PIG11 over-expression predicts good prognosis and induces HepG2 cell apoptosis via reactive oxygen species-dependent mitochondrial pathway

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成果类型：

期刊论文

作者：

Wang, Yan;Liu, Xiaomin;Liu, Gang;Wang, Xiaojuan;Hu, Rong;...

通讯作者：

Liang, Xiaoqiu

作者机构：

[Wang, Yan] Nantong Univ, Affiliated Hosp, Dept Pathol, Nantong 226001, Peoples R China.

[Liang, Xiaoqiu; Liu, Xiaomin; Wang, Xiaojuan; Hu, Rong; Wang, Yan] Univ South China, Canc Res Inst, Hunan Prov Key Lab Tumor Cellular & Mol Pathol, Hengyang 421001, Hunan, Peoples R China.

[Liang, Xiaoqiu; Liu, Xiaomin; Wang, Xiaojuan; Hu, Rong; Wang, Yan] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Hunan, Peoples R China.

[Liu, Gang] Inner Mongolia Univ, Coll Biol Sci, Hohhot 010021, Neimenggu, Peoples R China.

通讯机构：

[Liang, Xiaoqiu] U

Univ South China, Canc Res Inst, Hunan Prov Key Lab Tumor Cellular & Mol Pathol, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

PIG11;Apoptosis;Hepatocellular carcinoma (HCC);HepG2 cell;Reactive oxygen species (ROS);Mitochondria

期刊：

Biomedicine & Pharmacotherapy

ISSN：

0753-3322

年：

2018

卷：

108

页码：

435-442

DOI：

10.1016/j.biopha.2018.09.062

基金类别：

This study was supported by the National Natural Science Foundation of China (grant no. 81472449 and 81101988 ) and the Hunan Provincial Education Department Foundation of China (grant no. 11C1091 ). The study was performed using equipment purchased with funding from the construction program of the key discipline in Hunan Province, China (Basic Medicine Sciences in University of South China) .

机构署名：

本校为通讯机构

院系归属：

医学院

药学与生物科学学院

摘要：

P53-induced protein 11 (PIG11), one of the primeval transcriptional targets of p53, is up-regulated in apoptosis induced by multiple chemopreventive agents and is involved in tumorigenesis or tumor development. Nevertheless, the clinical value and biological role of PIG11 in hepatocellular carcinoma (HCC) are still unknown. In the present article, we explored the expression pattern of PIG11 in HCC tumor tissues, the prognostic value of PIG11 for HCC patients, and the biological functions on the apoptosis of HepG2 cells. We discovered that high PIG11 expression was negatively associated with ce...

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PIG11 over-expression predicts good prognosis and induces HepG2 cell apoptosis via reactive oxygen species-dependent mitochondrial pathway

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