating that they both crystallized from the melt at the same stage. (iii) CL-bright zircon rims (ca. 212-211 Ma) preserve low-pressure mineral inclusions of plagioclase, Kfeldspar and quartz, and they show low Th/U ratios (0.03-0.12) and steep HREE patterns with negative Eu anomalies, witnessing amphibolite-facies overprinting at 1.0-0.8 GPa/610-550 degrees C. Combined with the metamorphic peak conditions of 3.2 GPa/840 degrees C at ca. 232 Ma constrained by previous studies from the same area, the P-T-t path of the northern Sulu UHP belt is reconstructed. The data reflects two-stage exhumation of this terrane, including an early-stage (5.8 km/m.y.) and a later-stage slower (3.1 km/m.y.) exhumation processes. The faster exhumation during early decompression was probably enhanced by extensive melting activity recorded by the CL-dark zircon mantles from the orthogneisses.
作者：
Fujita, Mitsutoshi;He, Song;Sun, Yuan;Zhang, Jun
期刊：
Journal of High Energy Physics,2024年(1) ISSN：1029-8479
通讯作者：
Fujita, M
作者机构：
[Fujita, M; Fujita, Mitsutoshi] Univ South China, Sch Nucl Sci & Technol, Hengyang 421001, Peoples R China.;[He, Song] Jilin Univ, Coll Phys, Ctr Theoret Phys, Changchun 130012, Peoples R China.;[He, Song] Albert Einstein Inst, Max Planck Inst Grav Phys, Muhlenberg 1, D-14476 Golm, Germany.;[Sun, Yuan] Cent South Univ, Sch Phys & Elect, Changsha 418003, Peoples R China.;[Zhang, Jun] Univ Alabama, Dept Phys & Astron, 514 Univ Blvd, Tuscaloosa, AL 35487 USA.
通讯机构：
[Fujita, M ] U;Univ South China, Sch Nucl Sci & Technol, Hengyang 421001, Peoples R China.
关键词：
Gauge-Gravity Correspondence;Holography and Condensed Matter Physics (AdS/CMT);Confinement
摘要：
We compute holographic entanglement entropy (EE) and the renormalized EE in AdS solitons with gauge potential for various dimensions. The renormalized EE is a cutoff-independent universal component of EE. Via Kaluza-Klein compactification of S1 and considering the low-energy regime, we deduce the (d - 1)-dimensional renormalized EE from the odd-dimensional counterpart. This corresponds to the shrinking circle of AdS solitons, probed at large l. The minimal surface transitions from disk to cylinder dominance as l increases. The quantum phase transition occurs at a critical subregion size, with renormalized EE showing non-monotonic behavior around this size. Across dimensions, massive modes decouple at lower energy, while degrees of freedom with Wilson lines contribute at smaller energy scales.
