C1q tumor necrosis factor-related protein 9 in atherosclerosis: Mechanistic insights and therapeutic potential

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Yu, Xiao-Hua;Zhang, Da-Wei;Zheng, Xi-Long;Tang, Chao-Ke*

通讯作者：

Tang, Chao-Ke

作者机构：

[Tang, Chao-Ke; Yu, Xiao-Hua] Univ South China, Inst Cardiovasc Res, Key Lab Atherosclerol Hunan Prov, Med Res Expt Ctr,Hunan Prov Cooperat Innovat Ctr, Hengyang 421001, Hunan, Peoples R China.

[Zhang, Da-Wei] Univ Alberta, Dept Pediat, Edmonton, AB, Canada.

[Zhang, Da-Wei] Univ Alberta, Grp Mol & Cell Biol Lipids, Edmonton, AB, Canada.

[Zheng, Xi-Long] Univ Calgary, Hlth Sci Ctr, Cumming Sch Med, Dept Biochem & Mol Biol,Libin Cardiovasc Inst Alb, 3330 Hosp Dr NW, Calgary, AB T2N 4N1, Canada.

通讯机构：

[Tang, Chao-Ke] U

Univ South China, Inst Cardiovasc Res, Key Lab Atherosclerol Hunan Prov, Med Res Expt Ctr,Hunan Prov Cooperat Innovat Ctr, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

AdipoR1;Adiponectin;Atherosclerosis;CTRP9;N-cadherin

期刊：

Ateroskleroz

ISSN：

2078-256X

年：

2018

卷：

276

页码：

109-116

DOI：

10.1016/j.atherosclerosis.2018.07.022

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81770461]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

药学与生物科学学院

摘要：

C1q tumor necrosis factor-related protein 9 (CTRP9), a newly discovered adipokine, is the closest paralog of adiponectin. After proteolytic cleavage, it can release the globular domain (gCTRP9) that serves as the major circulatory isoform. Upon binding to adiponectin receptor 1 (AdipoR1) and N-cadherin, CTRP9 can activate a variety of signaling pathways to regulate glucose and lipid metabolism, vascular relaxation and cell differentiation. Circulating CTRP9 levels are significantly decreased in patients with coronary atherosclerosis disease. Data obtained from in vitro experiments and animal m...

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C1q tumor necrosis factor-related protein 9 in atherosclerosis: Mechanistic insights and therapeutic potential

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