作者机构：
School of Resources Environment and Safety Engineering, University of South China, Hengyang 421001, China;National & Local Joint Engineering Research Center for Airborne Pollutants Control and Radioactivity Protection in Buildings, Hengyang 421001, China;Key Laboratory of Prefabricated Building Energy Saving Technology of Hunan Province, Hengyang 421001, China;[Caiting Li] College of Environmental Science and Engineering, Hunan University, Changsha 410082, China;[Jiajie Wang; Jie Liu; Huiyu Xiong; Jiaqi Xie; Yueguo Pan] School of Resources Environment and Safety Engineering, University of South China, Hengyang 421001, China<&wdkj&>National & Local Joint Engineering Research Center for Airborne Pollutants Control and Radioactivity Protection in Buildings, Hengyang 421001, China<&wdkj&>Key Laboratory of Prefabricated Building Energy Saving Technology of Hunan Province, Hengyang 421001, China
通讯机构：
[Lei Gao] S;School of Resources Environment and Safety Engineering, University of South China, Hengyang 421001, China<&wdkj&>National & Local Joint Engineering Research Center for Airborne Pollutants Control and Radioactivity Protection in Buildings, Hengyang 421001, China<&wdkj&>Key Laboratory of Prefabricated Building Energy Saving Technology of Hunan Province, Hengyang 421001, China<&wdkj&>College of Environmental Science and Engineering, Hunan University, Changsha 410082, China
摘要：
In this study, a string of Cr-Mn co-modified activated coke catalysts (XCryMn1-y/AC) were prepared to investigate toluene and Hg0 removal performance. Multifarious characterizations including XRD, TEM, SEM, in situ DRIFTS, BET, XPS and H2-TPR showed that 4%Cr0.5Mn0.5/AC had excellent physicochemical properties and exhibited the best toluene and Hg0 removal efficiency at 200℃. By varying the experimental gas components and conditions, it was found that too large weight hourly space velocity would reduce the removal efficiency of toluene and Hg0. Although O2 promoted the abatement of toluene and Hg0, the inhibitory role of H2O and SO2 offset the promoting effect of O2 to some extent. Toluene significantly inhibited Hg0 removal, resulting from that toluene was present at concentrations orders of magnitude greater than mercury's or the catalyst was more prone to adsorb toluene, while Hg0 almost exerted non-existent influence on toluene elimination. The mechanistic analysis showed that the forms of toluene and Hg0 removal included both adsorption and oxidation, where the high-valent metal cations and oxygen vacancy clusters promoted the redox cycle of Cr3+ + Mn3+/Mn4+ ↔ Cr6+ + Mn2+, which facilitated the conversion and replenishment of reactive oxygen species in the oxidation process, and even the CrMn1.5O4 spinel structure could provide a larger catalytic interface, thus enhancing the adsorption/oxidation of toluene and Hg0. Therefore, its excellent physicochemical properties make it a cost-effective potential industrial catalyst with outstanding synergistic toluene and Hg0 removal performance and preeminent resistance to H2O and SO2.
作者机构：
[Min Hu; Siying He; Yuhang Ye; Yinping Xiang; Haihao Peng; Honglin Zhang; Weixiang Li; Shudian Peng] College of Environmental Science and Engineering, Hunan University and Key Laboratory of Environmental Biology and Pollution Control (Hunan University), Ministry of Education, Changsha 410082, China;Hunan Boke Environmental Engineering Co. Ltd., Hengyang 421099, China;College of Environmental Protection and Safety Engineering, University of South China, Hengyang 421001, China;[Zhengyong Xu] Hunan Modern Environmental Technology Co. Ltd., Changsha 410004, China;[Weiping Xiong] College of Environmental Science and Engineering, Hunan University and Key Laboratory of Environmental Biology and Pollution Control (Hunan University), Ministry of Education, Changsha 410082, China<&wdkj&>Hunan Boke Environmental Engineering Co. Ltd., Hengyang 421099, China
通讯机构：
[Weiping Xiong] C;College of Environmental Science and Engineering, Hunan University and Key Laboratory of Environmental Biology and Pollution Control (Hunan University), Ministry of Education, Changsha 410082, China<&wdkj&>Hunan Boke Environmental Engineering Co. Ltd., Hengyang 421099, China
摘要：
Microplastics (MPs) are of particular concern due to their ubiquitous occurrence and propensity to interact and concentrate various waterborne contaminants from aqueous surroundings. Studies on the interaction and joint toxicity of MPs on engineered nanoparticles (ENPs) are exhaustive, but limited research on the effect of MPs on the properties of ENPs in multi-solute systems. Here, the effect of MPs on adsorption ability of ENPs to antibiotics was investigated for the first time. The results demonstrated that MPs enhanced the adsorption affinity of ENPs to antibiotics and MPs before and after aging showed different effects on ENPs. Aged polyamide prevented aggregation of ZnONPs by introducing negative charges, whereas virgin polyamide affected ZnONPs with the help of electrostatic attraction. FT-IR and XPS analyses were used to probe the physicochemical interactions between ENPs and MPs. The results showed no chemical interaction and electrostatic interaction was the dominant force between them. Furthermore, the adsorption rate of antibiotics positively correlated with pH and humic acid but exhibited a negative correlation with ionic strength. Our study highlights that ENPs are highly capable of accumulating and transporting antibiotics in the presence of MPs, which could result in a widespread distribution of antibiotics and an expansion of their environmental risks and toxic effects on biota. It also improves our understanding of the mutual interaction of various co-existing contaminants in aqueous environments.
期刊：
Materials Science and Engineering B-Advanced Functional Solid-State Materials,2024年302:117245 ISSN：0921-5107
通讯作者：
Gao, F
作者机构：
[Fujita, Toyohisa; Wang, Xinpeng; Gao, F; Li, Ao; Huang, Jiaming; Mi, Shuxin; Gao, Feng; Ren, Feng] Guangxi Univ, State Key Lab Featured Met Mat & Life Cycle Safety, MOE Key Lab New Proc Technol Nonferrous Met & Mat, Key Lab High Performance Struct Mat & Thermo surfa, Nanning 530004, Guangxi, Peoples R China.;[Fujita, Toyohisa; Wang, Xinpeng; Gao, F; Li, Ao; Huang, Jiaming; Mi, Shuxin; Gao, Feng; Ren, Feng] Guangxi Univ, Coll Resources Environm & Mat, Nanning 530004, Peoples R China.;[Ning, Shunyan] Univ South China, Sch Nucl Sci & Technol, Hengyang 421001, Peoples R China.
通讯机构：
[Gao, F ] G;Guangxi Univ, State Key Lab Featured Met Mat & Life Cycle Safety, MOE Key Lab New Proc Technol Nonferrous Met & Mat, Key Lab High Performance Struct Mat & Thermo surfa, Nanning 530004, Guangxi, Peoples R China.;Guangxi Univ, Coll Resources Environm & Mat, Nanning 530004, Peoples R China.
摘要：
The effects of different sintering temperatures on the structure and upconversion luminescent properties of Li+ doped Bi3.46Ho0.04Yb0.5Ti3O12: 0.05Li (BHYTO: Li) phosphors were investigated. The upconversion emission intensity first increases and then decreases with the increase of sintering temperature from 700 to 1000 degrees C. The temperature induced grain growth contributes to the enhancement of UC luminescence, but the increased defects such as Bi and O degrade the luminescence. The combined effect of them makes the optimal luminescence appears in the specimens sintered at 800 degrees C, which is about 2 times stronger than that of those specimens sintered at 700 and 1000 degrees C. The mean lifetime for the specimens sintered from 700 to 1000 degrees C increases monotonically from 60.2 to 81.5 mu s, with band gap (E-g) from 2.8 to 3.0 eV. The maximal quantum efficiency can reach 0.28 % due to enhanced crystallinity.
期刊：
JOURNAL OF MATERIALS CHEMISTRY B,2024年12(6):1530-1537 ISSN：2050-750X
通讯作者：
Cheng, D;He, Longwei
作者机构：
[Cheng, Dan; He, Longwei; He, LW; Jiang, Renfeng] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dru, Sch Pharmaceut Sci, Hengyang Med Sch, Hengyang 421002, Hunan, Peoples R China.;[Cheng, Dan; Zhang, Hongshuai; Yang, Xuefeng] Univ South China, Affiliated Nanhua Hosp, Hengyang Med Sch, Dept Gastroenterol, Hengyang 421002, Hunan Prov, Peoples R China.;[Cheng, Dan; Liu, Qian; Zhang, Hongshuai; Yang, Xuefeng; Xia, Yuqing] Univ South China, Affiliated Nanhua Hosp, Hunan Prov Clin Res Ctr Metab Associated Fatty Liv, Hengyang Med Sch, Hengyang 421002, Hunan, Peoples R China.
通讯机构：
[Cheng, D ; He, LW] U;Univ South China, Affiliated Nanhua Hosp, Hengyang Med Sch, Dept Gastroenterol, Hengyang 421002, Hunan Prov, Peoples R China.;Univ South China, Affiliated Nanhua Hosp, Hunan Prov Clin Res Ctr Metab Associated Fatty Liv, Hengyang Med Sch, Hengyang 421002, Hunan, Peoples R China.;Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dru, Sch Pharmaceut Sci, Hengyang Med Sch, Hengyang 421002, Hunan, Peoples R China.
摘要：
Carboxylesterases (CESs) are critical for metabolizing ester-containing biomolecules and are specifically important in liver metabolic disorders. The modulation of CESs is also an important issue in pharmacology and clinical applications. Herein, we present a near-infrared (NIR) CES fluorescent probe (NCES) based on the protection-deprotection of the hydroxyl group for monitoring CES levels in living systems. The NCES probe has good selectivity and sensitivity for CESs with a limit of detection (LOD) of 5.24 mU mL-1, which allows for tracing the fluctuation of cellular CES after treatment with anticancer drugs and under inflammation and apoptosis states. Furthermore, NCES can be successfully applied for guiding liver cancer surgery with high-contrast in vivo imaging and detecting clinical serum samples from liver cancer patients. This work showed that the NCES probe has great potential in drug development, imaging applications for medical diagnosis, and early-stage detection for clinical liver diseases. A carboxylesterase-activated near-infrared fluorescent probe with high sensitivity and selectivity was developed to guide surgical resection of liver tumors and monitor clinical serum samples from liver cancer patients.
作者机构：
[Meng-qi Jin; Kai Weng; Zhou-ping Guo; Deng-hui Chen; Xiao-jian Zhao] Xi'an Center,China Geological Survey,Ministry of Natural Resources,Xi'an 710054,China;[Xiao-jian Zhao] Xinjiang Research Center for Mineral Resources,Xinjiang Institute of Ecology and Geography,Chinese Academy of Sciences,Urumqi 830011,China;[Xiao-jian Zhao] College of Geography and Remote Sensing Sciences,Xinjiang University,Urumqi 830046,China;[Xiao-jian Zhao] University of Chinese Academy of Sciences,Beijing 100029,China;[Ming Wang] No.8 Geological Party,Xinjiang Bureau of Geology and Mineral Exploration and Development,Aksu 843000,China
关键词：
strata;Triassic;Xinjiang
摘要：
1. Objective
In the past decade, a group of medium to giant lead-zinc deposits, represented by Huoshaoyun, Sachakou, and Yuanbaoling, have been discovered in the Aksai Chin region of Karakoram, Xinjiang. They are all located in the Mesozoic carbonate and clastic rock formations. The Sachakou lead-zinc mining area is adjacent to the northwest of the Huoshaoyun lead-zinc mining area and is in the same stratigraphic layer as Huoshaoyun. Although many scholars have been arguing about the type and age of Huoshaoyun lead-zinc mineralization, few scholars have paid attention to the classification of the ore-bearing strata in the area. The stratigraphy of the Lower Permian Shenxianwan Group to the Upper Cretaceous Tielongtan Group is exposed in the Sachakou area of Karakorum, Xinjiang, however, the Late Permian-Early Triassic stratigraphy is missing (Fig. 1a). Due to the harsh natural conditions in the area and the low level of work, the stratigraphic delineation is not exhaustive, and the regional lithology is dominated by carbonates and clastic rocks, which makes it difficult to identify the age of the regional lithology and causes problems for the exploration and research of lead-zinc in the area.
摘要：
Altered gut microbiota and metabolites are important for non-alcoholic fatty liver disease (NAFLD) in children. We aimed to comprehensively examine the effects of gut metabolites on NAFLD progression. We performed integrative metabolomics (untargeted discovery and targeted validation) analysis of non-alcoholic fatty liver (NAFL), non-alcoholic steatohepatitis (NASH), and obesity in children. Fecal samples were collected from 75 subjects in the discovery cohort (25 NAFL, 25 NASH, and 25 obese control children) and 145 subjects in an independent validation cohort (53 NAFL, 39 NASH, and 53 obese control children). Among 2,491 metabolites, untargeted metabolomics revealed a complete NAFLD metabolic map containing 318 increased and 123 decreased metabolites. Then, machine learning selected 65 important metabolites that can distinguish the severity of the NAFLD. Furthermore, precision-targeted metabolomics selected 5 novel gut metabolites from 20 typical metabolites. The functionality of candidate metabolites was validated in hepatocyte cell lines. In the end, this study annotated two novel elevated pathogenic metabolites (dodecanoic acid and creatinine) and a relationship between depleted protective gut microbiota (Butyricicoccus and Alistipes), increased inflammation (IL-1 beta), lipid metabolism (TG), and liver function (ALT and AST). This study demonstrates the role of novel gut metabolites (dodecanoic acid and creatinine), as the fatty acid metabolism regulator contributing to NAFLD development through its influence on inflammation and liver function.IMPORTANCEAltered gut microbiota and metabolites are a major cause of non-alcoholic fatty liver disease (NAFLD) in children. This study demonstrated a complete gut metabolic map of children with NAFLD, containing 318 increased and 123 decreased metabolites by untargeted metabolomic. Multiple validation approaches (machine learning and targeted metabolomic) selected five novel gut metabolites for targeted metabolomics, which can distinguish NAFLD status and severity. The gut microbiota (Butyricicoccus and Alistipes) and metabolites (creatinine and dodecanoic acid) were novel biomarkers associated with impaired liver function and inflammation and validated by experiments of hepatocyte cell lines. The data provide a better understanding of the importance of gut microbiota and metabolite alterations in NAFLD, which implies that the altered gut microbiota and metabolites may represent a potential target to prevent NAFLD development. Altered gut microbiota and metabolites are a major cause of non-alcoholic fatty liver disease (NAFLD) in children. This study demonstrated a complete gut metabolic map of children with NAFLD, containing 318 increased and 123 decreased metabolites by untargeted metabolomic. Multiple validation approaches (machine learning and targeted metabolomic) selected five novel gut metabolites for targeted metabolomics, which can distinguish NAFLD status and severity. The gut microbiota (Butyricicoccus and Alistipes) and metabolites (creatinine and dodecanoic acid) were novel biomarkers associated with impaired liver function and inflammation and validated by experiments of hepatocyte cell lines. The data provide a better understanding of the importance of gut microbiota and metabolite alterations in NAFLD, which implies that the altered gut microbiota and metabolites may represent a potential target to prevent NAFLD development.
摘要：
Electrochemical conversion of nitrate offers an efficient solution to nitrate pollution and a sustainable strategy for ammonia generation. Cu and Fe bimetallic electrocatalysts exhibit excellent electrochemical reduction of nitrate (NO3RR) reactivity but the conventional preparation strategy is complex and time-consuming and this reaction is still suffers from unsatisfied kinetic and unidentified mechanisms. Herein, in situ electrodeposition strategy is employed to induce Cu to modify the Fe active sites of iron-based N-doping carbon nanofiber electrode (Fe/Fe3C@NCNFs) during NO3RR in Cu-contained nitrate solution. Benefiting from the synergistic effect between Cu and Fe sites of CuFe/Fe3C@NCNFs electrode, superior activity of rate-determining reaction (*NO(3 )to *NO2) and reduced energy barriers of the following deoxidation and hydrogenation steps are achieved. Compared with Fe/Fe3C@NCNFs-500, the pseudo-first-order (PFO) rate constant for NO3RR by CuFe/Fe3C@NCNFs demonstrates nearly two-fold improvement with high current efficiencies over wide pH and voltage range. Furthermore, the maximum NO3N removal capacity and N-2 selectivity of CuFe/Fe3C@NCNFs reach 15593.8 mg N g(-1) Fe and ca. 92% after twenty cycles. This work offers an avenue for highly active bimetallic electrode design, paving more insights into the interactions between active site construction and NO3RR performance.
期刊：
Biological Trace Element Research,2024年 ISSN：0163-4984
通讯作者：
Peng, CY;Liao, HQ
作者机构：
[Peng, Cuiying; Wang, Die; Zhou, Cuilan; Yin, Dan; Mao, Rui; Yu, Ping; Liu, Jun; Li, Suyun] Univ South China, Inst Cytol & Genet,Key Lab Typ Environm Pollut & H, Sch Basic Med Sci,Dept Educ,Key Lab Hengyang City, Hengyang Med Sch,Key Lab Ecol Environm & Crit Huma, Hengyang 421001, Hunan, Peoples R China.;[Nie, Yulin; Liao, Hongqing] Univ South China, Affiliated Hosp 2, Dept Obstet & Gynecol, 30 Jiefang Rd, Hengyang 421001, Hunan, Peoples R China.
通讯机构：
[Liao, HQ ; Peng, CY ] U;Univ South China, Inst Cytol & Genet,Key Lab Typ Environm Pollut & H, Sch Basic Med Sci,Dept Educ,Key Lab Hengyang City, Hengyang Med Sch,Key Lab Ecol Environm & Crit Huma, Hengyang 421001, Hunan, Peoples R China.;Univ South China, Affiliated Hosp 2, Dept Obstet & Gynecol, 30 Jiefang Rd, Hengyang 421001, Hunan, Peoples R China.
关键词：
ART outcomes;Plasma metal levels;Polycystic ovary syndrome;in vitro fertilization
摘要：
The objective of this study is to explore the correlation of metal levels with assisted reproductive technology (ART) outcomes in polycystic ovary syndrome (PCOS) patients. The individuals were recruited who met the research criteria, only tubal factor or male infertility served as the control group (n = 40) and patient group was PCOS patients (n = 35). Individuals (n = 75) were divided into PCOS group (n = 35) and control group (n = 40). The normal body mass index (BMI) group (control) includes women with BMI < 25kg/m(2) in PCOS group (n = 24) and control group (n = 33), and BMI ≥ 25kg/m(2) in PCOS group (n = 11) and control group (n = 7). We performed an analysis of insulin resistance (IR) (n = 15) group and without insulin resistance (NIR) group (n = 20) in PCOS patient and control patients. Comparing difference demographic data, ART outcomes and the metal levels in every group respectively, the correlation of metal levels and ART outcomes in control participants and PCOS patients were analyzed by the Spearman correlation analysis, and multiple linear regression model was used to examine the association between the concentration of 19 metals and ART outcomes in PCOS group and control group. Plasma manganese (Mn), titanium (Ti), sodium (Na), magnesium (Mg), copper (Cu), calcium (Ca)/Mg ratio, and Cu/zinc (Zn) ratio levels in PCOS patients were higher than that in control, while Zn and Ca levels were lower in PCOS patients than that in control. The Mg levels had a positive connection with the number of eggs recovered, and the iron (Fe) levels were positively associated with the number of transplanted embryos in PCOS-IR. In PCOS-NIR, Mn levels positively correlated with the number of follicles and the number of good embryos. Silver (Ag) levels were negatively correlated with the number of follicles, and aluminum (Al) levels were negatively related with the normal fertilization and the number of good embryos. The Spearman analysis in PCOS-BMI ≥ 25 group exhibited that nickel (Ni) levels were negatively associated with the number of follicles. The plasma metal levels seem to affect the clinical manifestations and in vitro fertilization outcomes in assisted reproduction.
摘要：
The super tau-charm facility (STCF) is an electron-positron collider proposed by the Chinese particle physics community. It is designed to operate in a center-of-mass energy range from 2 to 7 GeV with a peak luminosity of 0.5 x 1035 cm-2 center dot s-1 or higher. The STCF will produce a data sample about a factor of 100 larger than that of the present tau-charm factory - the BEPCII, providing a unique platform for exploring the asymmetry of matter-antimatter (charge-parity violation), in-depth studies of the internal structure of hadrons and the nature of non-perturbative strong interactions, as well as searching for exotic hadrons and physics beyond the Standard Model. The STCF project in China is under development with an extensive R&D program. This document presents the physics opportunities at the STCF, describes conceptual designs of the STCF detector system, and discusses future plans for detector R&D and physics case studies.
摘要：
BACKGROUND: Opa-interacting protein 5 antisense transcript 1 (OIP5-AS1) has been demonstrated to play vital roles in development and progression of tumors such as gastric cancer (GC). However, the detailed molecular mechanism of OIP5-AS1 has not been completely elucidated. Our study aimed to investigate the role and the epigenetic regulation mechanism of OIP5-AS1 in GC. METHODS: OIP5-AS1 expression in GC tissues was detected by RT-qPCR. Loss- and gain-of-function experiments were conducted to assess the biological function of OIP5-AS1 in vitro and in vivo. The interaction of OIP5-AS1 with insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) or heterogeneous nuclear nucleoprotein A1 (hnRNPA1) was verified by bioinformatics analysis, RNA pull-down assays, and RNA immunoprecipitation assays. RESULTS: In this study, we identified that OIP5-AS1 is specifically overexpressed in GC tumor tissues and cell lines and correlated with a poor prognosis. The loss of OIP5-AS1 suppressed the proliferation, migration, invasion, epithelial-mesenchymal transition (EMT), and glycolysis of GC cells, but the ectopic expression of OIP5-AS1 had the opposite impact. Meanwhile, knockdown of OIP5-AS1 inhibited tumor growth in patient-derived xenograft models, as well as repressed tumor metastasis. Mechanistically, IGF2BP3 could bind to OIP5-AS1 by N6-methyladenosine (m6A) modification sites on OIP5-AS1, thereby stabilizing OIP5-AS1. Moreover, OIP5-AS1 prevented Trim21-mediated ubiquitination and degradation of hnRNPA1, stabilizing hnRNPA1 protein and promoting the malignant progression of GC by regulating PKM2 signaling pathway. CONCLUSIONS: In conclusion, this study highlighted that OIP5-AS1 is an oncogenic m6A-modified long non-coding RNA (lncRNA) in GC and that IGF2BP3/OIP5-AS1/hnRNPA1 axis may provide a potential diagnostic or prognostic target for GC.
摘要：
In this paper, nitrogen-doped carbon dots (NCDs) were synthesized via a facile hydrothermal method using gum arabic (GA) and tris(hydroxymethyl)methyl aminomethane (tris) as precursors. The resultant NCDs show uniform size distribution and stable optical performance. Then a fluorescent signal quenching probe based on NCDs was proposed for the quantitative detection of mercury ions (Hg2+). The developed fluorescent nanoprobe based on NCDs demonstrated a good linear relationship in the range of 10 to 120 mu M (R-2 = 0.99265) for toxic mercury(ii), with a detection limit of 4.87 mu M. Additionally, the present assay system could be efficiently used for the detection of Hg2+ in real water samples with a satisfactory recovery rate (96.11-104.04%). The metal-free NCDs, which exhibited little cytotoxicity, were successfully applied to in vitro fluorescence imaging of human triple negative breast cancer (TNBC) cells, achieving visualization of Hg2+ in cells. With good water solubility and biocompatibility, the nitrogen-doped carbon dots synthesized by this economical and ecologically friendly process are suitable for use in analytical testing and biological research.
期刊：
MINI-REVIEWS IN MEDICINAL CHEMISTRY,2024年24(13):1228-1237 ISSN：1389-5575
作者机构：
Hunan University of Chinese Medicine & Hunan Engineering Technology Center of Standardization and Function of
Chinese Herbal Decoction Pieces, Changsha, 410208, Hunan, China;State Key Laboratory of Bioactive Substances and
Functions of Natural Medicines, Institute of Materia Medica & Neuroscience Center, Chinese Academy of Medical Sciences
and Peking Union Medical College, Beijing, 100050, China;Shanxi Key Laboratory of Traditional Chinese
Medicine Encephalopathy, Shanxi University of Traditional Chinese Medicine, Taiyuan, 030024, China;Research lab of translational medicine, Hengyang Medical
College, University of South China, Hengyang, Hunan 421001, China;[Feng, Juling] Hunan University of Chinese Medicine & Hunan Engineering Technology Center of Standardization and Function of
Chinese Herbal Decoction Pieces, Changsha, 410208, Hunan, China <&wdkj&> Research lab of translational medicine, Hengyang Medical
College, University of South China, Hengyang, Hunan 421001, China
摘要：
Ginsenoside is the principal active ingredient in ginseng. Several investigations have found that ginsenosides have anti-inflammatory, antioxidant, anti-apoptotic, anti-cancer, and antiallergic activities. Ferroptosis is an iron-dependent, non-apoptotic form of cell-regulated death caused by lipid peroxidation. Iron, lipid, and amino acid metabolism orchestrate the complex ferroptosis response through direct or indirect regulation of iron accumulation or lipid peroxidation. More and more research has demonstrated that ginsenoside impacts illnesses via ferroptosis, implying that ferroptosis might be employed as a novel target of ginsenoside for disease therapy. This article examines the molecular mechanism of ferroptosis as well as the current advancement of ginsenoside in influencing disorders via ferroptosis.
摘要：
Uranium contamination is a key issue in the sustainable development of nuclear energy. In this study, a cellulose/sericite hybrid aerogel with a layer-stacked network structure (MCC/AS-P) was prepared for uranium-contaminated wastewater treatment. Systematic characterization and multiple-batch static adsorption experiments were conducted to analyze the aerogel's preparation, adsorption, and desorption. The kinetics demonstrated a noticeable transition between mass transfer diffusion control and mass transfer control, approaching adsorption equilibrium within 8 min and 180 min, respectively, wherein polymer layers led to a more stable adsorption process. Adsorption isotherm and thermodynamic studies established that the theoretical adsorption capacity of MCC/AS-P for U(VI) at T = 298 K could reach 374.5 mg.g(-1). The adsorption behavior was endothermic and spontaneous, and the DFT calculations demonstrated that the adsorption energy of MCC/AS for UO22+ was 506.5 kcal/mol. Temperature, U(VI) concentration, and desorption can all lead to a transition of the dominant mechanism between chemisorption and physisorption. After six swelling-deswelling adsorption cycles, the adsorption efficiency remained above 80%, and the structure remained intact. Furthermore, the excellent performance in terms of interference resistance and chemical stability offers potential for practical application.
作者机构：
[Li, Li] The First Affiliated Hospital, Department of Gastrointestinal Surgery, Hengyang Medical School, University of South China, Hengyang, China
摘要：
Small bowel adenocarcinoma (SBA) is a rare tumor entity with a relatively poor prognosis. Diagnosis and management of SBA are still challenging despite recent advancement of diagnostic methods and publication of guidelines. This study aimed to analyze and visualize the trending of SBA research in the past 22 years in the 21st century through bibliometric analysis. Our study collected 1270 publication records of SBA from 2000 Jan 1st to 2022 December 31 from Web of Science and used VOSviewer and CiteSpace to analyze countries, institutions, journals, authors, references and keywords to present the latest trends in SBA research. The USA was the most productive country in terms of the total number of publications (n = 418). The Mayo Clinic (n = 22) and University of Texas MD Cancer Center (n = 22) were the institutions with top publications. The "World Journal Of Gastroenterology" (n = 30) had the largest publications. Overman Michael J (n = 17) was the most active and prolific author. The "small bowel adenocarcinoma" was the most frequent keyword. Our bibliometric analysis provides a comprehensive overview of the trends and gaps in the research of SBA. Despite the challenges faced, researchers from USA, Japan and China have made significant contributions to the field of SBA research, and further research is necessary to develop evidence-based guidelines, and advance the understanding and management of SBA.
摘要：
To explore the influence of lithology on the failure behavior of layered tunnel, true triaxial compression experiments were undertaken on cubical phyllite and yellow sandstone samples containing a "D" shaped hole. The failure progress of the hole sidewalls was monitored and captured using a miniature camera. The results reveal that the initial vertical failure stress of the phyllite samples presents a "U" shaped change as the bedding angle increases. At the bedding angle of 45 degrees, compared with the initial vertical failure stress of the yellow sandstone tunnel, that of the phyllite tunnel is lower, resulting in larger rock fragments and deeper V-shaped grooves. The failure pattern of the phyllite tunnel is primarily manifested as extensive shear sliding failure, and the failure is more severe. The failure of the yellow sandstone tunnel is primarily characterized by the sequential laminar fracturing along the maximum principal stress direction, predominantly manifesting as tensile failure. The primary factors influencing the failure of two types of layered rocks are the significant variations in the clay mineral content within the rocks. For the phyllite, it contains nearly one-third of montmorillonite (a clay mineral). This results in the formation of weak bedding planes within surrounding rocks, which induces shear slip failures along these bedding planes. In contrast, the yellow sandstone has a lower clay mineral content, leading to the absence of distinct weak bedding planes within the surrounding rock. In this case, bedding planes present ignorable effect on the surrounding rock.
摘要：
In order to improve the reliability and maintainability of rod control power cabinets in nuclear power plants, this paper uses insulated gate bipolar transistors (IGBTs), the key power device of rod control power cabinets, as the object of research on cross-working-condition fault prediction. An improved transfer learning (TL) model based on a temporal convolutional network (TCN) is proposed to solve the problem of low fault prediction accuracy across operating conditions. First, the peak emitter voltage of an IGBT aging dataset is selected as the source domain failure characteristic, and the TCN model is trained after the removal of outliers and noise reduction. Then, the time–frequency features are extracted according to the characteristics of the target domain data, and the target domain representation data are obtained using kernel principal component analysis (KPCA) for dimensionality reduction. Finally, the TCN model trained on the source domain is transferred; the model is fine-tuned according to the target domain data, and the learning rate, the number of hidden layer nodes, and the number of training times in the network model are optimized using the dung beetle optimization (DBO) algorithm to obtain the optimal network, making it more suitable for target sample fault prediction. The prediction results of this TCN model, the long short-term memory (LSTM) model, the gated recurrent unit (GRU) model, and the recursive neural network (RNN) model are compared and analyzed by selecting prediction performance evaluation indexes. The results show that the TCN model has a better predictive effect. Comparing the prediction results of the TCN-based optimized transfer learning model with those of the directly trained TCN model, the mean square error, root mean square error, and mean absolute error are reduced by a factor of two to three, which provides an effective solution for fault prediction across operating conditions.
摘要：
ATP-binding cassette protein A1 (ABCA1) is a key protein in the transport of intracellular cholesterol to the extracellular and plays an important role in reduc-ing cholesterol accumulation in surrounding tissues. Bibliometric analysis refers to the cross-science of quan-titative analysis of a variety of documents by mathemati-cal and statistical methods. It combines an analysis of structural and temporal patterns in scholarly publica-tions with a description of topic concentration and types of uncertainty. This paper analyzes the history, hotspot, and development trend of ABCA1 through bibliometrics. It will provide readers with the research status and development trend of ABCA1 and help the hot research in this field explore new research directions. After screening, the research on ABCA1 is still in a hot phase in the past 20 years. ABCA1 is emerging in previously unrelated disciplines such as cancer. There were 551 key-words and 6888 breakout citations counted by CiteSpace. The relationship between cancer and cardiovascular dis-ease has been linked by ABCA1. This review will guide readers who are not familiar with ABCA1 research to quickly understand the development process of ABCA1 and provide researchers with a possible future research focus on ABCA1. (Curr Probl Cardiol 2024;49:102036.)
摘要：
Objectives: This study aimed to evaluate the therapeutic effects and mechanism of genistein on dextran sulfate sodium-induced mouse model of ulcerative colitis (UC).Materials and Methods: A DSS-induced mouse model for UC was used in this study. Mice were then treated with genistein or a combination of genistein and the G protein-coupled estrogen receptor (GPER) antagonist G15. Colon length, disease activity index (DAI), spleen index (SI), histopathological alterations, and integrity of the colonic barrier were evaluated. The expression of inflammatory cytokines and antioxidant capacity were detected. Populations of T helper 17 cells (Th17) and Regulatory T cells (Treg) in the mesenteric lymph nodes (MLN) were analyzed. The expression of a transcription factor for Th17 and Treg in the colonic tissues was detected.Results: Genistein treatment significantly alleviated DSS-induced colitis, summarized as increased colonic length, decreased DAI, SI, improved histopathological alterations, and colonic barrier integrity. Genistein treatment restrained pro-inflammatory cytokines and oxidative enzyme release while promoting anti-inflammatory and anti-oxidative enzyme release. Flow cytometry indicated that genistein significantly reduced the Th17 population while boosting Treg populations. Furthermore, genistein inhibited the expression of transcription factors associated with Th17 and promoted the expression of transcription factors associated with Treg in the colonic tissue. Intriguingly, these observed effects of genistein were abolished when UC mice were treated with a combination of genistein and GPER antagonist G15.Conclusion: This study suggests that genistein is potent in protecting against DSS-induced colonic injuries by rebalancing Th17/Treg and that GPER may be a vital target for genistein-mediated immunomodulatory effects in UC.
