Ultrasensitive determination of alpha-glucosidase activity using CoOOH nanozymes and its application to inhibitor screening

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成果类型：

期刊论文

作者：

Ma, Demiao*;Ge, Jia;Wang, Ang;Li, Jingxian;Yang, Hongfen;...

通讯作者：

Ma, Demiao;Zhai, Wenlei

作者机构：

[Wang, Ang; Ma, Demiao; Ge, Jia] Zhengzhou Univ, Coll Chem, Zhengzhou 450001, Peoples R China.

[Li, Jingxian; Ma, Demiao; Cai, Ren] Hunan Univ, Coll Chem & Chem Engn, Coll Biol Coll Mat Sci & Engn, Mol Sci & Biomed Lab,State Key Lab Chemo Biosensin, Changsha 410082, Peoples R China.

[Li, Jingxian; Ma, Demiao; Cai, Ren] Hunan Univ, Collaborat Res Ctr Mol Engn Theranost, Changsha 410082, Peoples R China.

[Zhai, Wenlei] Beijing Acad Agr & Forestry Sci, Inst Qual Stand & Testing Technol, Beijing 100097, Peoples R China.

[Yang, Hongfen] Univ South China, Sch Publ Hlth, Hengyang Med Sch, Hunan Key Lab Typ Environm Pollut & Hlth Hazards, Hengyang 421001, Peoples R China.

通讯机构：

[Ma, Demiao] M

[Zhai, Wenlei] I

[Ma, Demiao] C

Institute of Quality Standard and Testing Technology, Beijing Academy of Agriculture and Forestry Sciences, Beijing 100097, China<&wdkj&>College of Chemistry, Zhengzhou University, Zhengzhou 450001, P.R. China<&wdkj&>Molecular Science and Biomedicine Laboratory, State Key Laboratory for Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Biology College of Material Science and Engineering, and Collaborative Research Center of Molecular Engineering for Theranostics, Hunan University, Changsha, China

语种：

英文

期刊：

JOURNAL OF MATERIALS CHEMISTRY B

ISSN：

2050-750X

年：

2023

卷：

期：

页码：

2727-2732

DOI：

10.1039/d2tb02580a

基金类别：

Natural Science Foundation of Henan Province [212300410408]; Natural Science Foundation of Zhengzhou University [JC22261008]; National Natural Science Foundation of China [22004032]; Hunan Provincial Natural Science Foundation of China [2021JJ20020]; Innovation and Capacity-building Project by Beijing Academy of Agriculture and Forestry Science [KJCX20210407]

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本校为其他机构

院系归属：

公共卫生学院

摘要：

In this work, a novel method for the colorimetric sensing of alpha-glucosidase (alpha-Glu) activity was developed based on CoOOH nanoflakes (NFs), which exhibit efficient oxidase-mimicking activity. Colorless 3,3 ',5,5 '-tetramethylbenzidine (TMB) can be oxidized by CoOOH NFs into blue-colored oxidized TMB (oxTMB) in the absence of H2O2. l-Ascorbic acid-2-O-alpha-d-glucopyranose (AAG) can be hydrolysed by alpha-glucosidase to produce ascorbic acid, resulting in a significant decrease of catalytic activity of CoOOH NFs. Thus, a colorimetric alpha-glucosidase activity detection method was design...

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Ultrasensitive determination of alpha-glucosidase activity using CoOOH nanozymes and its application to inhibitor screening

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