scGRN: a comprehensive single-cell gene regulatory network platform of human and mouse

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成果类型：

期刊论文

作者：

Huang, Xuemei;Song, Chao;Zhang, Guorui;Li, Ye;Zhao, Yu;...

通讯作者：

Li, CQ

作者机构：

[Li, Ye; Zhang, Yuexin; Li, Chunquan; Zhao, Yu; Huang, Xuemei; Xie, Liyuan; Zhang, Guorui; Zhao, Jun; Fan, Shifan; Song, Chao] Univ South China, Hengyang Med Sch, Affiliated Hosp 1, Hengyang 421001, Hunan, Peoples R China.

[Li, Ye; Zhang, Yuexin; Li, Chunquan; Zhao, Yu; Huang, Xuemei; Xie, Liyuan; Zhang, Guorui; Zhao, Jun; Fan, Shifan; Song, Chao] Univ South China, Hengyang Med Sch, MOE Key Lab Rare Pediat Dis, Hengyang 421001, Hunan, Peoples R China.

[Li, Ye; Zhang, Yuexin; Zhang, Qinyi; Li, Chunquan; Zhao, Yu; Huang, Xuemei; Xie, Liyuan; Zhang, Guorui; Fan, Shifan; Song, Chao] Univ South China, Sch Comp, Hengyang 421001, Hunan, Peoples R China.

[Li, Chunquan] Univ South China, Hunan Prov Maternal & Child Hlth Care Hosp, Hengyang Med Sch, Key Lab Birth Defect Res & Prevent,Natl Hlth Commi, Hengyang 421001, Hunan, Peoples R China.

[Li, Ye; Zhang, Yuexin; Li, Chunquan; Zhao, Yu; Huang, Xuemei; Xie, Liyuan; Zhang, Guorui; Fan, Shifan; Song, Chao] Univ South China, Affiliated Hosp 1, Cardiovasc Lab Big Data & Imaging ArtificialIntell, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Li, CQ ] U

Univ South China, Hengyang Med Sch, Affiliated Hosp 1, Hengyang 421001, Hunan, Peoples R China.

Univ South China, Hengyang Med Sch, MOE Key Lab Rare Pediat Dis, Hengyang 421001, Hunan, Peoples R China.

Univ South China, Sch Comp, Hengyang 421001, Hunan, Peoples R China.

Univ South China, Hunan Prov Maternal & Child Hlth Care Hosp, Hengyang Med Sch, Key Lab Birth Defect Res & Prevent,Natl Hlth Commi, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

genes;mice;candidate disease gene;inference;multiomics;oncogenes;enhancer of transcription;cell lines;transcription factor

期刊：

Nucleic Acids Research

ISSN：

0305-1048

年：

2024

卷：

期：

页码：

D293-D303

DOI：

10.1093/nar/gkad885

基金类别：

National Natural Science Foundation of China [62171166]; Research Foundation of the First Affiliated Hospital of University of South China for Advanced Talents [20210002-1005 USCAT-2021-01]; China Postdoctoral Science Foundation [2019M661311]; Postdoctoral Science Foundation of Heilongjiang Province of China [LBH-Z19075]; Natural Science Foundation of Hunan Province [2023JJ40594, 2023JJ30536]; Clinical Research 4310 Program of the University of South China [20224310NHYCG05]; Funding for open access charge: National Natural Science Foundation of China [62171166].

机构署名：

本校为第一且通讯机构

院系归属：

化学化工学院

医学院

药学与生物科学学院

摘要：

Gene regulatory networks (GRNs) are interpretable graph models encompassing the regulatory interactions between transcription factors (TFs) and their downstream target genes. Making sense of the topology and dynamics of GRNs is fundamental to interpreting the mechanisms of disease etiology and translating corresponding findings into novel therapies. Recent advances in single-cell multi-omics techniques have prompted the computational inference of GRNs from single-cell transcriptomic and epigenomic data at an unprecedented resolution. Here, we present scGRN (https://bio.liclab.net/scGRN/), a co...

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scGRN: a comprehensive single-cell gene regulatory network platform of human and mouse

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