Carboxylesterase-activated near-infrared fluorescence probe for highly sensitive imaging of liver tumors

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成果类型：

期刊论文

作者：

Jiang, Renfeng;Xia, Yuqing;Liu, Qian;Zhang, Hongshuai;Yang, Xuefeng;...

通讯作者：

Cheng, D;He, Longwei

作者机构：

[Cheng, Dan; He, Longwei; He, LW; Jiang, Renfeng] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dru, Sch Pharmaceut Sci, Hengyang Med Sch, Hengyang 421002, Hunan, Peoples R China.

[Cheng, Dan; Zhang, Hongshuai; Yang, Xuefeng] Univ South China, Affiliated Nanhua Hosp, Hengyang Med Sch, Dept Gastroenterol, Hengyang 421002, Hunan Prov, Peoples R China.

[Cheng, Dan; Liu, Qian; Zhang, Hongshuai; Yang, Xuefeng; Xia, Yuqing] Univ South China, Affiliated Nanhua Hosp, Hunan Prov Clin Res Ctr Metab Associated Fatty Liv, Hengyang Med Sch, Hengyang 421002, Hunan, Peoples R China.

通讯机构：

[Cheng, D ; He, LW] U

Univ South China, Affiliated Nanhua Hosp, Hengyang Med Sch, Dept Gastroenterol, Hengyang 421002, Hunan Prov, Peoples R China.

Univ South China, Affiliated Nanhua Hosp, Hunan Prov Clin Res Ctr Metab Associated Fatty Liv, Hengyang Med Sch, Hengyang 421002, Hunan, Peoples R China.

Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dru, Sch Pharmaceut Sci, Hengyang Med Sch, Hengyang 421002, Hunan, Peoples R China.

语种：

英文

期刊：

JOURNAL OF MATERIALS CHEMISTRY B

ISSN：

2050-750X

年：

2024

卷：

期：

页码：

1530-1537

DOI：

10.1039/d3tb02759g

基金类别：

Natural Science Foundation of Hunan Province [2022JJ10042, 2022JJ30484]; Hunan Provincial Natural Science Foundation of China [2021RC3108]; Science and Technology Project of Hunan Province [2021SK4031]; Special Funding for the Construction of Innovative Provinces in Hunan [2020T130184]; China Postdoctoral Science Foundation

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Carboxylesterases (CESs) are critical for metabolizing ester-containing biomolecules and are specifically important in liver metabolic disorders. The modulation of CESs is also an important issue in pharmacology and clinical applications. Herein, we present a near-infrared (NIR) CES fluorescent probe (NCES) based on the protection-deprotection of the hydroxyl group for monitoring CES levels in living systems. The NCES probe has good selectivity and sensitivity for CESs with a limit of detection (LOD) of 5.24 mU mL-1, which allows for tracing the fluctuation of cellular CES after treatment with...

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Carboxylesterase-activated near-infrared fluorescence probe for highly sensitive imaging of liver tumors

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