C1q tumor necrosis factor-related protein 9 in atherosclerosis: Mechanistic insights and therapeutic potential
作者：
Yu, Xiao-Hua;Zhang, Da-Wei;Zheng, Xi-Long;Tang, Chao-Ke*
期刊：
Atherosclerosis ,2018年276:109-116 ISSN：0021-9150
通讯作者：
Tang, Chao-Ke
作者机构：
[Tang, Chao-Ke; Yu, Xiao-Hua] Univ South China, Inst Cardiovasc Res, Key Lab Atherosclerol Hunan Prov, Med Res Expt Ctr,Hunan Prov Cooperat Innovat Ctr, Hengyang 421001, Hunan, Peoples R China.;[Zhang, Da-Wei] Univ Alberta, Dept Pediat, Edmonton, AB, Canada.;[Zhang, Da-Wei] Univ Alberta, Grp Mol & Cell Biol Lipids, Edmonton, AB, Canada.;[Zheng, Xi-Long] Univ Calgary, Hlth Sci Ctr, Cumming Sch Med, Dept Biochem & Mol Biol,Libin Cardiovasc Inst Alb, 3330 Hosp Dr NW, Calgary, AB T2N 4N1, Canada.
通讯机构：
[Tang, Chao-Ke] U;Univ South China, Inst Cardiovasc Res, Key Lab Atherosclerol Hunan Prov, Med Res Expt Ctr,Hunan Prov Cooperat Innovat Ctr, Hengyang 421001, Hunan, Peoples R China.
关键词：
AdipoR1;Adiponectin;Atherosclerosis;CTRP9;N-cadherin
摘要：
C1q tumor necrosis factor-related protein 9 (CTRP9), a newly discovered adipokine, is the closest paralog of adiponectin. After proteolytic cleavage, it can release the globular domain (gCTRP9) that serves as the major circulatory isoform. Upon binding to adiponectin receptor 1 (AdipoR1) and N-cadherin, CTRP9 can activate a variety of signaling pathways to regulate glucose and lipid metabolism, vascular relaxation and cell differentiation. Circulating CTRP9 levels are significantly decreased in patients with coronary atherosclerosis disease. Data obtained from in vitro experiments and animal models suggest that CTRP9 exerts an atheroprotective effect by altering multiple pathological processes involved in atherosclerosis, including inflammation, foam cell formation, endothelial dysfunction, insulin resistance, and vascular smooth muscle cell dedifferentiation, proliferation and migration. In this review, we summarize the latest advances regarding the roles of CTRP9 in atherosclerosis with an emphasis on its potential as a novel therapeutic target in cardiovascular disease.
语种：
英文
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Ginnalin A from Kujin tea (: Acer tataricum subsp. ginnala) exhibits a colorectal cancer chemoprevention effect via activation of the Nrf2/HO-1 signaling pathway
作者：
Bi, Wu;He, Chun-nian;Li, Xiao-xiao;Zhou, Liu-ying;Liu, Rui-jie;...
期刊：
FOOD & FUNCTION ,2018年9(5):2809-2819 ISSN：2042-6496
通讯作者：
Zhang, Peng-fei
作者机构：
[Liu, Rui-jie; Bi, Wu; Li, Xiao-xiao; Zhang, Sai; Zhou, Liu-ying; Zhang, Peng-fei; Chen, Zhu-chu] Cent S Univ, Xiangya Hosp, Chinese Minist Hlth, Key Lab Canc Prote, Changsha 410008, Hunan, Peoples R China.;[He, Chun-nian] Chinese Acad Med Sci, Minist Educ, Inst Med Plant Dev, Key Lab Bioact Subst & Resources Utilizat Chinese, Beijing 100193, Peoples R China.;[He, Chun-nian] Peking Union Med Coll, Beijing 100193, Peoples R China.;[Li, Guo-qing] Univ South China, Sch Pharm & Life Sci, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Hunan, Peoples R China.
通讯机构：
[Zhang, Peng-fei] C;Cent S Univ, Xiangya Hosp, Chinese Minist Hlth, Key Lab Canc Prote, Changsha 410008, Hunan, Peoples R China.
摘要：
Ginnalin A (also known as acertannin) is one of the most important phenolic compounds of several beverage Acer plants. In this study, it is reported for the first time that ginnalin A is an activator of the Nrf2 signaling pathway in human colon cancer cells. Ginnalin A, isolated from the leaves of Acer tataricum subsp. ginnala, exhibited promising preventive activity against colon cancer cells (HCT116, SW480 and SW620) with IC50 values of 24.8 μM, 22.0 μM and 39.7 μM, respectively. In addition, it significantly reduced the colony formation of these cells. Flow cytometry analysis indicated that ginnalin A suppressed cancer proliferation via the induction of cell cycle arrest at the S-phase. Real time PCR analysis demonstrated that ginnalin A can upregulate the mRNA expression levels of Nrf2-related antioxidant genes Nrf2, HO-1 and NQO1. Western blotting analysis revealed that ginnalin A promoted the Nrf2 nuclear translocation and upregulated the proteins Nrf2, HO-1 and NQO1. Moreover, the upregulation of p62 and the inhibition of Keap1 were also found by Western blotting analysis. Therefore, the activation of the Nrf2 signaling pathway was probably induced through the upregulation of p62 and the inhibition of Keap1. © 2018 The Royal Society of Chemistry.
语种：
英文
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Synthetic Transformations of Alkenyl MIDA Boronates toward the Efficient Construction of Organoborons
作者：
Wang, Honggen* ;Zeng, Yao-Fu;Lv, Wen-Xin;Tan, Dong-Hang
期刊：
SYNLETT ,2018年29(11):1415-1420 ISSN：0936-5214
通讯作者：
Wang, Honggen
作者机构：
[Wang, Honggen; Lv, Wen-Xin; Tan, Dong-Hang] Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R China.;[Zeng, Yao-Fu] Univ South China, Inst Pharm & Pharmacol, Hengyang 421001, Peoples R China.
通讯机构：
[Wang, Honggen] S;Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R China.
关键词：
alkenes;boranes;organoboron compounds;oxidation;sp 3 hybridization
摘要：
The attachment of N-methyliminodiacetyl boron (MIDA boron) to alkenes leads to a new type of activated alkenes. Synthetic manipulation of the alkene double bond while retaining the boron moiety offers an unprecedented opportunity for the construction of organoborons. These reactions feature unique reactivity, good regioselectivity, and they can be used to access organoborons that are historically difficult to prepare. Herein, we give a brief summary of advances in the use of alkenyl MIDA boronates as starting materials for organoboron synthesis. Mechanisms are discussed where relevant.
语种：
英文
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Bromotrifluoromethane: A Useful Reagent for Hydrotrifluoro-methylation of Alkenes and Alkynes
作者：
Ren, Yu-Yan;Zheng, Xing* ;Zhang, Xingang*
期刊：
SYNLETT ,2018年29(8):1028-1032 ISSN：0936-5214
通讯作者：
Zheng, Xing;Zhang, Xingang
作者机构：
[Ren, Yu-Yan; Zheng, Xing] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Inst Pharm & Pharmacol, 28 Western Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.;[Zhang, Xingang] Chinese Acad Sci, Shanghai Inst Organ Chem, Ctr Excellence Mol Synth, Key Lab Organofluorine Chem, 345 Lingling Rd, Shanghai 200032, Peoples R China.
通讯机构：
[Zheng, Xing] U;[Zhang, Xingang] C;Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Inst Pharm & Pharmacol, 28 Western Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.;Chinese Acad Sci, Shanghai Inst Organ Chem, Ctr Excellence Mol Synth, Key Lab Organofluorine Chem, 345 Lingling Rd, Shanghai 200032, Peoples R China.
关键词：
bromotrifluoromethane;hydrotrifluoromethylation;alkenes;alkynes;visible-light-induced
摘要：
Bromotrifluoromethane (CF3Br) is a simple, inexpensive and abundant industrial material employed as a trifluoromethylating reagent. However, only limited strategies using CF3Br as a fluorine source are reported. Herein, we describe a visible-light-induced hydrotrifluoromethylation of alkenes and alkynes with CF3Br. The reaction proceeds under mild conditions with good functional group tolerance, providing a new route for the application of BrCF3 in organic synthesis.
语种：
英文
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A Selective Medium for Pyocyanin-dependent Fast Electrochemical Detection of Pseudomonas aeruginosa in Environmental Microbial Samples
作者：
Li, Shuihong* ;Mou, Qianqian;Feng, Nuozhou;Leung, Polly H. M.
期刊：
International Journal of Electrochemical Science ,2018年13(4):3789-3798 ISSN：1452-3981
通讯作者：
Li, Shuihong
作者机构：
[Li, Shuihong] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Peoples R China.;[Feng, Nuozhou; Mou, Qianqian; Li, Shuihong; Leung, Polly H. M.] Hong Kong Polytech Univ, Dept Hlth Technol & Informat, Hong Kong 999077, Hong Kong, Peoples R China.
通讯机构：
[Li, Shuihong] U;[Li, Shuihong] H;Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Peoples R China.;Hong Kong Polytech Univ, Dept Hlth Technol & Informat, Hong Kong 999077, Hong Kong, Peoples R China.
关键词：
Pseudomonas aeruginosa;pyocyanin;electrochemical detection;selective medium;differential pulse voltammetry
摘要：
In this work, a selective medium was developed for pyocyanina-dependent qualitative detection of Pseudomonas aeruginosa in raw microbial samples using electrochemical analysis. To obtain an optimum nutritive formulation, the effect of different media (BYEB, LB, SDB, MHB, TSB, and NB), positive ions (K+, Na+, Ca2+, Fe3+, and Mg2+) and selected additives (1-naphthylamine, acetamide, and benzylpenicillin sodium) on the amount of synthesized pyocyanin were investigated and compared. NB was found to be the most favourable medium for the electrochemical detection of pyocyanin, and Mg2+ was shown to be the most effective supporting additive ion for the detection. 1-Naphthylamine was shown to be the most effective supporting antibiotic reagent when supplied in the medium to enhancing the presence of pyocyanina compared to the other two antibiotics. The results indicated that the improved selective medium (ISM) can effectively inhibit/limit the growth of various microorganisms other than P. aeruginosa and obviously enhance the production of pyocyanin in environmental samples that contained P. aeruginosa. This study provided a method for simple and fast electrochemical detection of P. aeruginosa in complex microbial samples. © 2018 The Authors.
语种：
英文
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PIG11 over-expression predicts good prognosis and induces HepG2 cell apoptosis via reactive oxygen species-dependent mitochondrial pathway
作者：
Wang, Yan;Liu, Xiaomin;Liu, Gang;Wang, Xiaojuan;Hu, Rong;...
期刊：
Biomedicine & Pharmacotherapy ,2018年108:435-442 ISSN：0753-3322
通讯作者：
Liang, Xiaoqiu
作者机构：
[Wang, Yan] Nantong Univ, Affiliated Hosp, Dept Pathol, Nantong 226001, Peoples R China.;[Liang, Xiaoqiu; Liu, Xiaomin; Wang, Xiaojuan; Hu, Rong; Wang, Yan] Univ South China, Canc Res Inst, Hunan Prov Key Lab Tumor Cellular & Mol Pathol, Hengyang 421001, Hunan, Peoples R China.;[Liang, Xiaoqiu; Liu, Xiaomin; Wang, Xiaojuan; Hu, Rong; Wang, Yan] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Hunan, Peoples R China.;[Liu, Gang] Inner Mongolia Univ, Coll Biol Sci, Hohhot 010021, Neimenggu, Peoples R China.
通讯机构：
[Liang, Xiaoqiu] U;Univ South China, Canc Res Inst, Hunan Prov Key Lab Tumor Cellular & Mol Pathol, Hengyang 421001, Hunan, Peoples R China.
关键词：
PIG11;Apoptosis;Hepatocellular carcinoma (HCC);HepG2 cell;Reactive oxygen species (ROS);Mitochondria
摘要：
P53-induced protein 11 (PIG11), one of the primeval transcriptional targets of p53, is up-regulated in apoptosis induced by multiple chemopreventive agents and is involved in tumorigenesis or tumor development. Nevertheless, the clinical value and biological role of PIG11 in hepatocellular carcinoma (HCC) are still unknown. In the present article, we explored the expression pattern of PIG11 in HCC tumor tissues, the prognostic value of PIG11 for HCC patients, and the biological functions on the apoptosis of HepG2 cells. We discovered that high PIG11 expression was negatively associated with certain clinical characteristics, and higher expression of PIG11 resulted in better prognosis of patients with HCC. PIG11 over-expression induced HepG2 cell apoptosis through the mitochondrial pathway, and reactive oxygen species played a regulatory role in this process. Hence, PIG11 may act as a candidate liver tumor suppressor and exhibit potential as a novel prognostic biomarker for HCC.
语种：
英文
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Facile fabrication of a novel hybrid nanoparticles by self-assembling based on pectin-doxorubicin conjugates for hepatocellular carcinoma therapy
作者：
Ye, Peng-Ju;Huang, Can;Yang, Sa;Gao, Pei;Li, Zhi-Ping;...
期刊：
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY ,2018年46(sup3):S661-S670 ISSN：2169-1401
通讯作者：
Yu, Cui-Yun
作者机构：
[Huang, Can; Li, Zhi-Ping; Ye, Peng-Ju; He, Dong-Xiu; Xiang, Ya; Tang, Si-Yue; Chen, Yu-Ping; Yang, Sa; Liu, Yu-Feng; Yu, Cui-Yun] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Peoples R China.;[Ye, Peng-Ju; Yu, Cui-Yun; Gao, Pei] Univ South China, Inst Pharm & Pharmacol, Hengyang, Peoples R China.
通讯机构：
[Yu, Cui-Yun] U;Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Peoples R China.
关键词：
Drug delivery system;doxorubicin;hepatocellular carcinoma;macromolecular pro-drug;pectin-doxorubicin conjugates;solution self-assembling
摘要：
Hepatocellular carcinoma (HCC) is one of the greatest public health problems worldwide, and chemotherapy remains the major approach for the HCC treatment. Doxorubicin (DOX) is one of the anthracycline antibiotics but its clinical use is limited due to its severe cardiotoxicity. In this study, novel hybrid nanoparticles by self-assembling based on pectin-doxorubicin conjugates (PDC-NPs) were fabricated for HCC treatment. The stabilized structure of the PDC-NPs was characterized by methylene blue absorption, the size, zeta potential and the morphology, which was investigated by Zetasizer nanoparticle analyzer and transmission electron microscope (TEM), of nanoparticles. The PDC-NPs achieved a sustained and prolonged release ability, which was illustrated with in vitro drug release profiles, anti-cell proliferation study, cellular uptake assay and in vivo pharmacokinetics analysis. Biocompatibility of the PDC-NPs was assessed with bovine serum albumin (BSA) adsorption test, hemolysis activity examination and viability evaluation of human umbilical vein endothelial cells. Importantly, in vivo studies of the PDC-NPs, which were performed in the athymic BALB/c nude mice, demonstrated that the PDC-NPs significantly reduced the lethal side effect of DOX. Additionally, the H&E staining and serum biochemistry study further confirmed the excellent biological security of the PDC-NPs. © 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group.
语种：
英文
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Sortilin promotes macrophage cholesterol accumulation and aortic atherosclerosis through lysosomal degradation of ATP-binding cassette transporter A1 protein
作者：
Lv, Yuncheng;Yang, Jing;Gao, Anbo;Sun, Sha;Zheng, Xilong;...
期刊：
生物化学与生物物理学报 ,2018年51(5):471-483 ISSN：1672-9145
通讯作者：
Peng, Tianhong;Zhong, Liyuan;Zhao, Guojun
作者机构：
[Chen, Xi; Sun, Sha; Lv, Yuncheng; Wan, Wei; Gao, Anbo; Xie, Wei; Peng, Tianhong; Guo, Dongming; Zhong, Liyuan; Li, Suyun; Peng, TH] Univ South China, Clin Anat & Reprod Med Applicat Inst, Hengyang 421001, Peoples R China.;[Yang, Jing] Univ South China, Affiliated Hosp 1, Clin Med Res Inst, Hengyang 421001, Peoples R China.;[Zheng, Xilong] Univ Calgary, Libin Cardiovasc Inst Alberta, Dept Biochem & Mol Biol, Hlth Sci Ctr, Calgary T2N 4N1, AB, Canada.;[Tang, Chaoke] Univ South China, Inst Cardiovasc Res, Med Res Ctr, Hengyang 421001, Peoples R China.;[Zhao, Guojun] Guilin Med Univ, Dept Histol & Embryol, Guilin 541004, Peoples R China.
通讯机构：
[Peng, TH; Zhong, LY] U;[Zhao, Guojun] G;Univ South China, Clin Anat & Reprod Med Applicat Inst, Hengyang 421001, Peoples R China.;Guilin Med Univ, Dept Histol & Embryol, Guilin 541004, Peoples R China.
关键词：
sortilin;ABCA1;macrophage;cholesterol efflux;atherosclerosis
摘要：
Sortilin is closely associated with hyperlipidemia and the risk of atherosclerosis (AS). The role of sortilin and the underlying mechanism in peripheral macrophage are not fully understood. In this study, we investigated the effect of macrophage sortilin on ATP-binding cassette transporter A1 (ABCA1) expression, ABCA1-mediated cholesterol efflux, and aortic AS. Macrophage sortilin expression was upregulated by oxidized low-density lipoproteins (ox-LDLs) in both concentrationand time-dependent manners. Its expression reached the peak level when cells were incubated with 50 ?g/ml ox-LDL for 24 h. Overexpression of sortilin in macrophage reduced cholesterol efflux, leading to an increase in intracellular total cholesterol, free cholesterol, and cholesterol ester. Sortilinwas found to bind with ABCA1 protein and suppress macrophage ABCA1 expression, resulting in a decrease in cholesterol efflux from macrophages. The inhibitory effect of sortilin in cholesterol efflux was partially reversed by treatment with chloroquine, a lysosomal inhibitor. On the contrary, the ABCA1 protein level and ABCA1-mediated cholesterol efflux is increased by sortilin short hairpin RNA transfection. The fecal and biliary cholesterol 3H-sterol from cholesterolladen mouse peritoneal macrophage was reduced by sortilin overexpression through lentivirus vector (LV)-sortilin in low-density lipoprotein receptor knockout mice, which was prevented by cotreatment with chloroquine. Treatment with LV-sortilin reduced plasma high-density lipoprotein and increased plasma ox-LDL levels. Accordingly, aortic lipid deposition and plaque area were exacerbated, and ABCA1 expression was reduced in mice in response to infection with LVsortilin alone. These effects of LV-sortilin were partially reversed by chloroquine. Sortilin enhances lysosomal degradation of ABCA1 protein and suppresses ABCA1-mediated cholesterol efflux from macrophages, leading to foam cell formation and AS development. © 2019 The Author(s) .
语种：
英文
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Design, synthesis and biological evaluation of flavonoid salicylate derivatives as potential anti-tumor agents
作者：
Deng, Xiangping;Wang, Zhe;Liu, Juan;Xiong, Shujuan;Xiong, Runde;...
期刊：
RSC Advances ,2017年7(61):38171-38178 ISSN：2046-2069
通讯作者：
Tang, Guotao
作者机构：
[Wang, Zhe; Deng, Xiangping; Liu, Juan; Xiong, Shujuan; Tang, Guotao; Xiong, Runde; Cao, Xuan; Zheng, Xing] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Inst Pharm & Pharmacol, Hengyang 421001, Hunan, Peoples R China.;[Chen, Yanming] Mudanjiang Youbo Pharmaceut Co Ltd, Mudanjiang, Peoples R China.
通讯机构：
[Tang, Guotao] U;Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Inst Pharm & Pharmacol, Hengyang 421001, Hunan, Peoples R China.
摘要：
A series of flavonoid salicylate derivatives containing trimethoxybenzene and a series of chrysin salicylate derivatives were synthesized for use as anti-tumor agents, and evaluated for antiproliferative activity using three human tumor cells: MCF-7 (breast carcinoma cells), HepG2 (liver carcinoma cells), MGC-803 (gastric carcinoma cells) and the mice tumor cells MFC (forestomach carcinoma cells). A substituent group of a suitable size and the trimethoxybenzene had a certain influence on the bioactivity of the flavonoid salicylate derivatives. Compound 2 and its salicylate derivatives 7a-7g containing the trimethoxybenzene exhibited more antiproliferative activity. Among them, compound 7g displayed the most potent antiproliferative activity against MGC-803 cells and MFC cells with the concentration causing 50% inhibition of cell growth (IC50) values of 11.05 ± 1.58 μM and 13.73 ± 2.04 μM, respectively. The flow cytometry results showed that compound 7g caused the cell cycle to be arrested in the G0/G1 phase and induced apoptosis of MFC cells in a dose-dependent manner. Furthermore, compound 7g showed good anti-tumor activity in vivo. These results suggested that compound 7g could be a new, potent anti-tumor candidate which should be optimized and evaluated further. © 2017 The Royal Society of Chemistry.
语种：
英文
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Proprotein convertase furin/PCSK3 and atherosclerosis: New insights and potential therapeutic targets
作者：
Ren, Kun;Jiang, Ting;Zheng, Xi-Long;Zhao, Guo-Jun*
期刊：
Atherosclerosis ,2017年262:163-170 ISSN：0021-9150
通讯作者：
Zhao, Guo-Jun
作者机构：
[Zhao, Guo-Jun; Jiang, Ting; Ren, Kun] Guilin Med Univ, Dept Histol & Embryol, Guilin 541004, Guangxi, Peoples R China.;[Ren, Kun] Univ South China, Inst Cardiovasc Res, Key Lab Atherosclerol Hunan Prov, Hengyang 421001, Peoples R China.;[Zheng, Xi-Long] Univ Calgary, Dept Biochem & Mol Biol, Libin Cardiovasc Inst Alberta, Hlth Sci Ctr, 3330 Hosp Dr NW, Calgary, AB T2N 4N1, Canada.
通讯机构：
[Zhao, Guo-Jun] G;Guilin Med Univ, Dept Histol & Embryol, Guilin 541004, Guangxi, Peoples R China.
关键词：
*Atherosclerosis;*Furin;*Inflammation;*Lipid metabolism
摘要：
Furin, a member of the mammalian proprotein convertases family, can promote the proteolytic maturation of proproteins. It is known that furin is predominantly present in certain cell types of human atherosclerotic lesions and neointima in animal models, including vascular smooth muscle cells, endothelial cells and mononuclear inflammatory cells. Evidence suggests that furin participates in the initiation and progression of atherosclerosis through regulation of lipid and cholesterol metabolism, inflammatory response, blood pressure and the formation of atherosclerotic lesions. This review provides a panorama of the roles of furin in atherosclerosis and the insights into the prevention and treatment of atherosclerosis and cardiovascular disease.
语种：
英文
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Forkhead Box M1 Regulates Methionine Adenosyltransferase Genes Differentially to Drive Liver Cancers
作者：
Tu, Jian;Yang, Heping;Zhou, Zhigang;Liu, Ting;Xiong, Ting;...
作者机构：
[Lei, Xiaoyong; Tu, Jian; Huang, Xuelong] Univ South China, Inst Pharm & Pharmacol, Hengyang 421001, Peoples R China.;[Yang, JinWon; Lu, Shelly C.; Wang, Jiaohong; Fan, Wei; Li, Tony; Xiong, Ting; Tu, Jian; Yang, Heping] Cedars Sinai Med Ctr, Div Digest & Liver Dis, Los Angeles, CA 90048 USA.;[Zhou, Zhigang] Univ South China, Affiliated Hosp 1, Dept Anesthesia, Hengyang 421001, Peoples R China.;[Liu, Ting] Cent S Univ, Xiangya Hosp, Dept Gastroenterol, Changsha, Hunan, Peoples R China.;[Fan, Wei] Guangzhou First Peoples Hosp, Dept Geriatr, Guangzhou 510180, Guangdong, Peoples R China.
会议名称：
68th Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD) / Liver Meeting
会议时间：
OCT 20-24, 2017
会议地点：
Washington, DC
语种：
英文
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Spider Toxin Peptide Lycosin-I Functionalized Gold Nanoparticles for in vivo Tumor Targeting and Therapy
作者：
Tan, Huaxin;Huang, Yazhou;Xu, Jianghong;Chen, Bo;Zhang, Peng;...
期刊：
THERANOSTICS ,2017年7(12):3168-3178 ISSN：1838-7640
通讯作者：
Liu, Zhonghua;Xiao, Lehui
作者机构：
[Tan, Huaxin; Zhang, Peng; Liu, Zhonghua; Liang, Songping; Huang, Yazhou] Hunan Normal Univ, Coll Life Sci, Natl & Local Joint Engn Lab Anim Peptide Drug Dev, Changsha 410081, Hunan, Peoples R China.;[Tan, Huaxin; Xu, Jianghong; Ye, Zhongju; Xiao, Lehui; Chen, Bo] Hunan Normal Univ, Coll Chem & Chem Engn, Key Lab Phytochem R&D Hunan Prov, Changsha 410081, Hunan, Peoples R China.;[Xiao, Lehui] Nankai Univ, Coll Chem, State Key Lab Med Chem Biol, Tianjin Key Lab Biosensing & Mol Recognit, Tianjin 300071, Peoples R China.;[Tan, Huaxin] Univ South China, Dept Biochem & Mol Biol, Sch Pharmaceut & Biol Sci, Hengyang 421001, Peoples R China.
通讯机构：
[Liu, Zhonghua; Xiao, Lehui] H;[Xiao, Lehui] N;Hunan Normal Univ, Coll Life Sci, Natl & Local Joint Engn Lab Anim Peptide Drug Dev, Changsha 410081, Hunan, Peoples R China.;Hunan Normal Univ, Coll Chem & Chem Engn, Key Lab Phytochem R&D Hunan Prov, Changsha 410081, Hunan, Peoples R China.;Nankai Univ, Coll Chem, State Key Lab Med Chem Biol, Tianjin Key Lab Biosensing & Mol Recognit, Tianjin 300071, Peoples R China.
关键词：
*Gold nanorods;*Intracellular delivery;*Photothermal therapy.;*Spherical gold nanoparticles;*Spider anticancer peptide lycosin-I
摘要：
Cell penetrating peptides (CPPs) are commonly Cell penetrating peptides (CPPs) are commonly utilized for intracellular delivery of functional materials to circumvent biomembrane barrier. However, further application of CPPs is hindered by lacking selectivity toward targeted cells. The spider venom peptide, lycosin-I, is a CPP with potent cytotoxicity to cancer cells, which might enable lycosin-I to deliver functional materials into cancer cells selectively. In this study, we demonstrated that the lycosin-I-conjugated spherical gold nanoparticles (LGNPs) not only exhibited efficient cellular internalization efficiency toward cancer cells but also displayed unprecedented selectivity over noncancerous cells. Although LGNPs were removed from the living circulatory system via reticuloendothelial system-dominant clearance modes without noticeable adverse effects to animals, they actually displayed active tumor-targeting effects and efficient accumulation in tumors in vivo. Furthermore, the potential application of this platform for cancer therapy was explored by lycosin-I-conjugated gold nanorods (LGNRs). LGNRs exhibited selective intracellular translocation towards cancer cells and efficient photothermal effect under near infrared (NIR, 808 nm) irradiation, which consequently killed cancer cells in vitro and in vivo effectively. Therefore, the established LGNPs and LGNRs possessed great potential in cancer-targeting delivery and photothermal therapy. © Ivyspring International Publisher.
语种：
英文
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miR-467b regulates the cholesterol ester formation via targeting ACAT1 gene in RAW 264.7 macrophages
作者：
Wang, Bo;He, Ping-Ping;Zeng, Gao-Feng;Zhang, Tao;Yang, Xin-Ping Ou
期刊：
Biochimie ,2017年132:38-44 ISSN：0300-9084
通讯作者：
Tao Zhang<&wdkj&>Xin-Ping Ou Yang
作者机构：
[Wang, Bo; Zeng, Gao-Feng] Univ South China, Affiliated Hosp 2, Dept Cardiovasc Med, Hengyang 421001, Hunan, Peoples R China.;[He, Ping-Ping; Yang, Xin-Ping Ou] Univ South China, Inst Cardiovasc Res, Key Lab Atherosclerol Hunan Prov, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Hunan, Peoples R China.;[He, Ping-Ping; Yang, Xin-Ping Ou] Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, 28 West Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.;[He, Ping-Ping] Univ South China, Sch Nursing, Hengyang 421001, Hunan, Peoples R China.;[Zhang, Tao] Univ South China, Dept Urol, Affiliated Hosp 2, Hengyang 421001, Hunan, Peoples R China.
通讯机构：
[Tao Zhang] D;[Xin-Ping Ou Yang] I;Institute of Cardiovascular Research, Key Laboratory for Atherosclerology of Hunan Province, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang, Hunan 421001, China<&wdkj&>Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, 28 West Changsheng Road, Hengyang 421001, Hunan, China<&wdkj&>Department of Physiology, The Neuroscience Institute, Medical College, University of South China, Hengyang, Hunan 421001, China<&wdkj&>Departments of Urology, The Second Affiliated Hospital, University of South China, Hengyang, Hunan 421001, China
关键词：
ABCA1;ACAT1;Atherosclerosis;CE:FC ratio;miR-467b
摘要：
Previous studies have shown that miR-467b plays a central role in the progression of atherosclerosis via regulating LPL expression. However, the regulatory mechanism of miR-467b in regulateing the CE and FC formation is still unclear. Interestingly, computational analysis demonstrated that ACAT1 which converts intracellular FC into the storage form of CE, and ABCA1 which promotes cellular FC efflux may be target gene of miR-467b. Here, we examined whether miR-467b could target ACAT1 and ABCA1, thereby affecting the CE and FC formation in oxLDL-treatment RAW 264.7 cells. We found that miR-467b regulates the CE:FC ratio in oxLDL-treatment RAW 264.7 macrophages, and the luciferase activity of ACAT1 is regulated by the miR-467b, but the luciferase activity of ABCA1 has no effect. Furthermore, our data suggested that miR-467b highly regulates the endogenous levels of ACAT1 expression, thereby affecting the CE formation in oxLDL-treatment RAW 264.7 macrophages. Taken together, our findings demonstrate that ACAT1 is a target gene of miR-467b, and miR-467b regulated the CE and FC formation via directly target the ACAT1 3'UTR. © 2016
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英文
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MicroRNA-134 plasma levels before and after treatment with valproic acid for epilepsy patients
作者：
Wang, Xiaofeng;Luo, Yifeng;Liu, Shuangxi;Tan, Liming;Wang, Sanhu;...
期刊：
Oncotarget ,2017年8(42):72748-72754 ISSN：1949-2553
通讯作者：
Man, Rongyong
作者机构：
[Luo, Yifeng; Wang, Xiaofeng] Southern Med Univ, Affiliated Hosp 3, Dept Neurol, Guangzhou 510630, Guangdong, Peoples R China.;[Liu, Shuangxi; Man, Rongyong] Univ South China, Peoples Hosp Huaihua 1, Dept Neurol, Huaihua 418000, Hunan, Peoples R China.;[Tan, Liming] Univ South China, Peoples Hosp Huaihua 1, Dept Pharm, Huaihua 418000, Hunan, Peoples R China.;[Wang, Sanhu] Univ South China, Peoples Hosp Huaihua 1, Med Res Ctr, Huaihua 418000, Hunan, Peoples R China.
通讯机构：
[Man, Rongyong] U;Univ South China, Peoples Hosp Huaihua 1, Dept Neurol, Huaihua 418000, Hunan, Peoples R China.
关键词：
biomarker;epilepsy;microRNA-134;temporal lobe epilepsy;valproic acid
摘要：
BACKGROUND: Temporal lobe epilepsy is the second most common neurological disorders characterized by recurrent spontaneous seizures. MicroRNAs play a vital role in regulating synaptic plasticity, brain development and post-transcriptional expression of proteins. In both animal models of epilepsy and human patients, miR-134, a brain-specific microRNA has recently been identified as a potential regulator of epileptogenesis. METHODS: microRNA identified as targets for the actions of valproic acid (VPA) are known to have important effects in brain function. In this study, 59 new-onset epilepsy patients and 20 controls matched by sex and age were enrolled. Patients with a score < 3 were allocated into the mild group, 3-5 into the moderate group and >5 into the severe group. The plasma miRNA-134 level was quantitatively measured using real-time PCR. RESULTS: Plasma miRNA-134 level in new-onset epilepsy patients was significantly up-regulated when compared with that in healthy controls, and then considerably down-regulated after oral intake of valproic acid medication. The up-regulated plasma miRNA-134 levels may be directly associated with the pathophysiology and severity of epilepsy. CONCLUSION: Plasma miRNA-134 in epilepsy may be considered as a potential peripheral biomarker that responds to the incidence of epilepsy and associates with use of anti-epilepsy drugs.
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英文
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The role of Krüppel-like factor 14 in the pathogenesis of atherosclerosis
作者：
Xie, Wei;Li, Liang;Zheng, Xi-Long;Yin, Wei-Dong* ;Tang, Chao-Ke*
期刊：
Atherosclerosis ,2017年263:352-360 ISSN：0021-9150
通讯作者：
Yin, Wei-Dong;Tang, Chao-Ke
作者机构：
[Tang, Chao-Ke; Yin, Wei-Dong; Tang, CK; Li, Liang; Xie, Wei] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Med Res Ctr, Inst Cardiovasc Res,Key Lab Atherosclerol Hunan P, Hengyang 421001, Hunan, Peoples R China.;[Xie, Wei] Univ South China, Lab Clin Anat, Hengyang 421001, Hunan, Peoples R China.;[Li, Liang] Univ South China, Dept Pathophysiol, Hengyang 421001, Hunan, Peoples R China.;[Zheng, Xi-Long] Univ Calgary, Hlth Sci Ctr, Cumming Sch Med, Dept Biochem & Mol Biol,Libin Cardiovasc Inst Alb, 3330 Hosp Dr NW, Calgary, AB T2N 4N1, Canada.
通讯机构：
[Yin, WD; Tang, CK] U;Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Med Res Ctr, Inst Cardiovasc Res,Key Lab Atherosclerol Hunan P, Hengyang 421001, Hunan, Peoples R China.
关键词：
*Atherosclerosis;*Inflammation;*KLF14;*Lipid metabolism;*Pathogenesis;*Type 2 diabetes
摘要：
The Krüppel-like factor (KLF) family, as the SP/XKLF transcription factors, plays important roles in regulating the expression of genes required for the proper execution of important biological and pathological processes. Recent studies have demonstrated that KLF14, a member of the KLF family, participates in the initiation and progression of atherosclerotic cardiovascular disease (CVD). From the molecular function aspect, this review focuses on the impact of KLF14-mediated regulation in major atherosclerosis-related diseases and pathological processes, such as insulin resistance, type 2 diabetes, dyslipidemia, inflammation, obesity, metabolic syndrome, cell proliferation and differentiation. This review was designed to help understand the roles of KLF14 in the pathogenesis of atherosclerosis and define KLF14 as a potential disease biomarker and a novel therapeutic target in CVD.
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英文
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Apelin/APJ system: A novel promising therapy target for pathological angiogenesis
作者：
Wu, Lele;Chen, Linxi;Li, Lanfang*
期刊：
Clinica Chimica Acta ,2017年466:78-84 ISSN：0009-8981
通讯作者：
Li, Lanfang
作者机构：
[Li, Lanfang; Wu, Lele; Chen, Linxi] Univ South China, Inst Pharm & Pharmacol, Learning Key Lab Pharmacoprote, Hunan Prov Cooperat Innovat Centerfor Mol Target, Hengyang 421001, Peoples R China.;[Li, Lanfang] Univ South China, Inst Pharm & Pharmacol, Learning Key Lab Pharmacoprote, Hengyang 421001, Peoples R China.
通讯机构：
[Li, Lanfang] U;Univ South China, Inst Pharm & Pharmacol, Learning Key Lab Pharmacoprote, Hengyang 421001, Peoples R China.
关键词：
APJ;Angiogenesis-related diseases;Apelin
摘要：
Apelin is the endogenous ligand of the G protein-coupled receptor APJ. Both Apelin and APJ receptor are widely distributed in various tissues such as heart, brain, limbs, retina and liver. Recent research indicates that the Apelin/APJ system plays an important role in pathological angiogenesis which is a progress of new blood branches developing from preexisting vessels via sprouting. In this paper, we review the important role of the Apelin/APJ system in pathological angiogenesis. The Apelin/APJ system promotes angiogenesis in myocardial infarction, ischemic stroke, critical limb ischemia, tumor, retinal angiogenesis diseases, cirrhosis, obesity, diabetes and other related diseases. Furthermore, we illustrate the detailed mechanism of pathological angiogenesis induced by the Apelin/APJ system. In conclusion, the Apelin/APJ system would be a promising therapeutic target for angiogenesis-related diseases. © 2016 Elsevier B.V.
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英文
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Treponema pallidum flagellins elicit proinflammatory cytokines from human monocytes via TLR5 signaling pathway
作者：
Xu, Man;Xie, Yafeng;Jiang, Chuanhao;Xiao, Yongjian;Kuang, Xingxing;...
期刊：
Immunobiology ,2017年222(5):709-718 ISSN：0171-2985
通讯作者：
Wu, Yimou
作者机构：
[Wu, Yimou; Zhao, Feijun; Xie, Yafeng; Tan, Manyi; Kuang, Xingxing; Tan, Yuan; Wen, Yating; Xu, Man; Zeng, Tiebing] Univ South China, Med Coll, Inst Pathogen Biol, Hengyang 421001, Peoples R China.;[Wu, Yimou; Zhao, Feijun; Xie, Yafeng; Tan, Manyi; Kuang, Xingxing; Tan, Yuan; Wen, Yating; Xu, Man; Zeng, Tiebing] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Peoples R China.;[Wu, Yimou; Zhao, Feijun; Xie, Yafeng; Tan, Manyi; Kuang, Xingxing; Tan, Yuan; Wen, Yating; Xu, Man; Zeng, Tiebing] Univ South China, Hunan Prov Key Lab Special Pathogens Prevent & Co, Hengyang 421001, Peoples R China.;[Xie, Yafeng; Xiao, Yongjian] Univ South China, Affiliated Hosp 2, Dept Clin Lab, Hengyang 421001, Peoples R China.;[Jiang, Chuanhao] Cent S Univ, Xiangya Hosp 2, Dept Lab Med, Changsha 410011, Hunan, Peoples R China.
通讯机构：
[Wu, Yimou] U;Univ South China, Med Coll, Inst Pathogen Biol, Hengyang 421001, Peoples R China.;Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Peoples R China.;Univ South China, Hunan Prov Key Lab Special Pathogens Prevent & Co, Hengyang 421001, Peoples R China.
关键词：
Flagellin;Human monocytes;Inflammation;TLR5 signaling;Treponema pallidum
摘要：
The tissue damage caused by syphilis infection may be associated with inflammation. However, the virulence factors of Treponema pallidum are still unclear, nor are the molecular mechanisms for leading to the productions of proinflammatory cytokines. Flagellin, a classic pathogen-associated molecular pattern (PAMP), is a potent immunogen that induces inflammation. In the present study, we have demonstrated that stimulations of human monocytes with Treponema pallidum FlaB1, FlaB2, and FlaB3 result in the up regulation of interleukin (IL)-6 and IL-8. Moreover, silencing of the Toll-like receptor 5 (TLR5) gene by using small interfering RNA was found to abrogate the T. pallidum flagellins-induced IL-6 and IL-8 expressions. Similarly, transfection with the dominant negative plasmid encoding MyD88 (pDeNy-hMyD88) was also giving rise to the down regulation of IL-6 and IL-8. We further investigated the relative contributions of mitogen-activated protein kinase (MAPK) and nuclear factor κB (NF-κB) signaling to transcriptions and translations of IL-6 and IL-8. Western Blot and immuno fluorescence experiments revealed that flagellins-mediated IL-6 and IL-8 expressions are heavily dependent on ERK, p38, and NF-κB. In addition, inhibitions of p38 kinase, ERK, and NF-κB were found to attenuate the productions of IL-6 and IL-8. Taken together, our results indicate that T. pallidum flagellins can upregulate IL-6 and IL-8 generations via TLR5 and MAPK/NF-κB signaling pathways in THP-1 cells, which will improve our understanding of the pathogenesis of T. pallidum. © 2017 Elsevier GmbH
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英文
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Selenophenes: Introducing a New Element into the Core of Non-Steroidal Estrogen Receptor Ligands
作者：
Zhang, Silong;Wang, Zhiyong;Hu, Zhiye;Li, Changhao;Tang, Chu;...
期刊：
ChemMedChem ,2017年12(3):235-249 ISSN：1860-7179
通讯作者：
Zhou, Hai-Bing;Huang, Jian
作者机构：
[Zhang, Silong; Zhou, Hai-Bing; Tang, Chu; Wang, Zhiyong; Dong, Chune; Luo, Junjie; Hu, Zhiye] Wuhan Univ, State Key Lab Virol, Key Lab Combinatorial Biosynth & Drug Discovery, Sch Pharmaceut Sci,Minist Educ, 185 East Lake Rd, Wuhan 430071, Peoples R China.;[Li, Changhao; Huang, Jian] Wuhan Univ, Coll Life Sci, 299 Bayi Rd, Wuhan 430072, Peoples R China.;[Carlson, Kathryn E.; Katzenellenbogen, John A.] Univ Illinois, Dept Chem, 600 South Mathews Ave, Urbana, IL 61801 USA.;[Zhou, Hai-Bing] Univ South China, Inst Pharm & Pharmacol, Hengyang 421001, Peoples R China.
通讯机构：
[Zhou, Hai-Bing; Huang, Jian] W;[Zhou, Hai-Bing] U;Wuhan Univ, State Key Lab Virol, Key Lab Combinatorial Biosynth & Drug Discovery, Sch Pharmaceut Sci,Minist Educ, 185 East Lake Rd, Wuhan 430071, Peoples R China.;Wuhan Univ, Coll Life Sci, 299 Bayi Rd, Wuhan 430072, Peoples R China.;Univ South China, Inst Pharm & Pharmacol, Hengyang 421001, Peoples R China.
关键词：
breast cancer;estrogen receptor;structural diversity;relative binding affinity;selenophenes
摘要：
The importance of the heterocyclic core elements with peripheral phenolic and alkyl substituents as a dominant structural motif of ligands for the estrogen receptor (ER) has been well recognized. In this study we expanded the structural diversity of core elements by preparing selenium-containing heterocycles and exploring the activities of these selenophenes on the two ERs, ERα and ERβ. Careful structure–activity relationship (SAR) analysis of their ER binding affinities showed that most selenophenes are ERβ-selective, with the position of the phenol substituents on the selenophene core and the nature of these substituents having a marked effect on their binding affinities. The compound bis(2-fluoro-4-hydroxyphenyl)selenophene (2 f) has the highest relative binding affinity (RBA) of 24.3 for ERβ. In transcription assays, most selenophenes were found to exhibit partial to full agonist activity for both ER subtypes, with compounds bis(2-methyl-4-hydroxyphenyl)selenophene (2 b), bis(4-fluoro-3-hydroxyphenyl)3-bromoselenophene (6 f), and 2,3,5-tris(hydroxyphenyl)thiophenes (8 b and 8 d) profiling as superagonists for ERα; however, several compounds display a range of ERα or ERβ antagonistic activities. A few selenophenes exhibited antiproliferative activity, with compound 8 c showing antiproliferative effects similar to that of 4-hydroxytamoxifen in breast cancer MCF-7 cells while being nontoxic to normal VERO cells. These new ligands could act as models for the development of novel agents leading to improved therapeutics that target the estrogen receptor. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
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英文
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Identification of a protein associated with the activity of cytokine-induced killer cells
作者：
Cao, Jingsong;Chen, Cong;Gao, Yongqiang;Hu, Li;Liang, Yu;...
期刊：
ONCOLOGY LETTERS ,2017年14(6):6937-6942 ISSN：1792-1074
通讯作者：
Xiao, Jianhua
作者机构：
[Liang, Yu; Xiao, Jianhua; Gao, Yongqiang; Hu, Li; Cao, Jingsong] Univ South China, Med Coll, Inst Pathogen Biol, Hunan Prov Key Lab Special Pathogens Prevent & Co, 5 Bldg,5 Changsheng West Rd, Hengyang 421001, Hunan, Peoples R China.;[Liang, Yu; Xiao, Jianhua; Gao, Yongqiang; Hu, Li; Cao, Jingsong] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Hunan, Peoples R China.;[Chen, Cong] Univ South China, Hosp 2, Lab Dept, Hengyang 421001, Hunan, Peoples R China.
通讯机构：
[Xiao, Jianhua] U;Univ South China, Med Coll, Inst Pathogen Biol, Hunan Prov Key Lab Special Pathogens Prevent & Co, 5 Bldg,5 Changsheng West Rd, Hengyang 421001, Hunan, Peoples R China.
关键词：
activity-enhancing mechanism;cytokine-induced killer cells;haptoglobin;liquid chromatography-mass spectrometry;related activity protein
摘要：
Cytokine-induced killer cells (CIKs) adoptive immunotherapy for efficient antitumor ability is used clinically, but details regarding the proteins associated with CIK activity remain unclear. In the current study, the cytotoxicity of CIKs on hepatoma was identified to be significantly downregulated by 1.61-fold following gentamincin treatment. Further research revealed that a differentially expressed protein (P43) was significantly downregulated by 1.22-fold using one-dimensional gel electrophoresis analysis. Of these, the P43 was identified as human haptoglobin using liquid chromatography-mass spectrometry. Western blotting demonstrated that the haptoglobin specifically reacted with rabbit anti-human-haptoglobin. Furthermore, western blotting results verified that the haptoglobin was significantly downregulated by 1.17-fold compared with the control group. In addition, the expression of haptoglobin mRNA was significantly downregulated by 1.73-fold following gentamincin treatment. Taken together, the results of the present study demonstrated that the expression of haptoglobin protein was associated with the activity of CIKs, and the results will be beneficial to the further investigation of CIK activity-enhancement mechanism. © 2017, Spandidos Publications. All rights reserved.
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英文
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A new anthraquinone and a new naphthoquinone from the whole plant of Spermacoce latifolia
作者：
Luo, Ying;Shen, Hai-Yan;Shen, Qing-Xiang;Cao, Zhao-Hui;Zhang, Min;...
期刊：
亚洲天然物产研究(英文版) ,2017年19(9):869-876 ISSN：1028-6020
通讯作者：
Tan, Jian-Wen
作者机构：
[Luo, Ying; Long, Shi-Yin; Wang, Zong-Bao; Cao, Zhao-Hui; Zhang, Min] Univ South China, Sch Pharm & Biol Sci, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hunan Prov Educ Dept, Hengyang 421001, Peoples R China.;[Luo, Ying; Tan, Jian-Wen] Chinese Acad Sci, South China Bot Garden, Guangdong Prov Key Lab Appl Bot, Guangzhou 510650, Guangdong, Peoples R China.;[Shen, Hai-Yan] Univ South China, Inst Pathogen Biol, Hengyang 421001, Peoples R China.;[Shen, Qing-Xiang] Univ South China, Affiliated Hosp 2, Dept Obstet & Gynaecol, Hengyang 421001, Peoples R China.
通讯机构：
[Tan, Jian-Wen] C;Chinese Acad Sci, South China Bot Garden, Guangdong Prov Key Lab Appl Bot, Guangzhou 510650, Guangdong, Peoples R China.
关键词：
Rubiaceae;Spermacoce latifolia;anthraquinone;antibacterial activity;naphthoquinone;alpha-glucosidase inhibitor
摘要：
A phytochemical study on the whole plant of Spermacoce latifolia led to the isolation of a new anthraquinone, 1,2,6-trihydroxy-5-methoxy-9,10-anthraquinone (1), and a new naphthoquinone, (2R)-6-hydroxy-7-methoxy-dehydroiso-α-lapachone (2), together with three known anthraquinones (3–5). Their structures were established on the basis of detailed spectroscopic analysis, including one- and two-dimensional NMR, ESI–MS, and HR–ESI–MS techniques. All the compounds were isolated from S. latifolia for the first time. Compounds 1, 2, 4, and 5 showed significant antibacterial activity toward Bacillus subtilis with MIC values ranging from 0.9 to 31.2 μg/ml, and compound 4 aslo exhibited antibacterial activity against Bacillus cereus with a MIC value 62.5 μg/ml. Compound 1 was further revealed to show significant in vitro α-glucosidase inhibitory activity with IC 50 value of 0.653 mM. © 2017 Informa UK Limited, trading as Taylor & Francis Group.
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英文
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