The role of Krüppel-like factor 14 in the pathogenesis of atherosclerosis

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成果类型：

期刊论文

作者：

Xie, Wei;Li, Liang;Zheng, Xi-Long;Yin, Wei-Dong*;Tang, Chao-Ke*

通讯作者：

Yin, Wei-Dong;Tang, Chao-Ke

作者机构：

[Tang, Chao-Ke; Yin, Wei-Dong; Tang, CK; Li, Liang; Xie, Wei] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Med Res Ctr, Inst Cardiovasc Res,Key Lab Atherosclerol Hunan P, Hengyang 421001, Hunan, Peoples R China.

[Xie, Wei] Univ South China, Lab Clin Anat, Hengyang 421001, Hunan, Peoples R China.

[Li, Liang] Univ South China, Dept Pathophysiol, Hengyang 421001, Hunan, Peoples R China.

[Zheng, Xi-Long] Univ Calgary, Hlth Sci Ctr, Cumming Sch Med, Dept Biochem & Mol Biol,Libin Cardiovasc Inst Alb, 3330 Hosp Dr NW, Calgary, AB T2N 4N1, Canada.

通讯机构：

[Yin, WD; Tang, CK] U

Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Med Res Ctr, Inst Cardiovasc Res,Key Lab Atherosclerol Hunan P, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

*Atherosclerosis;*Inflammation;*KLF14;*Lipid metabolism;*Pathogenesis;*Type 2 diabetes

期刊：

Atherosclerosis

ISSN：

0021-9150

年：

2017

卷：

263

页码：

352-360

DOI：

10.1016/j.atherosclerosis.2017.06.011

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81570408, 81170278]; Hunan Provincial Natural Science Foundation of ChinaNatural Science Foundation of Hunan Province [2017JJ2234]; University of South China; construct program of the key discipline in Hunan Province

机构署名：

本校为第一且通讯机构

院系归属：

医学院

药学与生物科学学院

摘要：

The Krüppel-like factor (KLF) family, as the SP/XKLF transcription factors, plays important roles in regulating the expression of genes required for the proper execution of important biological and pathological processes. Recent studies have demonstrated that KLF14, a member of the KLF family, participates in the initiation and progression of atherosclerotic cardiovascular disease (CVD). From the molecular function aspect, this review focuses on the impact of KLF14-mediated regulation in major atherosclerosis-related diseases and pathological ...

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The role of Krüppel-like factor 14 in the pathogenesis of atherosclerosis

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