LncRNA PSMB8-AS1 Instigates Vascular Inflammation to Aggravate Atherosclerosis

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成果类型：

期刊论文

作者：

Li, Shu;He, Run-Chao;Wu, Shao-Guo;Song, Yu;Zhang, Ke-Lan;...

通讯作者：

Hu, YW;Dai, XY

作者机构：

[He, Run-Chao; Hu, YW; Zhang, Ting; Jiang, Min; Li, Shu; Song, Yu; Wu, Jia; Zhang, Ke-Lan; Hu, Yan-Wei; Tang, Mao-Lin; Dong, Xian-Hui] Guangzhou Med Univ, Guangzhou Women & Children Med Ctr, Dept Clin Lab, Guangzhou 510600, Guangdong, Peoples R China.

[Dai, Xiaoyan] Guangzhou Med Univ, Guangzhou, Guangdong, Peoples R China.

[Wu, Shao-Guo] Guangzhou Twelfth Peoples Hosp, Dept Clin Lab, Guangzhou, Guangdong, Peoples R China.

[Bei, Yan-Rou] Southern Med Univ, Nanfang Hosp, Lab Med Ctr, Guangzhou, Guangdong, Peoples R China.

[Ma, Xin] Southern Med Univ, Nanfang Hosp, Dept Anesthesiol, Guangzhou, Guangdong, Peoples R China.

通讯机构：

[Hu, YW ; Dai, XY ] G

Guangzhou Med Univ, Guangzhou Women & Children Med Ctr, Dept Clin Lab, Guangzhou 510600, Guangdong, Peoples R China.

Guangzhou Med Univ, Guangzhou, Guangdong, Peoples R China.

语种：

英文

关键词：

adhesion molecule;atherosclerosis;cardiovascular diseases;knockout;vascular inflammation

期刊：

CIRCULATION RESEARCH

ISSN：

0009-7330

年：

2024

卷：

134

期：

页码：

60-80

DOI：

10.1161/CIRCRESAHA.122.322360

基金类别：

National Natural Science Foundation of China (CN)501100001809

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

BACKGROUND: Increasing evidence suggests that long noncoding RNAs play significant roles in vascular biology and disease development. One such long noncoding RNA, PSMB8-AS1, has been implicated in the development of tumors. Nevertheless, the precise role of PSMB8-AS1 in cardiovascular diseases, particularly atherosclerosis, has not been thoroughly elucidated. Thus, the primary aim of this investigation is to assess the influence of PSMB8-AS1 on vascular inflammation and the initiation of atherosclerosis. METHODS: We generated PSMB8-AS1 knockin ...

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LncRNA PSMB8-AS1 Instigates Vascular Inflammation to Aggravate Atherosclerosis

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