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Progress in Research on CNPY2 in Diseases

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成果类型:
期刊论文
作者:
Chen, Ke-qian;Zhang, Yu-qing;Wang, Zong-bao*;Wang, Shu-zhi
通讯作者:
Wang, Zong-bao;Wang, SZ
作者机构:
[Wang, Shu-zhi; Wang, SZ; Chen, Ke-qian; Wang, Zong-bao; Wang, ZB; Zhang, Yu-qing] Univ South China, Inst Pharm & Pharmacol, Sch Pharmaceut Sci, Hengyang Med Sch, Hengyang 421001, Peoples R China.
[Wang, Shu-zhi; Wang, SZ; Chen, Ke-qian; Wang, Zong-bao; Wang, ZB; Zhang, Yu-qing] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dru, Sch Pharmaceut Sci, Hengyang 421001, Peoples R China.
通讯机构:
[Wang, SZ ; Wang, ZB] U
Univ South China, Inst Pharm & Pharmacol, Sch Pharmaceut Sci, Hengyang Med Sch, Hengyang 421001, Peoples R China.
Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dru, Sch Pharmaceut Sci, Hengyang 421001, Peoples R China.
语种:
英文
关键词:
aloin;angiogenesis modulator;angiogenic factor;berberine;canopy FGF signaling regulator 1;canopy FGF signaling regulator 2;canopy FGF signaling regulator 3;canopy FGF signaling regulator 4;canopy FGF signaling regulator 5;cisplatin;dexmedetomidine;liraglutide;microRNA;microRNA 30a;microRNA 30e;unclassified drug;CNPY2 protein, human;signal transducing adaptor protein;angiogenesis;cancer chemotherapy;cancer mortality;cancer prognosis;cardiovascular disease;cerebral ischemia reperfusion injury;colorectal cancer;congenital malformation;early onset epileptic encephalopathy;esophageal squamous cell carcinoma;gastritis;glioma;heart failure;heart infarction;human;hypoxia;ischemic heart disease;liver cell carcinoma;lung adenocarcinoma;lung cancer;medical research;morbidity;myocardial ischemia reperfusion injury;non small cell lung cancer;nonalcoholic fatty liver;nonhuman;Parkinson disease;prostate cancer;renal cell carcinoma;reperfusion injury;Short Survey;spinal cord ischemia reperfusion injury;stomach cancer;tumor invasion;uterine cervix cancer;cardiovascular disease;liver tumor;lung tumor;male;metabolism;nonalcoholic fatty liver;pathology;reperfusion injury;Adaptor Proteins, Signal Transducing;Cardiovascular Diseases;Humans;Liver Neoplasms;Lung Neoplasms;Male;Non-alcoholic Fatty Liver Disease;Reperfusion Injury
期刊:
MINI-REVIEWS IN MEDICINAL CHEMISTRY
ISSN:
1389-5575
年:
2024
卷:
24
期:
4
页码:
391-402
基金类别:
This work was supported by the Scientific Research Project of the Hunan Provincial Department of Education (Grant No. 20K106) and the Project of the Hunan Provincial Health Committee (Grant No. D202302048902).
机构署名:
本校为第一且通讯机构
院系归属:
药学与生物科学学院
摘要:
Canopy FGF signaling regulator 2 (CNPY2) is a novel angiogenic growth factor. In recent years, increasing evidence highlights that CNPY2 has important functions in health and disease. Many new blood vessels need to be formed to meet the nutrient supply in the process of tumor growth. CNPY2 can participate in the development of tumors by promoting angiogenesis. CNPY2 also enhances neurite outgrowth in neurologic diseases and promotes cell proliferation and tissue repair, thereby improving cardiac function in cardiovascular diseases. Regrettably,...

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