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Ferroptosis is Involved in the Pharmacological Effect of Ginsenoside

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成果类型:
期刊论文
作者:
Feng, Juling;Chen, Haodong;Liu, Yangbo;Ai, Qidi;Yang, Yantao;...
通讯作者:
Chu, Shifeng;Chen, NH
作者机构:
[Ai, Qidi; Chen, Haodong; Feng, Juling; Yang, Yantao; Chen, Naihong; Liu, Yangbo] Hunan Univ Chinese Med, Changsha 410208, Hunan, Peoples R China.
[Ai, Qidi; Chen, Haodong; Feng, Juling; Yang, Yantao; Chen, Naihong; Liu, Yangbo] Hunan Engn Technol Ctr Standardizat & Funct Chine, Changsha 410208, Hunan, Peoples R China.
[Chen, Naihong; Chu, Shifeng; Chen, NH] Chinese Acad Med Sci & Peking Union Med Coll, Inst Mat Medica & Neurosci Ctr, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China.
[Zhao, Lei] Univ South China, Hengyang Med Coll, Res Lab Translat Med, Hengyang 421001, Hunan, Peoples R China.
[He, Wenbin] Shanxi Univ Tradit Chinese Med, Shanxi Key Lab Tradit Chinese Med Encephalopathy, Taiyuan 030024, Peoples R China.
通讯机构:
[Chu, SF; Chen, NH ] C
Chinese Acad Med Sci & Peking Union Med Coll, Inst Mat Medica & Neurosci Ctr, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China.
语种:
英文
关键词:
Ginsenoside;ferroptosis;pharmacological target;iron metabolism;lipid metabolism;amino acid metabolism
期刊:
MINI-REVIEWS IN MEDICINAL CHEMISTRY
ISSN:
1389-5575
年:
2024
卷:
24
期:
13
页码:
1228-1237
基金类别:
National Natural Science Foundation of China [81873026, 82074044, 81730096]; Beijing Natural Science Foundation [7192135]; Key R&D Program of Shanxi Province [201803D421006]; Health and Family Planning Commission of Hunan Province [202104010694]; Natural Science Foundation of Hunan Province [2022JJ80028]
机构署名:
本校为其他机构
院系归属:
医学院
摘要:
Abstract: Ginsenoside is the principal active ingredient in ginseng. Several investigations have found that ginsenosides have anti-inflammatory, antioxidant, anti-apoptotic, anti-cancer, and antiallergic activities. Ferroptosis is an iron-dependent, non-apoptotic form of cell-regulated death caused by lipid peroxidation. Iron, lipid, and amino acid metabolism orchestrate the complex ferroptosis response through direct or indirect regulation of iron accumulation or lipid peroxidation. More and more research has demonstrated that ginsenoside impacts illnesses via ferroptosis, implying that ferr...

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