作者机构：
[Peiguan Huang; Xiaojun Tang] Second Affiliated Hospital, Department of Joint Surgery, Hengyang Medical School, University of South China, Hengyang, Hunan, China
通讯机构：
[Peiguan Huang] S;Second Affiliated Hospital, Department of Joint Surgery, Hengyang Medical School, University of South China, Hengyang, Hunan, China
摘要：
At present, the suture bridge is a widely used surgical pattern in the treatment of supraspinatus tendon tear, but the shortcomings of a suture bridge, including expensive lateral-row anchor and increased type 2 retear rate, is obvious. The double-pulley suture-bridge described in this Technical Note uses a double-loaded suture anchor (medial-row anchor) as lateral-row anchor instead of traditional lateral-row anchor, combined with double-pulley technology forming suture-bridge in treatment of supraspinatus tendon tears. The surgical technique is described in pearls, pitfalls, advantages, and disadvantages.
摘要：
Multiple pesticides are often used in combination for plant protection and public health. Therefore, it is important to analyze the physiological changes induced by multiple pesticides exposure. The objective of this study was to investigate the combined toxicity of the widely-used organophosphorus and pyrethroid pesticides diazinon, dimethoate, and cypermethrin. Male Wistar rats were administrated by gavage once daily with the three pesticides individual or in combination for consecutive 28 days. The metabolic components of serum and urine samples were detected by using 1H nuclear magnetic resonance (NMR)-based metabolomics method. Histopathological examination of liver and kidneys and serum biochemical determination were also carried out. The results showed that after the 28-day subacute exposure, serum glutamic transaminase and albumin were significantly increased and blood urea nitrogen was significantly decreased in the rats exposed to the mixture of the pesticides compared with the control rats, suggesting that the co-exposure impaired liver and kidney function. Metabolomics analysis indicated that the indicators 14 metabolites were statistically significant altered in the rats after the exposure of the pesticides. The increase in 3-hydroxybutyric acid in urine or decrease of lactate and N-acetyl-L-cysteine in serum could be a potentially sensitive biomarker of the subchronic combined effects of the three insecticides. The reduction level of 2-oxoglutarate and creatinine in urine may be indicative of dysfunction of liver and kidneys. In summary, the exposure of rats to pesticides diazinon, dimethoate, and cypermethrin could cause disorder of lipid and amino acid metabolism, induction of oxidative stress, and dysfunction of liver and kidneys, which contributes to the understanding of combined toxic effects of the pesticides revealed by using the metabolomics analysis of the urine and serum profiles.
期刊：
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES,2024年34(3):691-698 ISSN：0939-4753
通讯作者：
Ling Liu
作者机构：
[Zhang, Miao; Liu, Ling; Xie, Yingying; Tan, Yangrong; Xu, Jin; Chen, Hao; Qu, Peiliu; Zhu, Liyuan] Department of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, PR China;[Xie, Yingying] Department of Cardiology, China-Japan Friendship Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, PR China;[Chen, Hao] Department of Cardiology, Second Affiliated Hospital of South China University, Hengyang, Hunan, PR China;[Zhang, Miao; Tan, Yangrong; Xu, Jin; Qu, Peiliu; Zhu, Liyuan] Modern Cardiovascular Disease Clinical Technology Research Center of Hunan Province, PR China;[Liu, Ling] Modern Cardiovascular Disease Clinical Technology Research Center of Hunan Province, PR China. Electronic address: feliuling@csu.edu.cn
通讯机构：
[Ling Liu] D;Department of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, PR China<&wdkj&>Modern Cardiovascular Disease Clinical Technology Research Center of Hunan Province, PR China
摘要：
BACKGROUND AND AIM: Evidence from prospective cohort studies has revealed an inverse association between cheese consumption and the development of atherosclerosis (AS), atherosclerotic cardiovascular diseases (ASCVD), and their complications. However, it remains unclear whether this observed association is influenced by potential confounding factors that may arise during the long-term development process of AS, ASCVD, and its complications. Therefore, to further clarify the causal relationship between cheese consumption and AS, ASCVD, and its complications, we conducted a two-sample Mendelian randomization (MR) analysis to explore the causal association between cheese intake and the aforementioned health outcomes. METHODS AND RESULTS: We employed a two-sample MR analysis based on publicly available genome-wide association studies (GWAS) to infer the causal relationship, with no overlap between their participating populations. The effect estimates were calculated using the random-effects inverse-variance-weighted method. Sensitivity analyses were conducted using Cochran's Q statistic, funnel plot, leave-one-out analysis, and MR-Egger intercept tests. The genetically predicted cheese intake was found to be associated with lower risks of coronary AS (odds ratio [OR]=0.72, 95% confidence interval [CI] 0.59-0.88, P=0.001), peripheral vascular AS (OR=0.56, 95% CI 0.37-0.84, P=0.006), other vascular AS (OR=0.66, 95% CI 0.44-0.99, P=0.043), coronary artery disease (OR=0.64, 95% CI 0.56-0.74, P=1.57e-09), angina pectoris (OR=0.70, 95% CI 0.58-0.84, P=4.92e-05), myocardial infarction (OR=0.63, 95% CI 0.52-0.77, P=3.56e-06), heart failure (OR=0.62, 0.49-0.79, P=1.20e-04), total ischemic stroke (OR=0.76, 95% CI 0.63-0.91, P=0.003), peripheral artery disease (OR=0.64, 95% CI 0.43-0.95, P=0.028), and cognitive impairment (OR=0.65, 95% CI 0.56-0.74, P=3.40e-10). However, no associations were observed for cerebrovascular AS, arrhythmia, cardiac death, ischemic stroke (large artery AS), ischemic stroke (small vessel), ischemic stroke (cardioembolic), and transient ischemic attack. CONCLUSION: This two-sample MR analysis reveals a causally inverse association between cheese intake and multi-vascular AS (including coronary AS, peripheral vascular AS, and other vascular AS), as well as multiple types of ASCVD and its complications (such as coronary artery disease, angina pectoris, myocardial infarction, heart failure, total ischemic stroke, and peripheral artery disease). The findings from this study may lay a stronger theoretical foundation and present new opportunities for the dietary management of future atherosclerotic cardiovascular diseases.
通讯机构：
[Zhu, HM ] U;Univ South China, Sch Mech Engn, Hengyang 421001, Hunan, Peoples R China.;Hunan Prov Key Lab Adv Laser Mfg Technol, Hengyang 421001, Hunan, Peoples R China.
关键词：
distortion;laser repairing;microstructure;properties;scanning strategy;temperature distribution
摘要：
In order to explore the effects of scanning strategies on the distortion and properties of laser-repaired thin-plate components, four commonly used strategies, including continuous raster scanning strategy, continuous orthogonal scanning strategy (COS), subarea W-type scanning strategy and subarea leap-type scanning strategy, were applied for laser-repairing thin-plate 2Cr13 steel. The finite element simulation and experimental results show that the temperature field of the laser-repaired layer prepared by COS exhibits symmetrical elliptical characteristic, with homogeneous temperature gradient along all directions. Consequently, the outermost of COS sample exhibits the smallest deformation of 2.86 mm, by avoiding both the unidirectional shrinkage of molten pool and the cumulative effect of longitudinal stress. In contrast, much larger distortion was produced by the other three scanning strategies due to the uneven temperature gradient. Dense martensite without defects was achieved by continuous scanning, while the coarsen martensite occurred by using subarea scanning. The repaired layer by using subarea scanning exhibits lower microhardness of 585-590 HV0.2 and poor wear resistance of 1.45 x 10-5-1.48 x 10-5 mm3/N m, in comparison to 613-618 HV0.2 and 0.9 x 10-5-0.92 x 10-5 mm3/N m obtained by using continuous strategy. COS is the most ideal strategy in laser-repairing thin-plate 2Cr13 steel in this work, exhibiting the lowest distortion as well as the highest microhardness and wear resistance.
通讯机构：
[Li, T ] U;Univ South China, Sch Resource Environm & Safety Engn, Hengyang 421001, Peoples R China.
摘要：
Low-concentration electrolyte demonstrates significant advantages in terms of low cost, low viscosity, and high wettability. However, its high solvent ratio usually induces a fragile organic-rich solid electrolyte interphase (SEI), which is not compatible with high-voltage lithium metal batteries (LMBs). Herein, a screening rule for diluents has been established based on the electrostatic potential, which guides the rational design of diluted low-concentration electrolyte (DLCE) with a high anion-to-solvent ratio. Specifically, the anti-solvating power of a diluent is positively correlated with its value of the most positive surface potential (ESPmax), and thus diluents with a high ESPmax value easily cause salt precipitation when diluting concentrated electrolyte to low concentration (<1 M). In light of this observation, a diluent with a low ESPmax value is selected to ensure the preparation of a transparent DLCE, thus maintaining a high anion-to-solvent ratio in DLCE. As an exemplary study, a 0.5 M ether-based DLCE is developed for high-voltage LMBs. Due to the high anion-to-solvent ratio, a robust LiF-rich SEI is formed and enables the stable operation of LMBs under high voltage (4.5 V) and a wide temperature range (-20 to 55 C-degrees). This work offers a guideline for screening diluents to design high-performance LCEs for high-voltage batteries.
期刊：
International Journal of Hydrogen Energy,2024年61:415-423 ISSN：0360-3199
通讯作者：
Rongli Jiang
作者机构：
[Yuan Gao; Qi Zhou; Hanlu Xu; Bo Liu; Qiong Zhang; Shaorong Wang; Rongli Jiang] School of Chemical Engineering and Technology, China University of Mining & Technology, Xuzhou, Jiangsu, 221116, China;[Zhongran Dai] School of Resource Environment and Safety Engineering, University of South China, Hengyang, 421001, China
通讯机构：
[Rongli Jiang] S;School of Chemical Engineering and Technology, China University of Mining & Technology, Xuzhou, Jiangsu, 221116, China
摘要：
The proton exchange membrane (PEM) is vital in proton exchange membrane fuel cells (PEMFCs), but current PEMs face issues including low conductivity, poor durability, and instability in maintaining proton transport across varying temperatures. This study proposes an innovative approach to address this issue by incorporating UiO-66-(COOH)2 as a filler in a polymeric matrix comprising polyvinylpyrrolidone and polyvinylidene fluoride (abbreviated as PP). Significantly, this facilitates forming hydrogen bonds between UiO-66-(COOH)2 and the PP matrix. The UiO-66-(COOH)2@PP composite membranes are comprehensively characterized through PXRD, TGA-DSC, FTIR, and SEM analyses. The remarkable water adsorption performance observed in the UiO-66-(COOH)2@PP-X series creates favourable conditions for enhancing proton conductivity. Proton conductivity studies highlight exceptional performance, particularly UiO-66-(COOH)2@PP-30 achieving a remarkable 5.8 × 10−3 S cm−1 at 98% RH, with sustained conductivity over one week. At 32% RH, UiO-66-(COOH)2@PP-30 exhibits a significantly reduced activation energy of 0.09 eV, indicating a stable proton transport pathway across a wide temperature range. Mechanism studies unveil that the collaborative interaction between UiO-66-(COOH)2 and PP establishes a continuous network of hydrogen bonds, strengthened by PP's hydrophilic properties. Additionally, the stabilization of water within UiO-66-(COOH)2 channels significantly contributes to the overall efficiency of proton conduction.
期刊：
Journal of Hazardous Materials,2024年469:134022 ISSN：0304-3894
通讯作者：
Xue, Wenjing
作者机构：
[Lin, Weilong; Liu, Hongdou; Wen, Siqi; He, Qi; Shi, Xiaoyu; Xu, Yiqun; Guo, Jiaming] College of Environmental Science and Engineering, Yangzhou University, Yangzhou 225009, PR China;[Gao, Yang] School of Hydraulic and Environmental Engineering, Changsha University of Science & Technology, Changsha 410114, PR China;[Wang, Rongzhong] School of Resource & Environment and Safety Engineering, University of South China, Hengyang 421001, PR China;[Xue, Wenjing] College of Environmental Science and Engineering, Yangzhou University, Yangzhou 225009, PR China. Electronic address: xuewenjing@yzu.edu.cn
通讯机构：
[Xue, Wenjing] C;College of Environmental Science and Engineering, Yangzhou University, Yangzhou 225009, PR China. Electronic address:
关键词：
Bacterial community;Cadmium;Precursor;Sediment;Sulfidized nanoscale zero-valent iron
摘要：
Sulfidized nanoscale zero-valent iron (S-nZVI) showed excellent removal capacity for cadmium (Cd) in aqueous phase. However, the remediation effects of S-nZVI on Cd-contaminated sediment and its interactions with microorganisms in relation to Cd fate remain unclear. The complexity of the external environment posed a challenge for Cd remediation. This study synthesized S-nZVI with different S and Fe precursors to investigate the effect of precursors and applied the optimal material to immobilize Cd in sediments. Characterization analysis revealed that the precursor affected the morphology, Fe(0) crystallinity, and the degree of oxidation of the material. Incubation experiments demonstrated that the immobilization efficiency of Cd using S-nZVI(Fe)(3+)(+S)(2-) (S/Fe = 0.14) reached the peak value of 99.54%. 1% and 5% dosages of S-nZVI significantly reduced Cd concentration in the overlying water, DTPA-extractable Cd content, and exchangeable (EX) Cd speciation (P<0.05). Cd leaching in sediment and total iron in the overlying water remained at low levels during 90 d of incubation. Notably, each treatment maintained a high Cd immobilization efficiency under different pH, water/sediment ratio, organic acid, and coexisting ion conditions. Sediment physicochemical properties, functional bacteria, and a range of adsorption, complexation and precipitation of CdS effects dominated Cd immobilization.
期刊：
Separation and Purification Technology,2024年335:126214 ISSN：1383-5866
通讯作者：
Xie, D
作者机构：
[Li, Suzhe; Tang, Zengming; Yang, Xiaomin] Univ South China, Sch Resource & Environm & Safety Engn, Hengyang 421001, Peoples R China.;[Xie, D; Xie, Dong; Li, Suzhe; Tang, Zengming; Yang, Xiaomin] Natl & Local Joint Engn Res Ctr Airborne Pollutant, Hengyang 421001, Peoples R China.;[Xie, D; Xie, Dong] Univ South China, Sch Civil Engn, Hengyang 421001, Peoples R China.
通讯机构：
[Xie, D ] N;Natl & Local Joint Engn Res Ctr Airborne Pollutant, Hengyang 421001, Peoples R China.;Univ South China, Sch Civil Engn, Hengyang 421001, Peoples R China.
摘要：
Finding an inexpensive and efficient porous adsorbent to capture the gaseous radioiodine generated during spent fuel reprocessing has been challenging. Herein, we present a design philosophy for waste control to develop porous carbon for gaseous iodine capture from sewage sludge waste. Among them, the novel in situ etching of polytetrafluoroethylene was employed to improve pore accessibility. The hazards of the conventional preparation of sludge-derived carbon using highly corrosive NaOH and HF solutions were overcome. Polytetrafluoro-ethylene etched porous carbon with large specific surface area (1103 m2/g), interconnected hierarchical porous structure, and excellent hydrophobicity (water contact angle 126.52 degrees), providing efficient adsorption of gaseous iodine in hot (30-150 degrees C) and humid (50-96% relative humidity [RH]) environments. The iodine adsorption of hierarchical porous carbon was tested under static and dynamic conditions, and high records have been achieved. Notably, due to the structural advantage of hydrophobicity, a considerable dynamic adsorption capacity (1746.77 mg/g) was also maintained in a mixed iodine gas stream containing water vapor in a humid (50% RH) hot (75 degrees C) condition. This study is the first to use an in situ etching strategy for polytetrafluoroethylene, which opens a new avenue for converting sludge waste into low-cost porous carbon and provides an attractive option for capturing iodine in hot and humid environments.
关键词：
Composites aerogel;Colorimetry;Controllable catalysis;Recyclable and accurate detection;Visual and on -site sensing
摘要：
Colorimetric detection methods have been attracted and preferred for analytes assessment. Although simple and highly efficient colorimetric strategies based on nanozymes have been developed, there remain inherent problems of intrinsic color interference for accurate analysis and erratic activity to lose controllable, recyclable, and sensitive efficacies. Herein, we have prepared a novel composite aerogel named PACO that is rationally assembled by the poly (vinyl alcohol) aerogel (PVA aerogel) and copper oxide nanoparticles (CuO NPs) to address these challenges. PACO has been proved to exhibit the controllable peroxidase (POD)-like activity through separating the solid PACO from the aqueous solutions. Meanwhile, PACO can avoid intrinsic color interferences and provide more accurate detection performance for naked eye discrimination. Furthermore, PACO shows the recyclable and long lifetime performances for sensitive detection of water pollutants including hydroquinone (HQ) and catechol (CC) with the LOD of 0.084 mu M and 0.101 mu M, respectively. Finally, we have constructed a smartphone-based colorimetric detection platform to realize the on-site and visualanalysis of water pollutants in real water samples. Overall, PACO achieves the advanced detection performances to exhibit great potential in nanozymes based sensing method development and colorimetric-related analytical research.
期刊：
Physica Status Solidi-Rapid Research Letters,2024年18(2):2300334- ISSN：1862-6254
通讯作者：
Huo, SY
作者机构：
[Fu, Chun-Ming; Li, Hong-Kang; Huo, Shao-Yong; Yao, Long-Chao] Univ South China, Coll Mech Engn, Hengyang 421001, Peoples R China.
通讯机构：
[Huo, SY ] U;Univ South China, Coll Mech Engn, Hengyang 421001, Peoples R China.
关键词：
defect states;elastic valley edge states;power dividers;rainbow trapping;topological phononic crystals
摘要：
Topological phononic crystals (PnCs) with topologically protected boundary states have important applications in the fields of acoustic wave transmission and control. However, previous studies based on solid-state PnC systems are mostly limited by fixed structures, resulting in the difficulty to deform the edge states, which partly limits its practical applications. Herein, a 2D solid topological PnC coupled with the defect is designed to achieve the adjustable valley edge state and rainbow trapping. First, by breaking the spatial inversion symmetry, the valley Hall phase transition of elastic wave is realized and valley edge states are obtained. Next, by introducing defects of different widths between the two different valleys' topological PnCs, both the defect-adjusted valley edge state and defect state are achieved. Then, by designing different topological PnCs waveguides, the robust transport characteristics of the two above states are compared. Subsequently, a new power divider based on the defect-adjusted valley edge state is designed, which is found to possess various manners of operation such as equal and unequal power divisions. Finally, based on defect adjustment of the edge states, a rainbow trapping is implemented. This research provides an important guidance for ultrasonic devices, such as waveguides, energy harvesters, and power dividers. By introducing the line defects in the topological domain wall for the elastic wave, the defect-adjusted valley edge states and defect states are presented, which further are applied to design the novel elastic ultrasonic devices, such as the equal or unequal power dividers and the rainbow trapping effects.image & COPY; 2023 WILEY-VCH GmbH
摘要：
Given that intricate toxicological profiles exist among different antibiotics and pose serious threats to the environment and human health, synchronous analysis of multiple residues becomes crucial. Sensor arrays show potential to achieve the above purpose, but it is challenging to develop easy-to-use and high-sensitivity tools because the state-of-the-art arrays often require more than one recognition unit and are monosignal dependent. Here we exquisitely designed a fluorescent nanoprobe (2-aminoterephthalic acid-anchored CdTe quantum dots with Eu3+ coordination, CdTe-ATPA-Eu3+) featuring triple emissions at the same excitation as the only element to fabricate a luminescent sensor array with ratiometric calculations for identifying multiple antibiotics. By taking tetracycline, chlortetracycline, doxycycline, oxytetracycline, penicillin G, and sulfamethoxazole as models, the six species exhibited distinguishable motivation or/and quenching impacts on the three emissions of CdTe-ATPA-Eu3+, which were employed as indicators to perform the ratiometric logical operation and further combined with pattern recognition analysis for multitarget determination. Evidently, such a design exhibits two advances: (1) with the triple-emission probe as the sole receptor requiring neither internal nor external adjustments, the fabricated array acts as an extremely facile tool for multianalyte detection; (2) the ratiometric calculations offer excellent sensitivity and reliability for high-performance determination. Consequently, accurate identification and quantification of individual antibiotics and their combinations at various levels were verified in both laboratory and practical matrices. Our work provides a new tool for simultaneously detecting multiple antibiotics, and it will inspire the development of advanced sensor arrays for multitarget analysis.
期刊：
Nuclear Engineering and Technology,2024年 ISSN：1738-5733
通讯作者：
Changjun Qiu
作者机构：
School of Resource Environment and Safety Engineering, University of South China, Hengyang, Hunan, 421001, China;School of Mechanical Engineering, University of South China, Hengyang, Hunan, 421001, China;Key Laboratory of Emergency Safety Technology and Equipment of Nuclear Facilities in Hunan Province, Hengyang, Hunan, 421001, China;[Wen Chen; Jianyong Dai; Meirong Zhang] School of Resource Environment and Safety Engineering, University of South China, Hengyang, Hunan, 421001, China<&wdkj&>Key Laboratory of Emergency Safety Technology and Equipment of Nuclear Facilities in Hunan Province, Hengyang, Hunan, 421001, China;[Shuliang Zou; Changjun Qiu] School of Mechanical Engineering, University of South China, Hengyang, Hunan, 421001, China<&wdkj&>Key Laboratory of Emergency Safety Technology and Equipment of Nuclear Facilities in Hunan Province, Hengyang, Hunan, 421001, China
通讯机构：
[Changjun Qiu] S;School of Mechanical Engineering, University of South China, Hengyang, Hunan, 421001, China<&wdkj&>Key Laboratory of Emergency Safety Technology and Equipment of Nuclear Facilities in Hunan Province, Hengyang, Hunan, 421001, China
摘要：
Modern risk management philosophy emphasizes the invulnerability of human beings to cope with all kinds of emergencies. The Nuclear Accidents Emergency Response Organization (NAERO) of Nuclear Power Plant (NPP) is the primary body responsible for nuclear accidents emergency response. The invulnerability of the organization to disturbance or attack from internal and external sources is crucial in the completion of its response missions, reduction of severity of accidents, and assurance of public and environmental safety. This paper focused on the NAERO of a certain NPP in China, and applied the complex network theory to construct the network model of the organization. The topological characteristics of the network were analyzed. Four importance evaluation indexes of network nodes including Degree Centrality (DC), Betweeness Centrality (BC), Closeness Centrality (CC) and Eigenvector Centrality (EC), along with Pearson coefficient correlation among the indexes were calculated and analyzed. Size of the Largest Connected Component (LCC) and Network Efficiency were used as measures regarding the invulnerability of the network. Simulation experiments were conducted to assess the invulnerability of network against various attack strategies. These experiments were conducted both in the absence of node protection measures and under protection measures with different node protection rates. This study evaluated the invulnerability of the NAERO network, and provided significant decision-making basis for the enhancement of the network's invulnerability.
摘要：
BACKGROUND: The newly approved third-generation oral anti-HIV-1 drug, ainuovirine (ANV), was used in combination with nucleoside reverse transcriptase inhibitors (NRTIs) in our study, and its effects on the lipid profile of antiretroviral-experienced HIV/AIDS patients are unclear. OBJECTIVES: This study aimed to examine the effects of antiretroviral agents on the lipid profile in patients with HIV/AIDS. METHODS: We conducted a real-world prospective study involving treatment-naive and treatment-experienced adult participants living with HIV-1 infection provided with ANV- or efavirenz (EFV)-based regimens. The primary endpoint was the proportion of participants with an HIV-1 RNA level of <50 copies/mL at week 24 of treatment. Secondary endpoints included the change from baseline in CD4+ T-cell count and lipid profile. RESULTS: A total of 60 treatment-naive and 47 treatment-experienced participants received an ANV-based regimen, while 88 treatment-naive and 47 treatment-experienced participants receiving an EFV-based regimen were, respectively, matched as controls. At week 24 following treatment, the proportion of participants with an HIV-1 RNA level of <50 copies/mL and the mean changes of CD4+ T-cell counts from baseline were significantly higher in naive-ANV group than those in naive-EFV group (p < 0.01). Compared with the EFV group, both naive and experienced ANV groups exhibited a favorable lipid profile, including constant changes in total cholesterol and triglycerides, a significant decrease in LDL-cholesterol (p < 0.0001), and a dramatic increase in HDL-cholesterol (p < 0.001). CONCLUSION: The efficacy of ANV was non-inferior to EFV when combined with two NRTIs. Patients receiving ANV-based regimens had a decreased prevalence of dyslipidemia.
期刊：
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING,2024年27(7):947-958 ISSN：1386-2073
作者机构：
[Xiang, Yijun; Yang, Zehua; Wang, Yanjie; Mi, Pengbing; Yao, Xu; Ai, Wenbin; Li, Jiaxin; Li, Xiaoshun; Zheng, Zitong; Jiang, Jingyi] Department of Pharmacy, Hunan Provincial Key Laboratory of tumor microenvironment responsive drug research, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, the Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, China
摘要：
Resveratrol is one of the most interesting naturally-occurring nonflavonoid phenolic compounds with various biological activities, such as anticancer, neuroprotection, antibacterial, and anti-inflammatory. However, there is no clinical usage of resveratrol due to either its poor activity or poor pharmacokinetic properties. Heteroarenes-modified resveratrol is one pathway to improve its biological activities and bioavailability, and form more modification sites. In this review, we present the progress of heteroaryl analogues of resveratrol with promising biological activities in the latest five years, ranging from the synthesis to the structure-activity relationship and mechanism of actions. Finally, introducing heteroarenes into resveratrol is an effective strategy, which focuses on the selectivity of structure-activity relationship in vivo.
通讯机构：
[Liu, M ] U;Univ South China, Coll Nucl Sci & Technol, Hengyang 421200, Hunan, Peoples R China.;Zhuhai Tsinghua Univ, Res Inst Innovat Ctr, 101 Univ Ave, Zhuhai 519000, Peoples R China.
摘要：
In this study, DyFe1-xCrxO3 (DFCO) was synthesized by sol-gel and underwent magnetic measurements and analysis. The experimental data were fitted and calculated by a four-sublattice molecular field model. Unlike previous studies, we found that in DyFe1-xCrxO3, the spin of the A-site rare earth ion Dy3+ also changed simultaneously with the spin reorientation of the Fe3+/Cr3+ ions. The effective spin is defined as the projection of the A site's total spin on the B site's spin plane, and the curve of temperature changes was obtained after fitting. This is convincing and, at the same time, provides a reference for the development of spintronic devices in the future.
期刊：
Chemical Communications,2024年60(25):3413-3416 ISSN：1359-7345
通讯作者：
Liu, Jie
作者机构：
[Liu, Jie; Guo, Yu; Peng, Xue; Zhang, Wei; Wang, Zhen; Zeng, Yao-Fu; Chen, Zhang] School of Pharmaceutical Science, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, China. guoyuhy@126.com;[Guo, Lu] Department of Sports Medicine, Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, China;[Wang, Zhen] MOE Key Lab of Rare Pediatric Diseases, University of South China, Hengyang, Hunan, 421001, China
通讯机构：
[Liu, Jie] S;School of Pharmaceutical Science, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, China.
摘要：
A photoredox-catalyzed unsymmetrical diamination of alkenes by using N-aminopyridinium salts and nitriles as the amination reagents has been developed. Various vicinal diamines were obtained in moderate to excellent yields under mild reaction conditions. Furthermore, this protocol could be applied in the late-stage modification of pharmaceuticals and natural products. Preliminary mechanistic studies suggested that this methodology may undergo a radical pathway followed by a Ritter-type reaction.
作者机构：
[Zhengjie Lin] Department of Metabolism and Endocrinology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, China;[Danyi Lin] Department of Pathology, Guangdong Provincial People's Hospital, Southern Medical University, Guangzhou, China. danyi_l@126.com;[Dane Lin] Neonatal Intensive Care Unit, Department of Pediatrics, The First Affiliated Hospital of Shantou University Medical College, No. 57 Changping Road, Shantou, Guangdong, China. m13715870419@163.com
通讯机构：
[Lin, Danyi] D;[Lin, Dane] N;Department of Pathology, Guangdong Provincial People's Hospital, Southern Medical University, Guangzhou, China.;Neonatal Intensive Care Unit, Department of Pediatrics, The First Affiliated Hospital of Shantou University Medical College, No. 57 Changping Road, Shantou, Guangdong, China.
摘要：
Chronic wound healing is a class of diseases influenced by multiple complex factors, causing severe psychological and physiological impact on patients. It is an intractable clinical challenge and its possible mechanisms are not yet clear. It has been proven that adipose stem cell-derived exosomes (ADSC-Exos) can promote wound healing and inhibit scar formation by regulating inflammation, promoting cell proliferation, migration, and angiogenesis, regulating matrix remodeling, which provides a new approach for wound healing through biological treatment. This review focuses on the mechanism, treatment, and administration methods of ADSC-Exos in wound healing, providing a comprehensive understanding the mechanisms of ADSC-Exos on wound healing. This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors
www.springer.com/00266
.
摘要：
Cancer immunotherapy, particularly with immune checkpoint inhibitors, has revolutionized the paradigm of cancer treatment. Nevertheless, the efficacy of cancer immunotherapy remains limited in most clinical settings due to the lack of a preexisting antitumor T-cell response in tumors. Therefore, the clinical outcomes of cancer immunotherapy must be improved crucially. With increased awareness of the importance of the innate immune response in the recruitment of T cells, as well as the onset and maintenance of the T cell response, great interest has been shown in activating the cGAS-STING signaling pathway to awaken the innate immune response, thereby orchestrating both innate and adaptive immune responses to induce tumor clearance. However, tumor cells have evolved to overexpress ectonucleotide pyrophosphate phosphodiesterase 1 (ENPP1), which degrades the immunotransmitter 2',3'-cGAMP and promotes the production of immune-suppressing adenosine, resulting in inhibition of the anticancer immune response in the tumor microenvironment. Clinically, ENPP1 overexpression is closely associated with poor prognosis in patients with cancer. Conversely, depleting or inhibiting ENPP1 has been verified to elevate extracellular 2',3'-cGAMP levels and inhibit the generation of adenosine, thereby reinvigorating the anticancer immune response for tumor elimination. A variety of ENPP1 inhibitors have recently been developed and have demonstrated significant promise for cancer immunotherapy. In this review, we provide an overview of ENPP1, dissect its immunosuppressive mechanisms, and discuss the development of ENPP1 inhibitors with the potential to further improve the efficacy of cancer immunotherapy.
摘要：
In this paper, we give six classes of permutation polynomials of the form (x(pm) - x + delta)(s) + a(x) over F-2(2m) and six classes of permutation polynomials of the form (x(pm) - x + delta)(s) + ax(pm) + a(pm) x over F-p(2m) (p being an odd prime), respectively. In addition, we also investigate permutation polynomials obtained from piecewise functions. Consequently, we find some complete permutation polynomials.
作者机构：
[Liang, Xianxiao; Zhao, Yang; Shi, Xuan; Shi, X; Deng, Xueyi] Chongqing Univ Posts & Telecommun, Sch Optoelect Engn, Chongqing 400065, Peoples R China.;[Liang, Xianxiao; Zhao, Yang; Shi, Xuan; Shi, X; Xiao, Zeyun; Peng, Xiaoyu; Deng, Xueyi] Chinese Acad Sci, Chongqing Inst Green & Intelligent Technol, Chongqing 400714, Peoples R China.;[Zhao, Hongquan] South China Univ, Sch Elect Engn, Hengyang, Peoples R China.;[Yuan, Hongkuan] Southwest Univ, Sch Phys Sci & Technol, Chongqing, Peoples R China.
通讯机构：
[Yuan, HK ; Zhao, HQ ] S;[Shi, X ] C;Chongqing Univ Posts & Telecommun, Sch Optoelect Engn, Chongqing 400065, Peoples R China.;Chinese Acad Sci, Chongqing Inst Green & Intelligent Technol, Chongqing 400714, Peoples R China.;South China Univ, Sch Elect Engn, Hengyang, Peoples R China.
关键词：
WSe2/Si2H heterojunction;first principles;extra electric field;optical absorption coefficient
摘要：
Van der Waals heterojunctions based on two-dimensional (2D) materials hold great potential applications in photodetectors. Using the density functional theory (DFT) method, the structures, electronic and optical properties of van der Waals WSe2/Si2H heterojunction are investigated. 1.32 eV of indirect bandgap is calculated from the WSe2/Si2H heterojunction, which is 0.3 eV and 0.1 eV smaller than those of its monolayer WSe2 and Si2H. This contributes to the photocarrier generations, and the Type-II heterojunction also benefits to the separation of the photogenerated electron and hole pairs. A significant hole mobility 1.05 x 10(4) cm(2) V-1 s(-1) of the heterojunction along the y-direction is obtained. Moreover, a high Ultraviolet light (UV) absorption coefficient is presented in the heterojunction. The heterojunction transforms to Type-I under a vertical electric field, with the bandgap, orientation and amount of transfer electrons modulated sufficiently. As a result, the optical absorption coefficient of the heterojunction is also improved significantly, leading to the red-shift of the absorption spectrum. These excellent properties address the WSe2/Si2H heterojunction one of the good candidates for UV detectors.
