期刊论文

Risk factors and active surveillance for abnormal liver function induced by parenteral nutrition

中文

中南药学

1672-2981

2024

22

3

575-579

10.7539/j.issn.1672-2981.2024.03.004

No.81803233:国家自然科学基金 No.2021M693561:中国博士后科学基金面上基金资助项目 No.202213054567:湖南省卫生健康委课题项目

本校为第一机构

目的 探索肠外营养所致肝功能异常在胃肠道恶性肿瘤患者中的发生率、临床特点及危险因素,降低临床用药风险.方法 通过中国医院药物警戒系统(CHPS)搜索2022年7月1日—12月31日在南华大学附属第二医院使用肠外营养治疗的胃肠道恶性肿瘤患者,病例组为CHPS中触发警报信号指示肝功能异常且经药师审核的患者,在未触发警报信号的患者中,剔除重复入院患者得到对照组,分析肝功能异常的发生情况,采用二元Logistic回归分析筛选潜在风险因素.结果 肠外营养所致肝功能异常在胃肠道恶性肿瘤患者的发生率为4.98％;85％发生在用药后5～10d,以轻度转氨酶升高为主要表现.二元Logistic回归分析显示败血症、合并脂肪...

Objective To determine the incidence,clinical characteristics and risk factors of abnormal liver function related to parenteral nutrition in patients with gastrointestinal malignancies,and reduce the risks of clinical drug use.Methods Patients with gastrointestinal malignancies admitted to our hospital between July 1st and December 31st,2022,and treated with parenteral nutrition were monitored with the China Hospital Pharmacovigilance System(CHPS).The experimental group comprised patients who had abnormal liver function and checked by pharmacis...