Methylprednisolone as Adjunct to Endovascular Thrombectomy for Large-Vessel Occlusion Stroke The MARVEL Randomized Clinical Trial

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成果类型：

期刊论文

作者：

Yang, Qingwu;Guo, Changwei;Yue, Chengsong;Song, Jiaxing;Yang, Jie;...

通讯作者：

Li, Fengli;Zi, WJ

作者机构：

[Xu, Xu; Peng, Zhouzhou; Yu, Nizhen; Jiang, Lin; Ma, Jinfu; Huang, Jiacheng; Zi, Wenjie; Li, Linyu; Tian, Yan; Fan, Shitao; Xie, Dongjing; Guo, Changwei; Liu, Xiang; Song, Jiaxing; Yue, Chengsong; Huang, Jiandi; Zi, WJ; Yang, Qingwu; Qiu, Zhongming; Li, Fengli; Hu, Jinrong; Yang, Jie; Yang, Dahong] Third Mil Med Univ, Mil Med Univ 3, Xinqiao Hosp, Dept Neurol, 183 Xinqiao Main St, Chongqing 400037, Peoples R China.

[Xu, Xu; Peng, Zhouzhou; Yu, Nizhen; Jiang, Lin; Ma, Jinfu; Huang, Jiacheng; Zi, Wenjie; Li, Linyu; Tian, Yan; Fan, Shitao; Xie, Dongjing; Guo, Changwei; Liu, Xiang; Song, Jiaxing; Yue, Chengsong; Huang, Jiandi; Zi, WJ; Yang, Qingwu; Qiu, Zhongming; Li, Fengli; Hu, Jinrong; Yang, Jie; Yang, Dahong] Third Mil Med Univ, Army Med Univ, Affiliated Hosp 2, 183 Xinqiao Main St, Chongqing 400037, Peoples R China.

[Chen, Yifei] Kunming Med Univ, Dept Neurol, Affiliated Hosp 1, Kunming, Peoples R China.

[Zheng, Chong] Fujian Med Univ, Dept Neurol, Longyan Affiliated Hosp 1, Longyan, Peoples R China.

[Jiang, Shunfu] Jingdezhen 1 Peoples Hosp, Dept Neurol, Jingdezhen, Peoples R China.

通讯机构：

[Zi, WJ ; Li, FL] T

Third Mil Med Univ, Mil Med Univ 3, Xinqiao Hosp, Dept Neurol, 183 Xinqiao Main St, Chongqing 400037, Peoples R China.

Third Mil Med Univ, Army Med Univ, Affiliated Hosp 2, 183 Xinqiao Main St, Chongqing 400037, Peoples R China.

语种：

英文

期刊：

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

ISSN：

0098-7484

年：

2024

卷：

331

期：

页码：

840-849

DOI：

10.1001/jama.2024.0626

基金类别：

National Natural Science Foundation of China [82071323, 82271349]; Chongqing Science and Health Joint Project [2023GGXM007]; National Natural Science Foundation of China Major Program [82090040]

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

IMPORTANCE: It is uncertain whether intravenous methylprednisolone improves outcomes for patients with acute ischemic stroke due to large-vessel occlusion (LVO) undergoing endovascular thrombectomy. OBJECTIVE: To assess the efficacy and adverse events of adjunctive intravenous low-dose methylprednisolone to endovascular thrombectomy for acute ischemic stroke secondary to LVO. DESIGN, SETTING, AND PARTICIPANTS: This investigator-initiated, randomized, double-blind, placebo-controlled trial was implemented at 82 hospitals in China, enrolling 1680...

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Methylprednisolone as Adjunct to Endovascular Thrombectomy for Large-Vessel Occlusion Stroke The MARVEL Randomized Clinical Trial

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