Spider Toxin Peptide Lycosin-I Functionalized Gold Nanoparticles for in vivo Tumor Targeting and Therapy

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成果类型：

期刊论文

作者：

Tan, Huaxin;Huang, Yazhou;Xu, Jianghong;Chen, Bo;Zhang, Peng;...

通讯作者：

Liu, Zhonghua;Xiao, Lehui

作者机构：

[Tan, Huaxin; Zhang, Peng; Liu, Zhonghua; Liang, Songping; Huang, Yazhou] Hunan Normal Univ, Coll Life Sci, Natl & Local Joint Engn Lab Anim Peptide Drug Dev, Changsha 410081, Hunan, Peoples R China.

[Tan, Huaxin; Xu, Jianghong; Ye, Zhongju; Xiao, Lehui; Chen, Bo] Hunan Normal Univ, Coll Chem & Chem Engn, Key Lab Phytochem R&D Hunan Prov, Changsha 410081, Hunan, Peoples R China.

[Xiao, Lehui] Nankai Univ, Coll Chem, State Key Lab Med Chem Biol, Tianjin Key Lab Biosensing & Mol Recognit, Tianjin 300071, Peoples R China.

[Tan, Huaxin] Univ South China, Dept Biochem & Mol Biol, Sch Pharmaceut & Biol Sci, Hengyang 421001, Peoples R China.

通讯机构：

[Liu, Zhonghua; Xiao, Lehui] H

[Xiao, Lehui] N

Hunan Normal Univ, Coll Life Sci, Natl & Local Joint Engn Lab Anim Peptide Drug Dev, Changsha 410081, Hunan, Peoples R China.

Hunan Normal Univ, Coll Chem & Chem Engn, Key Lab Phytochem R&D Hunan Prov, Changsha 410081, Hunan, Peoples R China.

Nankai Univ, Coll Chem, State Key Lab Med Chem Biol, Tianjin Key Lab Biosensing & Mol Recognit, Tianjin 300071, Peoples R China.

语种：

英文

关键词：

*Gold nanorods;*Intracellular delivery;*Photothermal therapy.;*Spherical gold nanoparticles;*Spider anticancer peptide lycosin-I

期刊：

THERANOSTICS

ISSN：

1838-7640

年：

2017

卷：

期：

页码：

3168-3178

DOI：

10.7150/thno.19780

基金类别：

NSFCNational Natural Science Foundation of China (NSFC) [31370783, 31670783, 31370854, 31570782, 21405045, 21522502]; Program for New Century Excellent Talents in University (China)Program for New Century Excellent Talents in University (NCET) [NCET-13-0789]; Hunan Natural Science Funds for Distinguished Young Scholar [14JJ1017, 14JJ1018]; Cooperative Innovation Center of Engineering and New Products for Developmental Biology of Hunan Province [20134486]

机构署名：

本校为其他机构

院系归属：

化学化工学院

药学与生物科学学院

摘要：

Cell penetrating peptides (CPPs) are commonly Cell penetrating peptides (CPPs) are commonly utilized for intracellular delivery of functional materials to circumvent biomembrane barrier. However, further application of CPPs is hindered by lacking selectivity toward targeted cells. The spider venom peptide, lycosin-I, is a CPP with potent cytotoxicity to cancer cells, which might enable lycosin-I to deliver functional materials into cancer cells selectively. In this study, we demonstrated that the lycosin-I-conjugated spherical gold nanoparticle...

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Spider Toxin Peptide Lycosin-I Functionalized Gold Nanoparticles for in vivo Tumor Targeting and Therapy

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