期刊论文

Zeng, P

英文

Naunyn-Schmiedeberg's Archives of Pharmacology

0028-1298

2024

397

1

583-598

10.1007/s00210-023-02628-w

This work was supported by grants from the Research Foundation of Scientific Research Program of Jianghan University (grant no. 2021yb 131), Research Foundation of Scientific Research Program of the University of South China (grant no. 220XQD090), Research Foundation of Education Bureau of Hunan Province (grant no. 22B0416), and Provincial Natural Science Foundation of Hunan (grant no. 2023JJ40560).

本校为通讯机构

Curcumin (CUR) exhibits a definite curative effect in the treatment of depression. To identify potential antidepressant targets and mechanisms of action of CUR. This study used network pharmacology to explore the signaling pathways and CUR-related targets in depression. C57BL/6J mice (male,12-14weeks old) were randomly divided into four groups (n = 8): saline-treated (control mice), lipopolysaccharide (LPS, 2mg/kg/day, intraperitoneally), LPS + CUR (50mg/kg/day, intragastrically), and LPS + CUR + LY294002 (7.5mg/kg/day, intraperitoneall...