Identification of a protein associated with the activity of cytokine-induced killer cells

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Cao, Jingsong;Chen, Cong;Gao, Yongqiang;Hu, Li;Liang, Yu;...

通讯作者：

Xiao, Jianhua

作者机构：

[Liang, Yu; Xiao, Jianhua; Gao, Yongqiang; Hu, Li; Cao, Jingsong] Univ South China, Med Coll, Inst Pathogen Biol, Hunan Prov Key Lab Special Pathogens Prevent & Co, 5 Bldg,5 Changsheng West Rd, Hengyang 421001, Hunan, Peoples R China.

[Liang, Yu; Xiao, Jianhua; Gao, Yongqiang; Hu, Li; Cao, Jingsong] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Hunan, Peoples R China.

[Chen, Cong] Univ South China, Hosp 2, Lab Dept, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Xiao, Jianhua] U

Univ South China, Med Coll, Inst Pathogen Biol, Hunan Prov Key Lab Special Pathogens Prevent & Co, 5 Bldg,5 Changsheng West Rd, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

activity-enhancing mechanism;cytokine-induced killer cells;haptoglobin;liquid chromatography-mass spectrometry;related activity protein

期刊：

ONCOLOGY LETTERS

ISSN：

1792-1074

年：

2017

卷：

期：

页码：

6937-6942

DOI：

10.3892/ol.2017.7042

基金类别：

Foundation of Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control Foundation [2014-5]; Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study [2015-351]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81101274]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

药学与生物科学学院

摘要：

Cytokine-induced killer cells (CIKs) adoptive immunotherapy for efficient antitumor ability is used clinically, but details regarding the proteins associated with CIK activity remain unclear. In the current study, the cytotoxicity of CIKs on hepatoma was identified to be significantly downregulated by 1.61-fold following gentamincin treatment. Further research revealed that a differentially expressed protein (P43) was significantly downregulated by 1.22-fold using one-dimensional gel electrophoresis analysis. Of these, the P43 was identified as...

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Identification of a protein associated with the activity of cytokine-induced killer cells

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