Reprogramming Macrophage Polarization, Depleting ROS by Astaxanthin and Thioketal-Containing Polymers Delivering Rapamycin for Osteoarthritis Treatment

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Li, Huiyun;Yuan, Yusong;Zhang, Lingpu;Xu, Chun;Xu, Hailin;...

通讯作者：

Chen, ZW;Xu, C;Xu, HL

作者机构：

[Chen, Zhiwei; Chen, ZW; Li, Huiyun] Univ South China, Affiliated Hosp 1, Dept Orthoped Surg, Hengyang 421001, Hunan, Peoples R China.

[Yuan, Yusong] China Japan Friendship Hosp, Dept Orthopaed Surg, 2 Yinghuayuan East St, Beijing 100029, Peoples R China.

[Zhang, Lingpu] Chinese Acad Sci, Beijing Natl Lab Mol Sci, State Key Lab Polymer Phys & Chem, Inst Chem, Beijing 100190, Peoples R China.

[Xu, C; Xu, Chun] Univ Queensland, Sch Dent, Brisbane 4006, Australia.

[Xu, Hailin; Xu, HL] Peking Univ Peoples Hosp, Diabetic Foot Treatment Ctr, Dept Trauma & Orthoped, 11th Xizhimen South St, Beijing 100044, Peoples R China.

通讯机构：

[Xu, C ; Chen, ZW ] U

[Xu, HL ] P

Univ South China, Affiliated Hosp 1, Dept Orthoped Surg, Hengyang 421001, Hunan, Peoples R China.

Univ Queensland, Sch Dent, Brisbane 4006, Australia.

Peking Univ Peoples Hosp, Diabetic Foot Treatment Ctr, Dept Trauma & Orthoped, 11th Xizhimen South St, Beijing 100044, Peoples R China.

语种：

英文

关键词：

Astaxanthin;macrophage polarization;osteoarthritis;rapamycin;thioketal

期刊：

Advanced Science

ISSN：

2198-3844

年：

2024

卷：

期：

页码：

2305363-

DOI：

10.1002/advs.202305363

基金类别：

National Key Research and Development Program of China; Science and Technology Innovation Program of Hunan Province [2021SK2017]; Health Commission of Hunan Province [20200476, 20201907]; University of Queensland; Medial Ethics Committee of the People's Hospital of Peking University, China [2022PHE050]; [2022YFC2504302]

机构署名：

本校为第一且通讯机构

摘要：

A novel reactive oxygen species‐responsive biodegradable nanoparticle (NP@PolyRHAPM) is designed, in which astaxanthin can reduce intracellular ROS levels and rapamycin‐enhanced autophagy levels, and restore mitochondrial function, hence successfully repolarizing M1 macrophages into M2 phenotypes. This repolarization enhances the proliferation and viability of chondrocytes while inhibiting apoptosis. Overall, this ROS‐responsive nanocarrier system provides a new avenue for progressive OA therapy. Abstract Osteoarthritis (OA) is a chronic joi...

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Reprogramming Macrophage Polarization, Depleting ROS by Astaxanthin and Thioketal-Containing Polymers Delivering Rapamycin for Osteoarthritis Treatment

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