lncRNA OIP5-AS1 promotes mitophagy to alleviate osteoarthritis by upregulating PPAR-γ to activate the AMPK/Akt/mTOR pathway

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Sun, Zhilu;Tang, Jie;You, Ting;Zhang, Bihong;Liu, Yu;...

通讯作者：

Liu, J

作者机构：

[Liu, Yu; You, Ting; Zhang, Bihong; Sun, Zhilu] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Emergency Med, Hengyang, Hunan, Peoples R China.

[Tang, Jie] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Pain, Hengyang, Hunan, Peoples R China.

[Liu, Jing] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Rehabil, 69 Chuanshan Rd, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Liu, J ] U

Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Rehabil, 69 Chuanshan Rd, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

OIP5-AS1;PPAR-γ;mitophagy;osteoarthritis

期刊：

Modern Rheumatology

ISSN：

1439-7595

年：

2024

DOI：

10.1093/mr/roae015

基金类别：

Natural Science Foundation of Hunan Province [2021JJ40500, 2023JJ30543]

机构署名：

本校为第一且通讯机构

摘要：

BACKGROUND: Osteoarthritis (OA) is the most common chronic joint degenerative disease. Mitophagy is closely related to OA pathogenesis. Herein, we investigated the role of lncRNA OIP5-AS1 in regulating mitophagy during OA. METHODS: RT-qPCR and Western blotting were utilized to analyze gene and protein levels. RIP and RNA pull down verified the relationship between OIP5-AS1, FUS and PPAR-γ. CCK-8 assay detected cells viability. ELISA evaluated the secretion of inflammatory cytokines. Flow cytometry measured the contents of ROS and Ca2+. Immunof...

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lncRNA OIP5-AS1 promotes mitophagy to alleviate osteoarthritis by upregulating PPAR-γ to activate the AMPK/Akt/mTOR pathway

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