While Kruppel-like factors (KLFs) are known to regulate many basic processes of macrophages, their modulatory roles in nanomaterial (NM)-caused bio-effects in macrophages are unclear. Recently we reported diameter-dependent induction of cytotoxicity, inflammation and lipid accumulation by multi-walled carbon nanotubes (MWCNTs) in THP-1 macrophages in vitro, and hereby we further investigated the roles of KLFs. RNA-sequencing data showed that MWCNTs diameter-dependently up-regulated a number of KLFs, including KLF6, a transcription factor (TF) m...
