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Ginnalin A from Kujin tea (: Acer tataricum subsp. ginnala) exhibits a colorectal cancer chemoprevention effect via activation of the Nrf2/HO-1 signaling pathway

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成果类型:
期刊论文
作者:
Bi, Wu;He, Chun-nian;Li, Xiao-xiao;Zhou, Liu-ying;Liu, Rui-jie;Zhang, Sai;Li, Guo-qing;Chen, Zhu-chu;Zhang, Peng-fei*
通讯作者:
Zhang, Peng-fei
作者机构:
[Liu, Rui-jie; Bi, Wu; Li, Xiao-xiao; Zhang, Sai; Zhou, Liu-ying; Zhang, Peng-fei; Chen, Zhu-chu] Cent S Univ, Xiangya Hosp, Chinese Minist Hlth, Key Lab Canc Prote, Changsha 410008, Hunan, Peoples R China.
[He, Chun-nian] Chinese Acad Med Sci, Minist Educ, Inst Med Plant Dev, Key Lab Bioact Subst & Resources Utilizat Chinese, Beijing 100193, Peoples R China.
[He, Chun-nian] Peking Union Med Coll, Beijing 100193, Peoples R China.
[Li, Guo-qing] Univ South China, Sch Pharm & Life Sci, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Hunan, Peoples R China.
通讯机构:
[Zhang, Peng-fei] Cent S Univ, Xiangya Hosp, Chinese Minist Hlth, Key Lab Canc Prote, Changsha 410008, Hunan, Peoples R China.
语种:
英文
期刊:
Food and Function
ISSN:
2042-6496
年:
2018
卷:
9
期:
5
页码:
2809-2819
基金类别:
National Natural Science Foundation of China [81372516]; China Postdoctoral Science Foundation [2017M612600]; Hunan Provincial Natural Science Foundation of China [2016JJ5013]; Project of Scientific Research Fund of the Hunan Provincial Education Department [16C1409]
机构署名:
本校为其他机构
院系归属:
药学与生物科学学院
摘要:
Ginnalin A (also known as acertannin) is one of the most important phenolic compounds of several beverage Acer plants. In this study, it is reported for the first time that ginnalin A is an activator of the Nrf2 signaling pathway in human colon cancer cells. Ginnalin A, isolated from the leaves of Acer tataricum subsp. ginnala, exhibited promising preventive activity against colon cancer cells (HCT116, SW480 and SW620) with IC<inf>50</inf>values of 24.8 &mu;M, 22.0 &mu;M and 39.7 &mu;M, respectively. In addition, it significantly reduced the colony formation of these cells. Flow cytometry analysis indicated that ginnalin A suppressed cancer proliferation via the induction of cell cycle arrest at the S-phase. Real time PCR analysis demonstrated that ginnalin A can upregulate the mRNA expression levels of Nrf2-related antioxidant genes Nrf2, HO-1 and NQO1. Western blotting analysis revealed that ginnalin A promoted the Nrf2 nuclear translocation and upregulated the proteins Nrf2, HO-1 and NQO1. Moreover, the upregulation of p62 and the inhibition of Keap1 were also found by Western blotting analysis. Therefore, the activation of the Nrf2 signaling pathway was probably induced through the upregulation of p62 and the inhibition of Keap1.<br/> &copy;2018 The Royal Society of Chemistry.

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