摘要：
This review provides an overview of the recent synthesis methods developed and made available for thiophene products preparation. Thiophene being an important sulfur‐containing heterocyclic motif finds use in pharmaceuticals, functional materials, organic chemistry and natural products, its efficient synthesis is equally important. Abstract Thiophene, as an important sulfur‐containing heterocyclic, is widely used in pharmaceuticals, functional materials, and natural products. Furthermore, thiophene is of great interest to synthetic chemists due to its diverse reactivities. Over the past few decades, many synthetic strategies are developed for functionalized thiophenes. Several reviews have been reported. However, there is no review on thiophene synthesis summarized based on the sulfur sources. The current review envisioned to summary the synthesis methods for thiophene with the respect of sulfur sources and give support for choose the appropriate tools to obtain thiophene substrates.
作者机构：
[Wen Luo] School of Nuclear Science and Technology, University of South China, Hengyang, 421001, People's Republic of China;[Ke Liu; Fuqiu Shao; Tongpu Yu] Department of Physics, National University of Defense Technology, Changsha, 410073, People's Republic of China;[Binglin Wang; Xiaojun Duan; Liang Yan] College of Sciences, National University of Defense Technology, Changsha, 410073, People's Republic of China;[Qian Dong] School of Nuclear Science and Technology, University of South China, Hengyang, 421001, People's Republic of China<&wdkj&>Department of Physics, National University of Defense Technology, Changsha, 410073, People's Republic of China
通讯机构：
[Wen Luo] S;[Tongpu Yu] D;School of Nuclear Science and Technology, University of South China, Hengyang, 421001, People's Republic of China<&wdkj&>Department of Physics, National University of Defense Technology, Changsha, 410073, People's Republic of China
摘要：
In Particle-In-Cell simulation, macro-particles represent clusters of numerous physical particles. Rational merging or splitting of these macro-particle clusters can significantly improve the efficiency of simulation and reduce unnecessary computational requirements and memory consumption. Here, we propose a dynamical particle merging and splitting algorithm. For macro-particle in different density regions, regional macro-particle clusters are obtained by dividing them with the Minkowski metric function. Dynamic merging and splitting of macro-particles is achieved by dynamically changing the number of macro-particle clusters to reduce the number of macro-particles without substantially distorting the physical description of the system. To test the capability of the algorithm, we also compare its performance under three types of classical plasma cases: two-stream instability (1D), QED cascades (2D), and magnetic shower (3D). The results show a good agreement with expectations.
作者机构：
[Jin, Liang; Zhai, Jinxia; Wang, Chao; Liu, Mingjie] Department of Neurology, The Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China;[Chen, Yongjun] Department of Neurology, The Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China. Electronic address: 2212680954@qq.com
通讯机构：
[Chen, Yongjun] D;Department of Neurology, The Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China. Electronic address:
摘要：
OBJECTIVE: This review aims to provide a comprehensive summary of the latest research progress regarding the relationship between epilepsy and circular RNA (circRNA). METHODS: Relevant literature from the PubMed database was meticulously searched and reviewed. The selected articles focused on investigating the association between epilepsy and circRNA, including studies on expression patterns, diagnostic markers, therapeutic targets, and functional mechanisms. RESULTS: Epilepsy, characterized by recurrent seizures, is a neurological disorder. Numerous studies have demonstrated significant alterations in the expression profiles of circRNA in epileptic brain tissues, animal models, and peripheral blood samples. These differential expressions of circRNA are believed to be closely linked with the occurrence and development of epilepsy. Moreover, circRNA has shown promising potential as diagnostic markers for epilepsy, as well as prognostic indicators for predicting disease outcomes. Furthermore, circRNA has emerged as a potential therapeutic target for epilepsy treatment, offering prospects for gene therapy interventions. CONCLUSION: The dysregulation of circRNA expression in epilepsy suggests its potential involvement in the pathogenesis and progression of this disorder. Identifying specific circRNA molecules associated with epilepsy may pave the way for novel diagnostic approaches and therapeutic strategies. However, further investigations are imperative to elucidate the precise functional mechanisms of circRNA in epilepsy and validate its clinical utility.
摘要：
Background: SN-38, recognized as the primary active derivative of the pivotal chemotherapeutic agent CPT-11, demonstrates substantially enhanced efficacy in colorectal cancer (CRC) management compared to CPT-11. Nonetheless, challenges such as low stability, inadequate aqueous solubility, limited bioavailability, and nonspecific targeting to cancer cells hinder its clinical adoption. In the present research, we synthesized SN-38loaded liposomes cloaked with macrophage membranes (SN-38@MM-LPs) to assess their therapeutic potential and safety profile in addressing CRC. Methods: SN-38@MM-LPs were synthesized using an incubation extrusion technique, combining a macrophage membrane with liposomes (LPs). It was characterized by size, zeta potential, transmission electron microscopy observations, polydispersity index and coomassie bright blue staining. CCK-8, EdU, and flow cytometry assays were performed to evaluate the viability and apoptosis rates of HCT116 and HCT8 cells after treatment with SN38@MM-LPs. A cellular uptake assay was conducted to evaluate the internalization of SN-38@MM-LPs in vitro. Moreover, the biodistribution, therapeutic efficacy, and safety of SN-38@MM-LPs were further assessed in orthotopic HCT116 xenograft model mice. Results: Characterization results revealed that SN-38@MM-LPs possess a spherical morphology with a consistent size distribution (129 nm) and a drug loading efficiency of 5.54 +/- 0.73%. SN-38 curtailed the growth and promoted apoptosis in both HCT8 and HCT116 cells. The impact of SN-38 was accentuated when delivered via SN-38@LPs and SN-38@MM-LPs. Notably, in the orthotopic xenograft model, SN-38@MM-LPs manifested superior tumor-targeting capabilities and therapeutic outcomes. Additionally, SN-38@MM-LPs presented negligible hepatic toxicity. Conclusions: SN-38@MM-LPs showcased potent and targeted antitumor actions in CRC. Consequently, SN38@MM-LPs emerge as a potential nanoparticle formulation that could amplify the antitumor efficacy of SN38, simultaneously mitigating liver toxicity concerns.
期刊：
Journal of Environmental Radioactivity,2024年272:107331 ISSN：0265-931X
通讯作者：
Hong, CS
作者机构：
[Wen, Jiale; Xie, Bingbing; Hong, CS; Hong, Changshou; Wang, Hong; Wang, Yuhang] Univ South China, Sch Resources Environm & Safety Engn, Hengyang 421001, Peoples R China.;[Wang, Hong] Univ South China, Sch Nucl Sci & Technol, Hengyang 421001, Peoples R China.;[Wen, Jiale; Xie, Bingbing; Hong, Changshou; Wang, Hong; Wang, Yuhang] Univ South China, Hunan Prov Engn Technol Res Ctr Uranium Tailings T, Hengyang 421001, Peoples R China.
通讯机构：
[Hong, CS ] U;Univ South China, Sch Resources Environm & Safety Engn, Hengyang 421001, Peoples R China.
关键词：
Numerical simulation;Radon concentration field;Ramp;Temperature field
摘要：
By introducing the parameters of radon exhalation rate and radon diffusion coefficient, the distribution of radon concentration field on ramp under the condition of superposition of temperature field and flow field is simulated. The simulation results show that the distribution of radon concentration in the ramp under the condition of low-speed ventilation is greatly affected by the temperature field and flow field, and the change of radon exhalation caused by temperature is the main factor leading to the change of radon concentration in the ramp. The change of temperature will cause the overall increase of radon concentration in the ramp. Under the condition of constant flow field, the radon concentration in the chamber is more than two times higher than the average radon concentration in the ramp. Some areas severely exceeded the limit.
通讯机构：
[Yin, XH ] U;Univ South China, Sch Nursing, Hengyang, Hunan, Peoples R China.
关键词：
Prehabilitation;Frailty;Aged;Meta-analysis
摘要：
Objective: The study investigates the impact of preoperative rehabilitation on the surgical prognosis of frail older patients. Method: The effect sizes of all studies retrieved and included by the nine databases were analyzed and expressed as RR and WMD. Results: 8 studies with 902 participants met the criteria for inclusion. A significant reduction in total complications (RR = 0.84, 95 % CI = 0.73 to 0.97, P = 0.021) and the 6MWT after surgery (WMD = 74.76, 95 % CI = 44.75 to 104.77, P = 0.000) was observed in the prehabilitation group. But it had no differences in mortality(RR = 1.89, 95 % CI = 0.75 to 4.72, P = 0.176), readmission rates(RR = 1.04, 95 % CI = 0.56 to 1.91, P = 0.906) and LOS(WMD = -0.24, 95 % CI = -1.00 to 0.52, P = 0.540). Conclusions: Prehabilitation had positive effect on postoperative complications and functional recovery in frail older patients. (c) 2023 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
作者机构：
[Yu, Xiaoping; Niu, Yue; Zhang, Yi; Yang, Yanhui] Graduate Collaborative Training base of Hunan Cancer Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China;[Yu, Xiaoping; Yang, Xiaohuang; Bi, Feng; Wen, Lu; Zhang, Yi] Department of Diagnostic Radiology, The Affiliated Cancer Hospital of Xiangya School of Medicine & Hunan Cancer Hospital, Central South University, Changsha, Hunan, China;[Lin, Huashan] Department of Pharmaceutical Diagnosis, General Electric (GE) Healthcare, Changsha, Hunan, China
摘要：
BACKGROUND: Pulmonary sclerosing pneumocytoma (PSP) and pulmonary carcinoid (PC) are difficult to distinguish based on conventional imaging examinations. In recent years, radiomics has been used to discriminate benign from malignant pulmonary lesions. However, the value of radiomics based on computed tomography (CT) images to differentiate PSP from PC has not been well explored. PURPOSE: We aimed to investigate the feasibility of radiomics in the differentiation between PSP and PC. METHODS: Fifty-three PSP and fifty-five PC were retrospectively enrolled and then were randomly divided into the training and test sets. Univariate and multivariable logistic analyses were carried to select clinical predictor related to differential diagnosis of PSP and PC. A total of 1316 radiomics features were extracted from the unenhanced CT (UECT) and contrast-enhanced CT (CECT) images, respectively. The minimum redundancy maximum relevance and the least absolute shrinkage and selection operator were used to select the most significant radiomics features to construct radiomics models. The clinical predictor and radiomics features were integrated to develop combined models. Two senior radiologists independently categorized each patient into PSP or PC group based on traditional CT method. The performances of clinical, radiomics, and combined models in differentiating PSP from PC were investigated by the receiver operating characteristic (ROC) curve. The diagnostic performance was also compared between the combined models and radiologists. RESULTS: In regard to differentiating PSP from PC, the area under the curves (AUCs) of the clinical, radiomics, and combined models were 0.87, 0.96, and 0.99 in the training set UECT, and were 0.87, 0.97, and 0.98 in the training set CECT, respectively. The AUCs of the clinical, radiomics, and combined models were 0.84, 0.92, and 0.97 in the test set UECT, and were 0.84, 0.93, and 0.98 in the test set CECT, respectively. In regard to the differentiation between PSP and PC, the combined model was comparable to the radiomics model, but outperformed the clinical model and the two radiologists, whether in the test set UECT or CECT. CONCLUSIONS: Radiomics approaches show promise in distinguishing between PSP and PC. Moreover, the integration of clinical predictor (gender) has the potential to enhance the diagnostic performance even further.
作者：
Zhe Peng;Bernhard Gillissen;Max S. Schlaak;Tobias Sinnberg;Jürgen Eberle*;...
期刊：
International Journal of Molecular Sciences,2024年25(6):3453- ISSN：1422-0067
通讯作者：
Jürgen Eberle
作者机构：
Clinical Medicine, University of South China, Hengyang 421001, China;[Max S. Schlaak] Skin Cancer Centre Charité, Department of Dermatology and Allergy, Charité—Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany;[Bernhard Gillissen; Antje Richter] Department of Hematology, Oncology, and Tumor Immunology, Charité—Universitätsmedizin Berlin, 13125 Berlin, Germany;Division of Dermatooncology, Department of Dermatology, University of Tübingen, 72076 Tübingen, Germany;Author to whom correspondence should be addressed.
通讯机构：
[Jürgen Eberle] S;Skin Cancer Centre Charité, Department of Dermatology and Allergy, Charité—Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany<&wdkj&>Author to whom correspondence should be addressed.
摘要：
Recent advances in melanoma therapy have significantly improved the prognosis of metastasized melanoma. However, large therapeutic gaps remain that need to be closed by new strategies. Antiapoptotic Bcl-2 proteins critically contribute to apoptosis deficiency and therapy resistance. They can be targeted by BH3 mimetics, small molecule antagonists that mimic the Bcl-2 homology domain 3 (BH3) of proapoptotic BH3-only proteins. By applying in vitro experiments, we aimed to obtain an overview of the possible suitability of BH3 mimetics for future melanoma therapy. Thus, we investigated the effects of ABT-737 and ABT-263, which target Bcl-2, Bcl-xL and Bcl-w as well as the Bcl-2-selective ABT-199 and the Mcl-1-selective S63845, in a panel of four BRAF-mutated and BRAF-WT melanoma cell lines. None of the inhibitors showed significant effectiveness when used alone; however, combination of S63845 with each one of the three ABTs almost completely abolished melanoma cell survival and induced apoptosis in up to 50–90% of the cells. Special emphasis was placed here on the understanding of the downstream pathways involved, which may allow improved applications of these strategies. Thus, cell death induction was correlated with caspase activation, loss of mitochondrial membrane potential, phosphorylation of histone H2AX, and ROS production. Caspase dependency was demonstrated by a caspase inhibitor, which blocked all effects. Upregulation of Mcl-1, induced by S63845 itself, as reported previously, was blocked by the combinations. Indeed, Mcl-1, as well as XIAP (X-linked inhibitor of apoptosis), were strongly downregulated by combination treatments. These findings demonstrate that melanoma cells can be efficiently targeted by BH3 mimetics, but the right combinations have to be selected. The observed pronounced activation of apoptosis pathways demonstrates the decisive role of apoptosis in the loss of cell viability by BH3 mimetics.
期刊：
Journal of Cleaner Production,2024年446:141306 ISSN：0959-6526
通讯作者：
Xilong Xue
作者机构：
Key Discipline Laboratory for National Defense for Biotechnology in Uranium Mining and Hydrometallurgy, University of South China, Hengyang, 421001, Hunan, China;[Pengcheng Sun; Jiale Li; Yan He] School of Resources, Environment and Safety Engineering, University of South China, Hengyang, 421001, Hunan, China;National Key Laboratory of Ni&Co Associated Minerals Resources Development and Comprehensive Utilization, Jinchuan Group Co., Ltd., Jinchang, 737100, Gansu, China;[Xiao Zhang; Dexin Ding] Key Discipline Laboratory for National Defense for Biotechnology in Uranium Mining and Hydrometallurgy, University of South China, Hengyang, 421001, Hunan, China<&wdkj&>School of Resources, Environment and Safety Engineering, University of South China, Hengyang, 421001, Hunan, China;[Xilong Xue] School of Resources, Environment and Safety Engineering, University of South China, Hengyang, 421001, Hunan, China<&wdkj&>National Key Laboratory of Ni&Co Associated Minerals Resources Development and Comprehensive Utilization, Jinchuan Group Co., Ltd., Jinchang, 737100, Gansu, China
通讯机构：
[Xilong Xue] S;School of Resources, Environment and Safety Engineering, University of South China, Hengyang, 421001, Hunan, China<&wdkj&>National Key Laboratory of Ni&Co Associated Minerals Resources Development and Comprehensive Utilization, Jinchuan Group Co., Ltd., Jinchang, 737100, Gansu, China
摘要：
Heap leaching uranium tailings (HLUTs) contain radionuclides and sulfuric acid, presenting some challenges for the disposal of cemented HLUTs backfill (CUTB), including low stability and potential environmental contamination. In light of these issues, using a blend of cement clinker (CL) and high content phosphorus slag (PS) as binders to replace traditional cement for the preparation of green and cost-effective CUTB were proposed. The fluidity, setting time (ST), mechanical properties, Radon (Rn) exhalation rate, uranium (U) occurrence form, U (Ⅵ) leaching behavior, and microstructure of CUTB with different PS contents were investigated. The results showed that the fluidity, bleeding rate and ST of slurry (PS content >40%) met the filling requirements. The strength of PS-based CUTB was initially low, but rapidly increased in subsequent periods, surpassing 2 MPa at 28 d and 4.5 MPa at 90 d (with 50–70% PS content). Moreover, the Rn exhalation rates and U (Ⅵ) leaching levels of CUTB were far lower than the stipulated limits. When PS content exceeded 50%, the migratory uranium content in CUTB was below 10% with low migration risks. With the addition of PS, the amount and degree of polymerization of C–S–H gels in the matrix increased, while gypsum and CH content decreased. The S/S of U (Ⅵ) and SO42− was attributed to the combined effects of chemical immobilization of nascent minerals and physical adsorption/encapsulation of hydration products. Additionally, these hydrates effectively sealed micro-cracks on HLUTs particles surfaces and filled interlocking pores to decrease Rn exhalation. PS-based CUTB exhibited a high capacity increasing ratio and low cost. This research can promote the utilization of hazardous solid wastes such as HLUTs, reduce carbon dioxide emissions, and provide a theoretical basis for ensuring green and safe production in mining.
摘要：
BACKGROUND: Opa-interacting protein 5 antisense transcript 1 (OIP5-AS1) has been demonstrated to play vital roles in development and progression of tumors such as gastric cancer (GC). However, the detailed molecular mechanism of OIP5-AS1 has not been completely elucidated. Our study aimed to investigate the role and the epigenetic regulation mechanism of OIP5-AS1 in GC. METHODS: OIP5-AS1 expression in GC tissues was detected by RT-qPCR. Loss- and gain-of-function experiments were conducted to assess the biological function of OIP5-AS1 in vitro and in vivo. The interaction of OIP5-AS1 with insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) or heterogeneous nuclear nucleoprotein A1 (hnRNPA1) was verified by bioinformatics analysis, RNA pull-down assays, and RNA immunoprecipitation assays. RESULTS: In this study, we identified that OIP5-AS1 is specifically overexpressed in GC tumor tissues and cell lines and correlated with a poor prognosis. The loss of OIP5-AS1 suppressed the proliferation, migration, invasion, epithelial-mesenchymal transition (EMT), and glycolysis of GC cells, but the ectopic expression of OIP5-AS1 had the opposite impact. Meanwhile, knockdown of OIP5-AS1 inhibited tumor growth in patient-derived xenograft models, as well as repressed tumor metastasis. Mechanistically, IGF2BP3 could bind to OIP5-AS1 by N6-methyladenosine (m6A) modification sites on OIP5-AS1, thereby stabilizing OIP5-AS1. Moreover, OIP5-AS1 prevented Trim21-mediated ubiquitination and degradation of hnRNPA1, stabilizing hnRNPA1 protein and promoting the malignant progression of GC by regulating PKM2 signaling pathway. CONCLUSIONS: In conclusion, this study highlighted that OIP5-AS1 is an oncogenic m6A-modified long non-coding RNA (lncRNA) in GC and that IGF2BP3/OIP5-AS1/hnRNPA1 axis may provide a potential diagnostic or prognostic target for GC.
摘要：
Radon-222 (Rn-222) is a global indoor health issue. A total of 74 points were measured in the woodland and grassland with the RAD7 device on the Hongxiang Campus of the University of South China. The results showed that the Rn-222 flux (RF) was 39.0 +/- 30.3 mBq m(-2) s(-1 )and 39.7 +/- 29.3 mBq m(-2) s(-1) in the woodland and grassland, respectively. The value of RF map was lower than 50 mBq m(-2) s(-1) in most campus areas. The results serve as essential reference data for future( 222)Rn risk-health assessment and management strategies on the campus.
期刊：
CALPHAD-COMPUTER COUPLING OF PHASE DIAGRAMS AND THERMOCHEMISTRY,2024年84:102666 ISSN：0364-5916
通讯作者：
Huixin Liu<&wdkj&>Shiyi Wen
作者机构：
[Hui Yang; Shipeng Huang; Xiangyang Yin; Peiqiong Zhou; Qianhui Min; Yuling Liu; Yong Du] State Key Laboratory of Powder Metallurgy, Central South University, Changsha, Hunan, 410083, China;[Huixin Liu] School of Energy and Mechanical Engineering, Hunan University of Humanities, Science and Technology, Loudi, Hunan, 417000, China;School of Metallurgy and Environment, Central South University, Changsha, Hunan, 410083, China;[Changfa Du] School of Mathematics and Statistics, Changsha University of Science and Technology, Changsha, Hunan, 410114, China;School of Mechanical Engineering, University of South China, Hengyang, Hunan, 421001, China
通讯机构：
[Huixin Liu; Shiyi Wen] S;School of Energy and Mechanical Engineering, Hunan University of Humanities, Science and Technology, Loudi, Hunan, 417000, China<&wdkj&>State Key Laboratory of Powder Metallurgy, Central South University, Changsha, Hunan, 410083, China<&wdkj&>School of Metallurgy and Environment, Central South University, Changsha, Hunan, 410083, China
摘要：
Diffusion study of the Ni–Si–V system is significant for the establishment of kinetic database of Ni-based alloys. In this work, the diffusion couple experiment combined with the numerical inverse method was adopted to evaluate the diffusivities and atomic mobilities for the Ni–Si–V fcc phase with high throughput. We prepared 12 fcc Ni–Si–V diffusion couples, which were annealed at 1273, 1373 and 1473 K, and their composition profiles after annealing were then measured by EPMA (Electron Probe Microanalysis). Subsequently, inputting the measured composition profiles as well as the available thermodynamic descriptions into the numerical inverse method incorporated in the CALTPP (CALculation of ThermoPhysical Properties) software, the composition- and temperature-dependent diffusivities and atomic mobilities for the Ni–Si–V fcc phase were simultaneously evaluated. In order to verify the reliability of the present evaluations, the CALTPP-simulated diffusion behaviors such as composition profiles and diffusion paths were compared with the measured ones, demonstrating reasonable agreements with each other. Meanwhile, the high-throughput determinations of diffusivities were confirmed by the ones obtained by the Matano-Kirkaldy method. Furthermore, applying the presently obtained diffusivities and atomic mobilities in combination with thermodynamic descriptions of the Ni–Si–V fcc phase, their diffusion flux, two-dimensional composition profile, activation energy and pre-frequency factor were predicted. It is expected that the presently obtained diffusivities and atomic mobilities of the Ni–Si–V fcc phase can contribute to the establishment of kinetic database of Ni-based alloys for their high-efficiency material design.
作者机构：
[Liu, Li; He, Jingzhe; Wang, Jiaren; Li, Ruining; Li, Qimei; Zeng, Lin; Xiao, Lushan; Li, Yan; Hong, Chang; Cui, Hao] Southern Med Univ, Nanfang Hosp, Hepatol Unit, Guangdong Prov Key Lab Viral Hepatitis Res, Guangzhou, Peoples R China.;[Liu, Li; He, Jingzhe; Wang, Jiaren; Li, Ruining; Li, Qimei; Zeng, Lin; Xiao, Lushan; Li, Yan; Hong, Chang; Cui, Hao] Southern Med Univ, Nanfang Hosp, Dept Infect Dis, Guangzhou, Peoples R China.;[Liu, Li; Wang, Jiaren; Xiao, Lushan] Southern Med Univ, Nanfang Hosp, Big Data Ctr, Guangzhou, Peoples R China.;[Wang, Weizhen] Southern Med Univ, Nanfang Hosp, Dept Ultrasound, Guangzhou, Peoples R China.;[Zhu, Hongbo] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Med Oncol, Hengyang, Hunan, Peoples R China.
通讯机构：
[Xiao, LS ; Liu, L ; Zhu, H ] S;Southern Med Univ, Nanfang Hosp, Guangzhou 510515, Peoples R China.;Southern Med Univ, Nanfang Hosp, Big Data Ctr, Guangzhou 510515, Peoples R China.;Southern Med Univ, Nanfang Hosp, Hepatol Unit, Guangdong Prov Key Lab Viral Hepatitis Res, Guangzhou 510515, Peoples R China.;Southern Med Univ, Nanfang Hosp, Dept Infect Dis, Guangzhou 510515, Peoples R China.
关键词：
CCR;MSFLD;risk factor;UK Biobank
摘要：
OBJECTIVE: Metabolic dysfunction-associated steatotic liver disease (MASLD) affects many populations, and screening out the high-risk populations at an early stage is a challenge. As a sarcopenia index, the relationship between creatinine to cystatin C ratio (CCR) and MASLD remains unclear. This cross-sectional, prospective study aimed to explore the relationship between CCR and MASLD. Design Firstly, explored the correlation between CCR and MASLD in cross-sectional analyses. Then excluded the population with baseeline diagnosis of MASLD and analyzed the association with baseline CCR levels and the onset of MASLD in the population with available follow-up data. Univariate and multivariate logistic regression analyses were used to calculate odds ratios (ORs) to evaluate the association between CCR levels and MASLD. PATIENTS AND MEASUREMENTS: This study included 368,634 participants from the UK Biobank for cross-sectional and prospective analyses. The demographic characteristics and laboratory measurements of all participants were obtained from the UK Biobank. MASLD was diagnosed according to the multi-society consensus nomenclature. Hepatic steatosis was defined as FLI ≥60. RESULTS: We grouped the study participants according to CCR tertiles. In cross-sectional analyses, participants in CCR tertile 1 had the highest MASLD risk (OR: 1.070, 95%CI: 1.053-1.088, p < .001). And the similar association was observed in the prospective analyses (CCR tertile 1 OR: 1.340, 95%CI: 1.077-1.660, p = .009; CCR tertile 2 OR: 1.217, 95%CI: 1.021-1.450, p = .029, respectively). After stratification by gender, the significant association between CCR and the onset of MASLD was only observed in males (CCR tertile 1 OR: 1.639, 95%CI: 1.160-2.317, p = .005; CCR tertile 2 OR: 1.322, 95%CI: 1.073-1.628, p = .005, respectively). CONCLUSION: Our results indicated that lower CCR was significantly associated with higher risk of MASLD, based on which predictive models can be developed to screen populations at high risk of developing MASLD.
作者机构：
[Yufei Lei; Qi Li; Qian Li; Dongxiu He; Jinhua Xue; Lifu Liao; Jikai Wang] School of Chemistry and Chemical Engineering, School of Pharmaceutical Science, School of Public Health, Hunan Key Laboratory for the Design and Application of Actinide Complexes, University of South China, Hengyang, Hunan 421001, P. R. China;State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University, Changsha, Hunan 410082, P. R. China;[Xilin Xiao] School of Chemistry and Chemical Engineering, School of Pharmaceutical Science, School of Public Health, Hunan Key Laboratory for the Design and Application of Actinide Complexes, University of South China, Hengyang, Hunan 421001, P. R. China<&wdkj&>State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University, Changsha, Hunan 410082, P. R. China
通讯机构：
[Jikai Wang; Xilin Xiao] S;School of Chemistry and Chemical Engineering, School of Pharmaceutical Science, School of Public Health, Hunan Key Laboratory for the Design and Application of Actinide Complexes, University of South China, Hengyang, Hunan 421001, P. R. China<&wdkj&>School of Chemistry and Chemical Engineering, School of Pharmaceutical Science, School of Public Health, Hunan Key Laboratory for the Design and Application of Actinide Complexes, University of South China, Hengyang, Hunan 421001, P. R. China<&wdkj&>State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University, Changsha, Hunan 410082, P. R. China
摘要：
In this paper, nitrogen-doped carbon dots (NCDs) were synthesized via a facile hydrothermal method using gum arabic (GA) and tris(hydroxymethyl)methyl aminomethane (tris) as precursors. The resultant NCDs show uniform size distribution and stable optical performance. Then a fluorescent signal quenching probe based on NCDs was proposed for the quantitative detection of mercury ions (Hg2+). The developed fluorescent nanoprobe based on NCDs demonstrated a good linear relationship in the range of 10 to 120 μM (R2 = 0.99265) for toxic mercury(II), with a detection limit of 4.87 μM. Additionally, the present assay system could be efficiently used for the detection of Hg2+ in real water samples with a satisfactory recovery rate (96.11–104.04%). The metal-free NCDs, which exhibited little cytotoxicity, were successfully applied to in vitro fluorescence imaging of human triple negative breast cancer (TNBC) cells, achieving visualization of Hg2+ in cells. With good water solubility and biocompatibility, the nitrogen-doped carbon dots synthesized by this economical and ecologically friendly process are suitable for use in analytical testing and biological research.
期刊：
Fuzzy Sets and Systems,2024年479:108856 ISSN：0165-0114
通讯作者：
Liu, HL
作者机构：
[Xiao, Qizhen; Liu, Hongliang; Liu, HL; Luo, Zhiyong] Univ South China, Sch Math & Phys, Hengyang 421001, Peoples R China.;[Xiao, Qizhen; Liu, Hongliang; Liu, HL] Univ South China, Hunan Key Lab Math Modeling & Sci Comp, Hengyang 421001, Peoples R China.
通讯机构：
[Liu, HL ] U;Univ South China, Sch Math & Phys, Hengyang 421001, Peoples R China.;Univ South China, Hunan Key Lab Math Modeling & Sci Comp, Hengyang 421001, Peoples R China.
关键词：
Aperiodic DoS attacks;Resilient synchronization;Fixed-time stability;Fuzzy neural networks;Reaction-diffusion terms
摘要：
This work focuses on the resilient fixed -time synchronization of delayed fuzzy memristive reaction -diffusion neural networks under denial -of -service (DoS) attacks. To efficaciously tolerate the aperiodic DoS attacks, a new appropriate controller is designed to ensure the fixed -time resilient synchronization of the systems. Moreover, two mild sufficient conditions are first proposed and the constrained techniques of attacking intervals are employed to overcome the challenge of estimating the upper bound of the settling time under aperiodic DoS attacks. Lastly, an example is utilized to illustrate the effectiveness and feasibility of the theoretical result.
作者机构：
[Li, Ye; Zhang, Yuexin; Li, Chunquan; Zhao, Yu; Huang, Xuemei; Xie, Liyuan; Zhang, Guorui; Zhao, Jun; Fan, Shifan; Song, Chao] Univ South China, Hengyang Med Sch, Affiliated Hosp 1, Hengyang 421001, Hunan, Peoples R China.;[Li, Ye; Zhang, Yuexin; Li, Chunquan; Zhao, Yu; Huang, Xuemei; Xie, Liyuan; Zhang, Guorui; Zhao, Jun; Fan, Shifan; Song, Chao] Univ South China, Hengyang Med Sch, MOE Key Lab Rare Pediat Dis, Hengyang 421001, Hunan, Peoples R China.;[Li, Ye; Zhang, Yuexin; Zhang, Qinyi; Li, Chunquan; Zhao, Yu; Huang, Xuemei; Xie, Liyuan; Zhang, Guorui; Fan, Shifan; Song, Chao] Univ South China, Sch Comp, Hengyang 421001, Hunan, Peoples R China.;[Li, Chunquan] Univ South China, Hunan Prov Maternal & Child Hlth Care Hosp, Hengyang Med Sch, Key Lab Birth Defect Res & Prevent,Natl Hlth Commi, Hengyang 421001, Hunan, Peoples R China.;[Li, Ye; Zhang, Yuexin; Li, Chunquan; Zhao, Yu; Huang, Xuemei; Xie, Liyuan; Zhang, Guorui; Fan, Shifan; Song, Chao] Univ South China, Affiliated Hosp 1, Cardiovasc Lab Big Data & Imaging ArtificialIntell, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.
通讯机构：
[Li, CQ ] U;Univ South China, Hengyang Med Sch, Affiliated Hosp 1, Hengyang 421001, Hunan, Peoples R China.;Univ South China, Hengyang Med Sch, MOE Key Lab Rare Pediat Dis, Hengyang 421001, Hunan, Peoples R China.;Univ South China, Sch Comp, Hengyang 421001, Hunan, Peoples R China.;Univ South China, Hunan Prov Maternal & Child Hlth Care Hosp, Hengyang Med Sch, Key Lab Birth Defect Res & Prevent,Natl Hlth Commi, Hengyang 421001, Hunan, Peoples R China.
关键词：
genes;mice;candidate disease gene;inference;multiomics;oncogenes;enhancer of transcription;cell lines;transcription factor
摘要：
Gene regulatory networks (GRNs) are interpretable graph models encompassing the regulatory interactions between transcription factors (TFs) and their downstream target genes. Making sense of the topology and dynamics of GRNs is fundamental to interpreting the mechanisms of disease etiology and translating corresponding findings into novel therapies. Recent advances in single-cell multi-omics techniques have prompted the computational inference of GRNs from single-cell transcriptomic and epigenomic data at an unprecedented resolution. Here, we present scGRN (https://bio.liclab.net/scGRN/), a comprehensive single-cell multi-omics gene regulatory network platform of human and mouse. The current version of scGRN catalogs 237 051 cell type-specific GRNs (62 999 692 TF-target gene pairs), covering 160 tissues/cell lines and 1324 single-cell samples. scGRN is the first resource documenting large-scale cell type-specific GRN information of diverse human and mouse conditions inferred from single-cell multi-omics data. We have implemented multiple online tools for effective GRN analysis, including differential TF-target network analysis, TF enrichment analysis, and pathway downstream analysis. We also provided details about TF binding to promoters, super-enhancers and typical enhancers of target genes in GRNs. Taken together, scGRN is an integrative and useful platform for searching, browsing, analyzing, visualizing and downloading GRNs of interest, enabling insight into the differences in regulatory mechanisms across diverse conditions. Graphical Abstract
期刊：
Case Studies in Thermal Engineering,2024年53:103820 ISSN：2214-157X
通讯作者：
He, Danqiu;Isa, MHM
作者机构：
[Isa, Mohd Hafizal Mohd; Isa, MHM; He, Danqiu; He, DQ] Univ Sains Malaysia, Sch Housing Bldg & Planning, George Town 11800, Malaysia.;[He, Danqiu] Univ South China, Solux Coll Architecture & Design, Hengyang 421001, Peoples R China.
通讯机构：
[Isa, MHM ; He, DQ] U;Univ Sains Malaysia, Sch Housing Bldg & Planning, George Town 11800, Malaysia.
关键词：
Indoor thermal comfort;Heritage building;Neutral temperature;Sustainable development
摘要：
The heritage buildings of a country or region are frequently considered to be of value and sig-nificance to the current generation. This study investigates the winter indoor thermal comfort of heritage buildings in hot summer and cold winter zone of China. Field measurements and questionnaire surveys were used to conduct specific studies on the winter indoor thermal comfort of two typical traditional residential buildings ("Yinziwu" and "Diaojiaolou") in the Yuan River basin heritage building area. The aim is to investigate the current status of building thermal comfort and provide a theoretical basis for promoting their sustainable development. The results show that 1) Indoor air temperatures in both types of buildings are significantly and positively correlated in winter, but both are below the human thermal comfort range. 2) Mean air temperatures measured in "Yinziwu" and "Diaojiaolou" are 8.8 degrees C and 9.4 degrees C, respectively, with neutral air temperatures of 11.1 degrees C and 13.8 degrees C. 3) Thermal sensation, thermal preference, and thermal comfort were significantly correlated in the two buildings, with ooccupants experiencing the coldest phase from 7:00-11:00 and the warmest phase from 15:00-19:00 daily. 4) "Yinziwu" occupants are more tolerant of the cold climate.
