Ultrasensitive determination of α-glucosidase activity using CoOOH nanozymes and its application to inhibitor screening

首页 > 成果 > 详情

认领

导出

Link by DOI

反馈

作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Ma, Demiao;Ge, Jia;Wang, Ang;Li, Jingxian;Yang, Hongfen;...

通讯作者：

Ge, Jia(jiage@zzu.edu.cn);Zhai, Wenlei(zhaiwl@iqstt.cn);Cai, Ren(cairen@hnu.edu.cn)

作者机构：

[Wang, Ang; Ma, Demiao; Ge, Jia] Zhengzhou Univ, Coll Chem, Zhengzhou 450001, Peoples R China.

[Li, Jingxian; Ma, Demiao; Cai, Ren] Hunan Univ, Coll Chem & Chem Engn, Coll Biol Coll Mat Sci & Engn, Mol Sci & Biomed Lab,State Key Lab Chemo Biosensin, Changsha 410082, Peoples R China.

[Li, Jingxian; Ma, Demiao; Cai, Ren] Hunan Univ, Collaborat Res Ctr Mol Engn Theranost, Changsha 410082, Peoples R China.

[Zhai, Wenlei] Beijing Acad Agr & Forestry Sci, Inst Qual Stand & Testing Technol, Beijing 100097, Peoples R China.

[Yang, Hongfen] Univ South China, Sch Publ Hlth, Hengyang Med Sch, Hunan Key Lab Typ Environm Pollut & Hlth Hazards, Hengyang 421001, Peoples R China.

通讯机构：

[Ma, Demiao] M

[Zhai, Wenlei] I

[Ma, Demiao] C

Institute of Quality Standard and Testing Technology, Beijing Academy of Agriculture and Forestry Sciences, Beijing 100097, China<&wdkj&>College of Chemistry, Zhengzhou University, Zhengzhou 450001, P.R. China<&wdkj&>Molecular Science and Biomedicine Laboratory, State Key Laboratory for Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Biology College of Material Science and Engineering, and Collaborative Research Center of Molecular Engineering for Theranostics, Hunan University, Changsha, China

语种：

英文

关键词：

Catalyst activity;Color;Colorimetry;Colorimetric sensing;D-glucopyranose;Glucosidase activity;Inhibitor screenings;ITS applications;L(+)-ascorbic acid;Nano-flakes;Novel methods;Tetramethylbenzidine;Ultrasensitive;Ascorbic acid;alpha glucosidase;HCoO2;hydrogen peroxide;oxide;oxidoreductase;human;alpha-Glucosidases;Humans;Hydrogen Peroxide;Oxides;Oxidoreductases

期刊：

JOURNAL OF MATERIALS CHEMISTRY B

ISSN：

2050-750X

年：

2023

卷：

期：

页码：

2727-2732

DOI：

10.1039/d2tb02580a

基金类别：

This work was supported by the Natural Science Foundation of Henan Province (212300410408), the Natural Science Foundation of Zhengzhou University (JC22261008), the National Natural Science Foundation of China (22004032), the Hunan Provincial Natural Science Foundation of China (2021JJ20020), and the Innovation and Capacity-building Project by Beijing Academy of Agriculture and Forestry Science (KJCX20210407).

机构署名：

本校为其他机构

院系归属：

公共卫生学院

摘要：

In this work, a novel method for the colorimetric sensing of α-glucosidase (α-Glu) activity was developed based on CoOOH nanoflakes (NFs), which exhibit efficient oxidase-mimicking activity. Colorless 3,3′,5,5′-tetramethylbenzidine (TMB) can be oxidized by CoOOH NFs into blue-colored oxidized TMB (oxTMB) in the absence of H2O2. l-Ascorbic acid-2-O-α-d-glucopyranose (AAG) can be hydrolysed by α-glucosidase to produce ascorbic acid, resulting in a significant decrease of catalytic activity of CoOOH NFs. Thus, a colorimetric α-glucosidase a...

反馈

产权有误：本人成果被他人认领

数据有误：数据基本信息有误

归属有误：成果的院系归属、机构署名归属有误

其他原因：

验证码：

看不清楚，换一个

确定

取消

成果认领

标题：

用户	作者	通讯作者	--
	请选择	请选择	--

确定

取消

Ultrasensitive determination of α-glucosidase activity using CoOOH nanozymes and its application to inhibitor screening

反馈

成果认领

提示

该栏目需要登录且有访问权限才可以访问