作者机构：
[Mingliang, Xu; Wahid, Junaid Abdul] School of Computer and Artificial Intelligence, Zhengzhou University, Zhengzhou, 450001, Henan, China;[Ayoub, Muhammad] School of Computer Science and Engineering, Central South University, Changsha, 410017, Hunan, China. ayoubncbae@gmail.com;[Husssain, Shabir] School of Architecture, Harbin Institute of Technology, Shenzhen, 518055, Guangdong, China;[Li, Lifeng] Department of Radiology, The Affiliated Changsha Central Hospital, Hengyang Medical school, University of South China, Changsha, 410017, China;[Shi, Lei] School of Cyberspace and Security, Zhengzhou University, Zhengzhou, 450001, Henan, China
摘要：
Myocardial infarction (MI) remains a significant contributor to global mortality and morbidity, necessitating accurate and timely diagnosis. Current diagnostic methods encounter challenges in capturing intricate patterns, urging the need for advanced automated approaches to enhance MI detection. In this study, we strive to advance MI detection by proposing a hybrid approach that combines the strengths of ResNet and Vision Transformer (ViT) models, leveraging global and local features for improved accuracy. We introduce a slim-model ViT design with multibranch networks and channel attention mechanisms to enhance patch embedding extraction, addressing ViT's limitations. By training data through both ResNet and modified ViT models, we incorporate a dual-pathway feature extraction strategy. The fusion of global and local features addresses the challenge of robust feature vector creation. Our approach showcases enhanced learning capabilities through modified ViT architecture and ResNet architecture. The dual-pathway training enriches feature extraction, culminating in a comprehensive feature vector. Preliminary results demonstrate significant potential for accurate detection of MI. Our study introduces a hybrid ResNet-ViT model for advanced MI detection, highlighting the synergy between global and local feature extraction. This approach holds promise for elevating MI classification accuracy, with implications for improved patient care. Further validation and clinical applicability exploration are warranted.
摘要：
Radon exhaled from building materials infiltrates the indoor atmosphere and is transported into the indoor space by buoyancy-driven airflow. This paper investigated the dynamic coupling of radon concentration in the building wall area and indoor space. An indoor radon migration model under natural convection caused by temperature gradient was established. The radon exhalation rate, average Nusselt number, and average Sherwood number at the building wall and indoor space interface were quantified. The mechanism of radon migration from building materials into the indoor atmosphere was elucidated. Results show that natural convection influences the flow of indoor air and the radon concentration distribution, which increases with the increase of temperature gradient.
期刊：
Qualitative Theory of Dynamical Systems,2024年23(2):1-17 ISSN：1575-5460
通讯作者：
Hu, SL
作者机构：
[Pan, Chaohong] Hunan First Normal Univ, Sch Math & Stat, Changsha 410205, Hunan, Peoples R China.;[Hu, Shulin; Pan, Chaohong; Wang, Hongyong] Univ South China, Sch Math & Phys, Hengyang 421001, Hunan, Peoples R China.
通讯机构：
[Hu, SL ] U;Univ South China, Sch Math & Phys, Hengyang 421001, Hunan, Peoples R China.
摘要：
In this paper, we investigate the speed selection mechanism of traveling wave solutions for a reaction–diffusion–advection equation with high-order terms in a cylindrical domain. The study focuses the problem under two cases for Neumann boundary condition and Dirichlet boundary condition. By using the upper and lower solutions method, general conditions for both linear and nonlinear selections are obtained. When the equation is expanded to higher dimensions, literature examining this particular topic is scarce. In light of this, new results have been obtained for both linear and nonlinear speed selections of the equation with high-order terms. For different power exponents m and n, specific sufficient conditions for linear and nonlinear selections with the minimal wave speed are derived by selecting suitable upper and lower solutions. The impact of the power exponents m and n on speed selection is analyzed.
作者机构：
[Huiting Liang; Chengtao Yue; Guizhi Zhao] School of Nuclear Science and Technology, University of South China, Hengyang 421001, China;[Xing Yang] State Key Laboratory of Solid Lubrication, Lanzhou Institute of Chemical Physics, Chinese Academy of Science, Lanzhou 730000, China;Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing 100049, China;[Junyan Zhang; Yongfu Wang] State Key Laboratory of Solid Lubrication, Lanzhou Institute of Chemical Physics, Chinese Academy of Science, Lanzhou 730000, China<&wdkj&>Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing 100049, China
通讯机构：
[Guizhi Zhao] S;School of Nuclear Science and Technology, University of South China, Hengyang 421001, China
摘要：
The wear of diamond in the drawing of ultra-fine metal wire leads to wire fracture and surface roughening, which inspires us to explore new pathways to solve problems. This study mimics the frictional behaviors of diamond and diamond-like carbon during the metal drawing process, and comparatively examines their frictional behaviors paired with Cu balls. When diamond-like carbon slide against the balls, the formation of a continuous and graphitized transfer film reduced friction and wear in the wide range of sliding velocities. Conversely, high friction and wear of diamond are primarily attributed to the presence of discontinuous and oxidized transfer films. The distinctive frictional behavior of diamond-like carbon contributes to effectively preventing problems such as wire breakage and uneven wire formation.
期刊：
International Journal of Biological Macromolecules,2024年:129220 ISSN：0141-8130
通讯作者：
Dai, Homg;Xie, Zhi-Hui;Liu, Yali
作者机构：
[Guo, Meng; Zhen, Deshuai; Luo, Xiaohu; Deng, Qiuhui] Engineering Research Center of Loss Efficacy and Anticorrosion of Materials of Guizhou, School of Chemistry and Chemical Engineering, Qiannan Normal University for Nationalities, Duyan 558000, PR China;[Luo, Xiaohu; Deng, Qiuhui] State Key Laboratory for Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, PR China;[Zhen, Deshuai] School of Public Health, Hengyang Medical School, University of South China, Hengyang 421001, PR China;[Zhen, Deshuai] State Key Laboratory for Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, PR China;[Mao, Haili] School of Public Health, Hengyang Medical School, University of South China, Hengyang 421001, PR China
通讯机构：
[Dai, Homg] E;[Xie, Zhi-Hui] C;[Liu, Yali] S;Engineering Research Center of Loss Efficacy and Anticorrosion of Materials of Guizhou, School of Chemistry and Chemical Engineering, Qiannan Normal University for Nationalities, Duyan 558000, PR China. Electronic address:;Chemical Synthesis and Pollution Control Key Laboratory of Sichuan Province, College of Chemistry and Chemical Engineering, China West Normal University, Nanchong 637002, PR China. Electronic address:
摘要：
In this work, a total of 18 types of choline chloride, betaine, and L-proline-based deep eutectic solvents (DESs) were synthesized to determine the extraction yield of a natural polysaccharide (PSA) from Dysosma versipellis using an ultrasound-assisted extraction method. Results indicate that the choline-oxalic acid-based DES has the best extraction yield for PSA due to the proper physical-chemical properties between PSA and DES. To evaluate the optimal extraction conditions, a response surface methodology was carried out. Under the optimal conditions, the extraction yield of PSA reaches 10.37 % (± 0.03 %), higher than the conventional extraction methods. Findings from FT-IR and NMR suggest that the extracted PSA belongs to a neutral polysaccharide with (1 → 6)-linked α-d-glucopyranose in the main chain. Interestingly, results from various electrochemical measurements show the extracted PSA exhibits excellent corrosion inhibition performance for mild steel (MS) in a 0.5 M HCl solution, with 90.8 % of maximum corrosion inhibition efficiency at 210 mg L(-1). SEM and XPS measurements reveal the formation of a protective layer on the MS surface. The adsorption behaviour of extracted PSA well obeys the Langmuir adsorption isotherm containing the chemisorption and physisorption. Additionally, theoretical calculations validate the experimental findings.
作者机构：
[Liu, Zihan; Gao, Ruijie; Zhang, Wei] Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, School of Pharmaceutical Science, Hengyang Medical School, University of South China, Hengyang, 421001, China;[Liu, Xinping] Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, School of Pharmaceutical Science, Hengyang Medical School, University of South China, Hengyang, 421001, China. Electronic address: xinpingliu@usc.edu.cn;[Wei, Hua] Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, School of Pharmaceutical Science, Hengyang Medical School, University of South China, Hengyang, 421001, China. Electronic address: weih@usc.edu.cn;[Yu, Cui-Yun] Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, School of Pharmaceutical Science, Hengyang Medical School, University of South China, Hengyang, 421001, China. Electronic address: yucuiyunusc@hotmial.com
通讯机构：
[Xinping Liu; Hua Wei; Cui-Yun Yu] H;Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, School of Pharmaceutical Science, Hengyang Medical School, University of South China, Hengyang, 421001, China
摘要：
Hypoxia is a common feature of most solid tumors, which promotes the proliferation, invasion, metastasis, and therapeutic resistance of tumors. Researchers have been developing advanced strategies and nanoplatforms to modulate tumor hypoxia to enhance therapeutic effects. A timely review of this rapidly developing research topic is therefore highly desirable. For this purpose, this review first introduces the impact of hypoxia on tumor development and therapeutic resistance in detail. Current developments in the construction of various nanoplatforms to enhance tumor treatment in response to hypoxia are also systematically summarized, including hypoxia-overcoming, hypoxia-exploiting, and hypoxia-disregarding strategies. We provide a detailed discussion of the rationale and research progress of these strategies. Through a review of current trends, it is hoped that this comprehensive overview can provide new prospects for clinical application in tumor treatment. STATEMENT OF SIGNIFICANCE: As a common feature of most solid tumors, hypoxia significantly promotes tumor progression. Advanced nanoplatforms have been developed to modulate tumor hypoxia to enhanced therapeutic effects. In this review, we first introduce the impact of hypoxia on tumor progression. Current developments in the construction of various nanoplatforms to enhance tumor treatment in response to hypoxia are systematically summarized, including hypoxia-overcoming, hypoxia-exploiting, and hypoxia-disregarding strategies. We discuss the rationale and research progress of the above strategies in detail, and finally introduce future challenges for treatment of hypoxic tumors. By reviewing the current trends, this comprehensive overview can provide new prospects for clinical translatable tumor therapy.
作者机构：
[He, Fang; Yang, Li; Deng, Xiaolu; Peng, Jing; Chen, Chen; Zhang, Ciliu; Wang, Xiaole; Yang, Lifen; Duan, Haolin; Mao, Leilei; Pang, Nan; Wang, Guoli; Zhang, Wen; Yin, Fei] Cent South Univ, Xiangya Hosp, Dept Pediat, Changsha 410008, Peoples R China.;[He, Fang; Yang, Li; Deng, Xiaolu; Peng, Jing; Chen, Chen; Zhang, Ciliu; Wang, Xiaole; Yang, Lifen; Duan, Haolin; Mao, Leilei; Pang, Nan; Wang, Guoli; Zhang, Wen; Yin, Fei] Cent South Univ, Xiangya Hosp, Clin Res Ctr Children Neurodev Disabil Hunan Prov, Changsha, Peoples R China.;[Xia, K; Li, Kuokuo; Chen, Meilin; Tan, Senwei; Guo, Hui; Xia, Kun] Cent South Univ, Ctr Med Genet, Sch Life Sci, Changsha 410078, Hunan, Peoples R China.;[Xia, K; Li, Kuokuo; Chen, Meilin; Tan, Senwei; Guo, Hui; Xia, Kun] Cent South Univ, Sch Life Sci, Hunan Key Lab Med Genet, Changsha 410078, Hunan, Peoples R China.;[Li, Kuokuo] Anhui Med Univ, Affiliated Hosp 1, Dept Oncol, Hefei 230022, Peoples R China.
通讯机构：
[Peng, J; Xia, K ; Yin, F ] C;Cent South Univ, Ctr Med Genet, Sch Life Sci, Changsha 410078, Hunan, Peoples R China.;Cent South Univ, Sch Life Sci, Hunan Key Lab Med Genet, Changsha 410078, Hunan, Peoples R China.;Univ South China, Hengyang Med Sch, Hengyang 421001, Peoples R China.;Cent South Univ, Xiangya Hosp, Clin Res Ctr Children Neurodev disabil Hunan Prov, Dept Pediat, Changsha, Peoples R China.
关键词：
Autism spectrum disorder;CDKL5;De novo variants;Epilepsy;Intellectual disability;Molecular inversion probes;Neurodevelopmental disorders;SCN1A
摘要：
With the continuous deepening of genetic research on neurodevelopmental disorders (NDDs), more patients have been identified the causal or candidate genes. However, it is still urgent needed to increase the sample size to confirm the associations between variants and clinical manifestations. We previously performed molecular inversion probe sequencing of autism spectrum disorder (ASD) candidate genes in 1543 ASD patients. In this study, we used the same method to detect de novo variants (DNVs) in 665 NDD patients with intellectual disability (ID) and/or epilepsy (EP) for genetic analysis and diagnosis. We compared findings from ID/EP and ASD patients to improve our understanding of different subgroups of NDDs. We identified 72 novel variants and 39 DNVs. A totally of 5.71% (38/665) of the patients were genetically diagnosed by this sequencing strategy. ID/EP patients demonstrated a higher prevalence of likely gene disruptive DNVs in ASD genes than the healthy population. Regarding high-risk genes, SCN1A and CKDL5 were more frequently mutated in ID/EP patients than in ASD patients. Our data provide an overview of the mutation burden in ID/EP patients from the perspective of high risk ASD genes, indicating the differences and association of NDDs subgroups.
摘要：
Chronic, non-healing wounds pose significant challenges for public health, particularly in the context of diabetes, and carry significant economic consequences. This article introduces a new solution in the form of a wireless theranostic patch, developed to meet the critical need for real-time monitoring and targeted treatments to facilitate optimal healing. The patch incorporates advanced materials that are both multifunctional and electro-responsive, leveraging a sophisticated blend of smart hydrogels and wearable bioelectronics to support diabetic wound management with unparalleled efficacy. With electro-responsive multifunctional polymer hydrogels at its core, the patch delivers a stretchable, antimicrobial, and moist environment for the wound, with added benefits such as conductivity and visibility. The materials also allow for continuous and autonomous monitoring of glucose and pH levels, providing precise and personalized treatments like insulin delivery via iontophoresis and electrical stimulation. Animal models have demonstrated that this integrated system is highly adaptable, effectively promoting wound closure and healing. Overall, the wireless theranostic system offers an exciting prospect for personalized healthcare solutions, adopting a patient-centric approach that prioritizes real-time, targeted care for chronic wounds. Its incorporation of advanced materials and electro-controlled treatments paves the way for new and innovative approaches to wound management. A wireless theranostic wound patch is designed to tackle the critical need by continuous monitoring of glucose and pH, on-demand delivering of insulin via iontophoresis, and electrical stimulation. Moreover, integrating wearable bioelectronics with advanced multifunctional and electro-responsive hydrogels provides a stretchable, antimicrobial, and moist environment for wounds, resulting in high efficacy in diabetic wound management. image
作者机构：
[Wan, Huijuan] Univ South China, Affiliated Hosp 2, Hengyang Med Sch, Dept Nephrol & Rheumatol, Hengyang 421001, Peoples R China.;[Zhang, Ya] Univ South China, Affiliated Nanhua Hosp, Hengyang Med Sch, Dept Gland Surg, Hengyang 421002, Peoples R China.;[Ning, Zhongxing] Sun Yat Sen Univ, Guangxi Hosp Div, Affiliated Hosp 1, Guangzhou, Peoples R China.;[Liu, Mingjiang] Univ South China, Affiliated Nanhua Hosp, Hengyang Med Sch, Dept Hand & Microsurg, Hengyang 421002, Peoples R China.;[Yang, SD; Yang, Shudong] Univ South China, Affiliated Hosp 2, Hengyang Med Sch, Dept Traumat Orthoped, 35 Jiefang Rd, Hengyang 421001, Hunan, Peoples R China.
通讯机构：
[Yang, SD ] U;Univ South China, Affiliated Hosp 2, Hengyang Med Sch, Dept Traumat Orthoped, 35 Jiefang Rd, Hengyang 421001, Hunan, Peoples R China.
摘要：
Rheumatoid Arthritis (RA) is an increasingly prevalent inflammatory disorder worldwide. Its complex etiology has recently brought dietary factors, particularly fiber intake, into focus as potential influencers. Our study investigates the intricate relationship between various sources of dietary fiber and RA, emphasizing the mediating role of the Dietary Inflammatory Index (DII). Leveraging data from the National Health and Nutrition Examination Survey spanning 2011 to 2020. We meticulously assessed dietary fiber intake through dual 24 h dietary recall interviews, while RA diagnoses were established based on comprehensive medical surveys. The relationships between fiber intake, RA prevalence, and DII mediation were analyzed using sophisticated multivariate logistic regression and mediation analysis. Among our study cohort, 7% were diagnosed with RA. We observed a notable inverse correlation between increased total fiber intake, particularly 5 g/day increments, and the incidence of RA, with cereal fiber intake emerging as the primary mitigating factor. Intriguingly, the DII played a significant role in mediating this association, especially regarding cereal fiber. Our findings reveal a significant association between higher cereal fiber consumption and a reduced prevalence of RA. Additionally, the DII stands out as a pivotal mediator in this relationship, highlighting dietary management's critical role in preventing and managing RA.
作者机构：
[Wang, Jingyu; Bai, Qinqin; Liang, H; Zheng, Yi; Zhao, Fengxia; Liang, Hao; Yan, Hangli; Wu, Linghao; Niu, Xiangheng] Univ South China, Sch Publ Hlth, Hengyang Med Sch, Dept Publ Hlth Lab Sci, Hengyang 421001, Peoples R China.;[Hu, Hongmei] Hengyang Ctr Dis Control & Prevent, Hengyang 421001, Peoples R China.
通讯机构：
[Liang, H ] U;Univ South China, Sch Publ Hlth, Hengyang Med Sch, Dept Publ Hlth Lab Sci, Hengyang 421001, Peoples R China.
摘要：
The detection of foodborne pathogens is crucial for food hygiene regulation and disease diagnosis. Colorimetry has become one of the main analytical methods in studying foodborne pathogens due to its advantages of visualization, low cost, simple operation, and no complex instrument. However, the low sensitivity limits its applications in early identification and on-site detection for trace analytes. In order to overcome such a limitation, herein we propose a joint strategy featuring dual signal amplification based on the hybridization chain reaction (HCR) and DNA-enhanced peroxidase-like activity of gold nanoparticles (AuNPs) for the sensitive visual detection of Escherichia coli. Target bacteria bound specifically to the aptamer domain in the capture hairpin probe, exposing the trigger domain for HCR and forming the extended double-stranded DNA (dsDNA) structures. The peroxidase-like catalytic capacity of AuNPs can be enhanced significantly by dsDNAs with the sticky ends of dsDNAs being adsorbed on AuNPs and the rigidity of dsDNAs causing the spatial regulation of AuNP concentration. The intensity of the enhancement was linearly related to the number of target bacteria. With the above strategy, the detection limit of our colorimetric method for Escherichia coli was down to 28 CFU mL(-1) within a short analytical time (50 min). This study provides a new perspective for the sensitive and visual detection of early bacterial contamination in foods.
作者机构：
[He, Run-Chao; Hu, YW; Zhang, Ting; Jiang, Min; Li, Shu; Song, Yu; Wu, Jia; Zhang, Ke-Lan; Hu, Yan-Wei; Tang, Mao-Lin; Dong, Xian-Hui] Guangzhou Med Univ, Guangzhou Women & Children Med Ctr, Dept Clin Lab, Guangzhou 510600, Guangdong, Peoples R China.;[Dai, Xiaoyan] Guangzhou Med Univ, Guangzhou, Guangdong, Peoples R China.;[Wu, Shao-Guo] Guangzhou Twelfth Peoples Hosp, Dept Clin Lab, Guangzhou, Guangdong, Peoples R China.;[Bei, Yan-Rou] Southern Med Univ, Nanfang Hosp, Lab Med Ctr, Guangzhou, Guangdong, Peoples R China.;[Ma, Xin] Southern Med Univ, Nanfang Hosp, Dept Anesthesiol, Guangzhou, Guangdong, Peoples R China.
通讯机构：
[Hu, YW ; Dai, XY ] G;Guangzhou Med Univ, Guangzhou Women & Children Med Ctr, Dept Clin Lab, Guangzhou 510600, Guangdong, Peoples R China.;Guangzhou Med Univ, Guangzhou, Guangdong, Peoples R China.
摘要：
BACKGROUND: Increasing evidence suggests that long noncoding RNAs play significant roles in vascular biology and disease development. One such long noncoding RNA, PSMB8-AS1, has been implicated in the development of tumors. Nevertheless, the precise role of PSMB8-AS1 in cardiovascular diseases, particularly atherosclerosis, has not been thoroughly elucidated. Thus, the primary aim of this investigation is to assess the influence of PSMB8-AS1 on vascular inflammation and the initiation of atherosclerosis. METHODS: We generated PSMB8-AS1 knockin and Apoe (Apolipoprotein E) knockout mice (Apoe(-/-)PSMB8-AS1(KI)) and global Apoe and proteasome subunit-β type-9 (Psmb9) double knockout mice (Apoe(-/-)Psmb9(-/-)). To explore the roles of PSMB8-AS1 and Psmb9 in atherosclerosis, we fed the mice with a Western diet for 12 weeks. RESULTS: Long noncoding RNA PSMB8-AS1 is significantly elevated in human atherosclerotic plaques. Strikingly, Apoe(-/-)PSMB8-AS1(KI) mice exhibited increased atherosclerosis development, plaque vulnerability, and vascular inflammation compared with Apoe(-/-) mice. Moreover, the levels of VCAM1 (vascular adhesion molecule 1) and ICAM1 (intracellular adhesion molecule 1) were significantly upregulated in atherosclerotic lesions and serum of Apoe(-/-)PSMB8-AS1(KI) mice. Consistently, in vitro gain- and loss-of-function studies demonstrated that PSMB8-AS1 induced monocyte/macrophage adhesion to endothelial cells and increased VCAM1 and ICAM1 levels in a PSMB9-dependent manner. Mechanistic studies revealed that PSMB8-AS1 induced PSMB9 transcription by recruiting the transcription factor NONO (non-POU domain-containing octamer-binding protein) and binding to the PSMB9 promoter. PSMB9 (proteasome subunit-β type-9) elevated VCAM1 and ICAM1 expression via the upregulation of ZEB1 (zinc finger E-box-binding homeobox 1). Psmb9 deficiency decreased atherosclerotic lesion size, plaque vulnerability, and vascular inflammation in Apoe(-/-) mice in vivo. Importantly, endothelial overexpression of PSMB8-AS1-increased atherosclerosis and vascular inflammation were attenuated by Psmb9 knockout. CONCLUSIONS: PSMB8-AS1 promotes vascular inflammation and atherosclerosis via the NONO/PSMB9/ZEB1 axis. Our findings support the development of new long noncoding RNA-based strategies to counteract atherosclerotic cardiovascular disease.
作者机构：
[Guo, Yuan; Chen, Fengling; Chen, Zhu] Hengyang Medical School, University of South China, Hengyang, Hunan, China;[He, Ziyu; Guo, Yuan; Chen, Fengling; Wang, Chengming] Department of Cardiovascular Medicine, Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou, Hunan, China;[Si, Jiajia; Guo, Yuan; Chen, Zhu] Hunan Key Laboratory of Biomedical Nanomaterials and Devices, Hunan University of Technology, Zhuzhou, China
摘要：
S100A9 is released by immune and tissue cells in response to stressors such as damage, inflammation, and oxidative stress. This leads to the amplification of inflammation, anti‐inflammatory effects, induction of endothelial dysfunction, promotion of vascular microcalcification, as well as stimulation of cell proliferation, autophagy, apoptosis, and death. S100A9 can serve as a biomarker for diagnosis, prediction, and evaluation of cardiovascular diseases, and it is also considered a potential therapeutic target. Abstract Cardiovascular disease (CVD) is a group of diseases that primarily affect the heart or blood vessels, with high disability and mortality rates, posing a serious threat to human health. The causative factors, pathogenesis, and characteristics of common CVD differ, but they all involve common pathological processes such as inflammation, oxidative stress, and fibrosis. S100A9 belongs to the S100 family of calcium‐binding proteins, which are mainly secreted by myeloid cells and bind to the Toll‐like receptor 4 and receptor for advanced glycation end products and is involved in regulating pathological processes such as inflammatory response, fibrosis, vascular calcification, and endothelial barrier function in CVD. The latest research has found that S100A9 is a key biomarker for diagnosing and predicting various CVD. Therefore, this article reviews the latest research progress on the diagnostic and predictive, and therapeutic value of S100A9 in inflammatory‐related CVD such as atherosclerosis, myocardial infarction, and arterial aneurysm and summarizes its molecular mechanisms in the progression of CVD, aiming to explore new predictive methods and to identify potential intervention targets for CVD in clinical practice.
作者机构：
[Yaqiang Shu; Chuanfu Li; Bo Liu; Fan Wu; Chao Zhang; Muyu Fu; Xiaohua Lei; Guodong Chen] The First Affiliated Hospital, Department of Hepato-Biliary-Pancreatic Surgery, Hengyang Medical School, University of South China, Hengyang, Hunan, China
通讯机构：
[Xiaohua Lei; Guodong Chen] T;The First Affiliated Hospital, Department of Hepato-Biliary-Pancreatic Surgery, Hengyang Medical School, University of South China, Hengyang, Hunan, China
摘要：
Duodenum-preserving pancreatic head resection (DPPHR) has been widely used in benign tumors, low-grade malignant tumors of the pancreatic head and chronic pancreatitis. Nevertheless, to date, there has been no report about indocyanine (ICG) fluorescence in robotic DPPHR. This report describes the technique of robotic DPPHR with preoperative three-dimensional reconstruction visualization and intraoperative real-time ICG fluorescence imaging navigation. The results show that the technique is safe and effective for benign masses of the head of the pancreas and may offer a benefit for maintaining the integrity of duodenal blood flow and the biliary system.
作者机构：
Key Laboratory of Advanced Nuclear Energy Design and Safety, Ministry of Education, University of South China, Hengyang 421001, China;School of Nuclear Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, China;[Cong Li; Qi Zheng] School of Nuclear Science and Technology, University of South China, Hengyang 421001, China;School of Resources Environment and Safety Engineering, University of South China, Hengyang 421001, China;Author to whom correspondence should be addressed.
通讯机构：
[Tianjiao Jiang] K;Key Laboratory of Advanced Nuclear Energy Design and Safety, Ministry of Education, University of South China, Hengyang 421001, China<&wdkj&>School of Nuclear Science and Technology, University of South China, Hengyang 421001, China<&wdkj&>Author to whom correspondence should be addressed.
关键词：
ruthenium;adsorption;high level liquid waste;nitrite–nitric acid system
摘要：
Ruthenium is required to separate from high-level liquid waste (HLLW) because Ru is a valuable resource and is negatively influential on the vitrification process of HLLW. However, the separation of Ru is very challenging due to its complicated complexation properties. In this study, the adsorption and desorption characteristics of ruthenium on a synthesized SiPyR-N3 (weak-base anion exchange resin with pyridine functional groups) composite were investigated in nitric acid and nitrite–nitric acid systems, respectively, and the adsorption mechanism was explored. The experimental results showed that SiPyR-N3 has a significantly better adsorption effect on Ru in the nitrite–nitric acid system than in the nitric acid system, with an increase in the adsorption capacity of approximately three times. The maximum adsorption capacity of Ru is 45.6 mg/g in the nitrite–nitric acid system. The SiPyR-N3 possesses good adsorption selectivity (SFRu/other metal ions is around 100) in 0.1 M NO2−–0.1 M HNO3 solution. The adsorption processes of Ru in the two different systems are fitted with the pseudo-second-order kinetic model and Langmuir model for uptake kinetics and adsorption isotherms, respectively. The results obtained from the FT-IR, XPS, and UV absorption spectrometry indicate that NO2− was involved in the adsorption process either as a complexing species with the metal ions or as free NO2− from the solution. A 0.1 M HNO3 + 1 M thiourea mixed solution shows effective desorption performance, and the desorption efficiency can reach 92% at 328 K.
作者机构：
[Liu, Yu; You, Ting; Zhang, Bihong; Sun, Zhilu] The First Affiliated Hospital, Emergency Medicine, Hengyang Medical School, University of South China, Hengyang, Hunan Province, P.R. China;[Tang, Jie] The First Affiliated Hospital, Department of Pain, Hengyang Medical School, University of South China, Hengyang, Hunan Province, P.R. China;[Liu, Jing] The First Affiliated Hospital, Department of Rehabilitation, Hengyang Medical School, University of South China, Hengyang, Hunan Province, P.R. China
通讯机构：
[Jing Liu] T;The First Affiliated Hospital, Department of Rehabilitation, Hengyang Medical School, University of South China , Hengyang, Hunan Province, P.R. China
关键词：
OIP5-AS1;PPAR-γ;mitophagy;osteoarthritis
摘要：
BACKGROUND: Osteoarthritis (OA) is the most common chronic joint degenerative disease. Mitophagy is closely related to OA pathogenesis. Herein, we investigated the role of lncRNA OIP5-AS1 in regulating mitophagy during OA. METHODS: RT-qPCR and Western blotting were utilized to analyze gene and protein levels. RIP and RNA pull down verified the relationship between OIP5-AS1, FUS and PPAR-γ. CCK-8 assay detected cells viability. ELISA evaluated the secretion of inflammatory cytokines. Flow cytometry measured the contents of ROS and Ca2+. Immunofluorescence staining analyzed TOMM20 and LC3B levels. JC-1 staining was adopted to measure mitochondrial membrane potential. The changes of mitophagy were analyzed by TEM. RESULTS: LPS treatment contributed to the decrease of chondrocytes viability, calcium level and inhibited mitochondrial membrane potential, while elevated the secretion of inflammatory factors, ROS accumulation and TOMM20 expression. Additionally, LPS decreased the ratio of LC3II/I, Parkin and PINK1 protein levels, and increased p62 and TOMM20 protein levels. Furthermore, overexpression of OIP5-AS1 inhibited LPS-induced chondrocytes injury and activated mitophagy. OIP5-AS1 upregulated PPAR-γ mRNA level to regulate AMPK/Akt/mTOR signaling by interacting with FUS. In addition, PPAR-γ overexpression alleviated LPS induced chondrocytes injury by activating AMPK/Akt/mTOR signaling. Knockdown of PPAR-γ reversed the promotion of OIP5-AS1 upregulation on mitophagy. CONCLUSION: OIP5-AS1 promotes PPAR-γ expression to activate the AMPK/Akt/mTOR signaling, thereby enhancing mitophagy and alleviating OA progression. It is suggested that OIP5-AS1 may function as a protector in OA development.
作者机构：
[Deng, Jia; Wang, Gang; Zhang, Jingjing; Tang, Huifang; Li, Yueyan; Yu, Ying; Zou, Jin] Department of Cardiology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, China;[Yu, Ying] Clinical Research Center for Myocardial Injury in Hunan Province, Hengyang, Hunan, 421001, China;[Yu, Ying] The First Affiliated Hospital, Institute of Cardiovascular Disease, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, China;[Liao, Bihong] Department of Radiology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, China;[Wang, Qiuyu; Liu, Jiaqi; Qian, Fengcui] The First Affiliated Hospital, Cardiovascular Lab of Big Data and Imaging Artificial Intelligence, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, China
关键词：
Cardiac magnetic resonance;Left ventricular remodelling;T1 mapping;coronary heart disease;heart failure;strain
摘要：
BACKGROUND: Coronary Heart Disease (CHD) is one of the most common types of cardiovascular disease, and Heart Failure (HF) is an important factor in its progression. We aimed to evaluate the diagnostic value and predictors of multiparametric Cardiac Magnetic Resonance (CMR) in CHD patients with HF. METHODS: The study retrospectively included 145 CHD patients who were classified into CHD (HF+) (n = 91) and CHD (HF-) (n = 54) groups according to whether HF occurred. CMR assessed LV function, myocardial strain and T1 mapping. Multivariate linear regression analyses were performed to identify predictors of LV dysfunction, myocardial fibrosis, and LV remodeling. RESULTS: CHD (HF+) group had impaired strain, with increased native T1, ECV, and LVM index. The impaired strain was associated with LVM index (p < 0.05), where native T1 and ECV were affected by log-transformed amino-terminal pro-B-type natriuretic peptide (NT-proBNP) levels. ROC analysis showed the combination of global circumferential strain (GCS), native T1, and LVM had a higher diagnostic value for the occurrence of HF in CHD patients.<P> Meanwhile, log-transformed NT-proBNP was an independent determinant of impaired strain, increased LVM index, native T1 and ECV. CONCLUSION: HF has harmful effects on LV systolic function in patients with CHD. In CHD (HF+) group, LV dysfunction is strongly correlated with the degree of LV remodeling and myocardial fibrosis. The combination of the three is more valuable in diagnosing HF than conventional indicators.
期刊：
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION,2024年331(10):840-849 ISSN：0098-7484
通讯作者：
Li, Fengli;Zi, WJ
作者机构：
[Xu, Xu; Peng, Zhouzhou; Yu, Nizhen; Jiang, Lin; Ma, Jinfu; Huang, Jiacheng; Zi, Wenjie; Li, Linyu; Tian, Yan; Fan, Shitao; Xie, Dongjing; Guo, Changwei; Liu, Xiang; Song, Jiaxing; Yue, Chengsong; Huang, Jiandi; Zi, WJ; Yang, Qingwu; Qiu, Zhongming; Li, Fengli; Hu, Jinrong; Yang, Jie; Yang, Dahong] Third Mil Med Univ, Mil Med Univ 3, Xinqiao Hosp, Dept Neurol, 183 Xinqiao Main St, Chongqing 400037, Peoples R China.;[Xu, Xu; Peng, Zhouzhou; Yu, Nizhen; Jiang, Lin; Ma, Jinfu; Huang, Jiacheng; Zi, Wenjie; Li, Linyu; Tian, Yan; Fan, Shitao; Xie, Dongjing; Guo, Changwei; Liu, Xiang; Song, Jiaxing; Yue, Chengsong; Huang, Jiandi; Zi, WJ; Yang, Qingwu; Qiu, Zhongming; Li, Fengli; Hu, Jinrong; Yang, Jie; Yang, Dahong] Third Mil Med Univ, Army Med Univ, Affiliated Hosp 2, 183 Xinqiao Main St, Chongqing 400037, Peoples R China.;[Chen, Yifei] Kunming Med Univ, Dept Neurol, Affiliated Hosp 1, Kunming, Peoples R China.;[Zheng, Chong] Fujian Med Univ, Dept Neurol, Longyan Affiliated Hosp 1, Longyan, Peoples R China.;[Jiang, Shunfu] Jingdezhen 1 Peoples Hosp, Dept Neurol, Jingdezhen, Peoples R China.
通讯机构：
[Zi, WJ ; Li, FL] T;Third Mil Med Univ, Mil Med Univ 3, Xinqiao Hosp, Dept Neurol, 183 Xinqiao Main St, Chongqing 400037, Peoples R China.;Third Mil Med Univ, Army Med Univ, Affiliated Hosp 2, 183 Xinqiao Main St, Chongqing 400037, Peoples R China.
摘要：
IMPORTANCE: It is uncertain whether intravenous methylprednisolone improves outcomes for patients with acute ischemic stroke due to large-vessel occlusion (LVO) undergoing endovascular thrombectomy. OBJECTIVE: To assess the efficacy and adverse events of adjunctive intravenous low-dose methylprednisolone to endovascular thrombectomy for acute ischemic stroke secondary to LVO. DESIGN, SETTING, AND PARTICIPANTS: This investigator-initiated, randomized, double-blind, placebo-controlled trial was implemented at 82 hospitals in China, enrolling 1680 patients with stroke and proximal intracranial LVO presenting within 24 hours of time last known to be well. Recruitment took place between February 9, 2022, and June 30, 2023, with a final follow-up on September 30, 2023. INTERVENTIONS: Eligible patients were randomly assigned to intravenous methylprednisolone (n = 839) at 2 mg/kg/d or placebo (n = 841) for 3 days adjunctive to endovascular thrombectomy. MAIN OUTCOMES AND MEASURES: The primary efficacy outcome was disability level at 90 days as measured by the overall distribution of the modified Rankin Scale scores (range, 0 [no symptoms] to 6 [death]). The primary safety outcomes included mortality at 90 days and the incidence of symptomatic intracranial hemorrhage within 48 hours. RESULTS: Among 1680 patients randomized (median age, 69 years; 727 female [43.3%]), 1673 (99.6%) completed the trial. The median 90-day modified Rankin Scale score was 3 (IQR, 1-5) in the methylprednisolone group vs 3 (IQR, 1-6) in the placebo group (adjusted generalized odds ratio for a lower level of disability, 1.10 [95% CI, 0.96-1.25]; P = .17). In the methylprednisolone group, there was a lower mortality rate (23.2% vs 28.5%; adjusted risk ratio, 0.84 [95% CI, 0.71-0.98]; P = .03) and a lower rate of symptomatic intracranial hemorrhage (8.6% vs 11.7%; adjusted risk ratio, 0.74 [95% CI, 0.55-0.99]; P = .04) compared with placebo. CONCLUSIONS AND RELEVANCE: Among patients with acute ischemic stroke due to LVO undergoing endovascular thrombectomy, adjunctive methylprednisolone added to endovascular thrombectomy did not significantly improve the degree of overall disability. TRIAL REGISTRATION: ChiCTR.org.cn Identifier: ChiCTR2100051729.
摘要：
The appearance of recalcitrant organic pollutants such as antibiotics in water bodies has gained a lot of attention owing to their adverse effects on organisms and humans. The current study aims to develop a novel approach to eliminate antibiotic tetracycline (TC) from a synthetic aqueous solution based on the advanced oxidation process triggered by MnSO4-catalyzed NaIO4. Single-factor experiment was performed to observe the impact of pH, NaIO4 concentration, and MnSO4 dosage on TC decomposition, and a three-factor, three-level response surface experiment with TC removal rate as the dependent variable was designed based on the range of factors determined from the single-factor experiment. The single-factor experiment revealed that the ranges of pH, NaIO4 concentration, and MnSO4 dosage need to be further optimized. ANOVA (analysis of variance) results showed that the data from the response surface experiment were consistent with the quadratic model with high R2 (0.9909), and the predicted values were very close to the actual values. After optimization by response surface methodology, the optimal condition obtained was pH = 6.7, [NaIO4] = 0.39 mM, and [MnSO4] = 0.12 mM, corresponding to a TC removal of 96.56%. This optimization condition was fully considered to save the dosage of the high-priced chemical NaIO4. HIGHLIGHTS MnSO4/NaIO4 is a potential advanced oxidative process against antibiotics. The impact of pH, NaIO4 concentration, and MnSO4 dosage on TC decomposition is investigated. Box-Behnken model is adopted to determine the scheme of the experiment. The best experimental condition is optimized using response surface methodology.
关键词：
cancer precision treatment;metal-containing two-dimensional nanomaterials;nanotechnology-based therapy;theranostic platform
摘要：
In recent years, metal-containing two-dimensional (2D) nanomaterials, among various 2D nanomaterials have attracted widespread attention because of their unique physical and chemical properties, especially in the fields of biomedical applications. Firstly, the review provides a brief introduction to two types of metal-containing 2D nanomaterials, based on whether metal species take up the major skeleton of the 2D nanomaterials. After this, the synthetical approaches are summarized, focusing on two strategies similar to other 2D nanomaterials, top-down and bottom-up methods. Then, the performance and evaluation of these 2D nanomaterials when applied to cancer therapy are discussed in detail. The specificity of metal-containing 2D nanomaterials in physics and optics makes them capable of killing cancer cells in a variety of ways, such as photodynamic therapy, photothermal therapy, sonodynamic therapy, chemodynamic therapy and so on. Besides, the integrated platform of diagnosis and treatment and the clinical translatability through metal-containing 2D nanomaterials is also introduced in this review. In the summary and perspective section, advanced rational design, challenges and promising clinical contributions to cancer therapy of these emerging metal-containing 2D nanomaterials are discussed.
期刊：
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY,2024年14:1351540 ISSN：2235-2988
作者机构：
Nursing Department, The Second Affiliated Hospital, Hengyang Medical School, University of South China, China;Ottawa Hospital Research Institute, The Ottawa Hospital, Canada;School of Nursing, University of South China, China;Center for a Combination of Obstetrics and Gynecology and Reproductive Medicine, The First Affiliated Hospital, Hengyang Medical School, University of South China, China;Department of Obstetrics, The Second Affiliated Hospital, Hengyang Medical School, University of South China, China
摘要：
Relevant studies increasingly indicate that female reproductive health is confronted with substantial challenges. Emerging research has revealed that the microbiome interacts with the anatomy, histology, and immunity of the female reproductive tract, which are the cornerstone of maintaining female reproductive health and preventing adverse pregnancy outcomes. Currently, the precise mechanisms underlying their interaction and impact on physiological functions of the reproductive tract remain elusive, constituting a prominent area of investigation within the field of female reproductive tract microecology. From this new perspective, we explore the mechanisms of interactions between the microbiome and the anatomy, histology, and immunity of the female reproductive tract, factors that affect the composition of the microbiome in the female reproductive tract, as well as personalized medicine approaches in managing female reproductive tract health based on the microbiome. This study highlights the pivotal role of the female reproductive tract microbiome in maintaining reproductive health and influencing the occurrence of reproductive tract diseases. These findings support the exploration of innovative approaches for the prevention, monitoring and treatment of female reproductive tract diseases based on the microbiome.
