Genistein Alleviates Dextran Sulfate Sodium-induced Ulcerative Colitis in Mice by Regulating Th17/Treg Cell Balance: Implication for the G Protein-coupled Estrogen Receptor

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成果类型：

期刊论文

作者：

Shu, Baolian;Wu, Youxing;Wang, Xiaoyang;Hu, Jianlan;Zhang, Danxia;...

通讯作者：

Gui, RH

作者机构：

[Gui, Ruohu; Zhang, Danxia; Wu, Youxing; Shu, Baolian; Wang, Xiaoyang; Hu, Jianlan] Cent Hosp Hengyang City, Dept Gastroenterol, Hengyang, Hunan, Peoples R China.

[Gong, Xianghao] Cent Hosp Hengyang City, Dept Med Oncol, Hengyang, Hunan, Peoples R China.

[He, Saiqi] Cent Hosp Hengyang City, Dept Gen Surg, Hengyang, Hunan, Peoples R China.

[Chen, Xuan; Xie, Yangzhi] Univ South China, Affiliated Nanhua Hosp, Hengyang Med Sch, Dept Neurosci, Hengyang, Hunan, Peoples R China.

[Gui, Ruohu; Gui, RH] Cent Hosp Hengyang City, Dept Gastroenterol, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Gui, RH ] C

Cent Hosp Hengyang City, Dept Gastroenterol, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

Genistein;ulcerative colitis;Th17/Treg balance;G protein-coupled estrogen receptor

期刊：

Pharmacognosy Magazine

ISSN：

0973-1296

年：

2024

DOI：

10.1177/09731296231217599

基金类别：

Provincial Natural Science Foundation of Hunan [2020JJ8002]

机构署名：

本校为其他机构

摘要：

Objectives: This study aimed to evaluate the therapeutic effects and mechanism of genistein on dextran sulfate sodium-induced mouse model of ulcerative colitis (UC).Materials and Methods: A DSS-induced mouse model for UC was used in this study. Mice were then treated with genistein or a combination of genistein and the G protein-coupled estrogen receptor (GPER) antagonist G15. Colon length, disease activity index (DAI), spleen index (SI), histopathological alterations, and integrity of the colonic barrier were evaluated. The expression of inflammatory cytokines and antioxidant capacity were de...

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Genistein Alleviates Dextran Sulfate Sodium-induced Ulcerative Colitis in Mice by Regulating Th17/Treg Cell Balance: Implication for the G Protein-coupled Estrogen Receptor

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