Malic Enzyme 1 as a Novel Anti‐Ferroptotic Regulator in Hepatic Ischemia/Reperfusion Injury (Adv. Sci. 13/2023)

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Fang, Xuexian;Zhang, Jiawei;Li, You;Song, Yijing;Yu, Yingying;...

通讯作者：

Fang, XX;Wang, FD

作者机构：

[Yang, Jun; Zhang, Jiawei; Li, You; Song, Yijing; Lian, Fuzhi; Fang, Xuexian] Hangzhou Normal Univ, Sch Publ Hlth, Dept Nutr & Toxicol, Key Lab Elemene Class Anticanc Chinese Med Zhejian, Hangzhou 311121, Peoples R China.

[Min, Junxia; Wang, Fudi; Yu, Yingying] Zhejiang Univ, Affiliated Hosp 2, Affiliated Hosp 1, Inst Translat Med,Sch Med,State Key Lab Expt Hemat, Hangzhou 310058, Peoples R China.

[Wang, Fudi] Univ South China, Affiliated Hosp 1, Sch Publ Hlth, Hengyang Med Sch,Basic Med Sci, Hengyang 421001, Peoples R China.

通讯机构：

[Wang, FD ] Z

[Fang, XX ] H

Hangzhou Normal Univ, Sch Publ Hlth, Dept Nutr & Toxicol, Key Lab Elemene Class Anticanc Chinese Med Zhejian, Hangzhou 311121, Peoples R China.

Zhejiang Univ, Affiliated Hosp 2, Affiliated Hosp 1, Inst Translat Med,Sch Med,State Key Lab Expt Hemat, Hangzhou 310058, Peoples R China.

Univ South China, Affiliated Hosp 1, Sch Publ Hlth, Hengyang Med Sch,Basic Med Sci, Hengyang 421001, Peoples R China.

语种：

英文

关键词：

ferroptosis;hepatic ischemia;reperfusion injury;malate;malic enzyme 1;nicotinamide adenine dinucleotide phosphate

期刊：

Advanced Science

ISSN：

2198-3844

年：

2023

卷：

期：

页码：

e2205436

DOI：

10.1002/advs.202205436

基金类别：

National Natural Science Foundation of China [82170644, 31970689, 31930057]; National Key Research and Development Program of China [2018YFA0507801, 2018YFA0507802]; Natural Science Foundation of Zhejiang Province [LR23H020001, LY22C110002]

机构署名：

本校为通讯机构

院系归属：

公共卫生学院

摘要：

Ferroptosis has been linked to the pathogenesis of hepatic injury induced by ischemia/reperfusion (I/R). However, the mechanistic basis remains unclear. In this study, by using a mouse model of hepatic I/R injury, it is observed that glutathione (GSH) and cysteine depletion are associated with deficiency of the reducing power of nicotinamide adenine dinucleotide phosphate (NADPH). Genes involved in maintaining NADPH homeostasis are screened, and it is identified that I/R-induced hepatic ferroptosis is significantly associated with reduced expression and activity of NADP(+)-dependent malic enzy...

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Malic Enzyme 1 as a Novel Anti‐Ferroptotic Regulator in Hepatic Ischemia/Reperfusion Injury (Adv. Sci. 13/2023)

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