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Design, synthesis and biological evaluation of flavonoid salicylate derivatives as potential anti-tumor agents

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成果类型:
期刊论文
作者:
Deng, Xiangping;Wang, Zhe;Liu, Juan;Xiong, Shujuan;Xiong, Runde;...
通讯作者:
Tang, Guotao
作者机构:
[Wang, Zhe; Deng, Xiangping; Liu, Juan; Xiong, Shujuan; Tang, Guotao; Xiong, Runde; Cao, Xuan; Zheng, Xing] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Inst Pharm & Pharmacol, Hengyang 421001, Hunan, Peoples R China.
[Chen, Yanming] Mudanjiang Youbo Pharmaceut Co Ltd, Mudanjiang, Peoples R China.
通讯机构:
[Tang, Guotao] U
Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Inst Pharm & Pharmacol, Hengyang 421001, Hunan, Peoples R China.
语种:
英文
期刊:
RSC Advances
ISSN:
2046-2069
年:
2017
卷:
7
期:
61
页码:
38171-38178
基金类别:
Construct Program of the Key Discipline in Hunan Province; Hunan Province Cooperative Innovation Center for Molecular Target New Drug [Hunan Provincial Education Department document] [2014-405]; Department of Laboratory Animal Science
机构署名:
本校为第一且通讯机构
院系归属:
药学与生物科学学院
摘要:
A series of flavonoid salicylate derivatives containing trimethoxybenzene and a series of chrysin salicylate derivatives were synthesized for use as anti-tumor agents, and evaluated for antiproliferative activity using three human tumor cells: MCF-7 (breast carcinoma cells), HepG2 (liver carcinoma cells), MGC-803 (gastric carcinoma cells) and the mice tumor cells MFC (forestomach carcinoma cells). A substituent group of a suitable size and the trimethoxybenzene had a certain influence on the bioactivity of the flavonoid salicylate derivatives. ...

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