摘要：
Given that intricate toxicological profiles exist among different antibiotics and pose serious threats to the environment and human health, synchronous analysis of multiple residues becomes crucial. Sensor arrays show potential to achieve the above purpose, but it is challenging to develop easy-to-use and high-sensitivity tools because the state-of-the-art arrays often require more than one recognition unit and are monosignal dependent. Here we exquisitely designed a fluorescent nanoprobe (2-aminoterephthalic acid-anchored CdTe quantum dots with Eu3+ coordination, CdTe-ATPA-Eu3+) featuring triple emissions at the same excitation as the only element to fabricate a luminescent sensor array with ratiometric calculations for identifying multiple antibiotics. By taking tetracycline, chlortetracycline, doxycycline, oxytetracycline, penicillin G, and sulfamethoxazole as models, the six species exhibited distinguishable motivation or/and quenching impacts on the three emissions of CdTe-ATPA-Eu3+, which were employed as indicators to perform the ratiometric logical operation and further combined with pattern recognition analysis for multitarget determination. Evidently, such a design exhibits two advances: (1) with the triple-emission probe as the sole receptor requiring neither internal nor external adjustments, the fabricated array acts as an extremely facile tool for multianalyte detection; (2) the ratiometric calculations offer excellent sensitivity and reliability for high-performance determination. Consequently, accurate identification and quantification of individual antibiotics and their combinations at various levels were verified in both laboratory and practical matrices. Our work provides a new tool for simultaneously detecting multiple antibiotics, and it will inspire the development of advanced sensor arrays for multitarget analysis.
作者：
Fujita, Mitsutoshi;He, Song;Sun, Yuan;Zhang, Jun
期刊：
Journal of High Energy Physics,2024年(1) ISSN：1029-8479
通讯作者：
Fujita, M
作者机构：
[Fujita, M; Fujita, Mitsutoshi] Univ South China, Sch Nucl Sci & Technol, Hengyang 421001, Peoples R China.;[He, Song] Jilin Univ, Coll Phys, Ctr Theoret Phys, Changchun 130012, Peoples R China.;[He, Song] Albert Einstein Inst, Max Planck Inst Grav Phys, Muhlenberg 1, D-14476 Golm, Germany.;[Sun, Yuan] Cent South Univ, Sch Phys & Elect, Changsha 418003, Peoples R China.;[Zhang, Jun] Univ Alabama, Dept Phys & Astron, 514 Univ Blvd, Tuscaloosa, AL 35487 USA.
通讯机构：
[Fujita, M ] U;Univ South China, Sch Nucl Sci & Technol, Hengyang 421001, Peoples R China.
关键词：
Gauge-Gravity Correspondence;Holography and Condensed Matter Physics (AdS/CMT);Confinement
摘要：
We compute holographic entanglement entropy (EE) and the renormalized EE in AdS solitons with gauge potential for various dimensions. The renormalized EE is a cutoff-independent universal component of EE. Via Kaluza-Klein compactification of S1 and considering the low-energy regime, we deduce the (d - 1)-dimensional renormalized EE from the odd-dimensional counterpart. This corresponds to the shrinking circle of AdS solitons, probed at large l. The minimal surface transitions from disk to cylinder dominance as l increases. The quantum phase transition occurs at a critical subregion size, with renormalized EE showing non-monotonic behavior around this size. Across dimensions, massive modes decouple at lower energy, while degrees of freedom with Wilson lines contribute at smaller energy scales.
摘要：
Radon-222 (Rn-222) is a global indoor health issue. A total of 74 points were measured in the woodland and grassland with the RAD7 device on the Hongxiang Campus of the University of South China. The results showed that the Rn-222 flux (RF) was 39.0 +/- 30.3 mBq m(-2) s(-1 )and 39.7 +/- 29.3 mBq m(-2) s(-1) in the woodland and grassland, respectively. The value of RF map was lower than 50 mBq m(-2) s(-1) in most campus areas. The results serve as essential reference data for future( 222)Rn risk-health assessment and management strategies on the campus.
期刊：
FRONTIERS IN ENDOCRINOLOGY,2024年15:1330206 ISSN：1664-2392
通讯作者：
Liu, M
作者机构：
[Sun, Fei] Jiangnan Univ, Wuxi Med Coll, Wuxi, Peoples R China.;[Bi, Huiya; Liu, Min; Hu, Shanshan; Chen, Huijuan; Sun, Zhaona] Wuxi Matern & Child Hlth Care Hosp, Dept Nursing, Wuxi, Peoples R China.;[Xie, Ruijie] Univ South China, Dept Microsurg, Hengyang, Peoples R China.
通讯机构：
[Liu, M ] W;Wuxi Matern & Child Hlth Care Hosp, Dept Nursing, Wuxi, Peoples R China.
关键词：
Secondary infertility;weight-adjusted-waist index (WWI);Depression;NHANES;ROC;Mediating effect
摘要：
Background: Obesity and psychological factors were identified as risk factors for female infertility. The study investigated the correlation between WWI, depression, and secondary infertility, focusing on the potential mediating role of depression. Methods: According to the data from NHANES, this cross-sectional study used multiple regression analysis, subgroup analysis, and smooth curve fitting to explore the relationship between WWI, depression, and secondary infertility. The diagnostic ability of WWI was evaluated and compared to other obesity indicators using the ROC curve. The mediating effect test adopted the distribution of the product. Results: This study involved 2778 participants, including 381 (13.7%) women with secondary infertility. Results showed that higher WWI (OR = 1.31; 95% CI, 1.11-1.56) and depression scores (OR = 1.03; 95% CI, 1.01-1.06) were associated with secondary infertility. There was a positive correlation between WWI and secondary infertility (nonlinear p = 0.8272) and this association was still consistent in subgroups (all P for interaction> 0.05). Compared with other obesity indicators, WWI (AUC = 0.588) also shows good predictive performance for secondary infertility. Mediation analysis showed that depression mediated the relationship between 3.94% of WWI and secondary infertility, with a confidence interval of Z(a) * Z(b) excluding 0. Conclusion: WWI exhibited a relatively good correlation in predicting secondary infertility than other obesity indicators, and depression may be a mediator between WWI and secondary infertility. Focusing on the potential mediating role of depression, the risk of secondary infertility due to obesity may be beneficially reduced in women.
摘要：
Heap leaching uranium tailings (HLUTs) contain radionuclides and sulfuric acid, presenting some challenges for the disposal of cemented HLUTs backfill (CUTB), including low stability and potential environmental contamination. In light of these issues, using a blend of cement clinker (CL) and high content phosphorus slag (PS) as binders to replace traditional cement for the preparation of green and cost-effective CUTB were proposed. The fluidity, setting time (ST), mechanical properties, Radon (Rn) exhalation rate, uranium (U) occurrence form, U (VI) leaching behavior, and microstructure of CUTB with different PS contents were investigated. The results showed that the fluidity, bleeding rate and ST of slurry (PS content >40%) met the filling requirements. The strength of PS-based CUTB was initially low, but rapidly increased in subsequent periods, surpassing 2 MPa at 28 d and 4.5 MPa at 90 d (with 50-70% PS content). Moreover, the Rn exhalation rates and U (VI) leaching levels of CUTB were far lower than the stipulated limits. When PS content exceeded 50%, the migratory uranium content in CUTB was below 10% with low migration risks. With the addition of PS, the amount and degree of polymerization of C-S-H gels in the matrix increased, while gypsum and CH content decreased. The S/S of U (VI) and SO42- was attributed to the combined effects of chemical immobilization of nascent minerals and physical adsorption/encapsulation of hydration products. Additionally, these hydrates effectively sealed micro-cracks on HLUTs particles surfaces and filled interlocking pores to decrease Rn exhalation. PS-based CUTB exhibited a high capacity increasing ratio and low cost. This research can promote the utilization of hazardous solid wastes such as HLUTs, reduce carbon dioxide emissions, and provide a theoretical basis for ensuring green and safe production in mining.
摘要：
Canopy FGF signaling regulator 2 (CNPY2) is a novel angiogenic growth factor. In recent years, increasing evidence highlights that CNPY2 has important functions in health and disease. Many new blood vessels need to be formed to meet the nutrient supply in the process of tumor growth. CNPY2 can participate in the development of tumors by promoting angiogenesis. CNPY2 also enhances neurite outgrowth in neurologic diseases and promotes cell proliferation and tissue repair, thereby improving cardiac function in cardiovascular diseases. Regrettably, there are few studies on CNPY2 in various diseases. At the same time, its biological function and molecular mechanism in the process and development of disease are still unclear. This paper reviews the recent studies on CNPY2 in cervical cancer, renal cell carcinoma, prostate cancer, colorectal cancer, lung cancer, gastric cancer, hepatocellular carcinoma, cerebral ischemia-reperfusion injury, spinal cord ischemia-reperfusion injury, Parkinson's disease, ischemic heart disease, myocardial ischemia-reperfusion injury, myocardial infarction, heart failure, and non-alcoholic fatty liver disease. The biological function and molecular mechanism of CNPY2 in these diseases have been summarized in this paper. Many drugs that play protective roles in tumors, cardiovascular diseases, non-alcoholic fatty liver disease, and neurologic diseases by targeting CNPY2, have also been summarized in this paper. In addition, the paper also details the biological functions and roles of canopy FGF signaling regulator 1 (CNPY1), canopy FGF signaling regulator 3 (CNPY3), canopy FGF signaling regulator 4 (CNPY4), and canopy FGF signaling regulator 5 (CNPY5). The mechanism and function of CNPY2 should be continued to study in order to accelerate disease prevention in the future.
作者机构：
[Li, Ye; Zhang, Yuexin; Li, Chunquan; Zhao, Yu; Huang, Xuemei; Xie, Liyuan; Zhang, Guorui; Zhao, Jun; Fan, Shifan; Song, Chao] Univ South China, Hengyang Med Sch, Affiliated Hosp 1, Hengyang 421001, Hunan, Peoples R China.;[Li, Ye; Zhang, Yuexin; Li, Chunquan; Zhao, Yu; Huang, Xuemei; Xie, Liyuan; Zhang, Guorui; Zhao, Jun; Fan, Shifan; Song, Chao] Univ South China, Hengyang Med Sch, MOE Key Lab Rare Pediat Dis, Hengyang 421001, Hunan, Peoples R China.;[Li, Ye; Zhang, Yuexin; Zhang, Qinyi; Li, Chunquan; Zhao, Yu; Huang, Xuemei; Xie, Liyuan; Zhang, Guorui; Fan, Shifan; Song, Chao] Univ South China, Sch Comp, Hengyang 421001, Hunan, Peoples R China.;[Li, Chunquan] Univ South China, Hunan Prov Maternal & Child Hlth Care Hosp, Hengyang Med Sch, Key Lab Birth Defect Res & Prevent,Natl Hlth Commi, Hengyang 421001, Hunan, Peoples R China.;[Li, Ye; Zhang, Yuexin; Li, Chunquan; Zhao, Yu; Huang, Xuemei; Xie, Liyuan; Zhang, Guorui; Fan, Shifan; Song, Chao] Univ South China, Affiliated Hosp 1, Cardiovasc Lab Big Data & Imaging ArtificialIntell, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.
通讯机构：
[Li, CQ ] U;Univ South China, Hengyang Med Sch, Affiliated Hosp 1, Hengyang 421001, Hunan, Peoples R China.;Univ South China, Hengyang Med Sch, MOE Key Lab Rare Pediat Dis, Hengyang 421001, Hunan, Peoples R China.;Univ South China, Sch Comp, Hengyang 421001, Hunan, Peoples R China.;Univ South China, Hunan Prov Maternal & Child Hlth Care Hosp, Hengyang Med Sch, Key Lab Birth Defect Res & Prevent,Natl Hlth Commi, Hengyang 421001, Hunan, Peoples R China.
关键词：
genes;mice;candidate disease gene;inference;multiomics;oncogenes;enhancer of transcription;cell lines;transcription factor
摘要：
Gene regulatory networks (GRNs) are interpretable graph models encompassing the regulatory interactions between transcription factors (TFs) and their downstream target genes. Making sense of the topology and dynamics of GRNs is fundamental to interpreting the mechanisms of disease etiology and translating corresponding findings into novel therapies. Recent advances in single-cell multi-omics techniques have prompted the computational inference of GRNs from single-cell transcriptomic and epigenomic data at an unprecedented resolution. Here, we present scGRN (https://bio.liclab.net/scGRN/), a comprehensive single-cell multi-omics gene regulatory network platform of human and mouse. The current version of scGRN catalogs 237 051 cell type-specific GRNs (62 999 692 TF-target gene pairs), covering 160 tissues/cell lines and 1324 single-cell samples. scGRN is the first resource documenting large-scale cell type-specific GRN information of diverse human and mouse conditions inferred from single-cell multi-omics data. We have implemented multiple online tools for effective GRN analysis, including differential TF-target network analysis, TF enrichment analysis, and pathway downstream analysis. We also provided details about TF binding to promoters, super-enhancers and typical enhancers of target genes in GRNs. Taken together, scGRN is an integrative and useful platform for searching, browsing, analyzing, visualizing and downloading GRNs of interest, enabling insight into the differences in regulatory mechanisms across diverse conditions. Graphical Abstract
期刊：
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES,2024年34(3):691-698 ISSN：0939-4753
通讯作者：
Ling Liu
作者机构：
[Zhang, Miao; Liu, Ling; Xie, Yingying; Tan, Yangrong; Xu, Jin; Chen, Hao; Qu, Peiliu; Zhu, Liyuan] Department of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, PR China;[Xie, Yingying] Department of Cardiology, China-Japan Friendship Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, PR China;[Chen, Hao] Department of Cardiology, Second Affiliated Hospital of South China University, Hengyang, Hunan, PR China;[Zhang, Miao; Tan, Yangrong; Xu, Jin; Qu, Peiliu; Zhu, Liyuan] Modern Cardiovascular Disease Clinical Technology Research Center of Hunan Province, PR China;[Liu, Ling] Modern Cardiovascular Disease Clinical Technology Research Center of Hunan Province, PR China. Electronic address: feliuling@csu.edu.cn
通讯机构：
[Ling Liu] D;Department of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, PR China<&wdkj&>Modern Cardiovascular Disease Clinical Technology Research Center of Hunan Province, PR China
摘要：
BACKGROUND AND AIM: Evidence from prospective cohort studies has revealed an inverse association between cheese consumption and the development of atherosclerosis (AS), atherosclerotic cardiovascular diseases (ASCVD), and their complications. However, it remains unclear whether this observed association is influenced by potential confounding factors that may arise during the long-term development process of AS, ASCVD, and its complications. Therefore, to further clarify the causal relationship between cheese consumption and AS, ASCVD, and its complications, we conducted a two-sample Mendelian randomization (MR) analysis to explore the causal association between cheese intake and the aforementioned health outcomes. METHODS AND RESULTS: We employed a two-sample MR analysis based on publicly available genome-wide association studies (GWAS) to infer the causal relationship, with no overlap between their participating populations. The effect estimates were calculated using the random-effects inverse-variance-weighted method. Sensitivity analyses were conducted using Cochran's Q statistic, funnel plot, leave-one-out analysis, and MR-Egger intercept tests. The genetically predicted cheese intake was found to be associated with lower risks of coronary AS (odds ratio [OR]=0.72, 95% confidence interval [CI] 0.59-0.88, P=0.001), peripheral vascular AS (OR=0.56, 95% CI 0.37-0.84, P=0.006), other vascular AS (OR=0.66, 95% CI 0.44-0.99, P=0.043), coronary artery disease (OR=0.64, 95% CI 0.56-0.74, P=1.57e-09), angina pectoris (OR=0.70, 95% CI 0.58-0.84, P=4.92e-05), myocardial infarction (OR=0.63, 95% CI 0.52-0.77, P=3.56e-06), heart failure (OR=0.62, 0.49-0.79, P=1.20e-04), total ischemic stroke (OR=0.76, 95% CI 0.63-0.91, P=0.003), peripheral artery disease (OR=0.64, 95% CI 0.43-0.95, P=0.028), and cognitive impairment (OR=0.65, 95% CI 0.56-0.74, P=3.40e-10). However, no associations were observed for cerebrovascular AS, arrhythmia, cardiac death, ischemic stroke (large artery AS), ischemic stroke (small vessel), ischemic stroke (cardioembolic), and transient ischemic attack. CONCLUSION: This two-sample MR analysis reveals a causally inverse association between cheese intake and multi-vascular AS (including coronary AS, peripheral vascular AS, and other vascular AS), as well as multiple types of ASCVD and its complications (such as coronary artery disease, angina pectoris, myocardial infarction, heart failure, total ischemic stroke, and peripheral artery disease). The findings from this study may lay a stronger theoretical foundation and present new opportunities for the dietary management of future atherosclerotic cardiovascular diseases.
期刊：
FRONTIERS IN NEUROLOGY,2024年15:1322228 ISSN：1664-2295
通讯作者：
Zhu, Shuzhen;Wang, Q
作者机构：
[Zhu, Shuzhen; Li, Fangyi; Zhang, Wenjie; Deng, Bin; Zhu, SZ; Wang, Qing; Zhou, Hang; Wang, Q; Weng, Guomei; Luo, Yuqi] Southern Med Univ, Dept Neurol, Zhujiang Hosp, Guangzhou, Peoples R China.;[Li, Fangyi] Univ South China, Affiliated Changsha Cent Hosp, Hengyang Med Sch, Dept Neurol, Changsha, Peoples R China.;[Weng, Guomei] First Peoples Hosp Zhaoqing, Dept Neurol, Zhaoqing, Peoples R China.;[Tao, Xi] Hunan Normal Univ, Hunan Prov Peoples Hosp, Dept Neurol Rehabil, Affiliated Hosp 1, Changsha, Peoples R China.;[Deng, Mingzhu] Brain Hosp Hunan Prov, Peoples Hosp Hunan Prov 2, Dept Neurol, Changsha, Peoples R China.
通讯机构：
[Wang, Q ; Zhu, SZ] S;Southern Med Univ, Dept Neurol, Zhujiang Hosp, Guangzhou, Peoples R China.
关键词：
Parkinson’s disease;inflammation;lymphocyte-to-monocyte ratio;neutrophil-to-high-density lipoprotein ratio;neutrophil-to-lymphocyte ratio
摘要：
BACKGROUND: Inflammation plays a pivotal role in the pathogenesis of Parkinson's disease (PD). However, the correlation between peripheral inflammatory markers and the severity of PD remains unclear. METHODS: The following items in plasma were collected for assessment among patients with PD (n = 303) and healthy controls (HCs; n = 303) were assessed for the neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR) and neutrophil-to-high-density-lipoprotein ratio (NHR) in plasma, and neuropsychological assessments were performed for all patients with PD. Spearman rank or Pearson correlation was used to evaluate the correlation between the NLR, the LMR and the NHR and the severity of PD. Receiver operating characteristic (ROC) curves were used to evaluate the diagnostic performance of the NLR, LMR and NHR for PD. RESULTS: The plasma NLR and NHR were substantially higher in patients with PD than in HCs, while the plasma LMR was substantially lower. The plasma NLR was positively correlated with Hoehn and Yahr staging scale (H&Y), Unified Parkinson's Disease Rating Scale (UPDRS), UPDRS-I, UPDRS-II, and UPDRS-III scores. Conversely, it exhibited a negative relationship with Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) scores. Furthermore, the plasma NHR was positively correlated with H&Y, UPDRS, UPDRS-I, UPDRS-II and UPDRS-III scores. Moreover, negative associations were established between the plasma LMR and H&Y, UPDRS, UPDRS-I, UPDRS-II, and UPDRS-III scores. Finally, based on the ROC curve analysis, the NLR, LMR and NHR exhibited respectable PD discriminating power. CONCLUSION: Our research indicates that a higher NLR and NHR and a lower LMR may be relevant for assessing the severity of PD and appear to be promising disease-state biomarker candidates.
通讯机构：
[Yin, XH ] U;Univ South China, Sch Nursing, Hengyang, Hunan, Peoples R China.
关键词：
Prehabilitation;Frailty;Aged;Meta-analysis
摘要：
Objective: The study investigates the impact of preoperative rehabilitation on the surgical prognosis of frail older patients. Method: The effect sizes of all studies retrieved and included by the nine databases were analyzed and expressed as RR and WMD. Results: 8 studies with 902 participants met the criteria for inclusion. A significant reduction in total complications (RR = 0.84, 95 % CI = 0.73 to 0.97, P = 0.021) and the 6MWT after surgery (WMD = 74.76, 95 % CI = 44.75 to 104.77, P = 0.000) was observed in the prehabilitation group. But it had no differences in mortality(RR = 1.89, 95 % CI = 0.75 to 4.72, P = 0.176), readmission rates(RR = 1.04, 95 % CI = 0.56 to 1.91, P = 0.906) and LOS(WMD = -0.24, 95 % CI = -1.00 to 0.52, P = 0.540). Conclusions: Prehabilitation had positive effect on postoperative complications and functional recovery in frail older patients. (c) 2023 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
摘要：
A novel reactive oxygen species‐responsive biodegradable nanoparticle (NP@PolyRHAPM) is designed, in which astaxanthin can reduce intracellular ROS levels and rapamycin‐enhanced autophagy levels, and restore mitochondrial function, hence successfully repolarizing M1 macrophages into M2 phenotypes. This repolarization enhances the proliferation and viability of chondrocytes while inhibiting apoptosis. Overall, this ROS‐responsive nanocarrier system provides a new avenue for progressive OA therapy. Abstract Osteoarthritis (OA) is a chronic joint disease characterized by synovitis and joint cartilage destruction. The severity of OA is highly associated with the imbalance between M1 and M2 synovial macrophages. In this study, a novel strategy is designed to modulate macrophage polarization by reducing intracellular reactive oxygen species (ROS) levels and regulating mitochondrial function. A ROS‐responsive polymer is synthesized to self‐assemble with astaxanthin and autophagy activator rapamycin to form nanoparticles (NP@PolyRHAPM). In vitro experiments show that NP@PolyRHAPM significantly reduced intracellular ROS levels. Furthermore, NP@PolyRHAPM restored mitochondrial membrane potential, increased glutathione (GSH) levels, and promoted intracellular autophagy, hence successfully repolarizing M1 macrophages into the M2 phenotype. This repolarization enhanced chondrocyte proliferation and vitality while inhibiting apoptosis. In vivo experiments utilizing an anterior cruciate ligament transection (ACLT)‐induced OA mouse model revealed the anti‐inflammatory and cartilage‐protective effects of NP@PolyRHAPM, effectively mitigating OA progression. Consequently, the findings suggest that intra‐articular delivery of ROS‐responsive nanocarrier systems holds significant promise as a potential and effective therapeutic strategy for OA treatment.
作者机构：
[Zhu, Jin; Liu, Yuchen; He, Lie; Xiao, Wancheng; Luo, Siyuan; Wang, Xiaodong; Peng, Xiaoyu] School of Nuclear Science and Technology, University of South China, Hengyang 421001, People's Republic of China;[Zhu, Kun] State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Soochow University, Suzhou 215123, People's Republic of China
通讯机构：
[Xiaodong Wang] S;School of Nuclear Science and Technology, University of South China, Hengyang 421001, People's Republic of China
关键词：
DNA damage;Geant4-DNA;RBE;radiochemistry
摘要：
Uncertainties in the relative biological effectiveness (RBE) of proton remains a major barrier to the biological optimization of proton therapy. A large amount of experimental data suggest that proton RBE is variable. As an evolving Monte Carlo code toolkit, Geant4-DNA is able to simulate the initial DNA damage caused by particle beams through physical and chemical interactions at the nanometer scale over a short period of time. This contributes to evaluating the radiobiological effects induced by ionizing radiation. Based on the Geant4-DNA toolkit, this study constructed a DNA geometric model containing 6.32Gbp, simulated the relationship between radiochemical yields (G-values) and their corresponding chemical constructors, and calculated a detailed calculation of the sources of damage and the complexity of damage in DNA strand breaks. The damage model constructed in this study can simulate the relative biological effectiveness (RBE) in the proton Bragg peak region. The results indicate that: (1) When the electron energy is below 400 keV, the yield of OH(·)account for 18.1% to 25.3% of the total water radiolysis yields. (2) Under the influence of histone clearance function, the yield of indirect damage account for over 72.93% of the yield of DNA strand breaks (SBs). When linear energy transfer (LET) increased from 29.79 (keV/μm) to 64.29 (keV/μm), the yield of double strand breaks (DSB) increased from 17.27% to 32.65%. (3) By investigating the effect of proton Bragg peak depth on the yield of direct DSB (DSB(direct)) and total DSB (DSB(total)), theRBEDSBtotandRBEDSBdirlevels of cells show that the RBE value of protons reaches 2.2 in the Bragg peak region.
作者机构：
[Cao, Jing] Medical Department, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, China;[Zhu, Jinqi] Department of Respiratory and Critical Care Medicine, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, China;[Zhao, Sue] Department of Respiratory and Critical Care Medicine, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, NO.161 Shaoshan South Road, Changsha, Hunan, 410004, China. Electronic address: 2018050785@usc.edu.cn
通讯机构：
[Zhao, Sue] D;Department of Respiratory and Critical Care Medicine, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, NO.161 Shaoshan South Road, Changsha, Hunan, 410004, China. Electronic address:
摘要：
BACKGROUND: Several studies have shown that dietary isoflavones are negatively correlated with total cholesterol and low-density lipoprotein cholesterol. However, few studies have investigated the link between dietary isoflavones and remnant cholesterol (RC). OBJECTIVES: We used the National Health and Nutrition Examination Survey (NHANES) database to explore the association between dietary isoflavone intake and RC. METHODS: A cross-sectional study was conducted with 4731 participants aged ≥ 20 years from the 2007-2008, 2009-2010, and 2017-2018 NHANES databases. We adopted univariate and multiple linear regression analysis and restricted cubic spline (RCS) to assess the relationship between dietary isoflavone intake and RC. Moreover, we conducted stratified and interaction analyses to ensure the stability of the results and identify specific populations. RESULTS: The weighted multifactor linear regression model showed a negative correlation between dietary isoflavone intake and remnant cholesterol (Model 2, β = -0.049, 95% CI: (-0.096, -0.002), P = 0.040). The RCS analysis indicated that there was an L-shaped negative correlation between dietary isoflavone intake and RC (P-value for non-linearity was 0.0464). Stratified analyses showed the inverse relationship between dietary isoflavone intake and RC persisted in most subgroups and there was no interaction except for the recreational activity group. CONCLUSIONS: Our study found a non-linear and negative association between dietary isoflavone intake and RC in US adults, so we hypothesized that consuming an isoflavone-rich diet may help reduce blood RC and further reduce the risk of cardiovascular disease.
通讯机构：
[Hua, YL ] U;Univ South China, Sch Resource Environm & Safety Engn, Hengyang 421001, Peoples R China.
关键词：
Handling Editor: Dr P. Vincenzini;High-entropy design;Sintering aid;Proton-conducting electrolyte;PCFCs;SOFCs
摘要：
Sintering aids are commonly used to improve the sinterability of proton-conducting oxides, whereas the sintering aid elements are being used alone in previous research. In this study, a high-entropy design method for the BaCe0.4Zr0.4Y0.2O3 (BCZY) proton-conducting oxides sintering aid is proposed. In contrast to the use of sintering aids such as Ni, Fe, Cu, Co, and Zn alone, the high-entropy design allows for the simultaneous use of all five elements, resulting in the new composition BaCe0.4Zr0.4Y0.15Ni0.01Cu0.01Co0.01Fe0.01Zn0.01O3 (HE-BCZY). Compared to conventional BaCe0.4Zr0.4Y0.15M0.05O3 (BCZYM, M = Ni, Cu, Co, Fe, Zn) materials, the sinterability of the new HE-BCZY material is significantly greater than that of BCZYM, despite the fact that the concentration of sintering aids is the same. Following sintering at 1300 degrees C, the HE-BCZY electrolyte membrane is completely dense. In addition, the HE-BCZY electrolyte has a higher conductivity than BCZYM. The low sintering temperature allows the successful preparation of proton ceramic fuel cells (PCFCs) with the HE-BCZY electrolyte, and the fuel cell reaches a high peak power density of 1218 mW cm(-2) at 700 degrees C, which is much higher than that of PCFCs using BCZY-based electrolytes. In addition, the excellent chemical stability of HE-BCZY is maintained under both H2O and CO2 conditions. Consequently, a fuel cell employing the HE-BCZY electrolyte operates without detectable degradation for 200 h. This study demonstrates that although the high-entropy design is seldom used for sintering aids of proton-conducting oxides, it is an intriguing and promising strategy for creating high-performance electrolyte materials with good sinterability, high conductivity, and excellent stability.
摘要：
In this paper, a multi-objective decision model is formulated utilizing both single-layer and three-layer radon reduction layer materials by considering radon emanation rate and cost as decision objectives. Through a multi-objective non-dominated ranking method, the optimal solution is identified from a range of feasible alternatives. In the case of the example uranium tailings pond, the optimized three-layer radon reduction layer materials reduce the comprehensive cost by 47.8% compared with the single-layer radon reduction layer materials while meeting the radon emanation rate limit. Furthermore, the utilization of non-dominated multi-objective optimization techniques demonstrates higher efficiency in optimizing each radon reduction layer schemes.
作者机构：
[Peng, Hongchun] Univ South China, Affiliated Changsha Cent Hosp, Hengyang Med Sch, Dept Orthoped, Changsha, Peoples R China.;[Su, Yingjie; Ding, Ning; Ding, N] Univ South China, Affiliated Changsha Cent Hosp, Hengyang Med Sch, Dept Emergency Med, 161 Shaoshan South Rd, Changsha 410004, Hunan, Peoples R China.;[Luo, Ju] Univ South China, Affiliated Changsha Cent Hosp, Hengyang Med Sch, Dept Geriatr, 161 Shaoshan South Rd, Changsha 410004, Hunan, Peoples R China.
通讯机构：
[Luo, J ; Ding, N ] U;Univ South China, Affiliated Changsha Cent Hosp, Hengyang Med Sch, Dept Emergency Med, 161 Shaoshan South Rd, Changsha 410004, Hunan, Peoples R China.;Univ South China, Affiliated Changsha Cent Hosp, Hengyang Med Sch, Dept Geriatr, 161 Shaoshan South Rd, Changsha 410004, Hunan, Peoples R China.
关键词：
Hemoglobin;Sepsis;Mortality;Anemia
摘要：
This study aimed to explore the association between admission hemoglobin level and clinical outcomes in sepsis based on Medical Information Mart for Intensive Care IV(MIMIC-IV) database. It was a retrospective study. Sepsis patients in the database were included. Data extraction from MIMIC-IV was performed by PostgreSQL 9.6 software. Three different models including crude model (adjusted for none), model I (adjusted for gender and age) and model II (adjusted for all potential cofounders) were constructed. A generalized liner model and a smooth fitting curve for indicating the relationship between hemoglobin level and 30-day mortality were performed. 6249 septic patients with a 30.18% of 30-day mortality were included. With 1g/dl increment in hemoglobin level, the values of odds ratio (OR) in crude model, model I and model II were 0.96 (95% confidential interval (CI) 0.94-0.99, P = 0.0023), 0.96 (95%CI 0.93-0.98, P = 0.0010) and 0.87 (95%CI 0.79-0.95, P = 0.0020), respectively. The smooth fitting curve indicated a non-linear relationship and the turning point was 7.2g/dl. Compared the hemoglobin group < 7.2g/dl, the risk of 30-day mortality significantly decreased by 32% in the hemoglobin group ≥ 7.2g/dl (OR = 0.68, 95%CI 0.51-0.93, P = 0.0142). The non-linear relationship between admission hemoglobin level and 30-day mortality in sepsis was found. Hemoglobin supplementation might be beneficial for septic patients with hemoglobin level < 7.2g/dl.
作者机构：
[Liu, Yanwen] Phase 1 Drug Clinical Trial Ward. The Second Affiliated Hospital. Hengyang Medical School;[Zhou, Yan; Li, Xiaoping; Zhang, Jun] Department of Nephropathy and Rheumatism. The Second Affiliated Hospital. Hengyang Medical School. University of South China
摘要：
OBJECTIVE: to explore the influences of a trans-theoretical model-based diet nursing intervention on sarcopenia and quality of life in maintenance hemodialysis patients. METHODS: the clinical data of 243 patients with maintenance hemodialysis (MHD) admitted to our hospital from January 2019 to August 2020 were retrospectively analyzed. A 1:1 orientation score matching (PSM) method was adopted, and patients with different intervention methods were matched based on gender, age, education time, dialysis age, body mass index, underlying diseases, annual income, and whether they were malnourished. Finally, 82 cases were included in the control group (routine nursing and dietary guidance) and 80 cases in the intrevention group (dietary nursing intervention based on the trans-theoretical model), respectively. RESULTS: After PSM, 82 cases in the control group and 80 cases in the intrevention group were included in the study. After the intervention, the incidence of sarcopenia, the extracellular water rate (ECF/TBF) value, and the malnutrition rate of the intrevention group were lower than those of the control group (p < 0.05); the scores of self-care, facing difficulties, potassium intake management, salt intake management, fluid restriction management, the levels of serum albumin, prealbumin and transferrin were all higher than those of the control group (p < 0.05); the SF-36 Concise Health Scale score of the intrevention group was higher than that of the control group (p < 0.05). The 1-year survival rate in the intrevention group (95.00 %) was higher than that in the control group (85.37 %) (p < 0.05). CONCLUSION: a TTM-based diet nursing intervention can help improve the dietary management behavior of MHD patients, prevent malnutrition, reduce the incidence of sarcopenia, and improve their quality of life and survival rate.
摘要：
In recent years, frequency-modulated continuous-wave (FMCW) radars have been widely used in the automotive field to measure the relative distance and speed of external targets. To address the problems of poor sensitivity, narrow measurement range, and poor stability of current FMCW radar systems, a high-order all-digital phase-locked loop (ADPLL) based on a fast-integration structure was designed for the FMCW radar. According to the measurement principle of the distance and velocity of objects using radar, the loop structure was designed using integrated circuit chip technology. A Z-domain model of the loop system was built using MATLAB software, and stability analyses and comparisons were performed. The loop program was written using the hardware description language and simulated using the MODELSIM software. Simulation results were combined to verify the accuracy of the hardware design. The experimental results showed that the ADPLL effectively increased the phase-locking frequency, expanded the frequency modulation range by nearly ten times, reduced the system delay by approximately 36%, and improved system stability.
