MicroRNA-134 plasma levels before and after treatment with valproic acid for epilepsy patients

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Wang, Xiaofeng;Luo, Yifeng;Liu, Shuangxi;Tan, Liming;Wang, Sanhu;...

通讯作者：

Man, Rongyong

作者机构：

[Luo, Yifeng; Wang, Xiaofeng] Southern Med Univ, Affiliated Hosp 3, Dept Neurol, Guangzhou 510630, Guangdong, Peoples R China.

[Liu, Shuangxi; Man, Rongyong] Univ South China, Peoples Hosp Huaihua 1, Dept Neurol, Huaihua 418000, Hunan, Peoples R China.

[Tan, Liming] Univ South China, Peoples Hosp Huaihua 1, Dept Pharm, Huaihua 418000, Hunan, Peoples R China.

[Wang, Sanhu] Univ South China, Peoples Hosp Huaihua 1, Med Res Ctr, Huaihua 418000, Hunan, Peoples R China.

通讯机构：

[Man, Rongyong] U

Univ South China, Peoples Hosp Huaihua 1, Dept Neurol, Huaihua 418000, Hunan, Peoples R China.

语种：

英文

关键词：

biomarker;epilepsy;microRNA-134;temporal lobe epilepsy;valproic acid

期刊：

Oncotarget

ISSN：

1949-2553

年：

2017

卷：

期：

页码：

72748-72754

DOI：

10.18632/oncotarget.20292

基金类别：

7-9 General Program for Science and Technology of Huaihua [7-9]; Medical Scientific Research Foundation of Guangdong Province, China [A2015153]

机构署名：

本校为通讯机构

院系归属：

药学与生物科学学院

摘要：

BACKGROUND: Temporal lobe epilepsy is the second most common neurological disorders characterized by recurrent spontaneous seizures. MicroRNAs play a vital role in regulating synaptic plasticity, brain development and post-transcriptional expression of proteins. In both animal models of epilepsy and human patients, miR-134, a brain-specific microRNA has recently been identified as a potential regulator of epileptogenesis. METHODS: microRNA identified as targets for the actions of valproic acid (VPA) are known to have important effects in brain function. In this study, 59 new-onset epilepsy pat...

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MicroRNA-134 plasma levels before and after treatment with valproic acid for epilepsy patients

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