Metabolomic analysis of the serum and urine of rats exposed to diazinon, dimethoate, and cypermethrin alone or in combination

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成果类型：

期刊论文

作者：

Liang, Yu-Jie;Long, Ding-Xin;Wang, Shanshan;Wang, Hui-Ping;Wu, Yi-Jun

通讯作者：

Wu, YJ

作者机构：

[Liang, Yu-Jie; Wu, Yi-Jun; Long, Ding-Xin; Wang, Hui-Ping] Chinese Acad Sci, Inst Zool, Lab Mol Toxicol, State Key Lab Integrated Management Pest Insects &, Beijing 100101, Peoples R China.

[Liang, Yu-Jie] Jining Med Univ, Sch Rehabil Med, Jining 272067, Shandong, Peoples R China.

[Long, Ding-Xin] Univ South China, Sch Publ Hlth, Hengyang 421001, Hunan, Peoples R China.

[Wang, Shanshan] Chinese Acad Agr Sci, Minist Agr, Key Lab Agroprod Qual & Safety, Inst Qual Stand & Testing Technol Agroprod, Beijing 100081, Peoples R China.

通讯机构：

[Wu, YJ ] C

Chinese Acad Sci, Inst Zool, Lab Mol Toxicol, State Key Lab Integrated Management Pest Insects &, Beijing 100101, Peoples R China.

语种：

英文

关键词：

Multiple-pesticide exposure;Subacute toxicity;Organophosphate;Pyrethroid;Metabolomics analysis

期刊：

BMC PHARMACOLOGY & TOXICOLOGY

ISSN：

2050-6511

年：

2024

卷：

期：

页码：

1-10

DOI：

10.1186/s40360-023-00714-6

基金类别：

This work was supported in part by the grants from the National Natural Science Foundation of China (No. 31970416), and the State Key Laboratory of Integrated Management of Pest Insects and Rodents (No. IPM1905).

机构署名：

本校为其他机构

院系归属：

公共卫生学院

摘要：

Multiple pesticides are often used in combination for plant protection and public health. Therefore, it is important to analyze the physiological changes induced by multiple pesticides exposure. The objective of this study was to investigate the combined toxicity of the widely-used organophosphorus and pyrethroid pesticides diazinon, dimethoate, and cypermethrin. Male Wistar rats were administrated by gavage once daily with the three pesticides individual or in combination for consecutive 28 days. The metabolic components of serum and urine samples were detected by using 1H nuclear magnetic re...

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Metabolomic analysis of the serum and urine of rats exposed to diazinon, dimethoate, and cypermethrin alone or in combination

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