摘要：
How to fabricate a multifunctional coating with controllable ultralow refractive index (RI), high antifogging and anticorrosion performances by a facile method is still one of the great challenges. In this work, a simple and time-saving approach involving a microwave-assisted sol-sel process was developed to fabricate a novel core-shell structured silica nanoparticle sol by co-condensation of perfluorodecyltriethoxysilane (F-DTOS) and tetraethoxysilane (TEOS) and self-condensation of F-DTOS. Results suggest that both the co-condensations and self-condensations not only give a layer of low surface energy -C10H4F17 groups on the silica particles but also enlarge the hybrid silica particle size, providing more and larger voids to form the high porosity. After spinning the silica nanoparticles on the substrate, the obtained optical coating exhibits the controllable ultralow refractive index (RI) and outstanding transparency. The minimum RI and maximum transmittance of our developed coating is up to similar to 1.04 and similar to 100 %, respectively. Moreover, because of the high porosity and the presence of low surface energy -C10H4F17 groups in the coating, the coating has the high hydrophobicity (water contact angle similar to 108.8 degrees), which not only makes it excellent antifogging performance but also affords it high-efficient anticorrosion property. After immersion in a 3.5 wt% NaCl solution for 7 days, the R-ct value of the coating could be higher than 7.3 x 10(4) Omega cm(2). It is believed that our developed method used to fabricate such multifunctional coating does not need any costly equipments, complex steps and time-consuming, making it well suited for industrial application.
作者机构：
[Wang, Ang; Ma, Demiao; Ge, Jia] Zhengzhou Univ, Coll Chem, Zhengzhou 450001, Peoples R China.;[Li, Jingxian; Ma, Demiao; Cai, Ren] Hunan Univ, Coll Chem & Chem Engn, Coll Biol Coll Mat Sci & Engn, Mol Sci & Biomed Lab,State Key Lab Chemo Biosensin, Changsha 410082, Peoples R China.;[Li, Jingxian; Ma, Demiao; Cai, Ren] Hunan Univ, Collaborat Res Ctr Mol Engn Theranost, Changsha 410082, Peoples R China.;[Zhai, Wenlei] Beijing Acad Agr & Forestry Sci, Inst Qual Stand & Testing Technol, Beijing 100097, Peoples R China.;[Yang, Hongfen] Univ South China, Sch Publ Hlth, Hengyang Med Sch, Hunan Key Lab Typ Environm Pollut & Hlth Hazards, Hengyang 421001, Peoples R China.
通讯机构：
[Ma, Demiao] M;[Zhai, Wenlei] I;[Ma, Demiao] C;Institute of Quality Standard and Testing Technology, Beijing Academy of Agriculture and Forestry Sciences, Beijing 100097, China<&wdkj&>College of Chemistry, Zhengzhou University, Zhengzhou 450001, P.R. China<&wdkj&>Molecular Science and Biomedicine Laboratory, State Key Laboratory for Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Biology College of Material Science and Engineering, and Collaborative Research Center of Molecular Engineering for Theranostics, Hunan University, Changsha, China
摘要：
Ferroptosis has been linked to the pathogenesis of hepatic injury induced by ischemia/reperfusion (I/R). However, the mechanistic basis remains unclear. In this study, by using a mouse model of hepatic I/R injury, it is observed that glutathione (GSH) and cysteine depletion are associated with deficiency of the reducing power of nicotinamide adenine dinucleotide phosphate (NADPH). Genes involved in maintaining NADPH homeostasis are screened, and it is identified that I/R-induced hepatic ferroptosis is significantly associated with reduced expression and activity of NADP(+)-dependent malic enzyme 1 (Me1). Mice with hepatocyte-specific Me1 gene deletion exhibit aggravated ferroptosis and liver injury under I/R treatment; while supplementation with L-malate, the substrate of ME1, restores NADPH and GSH levels and eventually inhibits I/R-induced hepatic ferroptosis and injury. A mechanistic study further reveals that downregulation of hepatic Me1 expression is largely mediated by the phosphatase and tensin homologue (PTEN)-dependent suppression of the mechanistic target of rapamycin/sterol regulatory element-binding protein 1 (mTOR/SREBP1) signaling pathway in hepatic I/R model. Finally, PTEN inhibitor, mTOR activator, or SREBP1 over-expression all increase hepatic NADPH, block ferroptosis, and protect liver against I/R injury. Taken together, the findings suggest that targeting ME1 may provide new therapeutic opportunities for I/R injury and other ferroptosis-related hepatic conditions.
作者机构：
[Song, Fengmei; Tang, Xiaomin; Cao, Yi; Zhao, Weichao] Univ South China, Sch Publ Hlth, Hengyang Med Sch, Hunan Prov Key Lab Typ Environm Pollut & Hlth Haza, Hengyang 421001, Peoples R China.;[Huang, Chaobo] Nanjing Forestry Univ NFU, Coll Chem Engn, Nanjing 210037, Peoples R China.;[Dai, Xuyan] Hunan Agr Univ, Econ Coll, Changsha 410128, Peoples R China.
通讯机构：
[Yi Cao] H;Hunan Province Key Laboratory of Typical Environmental Pollution and Health Hazards, School of Public Health, Hengyang Medical School, University of South China, Hengyang 421001, China
作者机构：
[Yang, Shengyuan; Tan, Yan; Su, Wenen; Liu, Jinquan; Fan, Pengfei; Li, Qianji] Univ South China, Sch Publ Hlth, Hengyang Med Sch, Dept Publ Hlth Lab Sci, Hengyang 421001, Hunan, Peoples R China.;[Wu, Xiwen] Yueyang Cty Ctr Dis Control & Prevent, Yueyang 414100, Hunan, Peoples R China.;[Zhang, Xiaohuan] Yongding Dist Ctr Dis Control & Prevent, Zhangjiajie 427000, Hunan, Peoples R China.
通讯机构：
[Li, Qianji] D;Department of Public Health Laboratory Sciences, School of Public Health, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, People's Republic of China.
作者机构：
[Gao Xiao-yu; Qian Duo; Hu Cong-cong; Yang Sheng-yuan; Liu Zhi-yuan; Liu Bin; Su Wen-en; Yi Yu-xin] Univ South China, Sch Publ Hlth, Hengyang 421001, Peoples R China.
通讯机构：
[Yang, SY ] U;Univ South China, Sch Publ Hlth, Hengyang 421001, Peoples R China.
摘要：
炭疽杆菌是高致病性病原微生物, 引起的炭疽病在我国属于乙类传染病, 因此建立操作简便、 灵敏准确的炭疽杆菌检测方法对预防和控制炭疽传播, 维护公共卫生安全至关重要。 该研究创新性地提出以绿色材料大豆蛋白为保护剂和还原剂, 采用微波加热法合成了一种具有强烈红色荧光发射的大豆蛋白金纳米簇(SPI-AuNCs)。 采用TEM、 UV-Vis、 FL、 XPS、 FTIR等方法表征了SPI-AuNCs的成功合成和部分特殊性能。 结果表明SPI-AuNCs呈球形, 粒径大小在1.8~3.2 nm范围内, 平均粒径为2.65 nm, 在500～550 nm范围内未出现表面等离子体共振峰; SPI-AuNCs的最大激发波长为370 nm, 最大发射波长为680 nm。 SPI-AuNCs的表面官能团主要有—NH、 —COOH、 —OH、 —SH等官能团, 元素的组成主要包括C、 N、 O、 S、 Au元素。 根据Cu2+与SPI-AuNCs表面基团通过配位作用形成非荧光复合物, 使荧光猝灭; 而2,6-吡啶二羧酸(DPA)与Cu2+具有更高的亲和力, 可将Cu2+从SPI-AuNCs表面竞争下来, 使荧光恢复, 据此建立了一种荧光“关-开”策略检测DPA的新方法。 在最佳实验条件下, 荧光恢复率(ΔF/F1)与DPA的浓度在1.15～70.0 μmol·L-1范围内呈良好的线性关系, 线性方程为ΔF/F1=0.011c+0.131, 相关系数r=0.991, 方法检出限为0.34 μmol·L-1。 同时, 通过加标回收实验研究了湖水和牛奶样品中DPA, 得到加标回收率在97.3%～103.6%, 表明了该方法在环境和食品样本DPA的检测中具有很大的应用潜力, 可以为环境监测和食品安全提供方法学支持。 Bacillus anthracis is a highly pathogenic microorganism. Anthrax is an infectious disease caused by Bacillus anthracis, classified as Class B of our country’s statutory reporting infectious diseases. Therefore, the establishment of simple operation, rapid and sensitive detection methods for Bacillus anthracis is vital for preventing and contralling the spread of anthrax and maintaining public health security. This study innovatively proposed to synthesize soy protein gold nanoclusters (SPI-AuNCs) with strong red fluorescence emission by microwave heating using the green material soy protein as a protective agent and reducing agent.TEM, XPS, FTIR, FL, and UV-Vis characterizations were used to verify successful synthesis of SPI-AuNCs. SPI-AuNCs are spherical, which the particle size is in the range of 1.8～3.2 nm, an average diameter of 2.65 nm, and no surface plasma resonance absorption from 500 to 550 nm. The maximum excitation wavelength of SPI-AuNCs is 370 nm, and the maximum emission wavelength appears at 680 nm. The surface functional groups of SPI-AuNCs mainly include —NH, —COOH, —OH, —SH, and the element composition includes C, N, O, S, Au elements. The fluorescence of SPI-AuNCs could be quenched by the coordination between Cu2+ and surface groups of SPI-AuNCs, while DPA has a stronger chelation effect with Cu2+, which could compete for Cu2+ from the surface of SPI-AuNCs and restore the fluorescence of SPI-AuNCs. Accordingly, a new method for DPA detection based on the fluorescent “off-on” strategy was established. Under the optimal experimental conditions, the fluorescence recovery efficiency (ΔF/F1) performs a good linear relationship with DPA concentration in the range of 1.15~70.0 μmol·L-1. The linear regression equation is ΔF/F1=0.011c+0.131 with high correlation coefficient (r=0.991), and the detection limit is 0.34 μmol·L-1. In addition, the spiking experiments of the DPA in lake water and milk samples were performed. The spiked recoveries were 97.3%~103.6%, indicating that this method has great application potential in DPA detection for environmental and food samples, and can provide methodological guidance for environmental monitoring and food safety.
通讯机构：
[Jianming Pan] I;[Lizhang Xu; Xiangheng Niu] S;School of Agricultural Engineering, Jiangsu University, Zhenjiang 212013, China<&wdkj&>School of Agricultural Engineering, Jiangsu University, Zhenjiang 212013, China<&wdkj&>Institute of Green Chemistry and Chemical Technology, School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, China<&wdkj&>School of Public Health, Hengyang Medical School, University of South China, Hengyang 421001, China<&wdkj&>Institute of Green Chemistry and Chemical Technology, School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, China
作者机构：
[Liu, Jie; Yang, Shengyuan; Du, Wenfang; Tan, Yan; Li, Hong; Luo, Jie; Feng, Qianqian; Deng, Chenyi; Xiao, Fubing] Univ South China, Sch Publ Hlth, Hengyang Med Sch, Dept Publ Hlth Lab Sci,Hunan Key Lab Typ Environm, Hengyang 421001, Peoples R China.;[Du, Wenfang; Wu, Zhaoyang; Xiao, Fubing] Hunan Univ, Coll Chem & Chem Engn, State Key Lab Chemo Biosensing & Chemometr, Changsha 410082, Peoples R China.;[Du, Wenfang] Binzhou Univ, Coll Biol & Environm Engn, Binzhou 256600, Peoples R China.
通讯机构：
[Fubing Xiao] H;Hunan Key Laboratory of Typical Environmental Pollution and Health Hazards, Department of Public Health Laboratory Sciences, School of Public Health, Hengyang Medical School, University of South China, Hengyang 421001, China<&wdkj&>State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China
作者机构：
[Long, Xizi] Univ South China, Sch Key Lab Typ Environm Pollut & Hlth Hazards Hun, Sch Basic Med, Sch Publ Hlth,Hengyang Med Sch, Hengyang 421001, Peoples R China.;[Tokunou, Yoshihide; Long, Xizi; Okamoto, Akihiro] Int Ctr Mat Nanoarchitecton WPI MANA, Natl Inst Mat Sci, Tsukuba, Ibaraki 3050044, Japan.;[Tokunou, Yoshihide] Univ Tsukuba, Fac Life & Environm Sci, Tsukuba, Ibaraki 3058577, Japan.;[Okamoto, Akihiro] Hokkaido Univ, Grad Sch Chem Sci & Engn, Sapporo, Hokkaido 0608628, Japan.
通讯机构：
[Akihiro Okamoto] I;International Center for Materials Nanoarchitectonics (WPI-MANA), National Institute for Materials Science, 1-1 Namiki, Tsukuba, Ibaraki 305-0044, Japan<&wdkj&>Graduate School of Chemical Sciences and Engineering, Hokkaido University, North 13 West 8, Kitaku, Sapporo, Hokkaido 060-8628, Japan
关键词：
circular dichroism;electron transport;exciton coupling;mechanobiology;multi-heme cytochrome C
期刊：
Proceedings of SPIE - The International Society for Optical Engineering,2023年12715:119 ISSN：0277-786X
通讯作者：
Wu, Yan-Bin(wuyanbin@stu.usc.edu.cn)
作者机构：
[Wu, Yan-Bin] College of Computer Science, University of South China, Hunan, Hengyang, China;[Deng, Shu-Xiang] School of Public Health, University of South China, Hunan, Hengyang, China
通讯机构：
[Hao Liang; Sheng-yuan Yang] D;Department of Public Health Laboratory Sciences, School of Public Health, Hengyang Medical School, University of South China, Hengyang, China<&wdkj&>Department of Public Health Laboratory Sciences, School of Public Health, Hengyang Medical School, University of South China, Hengyang, China
通讯机构：
[Xilin Xiao] S;School of Chemistry and Chemical Engineering, School of Resource & Environment and Safety Engineering, School of Public Health, Hunan Key Laboratory for the Design and Application of Actinide Complexes, University of South China, Hengyang, Hunan 421001, P. R. China<&wdkj&>State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University, Changsha, Hunan 410082, P. R. China
摘要：
The widespread use of antibiotics results in harmful residues, posing a serious threat to ecosystems and human health. Given synergetic or antagonistic toxicological features often exist among different antibiotics, it is vital to develop methods to synchronously determine these contaminants. Herein, we develop a hand-held photoluminescent sensor array based on “turn-off” bimetallic lanthanide metal–organic frameworks (MOFs) to realize the identification and quantification of six common antibiotics. Three Tb/Eu-MOFs with different bimetallic proportions were synthesized and employed to provide signals toward multiple antibiotics based on their differential contributions to the photoluminescence quenching of these probes. By designing a 3D-printed smartphone-equipped signal capturing platform, tiny luminescence variations induced by different antibiotics were recorded and processed for the classification and identification of these targets via pattern recognition analysis. Compared to conventional sensor arrays requiring cumbersome signal reading instruments and complex sensing units, our platform really enables instrument-free in-field detection of multiple targets with only a basic material. The platform could identify not only single antibiotics in a wide level scope but also various combinations of two, three or even four antibiotics with good discrimination capacity. Differentiation of multiple antibiotics in river water, milk, and urine matrices was also demonstrated. Furthermore, over 90% accuracy was gained for unknown samples in double-blind tests. Our work offers a portable, low-cost, and high-performance tool to determine multiple antibiotics simultaneously, which will stimulate future exploration of hand-held sensor arrays with simple sensing elements for on-site analysis and point-of-care diagnosis.
The widespread use of antibiotics results in harmful residues, posing a serious threat to ecosystems and human health. Given synergetic or antagonistic toxicological features often exist among different antibiotics, it is vital to develop methods to synchronously determine these contaminants. Herein, we develop a hand-held photoluminescent sensor array based on “turn-off” bimetallic lanthanide metal–organic frameworks (MOFs) to realize the identification and quantification of six common antibiotics. Three Tb/Eu-MOFs with different bimetallic proportions were synthesized and employed to provide signals toward multiple antibiotics based on their differential contributions to the photoluminescence quenching of these probes. By designing a 3D-printed smartphone-equipped signal capturing platform, tiny luminescence variations induced by different antibiotics were recorded and processed for the classification and identification of these targets via pattern recognition analysis. Compared to conventional sensor arrays requiring cumbersome signal reading instruments and complex sensing units, our platform really enables instrument-free in-field detection of multiple targets with only a basic material. The platform could identify not only single antibiotics in a wide level scope but also various combinations of two, three or even four antibiotics with good discrimination capacity. Differentiation of multiple antibiotics in river water, milk, and urine matrices was also demonstrated. Furthermore, over 90% accuracy was gained for unknown samples in double-blind tests. Our work offers a portable, low-cost, and high-performance tool to determine multiple antibiotics simultaneously, which will stimulate future exploration of hand-held sensor arrays with simple sensing elements for on-site analysis and point-of-care diagnosis.
作者机构：
[Yang, Yunyin; Lv, Yitao; Li, Jingyan; Zhang, Yi; Zhang, Min] Northwest A&F Univ, Coll Food Sci & Engn, Yangling 712100, Shaanxi, Peoples R China.;[Wang, Jiacheng] Yangzhou Univ, Med Coll, Yangzhou 225009, Jiangsu, Peoples R China.;[Xiao, Xilin] Univ South China, Sch Publ Hlth, Hengyang Med Sch, Dept Publ Hlth Lab Sci, Hengyang 421001, Hunan, Peoples R China.
通讯机构：
[Xilin Xiao] D;[Min Zhang] C;College of Food Science and Engineering, Northwest A&F University, 22 Xinong Road, Yangling, Shaanxi 712100, China<&wdkj&>Department of Public Health Laboratory Sciences, School of Public Health, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China
期刊：
Sensors and Actuators B-Chemical,2023年380:133407 ISSN：0925-4005
通讯作者：
Yang, Hongfen(yanghf88@gmail.com)
作者机构：
[Li, Jingxian; Li, Run; Wang, Song; Cai, Ren; Tan, Weihong] Hunan Univ, Coll Mat Sci & Engn, Coll Chem & Chem Engn,Mol Sci & Biomed Lab, Coll Biol,State Key Lab Chemo Biosensing & Chemome, Changsha 410082, Peoples R China.;[Yang, Hongfen] Univ South China, Sch Publ Hlth, Hengyang Med Sch, Hunan Key Lab Typ Environm Pollut & Hlth Hazards, Hengyang 421001, Peoples R China.;[Tan, Weihong] Chinese Acad Sci, Univ Chinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp,Inst Basic Med & Canc IBMC, Hangzhou 310022, Zhejiang, Peoples R China.;[Tan, Weihong] Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Inst Mol Med, Shanghai 200240, Peoples R China.;[Tan, Weihong] Shanghai Jiao Tong Univ, Coll Chem & Chem Engn, Shanghai 200240, Peoples R China.
通讯机构：
[Hongfen Yang] H;[Run Li; Ren Cai] M;Hunan Key Laboratory of Typical Environmental Pollution and Health Hazards, School of Public Health, Hengyang Medical School, University of South China, Hengyang 421001, China<&wdkj&>Molecular Science and Biomedicine Laboratory, State Key Laboratory for Chemo/Bio-Sensing and Chemometrics, College of Material Science and Engineering, College of Chemistry and Chemical Engineering, College of Biology, Hunan University, Changsha 410082, China
摘要：
This work describes a novel "off-on" biosensor for super-sensitive and selective detection of aflatoxin B1 (AFB1). In the biosensor, electrochemiluminescence (ECL) and aggregation-induced emission (AIE) work together to enhance ECL performance by a dibenzo-[b,d]thiophene sulfone-based conjugated microporous polymer, and hairpin DNA1 (H1) and ferrocene (Fc)-apt act as the switches for the "off-on" mode. In the absence of target AFB1, the ECL signal is inhibited because of the steric-hindrance effect, and the biosensor remains in the "off" state. In the presence of AFB1, ECL signal recovery is observed caused by the specific recognition between the AFB1 and Fc-apt, i.e., the biosensor changes to the "on" state. Under optimal experimental conditions, AFB1 can be quantified from 1 pg center dot mL-1 to 1 mu g center dot mL-1 with an ultralow detection limit of 0.46 pg center dot mL-1 by the "off-on" biosensor. The biosensor exhibited good practicability for AFB1 assay in corn samples, thus providing a simple and sensitive method for monitoring food safety.
作者机构：
[Yu, Wenzhan; Xiao, Xilin] Univ South China, Sch Pharmaceut Sci, Hengyang 421001, Hunan, Peoples R China.;[Li, Qian; Liao, Lifu] Univ South China, Sch Chem & Chem Engn, Hengyang 421001, Hunan, Peoples R China.;[He, Liqiong; Zhou, Renlong; Xue, Jinhua] Univ South China, Sch Publ Hlth, Hengyang 421001, Hunan, Peoples R China.
通讯机构：
[Jinhua Xue; Xilin Xiao] S;School of Public Health, University of South China, Hengyang 421001, Hunan, PR China<&wdkj&>School of Pharmaceutical Science, University of South China, Hengyang 421001, Hunan, PR China
